499 research outputs found
Haemorrhagic pseudocyst of the pancreatic tail causing acute abdominal pain in a 12-year-old girl
Pancreatic disorders are a relatively uncommon event in children, particularly the development of pancreatic pseudocysts. The most common cause for the development of such pseudocysts is blunt abdominal trauma with injury of the pancreatic parenchyma. Further aetiologies include congenital anomalies of the pancreatic duct such as pancreatic divisum, hereditary or idiopathic pancreatitis. Various treatment options for pancreatic pseudocysts including internal or external drainage have been described. We describe the case of a 12-year-old girl with acute abdominal pain and a left-sided retroperitoneal tumour. She underwent laparotomy to identify the aetiology of her severe abdominal pain. A haemorrhagic pancreatic pseudocyst was identified as the underlying pathology. Internal drainage by pseudocyst jejunostomy was performed. The postoperative course was uneventful. The underlying aetiology of the pseudocyst remains unclear. As there was no previous history of pancreatitis, unrecognized blunt trauma was the most likely cause.Keywords: childhood, haemorrhage, pancreatic pseudocyst, retroperitoneal tumou
Psychosocial Stress and Prostate Cancer: A Theoretical Model
African-American men are more likely to develop and die from prostate cancer than are European-American men; yet, factors responsible for the racial disparity in incidence and mortality have not been elucidated. Socioeconomic disadvantage can lead to psychosocial stress and may be linked to negative lifestyle behaviors. Regardless of socioeconomic position, African-American men routinely experience racism-induced stress. We propose a theoretical framework for an association between psychosocial stress and prostate cancer. With the context of history and culture, we further propose that psychosocial stress may partially explain the variable incidence of prostate cancer between these diverse groups. Psychosocial stress may negatively impact teh immune system leaving the individual susceptible to malingnancies. Behavioral responses to psychosocial stress are amenable to change. If psychosocial stress is found to negatively impact prostate cancer risk, interventions may be designed to modify reactions to environmental demands
Comparison of breast and bowel cancer screening uptake patterns in a common cohort of South Asian women in England
Background: Inequalities in uptake of cancer screening by ethnic minority populations are well documented in a
number of international studies. However, most studies to date have explored screening uptake for a single cancer
only. This paper compares breast and bowel cancer screening uptake for a cohort of South Asian women invited to
undertake both, and similarly investigates these women's breast cancer screening behaviour over a period of fifteen
years.
Methods: Screening data for rounds 1, 2 and 5 (1989-2004) of the NHS breast cancer screening programme and for
round 1 of the NHS bowel screening pilot (2000-2002) were obtained for women aged 50-69 resident in the English
bowel screening pilot site, Coventry and Warwickshire, who had been invited to undertake breast and bowel cancer
screening in the period 2000-2002. Breast and bowel cancer screening uptake levels were calculated and compared
using the chi-squared test.
Results: 72,566 women were invited to breast and bowel cancer screening after exclusions. Of these, 3,539 were South
Asian and 69,027 non-Asian; 18,730 had been invited to mammography over the previous fifteen years (rounds 1 to 5).
South Asian women were significantly less likely to undertake both breast and bowel cancer screening; 29.9% (n =
1,057) compared to 59.4% (n = 40,969) for non-Asians (p < 0.001). Women in both groups who consistently chose to
undertake breast cancer screening in rounds 1, 2 and 5 were more likely to complete round 1 bowel cancer screening.
However, the likelihood of completion of bowel cancer screening was still significantly lower for South Asians; 49.5% vs.
82.3% for non-Asians, p < 0.001. South Asian women who undertook breast cancer screening in only one round were
no more likely to complete bowel cancer screening than those who decided against breast cancer screening in all
three rounds. In contrast, similar women in the non-Asian population had an increased likelihood of completing the
new bowel cancer screening test. The likelihood of continued uptake of mammography after undertaking screening in
round 1 differed between South Asian religio-linguistic groups. Noticeably, women in the Muslim population were less
likely to continue to participate in mammography than those in other South Asian groups.
