5,573 research outputs found
Evidence for metasomatic enrichment in the oceanic lithosphere and implication for the generation of intraplate basalts
Local electrical tuning of the nonlocal signals in a Cooper pair splitter
A Cooper pair splitter consists of a central superconducting contact, S, from
which electrons are injected into two parallel, spatially separated quantum
dots (QDs). This geometry and electron interactions can lead to correlated
electrical currents due to the spatial separation of spin-singlet Cooper pairs
from S. We present experiments on such a device with a series of bottom gates,
which allows for spatially resolved tuning of the tunnel couplings between the
QDs and the electrical contacts and between the QDs. Our main findings are
gate-induced transitions between positive conductance correlation in the QDs
due to Cooper pair splitting and negative correlations due to QD dynamics.
Using a semi-classical rate equation model we show that the experimental
findings are consistent with in-situ electrical tuning of the local and
nonlocal quantum transport processes. In particular, we illustrate how the
competition between Cooper pair splitting and local processes can be optimized
in such hybrid nanostructures.Comment: 9 pages, 6 figures, 2 table
Headache in 25 consecutive patients with atrial septal defects before and after percutaneous closure – a prospective case series
In contrast to patent foramen ovale, that is highly prevalent in the general population, atrial
septal defect (ASD) is a rare congenital heart defect. The effect of ASD closure on headache
and migraine remains a matter of controversy. The objectives of the study were (i) to
determine headache prevalence in consecutive patients with ASD scheduled for percutaneous
closure for cardiologic indications, using the classification of the International Headache
Society and (ii) to compare headache characteristics before and after closure of ASD. In this
observational case series no a priori power analysis was performed. Twenty-five consecutive
patients were prospectively included over 27 months. Median duration of follow-up was 12
months, [Interquartile range 0]. Prevalence of active headache seemed to be increased
compared to the general population: Any headaches 88% (95% confidence interval 70-96),
migraine without aura 28% (14-48), migraine with aura 16% (6-35). After ASD closure, we
observed a slightly lower headache frequency (median frequency 1.0 [2.6] vs. 0.3 [1.5]
headaches per month; p=0.067). In patients with ongoing headaches, a significant decrease in
headache intensity (median VAS 7 [3] vs. 5 [4]; p=0.036) was reported. Three patients with
migraine with aura before the intervention reported no migraine with aura attacks at followup,
two of them reported ongoing tension-type headache, one migraine without aura. In
summary, this prospective observational study confirms the high prevalence of headache,
particularly migraine, in ASD patients and suggests a possible small beneficial effect of ASD
closure
A Tableaux Calculus for Reducing Proof Size
A tableau calculus is proposed, based on a compressed representation of
clauses, where literals sharing a similar shape may be merged. The inferences
applied on these literals are fused when possible, which reduces the size of
the proof. It is shown that the obtained proof procedure is sound,
refutationally complete and allows to reduce the size of the tableau by an
exponential factor. The approach is compatible with all usual refinements of
tableaux.Comment: Technical Repor
Intelligent Self-Repairable Web Wrappers
The amount of information available on the Web grows at an incredible high rate. Systems and procedures devised to extract these data from Web sources already exist, and different approaches and techniques have been investigated during the last years. On the one hand, reliable solutions should provide robust algorithms of Web data mining which could automatically face possible malfunctioning or failures. On the other, in literature there is a lack of solutions about the maintenance of these systems. Procedures that extract Web data may be strictly interconnected with the structure of the data source itself; thus, malfunctioning or acquisition of corrupted data could be caused, for example, by structural modifications of data sources brought by their owners. Nowadays, verification of data integrity and maintenance are mostly manually managed, in order to ensure that these systems work correctly and reliably. In this paper we propose a novel approach to create procedures able to extract data from Web sources -- the so called Web wrappers -- which can face possible malfunctioning caused by modifications of the structure of the data source, and can automatically repair themselves.\u
Replica field theory for a polymer in random media
In this paper we revisit the problem of a (non self-avoiding) polymer chain
in a random medium which was previously investigated by Edwards and Muthukumar
(EM). As noticed by Cates and Ball (CB) there is a discrepancy between the
predictions of the replica calculation of EM and the expectation that in an
infinite medium the quenched and annealed results should coincide (for a chain
that is free to move) and a long polymer should always collapse. CB argued that
only in a finite volume one might see a ``localization transition'' (or
crossover) from a stretched to a collapsed chain in three spatial dimensions.
