8 research outputs found
Questioni di diritto sostanziale e tributario connesse al riconoscimento del trust nell'ordinamento italiano. Parte seconda
in "Fiducia e trust" n. 2/2002, allegato a "Il fisco" n. 34/200
The human cytomegalovirus US27 gene product enhances cell proliferation and alters cellular gene expression
The US27 gene product of human cytomegalovirus enhances signaling of host chemokine receptor CXCR4
Chemokine receptor oligomerization to tweak chemotactic responses
Chemokine receptors guide cell migration by responding to local chemokine gradients during immune surveillance and inflammation. Similar to other G protein-coupled receptors, chemokine receptors can form oligomeric complexes that might have distinct pharmacological and biochemical properties as compared to their individual constituents. The majority of evidence for chemokine receptor oligomers came from transfected cells using tagged receptors to monitor their close proximity or physical association. However, translation of these observations to (patho)-physiological consequences is puzzling for the majority of chemokine receptor oligomers due to experimental limitations and challenges to distinguish oligomer- from downstream signaling-mediated crosstalk. Recent methodological advances allow in situ validation of chemokine receptor oligomers in native cells, disruption of oligomers, and detection of oligomer-mediated signaling. Chemokine receptor oligomerization modulates cell migration in (patho)-physiology and consequently offers novel therapeutic targets