Thomas-Fermi approximation to static vortex states in superfluid trapped atomic gases

We revise the Thomas-Fermi approximation for describing vortex states in Bose condensates of magnetically trapped atoms. Our approach is based on considering the hbar -> 0 limit rather than the N -> infinity limit as Thomas-Fermi approximation in close analogy with the Fermi systems. Even for relatively small numbers of trapped particles we find good agreement between Gross-Pitaevskii and Thomas-Fermi calculations for the different contributions to the total energy of the atoms in the condensate. We also discuss the application of our approach to the description of vortex states in superfluid fermionic systems in the Ginzburg-Landau regime.Comment: 11 pages, 6 figures, revtex4, substantially revised versio

Semi-Classical Description of the Average Pairing Properties in Nuclei

We present a new semi-classical theory for describing pairing in finite Fermi systems. It is based in taking the $\hbar \to 0$, i.e. Thomas-Fermi, limit of the gap equation written in the basis of the mean field (weak coupling). In addition to the position dependence of the Fermi momentum, the size dependence of the matrix elements of the pairing force is also taken into account in this theory. An example typical for the nuclear situation shows the improvement of this new approach over the standard Local Density Approximation. We also show that if in this approach some shell fluctuations are introduced in the level density, the arch structure displayed by the quantal gaps along isotopic chains is almost recovered. We also point out that in heavy drip line nuclei pairing is strongly reduced

Access to diagnosis and treatment of Chagas disease/infection in endemic and non-endemic countries in the XXI century.

In this article, Médicos Sin Fronteras (MSF) Spain faces the challenge of selecting, piecing together, and conveying in the clearest possible way, the main lessons learnt over the course of the last seven years in the world of medical care for Chagas disease. More than two thousand children under the age of 14 have been treated; the majority of whom come from rural Latin American areas with difficult access. It is based on these lessons learnt, through mistakes and successes, that MSF advocates that medical care for patients with Chagas disease be a reality, in a manner which is inclusive (not exclusive), integrated (with medical, psychological, social, and educational components), and in which the patient is actively followed. This must be a multi-disease approach with permanent quality controls in place based on primary health care (PHC). Rapid diagnostic tests and new medications should be available, as well as therapeutic plans and patient management (including side effects) with standardised flows for medical care for patients within PHC in relation to secondary and tertiary level, inclusive of epidemiological surveillance systems

Deriving a Provisional Tolerable Intake for Intravenous Exposure to Silver Nanoparticles Released from Medical Devices

Silver nanoparticles (AgNP) are incorporated into medical devices for their anti-microbial characteristics. The potential exposure and toxicity of AgNPs is unknown due to varying physicochemical particle properties and lack of toxicological data. The aim of this safety assessment is to derive a provisional tolerable intake (pTI) value for AgNPs released from blood-contacting medical devices. A literature review of in vivo studies investigating critical health effects induced from intravenous (i. v.) exposure to AgNPs was evaluated by the Annapolis Accords principles and Toxicological Data Reliability Assessment Tool (ToxRTool). The point of departure (POD) was based on an i. v. 28-day repeated AgNP (20 nm) dose toxicity study reporting an increase in relative spleen weight in rats with a 5% lower confidence bound of the benchmark dose (BMDL05) of 0.14 mg/kg bw/day. The POD was extrapolated to humans by a modifying factor of 1,000 to account for intraspecies variability, interspecies differences and lack of long-term toxicity data. The pTI for long-term i. v. exposure to 20 nm AgNPs released from blood-contacting medical devices was 0.14 μg/kg bw/day. This pTI may not be appropriate for nanoparticles of other physicochemical properties or routes of administration. The methodology is appropriate for deriving pTIs for nanoparticles in general

Application of Laser Welding in Car Bodies Manufacturing

The paper deals with a problem of laser welding of zinc-coated steel (DX53D+Z and DX54D+Z) plates. Experiments were carried out with the use of steel plates 0.8; 1.0; 1.3; and 1.75 mm thick. High power 2.5-2.9 kW CO[2] laser was employed. CO[2] was used as the shielded gas. The optimal parameters of welding for material under study were determined. The mechanical properties of welded joints were measured through the tensile loading and microhardness measurement. Tensile performances of the specimens fabricated at different welding rate and laser beam power were compared with that of the base material

