Topological Symmetries

We introduce the notion of a topological symmetry as a quantum mechanical symmetry involving a certain topological invariant. We obtain the underlying algebraic structure of the Z_2-graded uniform topological symmetries of type (1,1) and (2,1). This leads to a novel derivation of the algebras of supersymmetry and $p=2$ parasupersummetry.Comment: Plain LaTeX Ref: Mod. Phys. Lett. A 15, 175-184 (2000

Evaluation of bred fish and seawater fish in terms of nutritional value, and heavy metals

In many parts of the world consumption of fish and seafood comprises a key proportion of man's diet and health. Despite of having many benefits, eating fish can be dangerous for instance the existence of nonorganic material, especially heavy metals, in some fish is dangerous. There are numerous fish breeding pools across the Lorestan province of Iran and the majority of the people living in these areas consume these kinds of fish, so, we were impelled to carry out a study to compare the nutrients and also heavy metals existent in freshwater fish and seawater fish available to the public across Khorramabad city of Iran. In this cross-sectional study, 9 samples of each five species of freshwater and sea water fish were purchased and their total protein, fat, omega 3, 6, and 9 fatty acids and also their heavy metals content including mercury, lead and cadmium of them were measured. There were no significant differences between mean protein content of the two types of fish. The amount of total fat and omega 3, 6 and 9 fatty acids of freshwater fish was higher than of seawater fish (P>0.001). The levels of cadmium in seawater fish was significantly higher than freshwater fish (P>0.001), and as for the level of mercury and lead, no significant difference was observed between the two types of freshwater fish and seawater fish. According to the results, we recommend that people can secure a part of their protein and unsaturated fatty acids need by consuming freshwater fish

Cultural robotics : The culture of robotics and robotics in culture

Copyright 2013 Samani et al.; licensee InTech. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedIn this paper, we have investigated the concept of "Cultural Robotics" with regard to the evolution o social into cultural robots in the 21st Century. By defining the concept of culture, the potential development of culture between humans and robots is explored. Based on the cultural values of the robotics developers, and the learning ability of current robots, cultural attributes in this regard are in the process of being formed, which would define the new concept of cultural robotics. According to the importance of the embodiment of robots in the sense of presence, the influence of robots in communication culture is anticipated. The sustainability of robotics culture based on diversity for cultural communities for various acceptance modalities is explored in order to anticipate the creation of different attributes of culture between robot and humans in the futurePeer reviewe

Antioxidant activity and properties of walnut brown seed coat extract

To date, there are few studies about the properties of walnut brown seed coat. The antioxidant activity and properties of walnut brown seed coat was considered in this study and the amounts of carotenoids, chlorophylla, chlorophyllb, vitamin E were determined. The antioxidant activity was determined by cupric assay, DPPH, and measurement of oxidative stability in sunflower oil against Copper sulfate. Walnut brown seed coat at 1 was effective antioxidant in comparison to BHT in inhibition of lipid peroxidation. This extract presented the highest vitamin E level (1.4± 0.042 mg/g). DPPH assay showed the extract had the high radical scavenging ability. The results of this study showed the walnut brown seed coat possessed strong antioxidant properties in vitro, hence it might be beneficial in human health. © 2009-2016, JGPT

Pembelajaran Pengelasan Las Busur Listrik Berbasis Project Based Learning untuk Meningkatkan Keterampilan Berpikir Kritis dan Hasil Belajar Siswa

This research is an experimental research which aims to find the information of the students' critical thinking, affective learning outcomes, cognitive learning outcomes, psychomotor learning outcomes and response after the students's are given project-based learning. This research uses experimental research by using Quasi Experimental Design by using Time Series Design. The subjects of the research are eleventh grade students' of welding engineering skill of Vocational School 6 Samarinda, East Kalimantan in the odd semester of academic year of 2014/2015. There are 31 students'. The data is collected through pre-test and post-test to find the students' critical thinking skill, affective learning outcomes, cognitive learning outcomes, and psychomotor learning outcomes. The response questionnaire is used to find the interest, innovation, pleasure, easiness, clarity and students' interest to the learning process.The data is analyzed by using N-Gain descriptive analysis and t-Test. The result of the research shows that the research instrument which is used is valid. The result shows that the average students' critical thinking is in the high categorized > 0,70. The other result shows that the project based learning model gives the effect for the affective, cognitive, and psychomotor learning outcomes. Three of them are in the category of pass. The students' response in the project based learning is good. Based on the result, it can be concluded that project based learning for electric arc welding improve the critical thinking of vocational school and can make the students' pass the affective, cognitive, and psychomotor learning outcomes. Keywords: Project Based Learning, Critical Thinking Skill, Students' Learning Outcomes

Potential algebra approach to position dependent mass Schroedinger equation

It is shown that for a class of position dependent mass Schroedinger equation the shape invariance condition is equivalent to a potential symmetry algebra. Explicit realization of such algebras have been obtained for some shape invariant potentials

Chromosome 1p13 genetic variants antagonize the risk of myocardial infarction associated with high ApoB serum levels

PMCID: PMC3480949This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Polymorphisms in the WNK1 gene are asociated with blood pressure variation and urinary potassium excretion