Conclusions: Culturally appropriate targeted interventions are required to reduce observed disparities in cancer
screening uptakes
A luminosity monitor for the A4 parity violation experiment at MAMI
A water Cherenkov luminosity monitor system with associated electronics has
been developed for the A4 parity violation experiment at MAMI. The detector
system measures the luminosity of the hydrogen target hit by the MAMI electron
beam and monitors the stability of the liquid hydrogen target. Both is required
for the precise study of the count rate asymmetries in the scattering of
longitudinally polarized electrons on unpolarized protons. Any helicity
correlated fluctuation of the target density leads to false asymmetries. The
performance of the luminosity monitor, investigated in about 2000 hours with
electron beam, and the results of its application in the A4 experiment are
presented.Comment: 22 pages, 12 figures, submitted to NIM
Property and Shape Modulation of Carbon Fibers Using Lasers
An exciting challenge is to create
unduloid-reinforcing fibers
with tailored dimensions to produce synthetic composites with improved
toughness and increased ductility. Continuous carbon fibers, the state-of-the-art
reinforcement for structural composites, were modified via controlled
laser irradiation to result in expanded outwardly tapered regions,
as well as fibers with Q-tip (cotton-bud) end shapes. A pulsed laser
treatment was used to introduce damage at the single carbon fiber
level, creating expanded regions at predetermined points along the
lengths of continuous carbon fibers, while maintaining much of their
stiffness. The range of produced shapes was quantified and correlated
to single fiber tensile properties. Mapped Raman spectroscopy was
used to elucidate the local compositional and structural changes.
Irradiation conditions were adjusted to create a swollen weakened
region, such that fiber failure occurred in the laser treated region
producing two fiber ends with outwardly tapered ends. Loading the
tapered fibers allows for viscoelastic energy dissipation during fiber
pull-out by enhanced friction as the fibers plough through a matrix.
In these tapered fibers, diameters were locally increased up to 53%,
forming outward taper angles of up to 1.8°. The tensile strength
and strain to failure of the modified fibers were significantly reduced,
by 75% and 55%, respectively, ensuring localization of the break in
the expanded region; however, the fiber stiffness was only reduced
by 17%. Using harsher irradiation conditions, carbon fibers were completely
cut, resulting in cotton-bud fiber end shapes. Single fiber pull-out
tests performed using these fibers revealed a 6.75-fold increase in
work of pull-out compared to pristine carbon fibers. Controlled laser
irradiation is a route to modify the shape of continuous carbon fibers
along their lengths, as well as to cut them into controlled lengths
leaving tapered or cotton-bud shapes
Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer.
The recognition that colorectal cancer (CRC) is a heterogeneous disease in terms of clinical behaviour and response to therapy translates into an urgent need for robust molecular disease subclassifiers that can explain this heterogeneity beyond current parameters (MSI, KRAS, BRAF). Attempts to fill this gap are emerging. The Cancer Genome Atlas (TGCA) reported two main CRC groups, based on the incidence and spectrum of mutated genes, and another paper reported an EMT expression signature defined subgroup. We performed a prior free analysis of CRC heterogeneity on 1113 CRC gene expression profiles and confronted our findings to established molecular determinants and clinical, histopathological and survival data. Unsupervised clustering based on gene modules allowed us to distinguish at least five different gene expression CRC subtypes, which we call surface crypt-like, lower crypt-like, CIMP-H-like, mesenchymal and mixed. A gene set enrichment analysis combined with literature search of gene module members identified distinct biological motifs in different subtypes. The subtypes, which were not derived based on outcome, nonetheless showed differences in prognosis. Known gene copy number variations and mutations in key cancer-associated genes differed between subtypes, but the subtypes provided molecular information beyond that contained in these variables. Morphological features significantly differed between subtypes. The objective existence of the subtypes and their clinical and molecular characteristics were validated in an independent set of 720 CRC expression profiles. Our subtypes provide a novel perspective on the heterogeneity of CRC. The proposed subtypes should be further explored retrospectively on existing clinical trial datasets and, when sufficiently robust, be prospectively assessed for clinical relevance in terms of prognosis and treatment response predictive capacity. Original microarray data were uploaded to the ArrayExpress database (http://www.ebi.ac.uk/arrayexpress/) under Accession Nos E-MTAB-990 and E-MTAB-1026. © 2013 Swiss Institute of Bioinformatics. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland
Evolution in random fitness landscapes: the infinite sites model
We consider the evolution of an asexually reproducing population in an
uncorrelated random fitness landscape in the limit of infinite genome size,
which implies that each mutation generates a new fitness value drawn from a
probability distribution . This is the finite population version of
Kingman's house of cards model [J.F.C. Kingman, \textit{J. Appl. Probab.}
\textbf{15}, 1 (1978)]. In contrast to Kingman's work, the focus here is on
unbounded distributions which lead to an indefinite growth of the
population fitness. The model is solved analytically in the limit of infinite
population size and simulated numerically for finite . When
the genome-wide mutation probability is small, the long time behavior of
the model reduces to a point process of fixation events, which is referred to
as a \textit{diluted record process} (DRP). The DRP is similar to the standard
record process except that a new record candidate (a number that exceeds all
previous entries in the sequence) is accepted only with a certain probability
that depends on the values of the current record and the candidate. We develop
a systematic analytic approximation scheme for the DRP. At finite the
fitness frequency distribution of the population decomposes into a stationary
part due to mutations and a traveling wave component due to selection, which is
shown to imply a reduction of the mean fitness by a factor of compared to
the limit.Comment: Dedicated to Thomas Nattermann on the occasion of his 60th birthday.
Submitted to JSTAT. Error in Section 3.2 was correcte
Measurement of the Transverse Beam Spin Asymmetry in Elastic Electron Proton Scattering and the Inelastic Contribution to the Imaginary Part of the Two-Photon Exchange Amplitude
We report on a measurement of the asymmetry in the scattering of transversely
polarized electrons off unpolarized protons, A, at two Q values of
\qsquaredaveragedlow (GeV/c) and \qsquaredaveragedhighII (GeV/c) and a
scattering angle of . The measured transverse
asymmetries are A(Q = \qsquaredaveragedlow (GeV/c)) =
(\experimentalasymmetry alulowcorr \statisticalerrorlow
\combinedsyspolerrorlowalucor) 10 and
A(Q = \qsquaredaveragedhighII (GeV/c)) = (\experimentalasymme
tryaluhighcorr \statisticalerrorhigh
\combinedsyspolerrorhighalucor) 10. The first
errors denotes the statistical error and the second the systematic
uncertainties. A arises from the imaginary part of the two-photon
exchange amplitude and is zero in the one-photon exchange approximation. From
comparison with theoretical estimates of A we conclude that
N-intermediate states give a substantial contribution to the imaginary
part of the two-photon amplitude. The contribution from the ground state proton
to the imaginary part of the two-photon exchange can be neglected. There is no
obvious reason why this should be different for the real part of the two-photon
amplitude, which enters into the radiative corrections for the Rosenbluth
separation measurements of the electric form factor of the proton.Comment: 4 figures, submitted to PRL on Oct.
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A day in the life of mitochondria reveals shifting workloads
Mitochondria provide energy for cellular function. We examine daily changing patterns of mitochondrial function and metabolism in Drosophila in vivo in terms of their complex (I-IV) activity, ATP production, glycolysis, and whole fly respiration in the morning, afternoon and night. Complex activity and respiration showed significant and unexpected variation, peaking in the afternoon. However, ATP levels by contrast are >40% greater in the morning and lowest at night when glycolysis peaks. Complex activity modulation was at the protein level with no evidence for differential transcription over the day. Timing differences between increased ATP production and peaks of complex activity may result from more efficient ATP production early in the day leaving complex activity with spare capacity. Optical stimulation of mitochondria is only possible in the mornings when there is such spare capacity.
These results provide first evidence of shifts in cellular energy capacity at the organism level. Understanding their translation may be significant to the chosen timing of energy demanding interventions to improve function and health
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