2,275 research outputs found
Non-contrast renal magnetic resonance imaging to assess perfusion and corticomedullary differentiation in health and chronic kidney disease
AIMS
Arterial spin labelling (ASL) MRI measures perfusion without administration of contrast agent. While ASL has been validated in animals and healthy volunteers (HVs), application to chronic kidney disease (CKD) has been limited. We investigated the utility of ASL MRI in patients with CKD.
METHODS
We studied renal perfusion in 24 HVs and 17 patients with CKD (age 22-77 years, 40% male) using ASL MRI at 3.0T. Kidney function was determined using estimated glomerular filtration rate (eGFR). T1 relaxation time was measured using modified look-locker inversion and xFB02;ow-sensitive alternating inversion recovery true-fast imaging and steady precession was performed to measure cortical and whole kidney perfusion.
RESULTS
T1 was higher in CKD within cortex and whole kidney, and there was association between T1 time and eGFR. No association was seen between kidney size and volume and either T1, or ASL perfusion. Perfusion was lower in CKD in cortex (136 ± 37 vs. 279 ± 69 ml/min/100 g; p < 0.001) and whole kidney (146 ± 24 vs. 221 ± 38 ml/min/100 g; p < 0.001). There was significant, negative, association between T1 longitudinal relaxation time and ASL perfusion in both the cortex (r = -0.75, p < 0.001) and whole kidney (r = -0.50, p < 0.001). There was correlation between eGFR and both cortical (r = 0.73, p < 0.01) and whole kidney (r = 0.69, p < 0.01) perfusion.
CONCLUSIONS
Significant differences in renal structure and function were demonstrated using ASL MRI. T1 may be representative of structural changes associated with CKD; however, further investigation is required into the pathological correlates of reduced ASL perfusion and increased T1 time in CKD
Generation of degenerate, factorizable, pulsed squeezed light at telecom wavelengths
We characterize a periodically poled KTP crystal that produces an entangled,
two-mode, squeezed state with orthogonal polarizations, nearly identical,
factorizable frequency modes, and few photons in unwanted frequency modes. We
focus the pump beam to create a nearly circular joint spectral probability
distribution between the two modes. After disentangling the two modes, we
observe Hong-Ou-Mandel interference with a raw (background corrected)
visibility of 86 % (95 %) when an 8.6 nm bandwidth spectral filter is applied.
We measure second order photon correlations of the entangled and disentangled
squeezed states with both superconducting nanowire single-photon detectors and
photon-number-resolving transition-edge sensors. Both methods agree and verify
that the detected modes contain the desired photon number distributions
Sub-mm detection of a high redshift Type 2 QSO
We report on the first SCUBA detection of a Type 2 QSO at z=3.660 in the
Chandra Deep Field South. This source is X-ray absorbed, shows only narrow
emission lines in the optical spectrum and is detected in the sub-mm: it is the
ideal candidate in an evolution scheme for AGN (e.g. Fabian (1999); Page et al.
(2004)) of an early phase corresponding to the main growth of the host galaxy
and formation of the central black hole. The overall photometry (from the radio
to the X-ray energy band) of this source is well reproduced by the spectral
energy distribution (SED) of NGC 6240, while it is incompatible with the
spectrum of a Type 1 QSO (3C273) or a starburst galaxy (Arp 220). Its sub-mm
(850 \mu m) to X-ray (2 keV) spectral slope (alpha_SX) is close to the
predicted value for a Compton-thick AGN in which only 1% of the nuclear
emission emerges through scattering. Using the observed flux at 850 \mu m we
have derived a SFR=550--680 M_dust=4.2 10^8 M_odotComment: 6 Pages, 5 Figures, accepted for publication in MNRA
CCAT-prime: Science with an Ultra-widefield Submillimeter Observatory at Cerro Chajnantor
We present the detailed science case, and brief descriptions of the telescope
design, site, and first light instrument plans for a new ultra-wide field
submillimeter observatory, CCAT-prime, that we are constructing at a 5600 m
elevation site on Cerro Chajnantor in northern Chile. Our science goals are to
study star and galaxy formation from the epoch of reionization to the present,
investigate the growth of structure in the Universe, improve the precision of
B-mode CMB measurements, and investigate the interstellar medium and star
formation in the Galaxy and nearby galaxies through spectroscopic,
polarimetric, and broadband surveys at wavelengths from 200 um to 2 mm. These
goals are realized with our two first light instruments, a large field-of-view
(FoV) bolometer-based imager called Prime-Cam (that has both camera and an
imaging spectrometer modules), and a multi-beam submillimeter heterodyne
spectrometer, CHAI. CCAT-prime will have very high surface accuracy and very
low system emissivity, so that combined with its wide FoV at the unsurpassed
CCAT site our telescope/instrumentation combination is ideally suited to pursue
this science. The CCAT-prime telescope is being designed and built by Vertex
Antennentechnik GmbH. We expect to achieve first light in the spring of 2021.Comment: Presented at SPIE Millimeter, Submillimeter, and Far-Infrared
Detectors and Instrumentation for Astronomy IX, June 14th, 201
Deep 1.1 mm-wavelength imaging of the GOODS-S field by AzTEC/ASTE - I. Source catalogue and number counts
[Abridged] We present the first results from a 1.1 mm confusion-limited map
of the GOODS-S field taken with AzTEC on the ASTE telescope. We imaged a 270
sq. arcmin field to a 1\sigma depth of 0.48 - 0.73 mJy/beam, making this one of
the deepest blank-field surveys at mm-wavelengths ever achieved. Although our
GOODS-S map is extremely confused, we demonstrate that our source
identification and number counts analyses are robust, and the techniques
discussed in this paper are relevant for other deeply confused surveys. We find
a total of 41 dusty starburst galaxies with S/N >= 3.5 within this uniformly
covered region, where only two are expected to be false detections. We derive
the 1.1mm number counts from this field using both a "P(d)" analysis and a
semi-Bayesian technique, and find that both methods give consistent results.
