Warfare in New Guinea a comparative study: a comparative study

Nearly all anthropologists who work in New Guinea comment upon the importance of warfare in the life of the people. This thesis attempts to make a comparative study of primitive war in New Guinea and trace the significance of certain military characteristics in native society. The subject matter of the thesis is divided up into four chapters. The first chapter is a discussion of the comparative method and anthropological theory relating to a study of warfare. After Malinowski (1941), war is defined as organized hostility with the aim of political gain. Primitive war is distinguished from advanced war because in the former, political aims are implicit and war sometimes occurs for reasons which are not political, whereas in the latter, the political aim is always explicit. The second chapter is a discussion of ecological theories which relate to primitive war. The suggestions of "cultural ecologists" (Vayda 1961, 1971: Rappaport 1968), that people fight when their population density increases and they suffer a shortage of resources, are tested with ecological material, demographic information and ethnographic examples. The conclusion of this chapter is that few wars in New Guinea can be explained by ecological factors alone. The third chapter is a discussion of social organization and war. The argument of this chapter is divided up into three parts. Firstly, an outline of the concepts and a definition of the terms used in the survey. Secondly, a series of twenty seven ethnographic examples accompanied by diagrams of political and descent group organization, and the fields of war. Thirdly, a comparative analysis of war and social organization facilitated by a series of computer programmes. The argument of this chapter, following the political criteria stipulated for war in the first chapter, is that war in New Guinea is basically a struggle between small political factions led by big men. The fourth chapter is a discussion of primitive military organization. This analysis is based on a series of military principles suggested by Turney-High (1949) and concludes with a comparative study of military organization and the different types of war discussed in the previous chapter

After the 'affluent society' : cost of living in the Papua New Guinea highlands according to time and energy expenditure- income

What is the cost of living in the Papua New Guinea highlands? An answer is sought using a time and energy accounting approach. The subsistence regime of Wola-speaking highlanders, the subjects of this investigation, comprises three components. The principal one is horticulture: people clearing gardens from forest and grassland, with tuberous crops predominating, notably sweet potato. The second component comprises animal rearing, notably of domestic pigs. The third, and least important, is hunting and gathering for food in the forest. The calculated returns on investments in these subsistence domains vary considerably. Gardens return in their crops between ten and fifteen times the energy expended in cultivation. Pigs may also give a good return, of four to five times the energy invested in rearing them, if slaughtered when adult, but people regularly keep animals for years and may incur negative energy returns on their labour investments. This relates to the high cultural premium put on pigs. Foraging for food is also energetically costly, the Wola expending four times more energy on these activities than they gain in return from the food they secure. This analysis of energy gains and losses challenges the relative notion of affluence as applied to foragers, by reviewing it in the comparative context of subsistence horticulture

Implementation of e-science tools for complex analysis of human-environmental interaction

An e-science approach allows the integration of different data types to develop coherent analyses of past and expected impacts of natural and human caused environmental change and the corresponding impact on human population structures. Demographic analyses have been possible for some time both with and without the aid of computational tools, however, the implementation of e-science tools allow a more dynamic manipulation of scenarios drawing on actual social, economic and demographic data and correlating that with GIS spatial data. The resulting implementation allows us to generate 'snapshots' in time to reconstruct the impact of past events or hypothetical events. In this way, we can test the feasibility of data extraction from diverse data sources produced for different research programs in different disciplines. The research is driven not by an interest in technological development, but rather as one part of a general strategy designed to inform policy decisions in a situation with a number of methodological and practical constraints

Arduino based configurable LED stimulus design for multi-frequency SSVEP-BCI

Steady state visually evoked potentials (SSVEP) are extensively used in the research of brain-computer interface (BCI) and require a configurable light source flashing at different frequencies. Precise control of simultaneous multiple frequencies are essential for SSVEP studies and also for reducing the visual fatigue. Instead of LCD based stimulus which requires more resources and power, light emitting diodes (LEDs) are used as a light source as they are energy efficient, consume lower power, have higher contrast, less tiring visually, have multi-chromatic function and supports wider frequency ranges. In this paper, we propose a visual stimulator using off-shelf components to build a simple and yet customisable LED stimulus for testing the performance and qualitative user comfort using SSVEP electroencephalogram (EEG) data

Quantification of SSVEP responses using multi-chromatic LED stimuli: Analysis on colour, orientation and frequency

Most LED visual stimulators used in steady state visual evoked potential (SSVEP) brain-computer interface (BCI) use single LED sources to elicit SSVEP responses. In this study, we tested the hypothesis that different orientations would have different responses in different participants and aimed to develop a portable LED based stimulus design which consists of a small number of RGB LEDs arranged in a line which can be oriented horizontally or vertically. The colour and frequency of the flicker were controlled by a portable microcontroller platform. The study investigated the performance of the SSVEP from five participants when the LED stimulus was displayed vertically and horizontally for a period of 30 seconds. The frequency range used was from 7 Hz to 11 Hz with three primary colours: red, green and blue in both orientations. Furthermore, we also compared the effect of vertical and horizontal orientations using four different frequencies and three colours to test visual fatigue reduction. The results of the analysis using band-pass filtering and Fast Fourier Transform showed that the green horizontal LED stimulus orientation gave the highest response and viewing comfort in all the participants rather than the vertical orientation