Here we carry out the replica calculation in the presence of an additional
confining harmonic potential that mimics the effect of a finite volume. Using a
variational scheme with five variational parameters we derive analytically for
d<4 the result R~(g |ln \mu|)^{-1/(4-d)} ~(g lnV)^{-1/(4-d)}, where R is the
radius of gyration, g is the strength of the disorder, \mu is the spring
constant associated with the confining potential and V is the associated
effective volume of the system. Thus the EM result is recovered with their
constant replaced by ln(V) as argued by CB. We see that in the strict infinite
volume limit the polymer always collapses, but for finite volume a transition
from a stretched to a collapsed form might be observed as a function of the
strength of the disorder. For d<2 and for large
V>V'~exp[g^(2/(2-d))L^((4-d)/(2-d))] the annealed results are recovered and
R~(Lg)^(1/(d-2)), where L is the length of the polymer. Hence the polymer also
collapses in the large L limit. The 1-step replica symmetry breaking solution
is crucial for obtaining the above results.Comment: Revtex, 32 page
Gene identification for the cblD defect of vitamin B12 metabolism
Background Vitamin B12 (cobalamin) is an essential cofactor in several metabolic pathways. Intracellular conversion of cobalamin to its two coenzymes, adenosylcobalamin in mitochondria and methylcobalamin in the cytoplasm, is necessary for the homeostasis of methylmalonic acid and homocysteine. Nine defects of intracellular cobalamin metabolism have been defined by means of somatic complementation analysis. One of these defects, the cblD defect, can cause isolated methylmalonic aciduria, isolated homocystinuria, or both. Affected persons present with multisystem clinical abnormalities, including developmental, hematologic, neurologic, and metabolic findings. The gene responsible for the cblD defect has not been identified.
Methods We studied seven patients with the cblD defect, and skin fibroblasts from each were investigated in cell culture. Microcell-mediated chromosome transfer and refined genetic mapping were used to localize the responsible gene. This gene was transfected into cblD fibroblasts to test for the rescue of adenosylcobalamin and methylcobalamin synthesis.
Results The cblD gene was localized to human chromosome 2q23.2, and a candidate gene, designated MMADHC (methylmalonic aciduria, cblD type, and homocystinuria), was identified in this region. Transfection of wild-type MMADHC rescued the cellular phenotype, and the functional importance of mutant alleles was shown by means of transfection with mutant constructs. The predicted MMADHC protein has sequence homology with a bacterial ATP-binding cassette transporter and contains a putative cobalamin binding motif and a putative mitochondrial targeting sequence.
Conclusions Mutations in a gene we designated MMADHC are responsible for the cblD defect in vitamin B12 metabolism. Various mutations are associated with each of the three biochemical phenotypes of the disorder
Magnetic field tuning and quantum interference in a Cooper pair splitter
Cooper pair splitting (CPS) is a process in which the electrons of naturally
occurring spin-singlet pairs in a superconductor are spatially separated using
two quantum dots. Here we investigate the evolution of the conductance
correlations in an InAs CPS device in the presence of an external magnetic
field. In our experiments the gate dependence of the signal that depends on
both quantum dots continuously evolves from a slightly asymmetric Lorentzian to
a strongly asymmetric Fano-type resonance with increasing field. These
experiments can be understood in a simple three - site model, which shows that
the nonlocal CPS leads to symmetric line shapes, while the local transport
processes can exhibit an asymmetric shape due to quantum interference. These
findings demonstrate that the electrons from a Cooper pair splitter can
propagate coherently after their emission from the superconductor and how a
magnetic field can be used to optimize the performance of a CPS device. In
addition, the model calculations suggest that the estimate of the CPS
efficiency in the experiments is a lower bound for the actual efficiency.Comment: 5 pages + 4 pages supplementary informatio
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