Closed-loop control of continuous piperacillin delivery: an in silico study

Background and objective: Sub-therapeutic dosing of piperacillin-tazobactam in critically-ill patients is associated with poor clinical outcomes and may promote the emergence of drug-resistant infections. In this paper, an in silico investigation of whether closed-loop control can improve pharmacokinetic-pharmacodynamic (PK-PD) target attainment is described. Method: An in silico platform was developed using PK data from 20 critically-ill patients receiving piperacillin-tazobactam where serum and tissue interstitial fluid (ISF) PK were defined. Intra-day variability on renal clearance, ISF sensor error, and infusion constraints were taken into account. Proportional-integral-derivative (PID) control was selected for drug delivery modulation. Dose adjustment was made based on ISF sensor data with a 30-minute sampling period, targeting a serum piperacillin concentration between 32-64 mg/L. A single tuning parameter set was employed across the virtual population. The PID controller was compared to standard therapy, including bolus and continuous infusion of piperacillin-tazobactam. Results: Despite significant inter-subject and simulated intra-day PK variability and sensor error, PID demonstrated a significant improvement in target attainment compared to traditional bolus and continuous infusion approaches. Conclusion: A PID controller driven by ISF drug concentration measurements has the potential to precisely deliver piperacillin-tazobactam in critically-ill patients undergoing treatment for sepsis

Personalized Optical Designs and Manipulating Optics: Applications on the Anterior Segment of the Eye

The image-forming properties of the eye can be described in terms of wave aberration. Understanding the link between aberrations and the anterior segment geometry is therefore of crucial importance for (i) comprehending how the eye works, (ii) modelling the optics of individual eyes, (iii) optimizing optical solutions, or (iv) designing surgical strategies. The eye has many innate adaptations that minimize optical aberrations. In most normal young eyes, the magnitude of aberrations of the cornea is significantly larger than for the whole eye, indicating a significant role of the crystalline lens in compensating corneal aberrations. However, due to geometrical and structural changes, this ocular compensation gets disturbed in different anterior segment conditions, such as keratoconus, presbyopia, or cataract. Keratoconus progressively degrades the corneal shape and, consequently, vision in the adolescence, with a prevalence of 0.05% in the general population. Meanwhile, presbyopia and cataract are conditions related to aging that affect the structure of the crystalline lens, one referring to a loss in accommodative amplitude (presbyopia) and the other to a progressive loss of transparency (cataract). Presbyopia affects 100% of the population older than 45¿years of age, ..

Whistler Waves Driven by Anisotropic Strahl Velocity Distributions: Cluster Observations

Observed properties of the strahl using high resolution 3D electron velocity distribution data obtained from the Cluster/PEACE experiment are used to investigate its linear stability. An automated method to isolate the strahl is used to allow its moments to be computed independent of the solar wind core+halo. Results show that the strahl can have a high temperature anisotropy (T(perpindicular)/T(parallell) approximately > 2). This anisotropy is shown to be an important free energy source for the excitation of high frequency whistler waves. The analysis suggests that the resultant whistler waves are strong enough to regulate the electron velocity distributions in the solar wind through pitch-angle scatterin

Cooper pair sizes in 11Li and in superfluid nuclei: a puzzle?

We point out a strong influence of the pairing force on the size of the two neutron Cooper pair in $^{11}$Li, and to a lesser extent also in $^6$He. It seems that these are quite unique situations, since Cooper pair sizes of stable superfluid nuclei are very little influenced by the intensity of pairing, as recently reported. We explore the difference between $^{11}$Li and heavier superfulid nuclei, and discuss reasons for the exceptional situation in $^{11}$Li.Comment: 9 pages. To be published in J. of Phys. G special issue on Open Problems in Nuclear Structure (OPeNST