Our data are well-fit by a Schechter function model with (S', N(3mJy), \alpha)
= (1.30+0.19 mJy, 160+27 (mJy/deg^2)^(-1), -2.0). Given the depth of this
survey, we put the first tight constraints on the 1.1 mm number counts at
S(1.1mm) = 0.5 mJy, and we find evidence that the faint-end of the number
counts at S(850\mu m) < 2.0 mJy from various SCUBA surveys towards lensing
clusters are biased high. In contrast to the 870 \mu m survey of this field
with the LABOCA camera, we find no apparent under-density of sources compared
to previous surveys at 1.1 mm. Additionally, we find a significant number of
SMGs not identified in the LABOCA catalogue. We find that in contrast to
observations at wavelengths < 500 \mu m, MIPS 24 \mu m sources do not resolve
the total energy density in the cosmic infrared background at 1.1 mm,
demonstrating that a population of z > 3 dust-obscured galaxies that are
unaccounted for at these shorter wavelengths potentially contribute to a large
fraction (~2/3) of the infrared background at 1.1 mm.Comment: 21 pages, 9 figures. Accepted to MNRAS
Furthering alternative cultures of valuation in higher education research
The value of higher education is often implicit or assumed in educational research. The underlying and antecedent premises that shape and influence debates about value remain unchallenged which perpetuates the dominant, but limiting, terms of the debate and fosters reductionism. I proceed on the premise that analyses of value are not self–supporting or self-referential but are embedded within prevailing cultures of valuation. I contend that challenging, and providing alternatives to, dominant narratives of higher education requires an appreciation of those cultures. I therefore highlight some of the existing cultures of valuation and their influence. I then propose Sayer’s concept of lay normativity as a culture of valuation and discuss how it translates into the practices of research into higher education, specifically the practice of analysis. I animate the discussion by detecting the presence of lay normativity in the evaluative space of the capability approach
Nuclear spin driven quantum relaxation in LiY_0.998Ho_0.002F_4
Staircase hysteresis loops of the magnetization of a LiY_0.998Ho_0.002F_4
single crystal are observed at subkelvin temperatures and low field sweep
rates. This behavior results from quantum dynamics at avoided level crossings
of the energy spectrum of single Ho^{3+} ions in the presence of hyperfine
interactions. Enhanced quantum relaxation in constant transverse fields allows
the study of the relative magnitude of tunnel splittings. At faster sweep
rates, non-equilibrated spin-phonon and spin-spin transitions, mediated by weak
dipolar interactions, lead to magnetization oscillations and additional steps.Comment: 5 pages, 5 eps figures, using RevTe
Ultrafast optical generation of coherent phonons in CdTe1-xSex quantum dots
We report on the impulsive generation of coherent optical phonons in
CdTe0.68Se0.32 nanocrystallites embedded in a glass matrix. Pump probe
experiments using femtosecond laser pulses were performed by tuning the laser
central energy to resonate with the absorption edge of the nanocrystals. We
identify two longitudinal optical phonons, one longitudinal acoustic phonon and
a fourth mode of a mixed longitudinal-transverse nature. The amplitude of the
optical phonons as a function of the laser central energy exhibits a resonance
that is well described by a model based on impulsive stimulated Raman
scattering. The phases of the coherent phonons reveal coupling between
different modes. At low power density excitations, the frequency of the optical
coherent phonons deviates from values obtained from spontaneous Raman
scattering. This behavior is ascribed to the presence of electronic impurity
states which modify the nanocrystal dielectric function and, thereby, the
frequency of the infrared-active phonons
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