WNK1 - a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control - is an excellent candidate gene for essential hypertension (EH). We and others have previously reported association between WNK1 and BP variation. Using tag SNPs (tSNPs) that capture 100% of common WNK1 variation in HapMap, we aimed to replicate our findings with BP and to test for association with phenotypes relating to WNK1 function in the British Genetics of Hypertension (BRIGHT) study case-control resource (1700 hypertensive cases and 1700 normotensive controls). We found multiple variants to be associated with systolic blood pressure, SBP (7/28 tSNPs min-p = 0.0005), diastolic blood pressure, DBP (7/28 tSNPs min-p = 0.002) and 24 hour urinary potassium excretion (10/28 tSNPs min-p = 0.0004). Associations with SBP and urine potassium remained significant after correction for multiple testing (p = 0.02 and p = 0.01 respectively). The major allele (A) of rs765250, located in intron 1, demonstrated the strongest evidence for association with SBP, effect size 3.14 mmHg (95%CI:1.23–4.9), DBP 1.9 mmHg (95%CI:0.7–3.2) and hypertension, odds ratio (OR: 1.3 [95%CI: 1.0–1.7]).We genotyped this variant in six independent populations (n = 14,451) and replicated the association between rs765250 and SBP in a meta-analysis (p = 7×10−3, combined with BRIGHT data-set p = 2×10−4, n = 17,851). The associations of WNK1 with DBP and EH were not confirmed. Haplotype analysis revealed striking associations with hypertension and BP variation (global permutation p10 mmHg reduction) and risk for hypertension (OR<0.60). Our data indicates that multiple rare and common WNK1 variants contribute to BP variation and hypertension, and provide compelling evidence to initiate further genetic and functional studies to explore the role of WNK1 in BP regulation and EH

Genetic Risk and Atrial Fibrillation in Patients with Heart Failure

Aims: To study the association between an atrial fibrillation (AF) genetic risk score with prevalent AF and all-cause mortality in patients with heart failure. Methods and results: An AF genetic risk score was calculated in 3759 European ancestry individuals (1783 with sinus rhythm, 1976 with AF) from the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF) by summing 97 single nucleotide polymorphism (SNP) alleles (ranging from 0–2) weighted by the natural logarithm of the relative SNP risk from the latest AF genome-wide association study. Further, we assessed AF risk variance explained by additive SNP variation, and performance of clinical or genetic risk factors, and the combination in classifying AF prevalence. AF was classified as AF or atrial flutter (AFL) at baseline electrocardiogram and/or a history of AF or AFL. The genetic risk score was associated with AF after multivariable adjustment. Odds ratio for AF prevalence per 1-unit increase genetic risk score was 2.12 (95% confidence interval 1.84–2.45, P = 2.15 × 10−24) in the total cohort, 2.08 (1.72–2.50, P = 1.30 × 10−14) in heart failure with reduced ejection fraction (HFrEF) and 2.02 (1.37–2.99, P = 4.37 × 10−4) in heart failure with preserved ejection fraction (HFpEF). AF-associated loci explained 22.9% of overall AF SNP heritability. Addition of the genetic risk score to clinical risk factors increased the C-index by 2.2% to 0.721. Conclusions: The AF genetic risk score was associated with increased AF prevalence in HFrEF and HFpEF. Genetic variation accounted for 22.9% of overall AF SNP heritability. Addition of genetic risk to clinical risk improved model performance in classifying AF prevalence

A network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic heart failure

Aims Heart failure (HF) is frequently caused by an ischaemic event (e.g. myocardial infarction) but might also be caused by a primary disease of the myocardium (cardiomyopathy). In order to identify targeted therapies specific for either ischaemic or non‐ischaemic HF, it is important to better understand differences in underlying molecular mechanisms. Methods and results We performed a biological physical protein–protein interaction network analysis to identify pathophysiological pathways distinguishing ischaemic from non‐ischaemic HF. First, differentially expressed plasma protein biomarkers were identified in 1160 patients enrolled in the BIOSTAT‐CHF study, 715 of whom had ischaemic HF and 445 had non‐ischaemic HF. Second, we constructed an enriched physical protein–protein interaction network, followed by a pathway over‐representation analysis. Finally, we identified key network proteins. Data were validated in an independent HF cohort comprised of 765 ischaemic and 100 non‐ischaemic HF patients. We found 21/92 proteins to be up‐regulated and 2/92 down‐regulated in ischaemic relative to non‐ischaemic HF patients. An enriched network of 18 proteins that were specific for ischaemic heart disease yielded six pathways, which are related to inflammation, endothelial dysfunction superoxide production, coagulation, and atherosclerosis. We identified five key network proteins: acid phosphatase 5, epidermal growth factor receptor, insulin‐like growth factor binding protein‐1, plasminogen activator urokinase receptor, and secreted phosphoprotein 1. Similar results were observed in the independent validation cohort. Conclusions Pathophysiological pathways distinguishing patients with ischaemic HF from those with non‐ischaemic HF were related to inflammation, endothelial dysfunction superoxide production, coagulation, and atherosclerosis. The five key pathway proteins identified are potential treatment targets specifically for patients with ischaemic HF