Shaping Diversity Into the Brain’s Form and Function

The brain contains a large diversity of unique cell types that use specific genetic programs to control development and instruct the intricate wiring of sensory, motor, and cognitive brain regions. In addition to their cellular diversity and specialized connectivity maps, each region’s dedicated function is also expressed in their characteristic gross external morphologies. The folds on the surface of the cerebral cortex and cerebellum are classic examples. But, to what extent does structure relate to function and at what spatial scale? We discuss the mechanisms that sculpt functional brain maps and external morphologies. We also contrast the cryptic structural defects in conditions such as autism spectrum disorders to the overt microcephaly after Zika infections, taking into consideration that both diseases disrupt proper cognitive development. The data indicate that dynamic processes shape all brain areas to fit into jigsaw-like patterns. The patterns in each region reflect circuit connectivity, which ultimately supports local signal processing and accomplishes multi-areal integration of information processing to optimize brain functions

CATH: an expanded resource to predict protein function through structure and sequence

The latest version of the CATH-Gene3D protein structure classification database has recently been released (version 4.1, http://www.cathdb.info). The resource comprises over 300 000 domain structures and over 53 million protein domains classified into 2737 homologous superfamilies, doubling the number of predicted protein domains in the previous version. The daily-updated CATH-B, which contains our very latest domain assignment data, provides putative classifications for over 100 000 additional protein domains. This article describes developments to the CATH-Gene3D resource over the last two years since the publication in 2015, including: significant increases to our structural and sequence coverage; expansion of the functional families in CATH; building a support vector machine (SVM) to automatically assign domains to superfamilies; improved search facilities to return alignments of query sequences against multiple sequence alignments; the redesign of the web pages and download site

The Gene3D Web Services: a platform for identifying, annotating and comparing structural domains in protein sequences

The Gene3D structural domain database provides domain annotations for 7 million proteins, based on the manually curated structural domain superfamilies in CATH. These annotations are integrated with functional, genomic and molecular information from external resources, such as GO, EC, UniProt and the NCBI Taxonomy database. We have constructed a set of web services that provide programmatic access to this integrated database, as well as the Gene3D domain recognition tool (Gene3DScan) and protein sequence annotation pipeline for analysing novel protein sequences. Example queries include retrieving all curated GO terms for a domain superfamily or all the multi-domain architectures for the human genome. The services can be accessed using simple HTTP calls and are able to return results in a range of formats for quick downloading and easy parsing, graphical rendering and data storage. Hence, they provide a simple, but flexible means of integrating domain annotations and associated data sets into locally run pipelines and analysis software. The services can be found at http://gene3d.biochem.ucl.ac.uk/WebServices/

Gene3D: expanding the utility of domain assignments

Gene3D http://gene3d.biochem.ucl.ac.uk is a database of domain annotations of Ensembl and UniProtKB protein sequences. Domains are predicted using a library of profile HMMs representing 2737 CATH superfamilies. Gene3D has previously featured in the Database issue of NAR and here we report updates to the website and database. The current Gene3D (v14) release has expanded its domain assignments to ∼20 000 cellular genomes and over 43 million unique protein sequences, more than doubling the number of protein sequences since our last publication. Amongst other updates, we have improved our Functional Family annotation method. We have also improved the quality and coverage of our 3D homology modelling pipeline of predicted CATH domains. Additionally, the structural models have been expanded to include an extra model organism (Drosophila melanogaster). We also document a number of additional visualization tools in the Gene3D website

KinFams: De-Novo Classification of Protein Kinases Using CATH Functional Units

Protein kinases are important targets for treating human disorders, and they are the second most targeted families after G-protein coupled receptors. Several resources provide classification of kinases into evolutionary families (based on sequence homology); however, very few systematically classify functional families (FunFams) comprising evolutionary relatives that share similar functional properties. We have developed the FunFam-MARC (Multidomain ARchitecture-based Clustering) protocol, which uses multi-domain architectures of protein kinases and specificity-determining residues for functional family classification. FunFam-MARC predicts 2210 kinase functional families (KinFams), which have increased functional coherence, in terms of EC annotations, compared to the widely used KinBase classification. Our protocol provides a comprehensive classification for kinase sequences from >10,000 organisms. We associate human KinFams with diseases and drugs and identify 28 druggable human KinFams, i.e., enriched in clinically approved drugs. Since relatives in the same druggable KinFam tend to be structurally conserved, including the drug-binding site, these KinFams may be valuable for shortlisting therapeutic targets. Information on the human KinFams and associated 3D structures from AlphaFold2 are provided via our CATH FTP website and Zenodo. This gives the domain structure representative of each KinFam together with information on any drug compounds available. For 32% of the KinFams, we provide information on highly conserved residue sites that may be associated with specificity.Adeyelu T, Bordin N, Waman VP, Sadlej M, Sillitoe I, Moya-Garcia AA, Orengo CA. KinFams: De-Novo Classification of Protein Kinases Using CATH Functional Units. Biomolecules. 2023; 13(2):277. https://doi.org/10.3390/biom1302027