Manipulation and Generation of Supercurrent in Out-of-Equilibrium Josephson Tunnel Nanojunctions

We demonstrate experimentally manipulation of supercurrent in Al-AlO_x-Ti Josephson tunnel junctions by injecting quasiparticles in a Ti island from two additional tunnel-coupled Al superconducting reservoirs. Both supercurrent enhancement and quenching with respect to equilibrium are achieved. We demonstrate cooling of the Ti line by quasiparticle injection from the normal state deep into the superconducting phase. A model based on heat transport and non-monotonic current-voltage characteristic of a Josephson junction satisfactorily accounts for our findings.Comment: 4 pages, 4 colour figures, published versio

Population regulation in Magellanic penguins: what determines changes in colony size?

Seabirds are often studied at individual colonies, but the confounding effects of emigration and mortality processes in open populations may lead to inappropriate conclusions on the mechanisms underlying population changes. Magellanic penguin (Spheniscus magellanicus) colonies of variable population sizes are distributed along the Argentine coastline. In recent decades, several population and distributional changes have occurred, with some colonies declining and others newly established or increasing. We integrated data of eight colonies scattered along ~600 km in Northern Patagonia (from 41°26´S, 65°01´W to 45°11´S, 66°30´W, Rio Negro and Chubut provinces) and conducted analysis in terms of their growth rates, production of young and of the dependence of those vital rates on colony age, size, and location. We contrasted population trends estimated from abundance data with those derived from population modeling to understand if observed growth rates were attainable under closed population scenarios. Population trends were inversely related to colony size, suggesting a density dependent growth pattern. All colonies located in the north — which were established during the last decades — increased at high rates, with the smallest, recently established colonies growing at the fastest rate. In central-southern Chubut, where colonies are the oldest, the largest breeding aggregations declined, but smaller colonies remained relatively stable. Results provided strong evidence that dispersal played a major role in driving local trends. Breeding success was higher in northern colonies, likely mediated by favorable oceanographic conditions. However, mean foraging distance and body condition of chicks at fledging were influenced by colony size. Recruitment of penguins in the northern area may have been triggered by a combination of density dependence, likely exacerbated by less favorable oceanographic conditions in the southern sector. Our results reaffirm the idea that individual colony trends do not provide confident indicators of population health, highlighting the need to redefine the scale for the study of population changes.Fil: Pozzi, Luciana Melina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaFil: Garcia Borboroglu, Jorge Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina. Global Penguin Society. Washington; Estados Unidos. University of Washington; Estados UnidosFil: Boersma, P. Dee. Global Penguin Society. Washington; Estados Unidos. University of Washington; Estados UnidosFil: Pascual, Miguel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina. Universidad Nacional de la Patagonia; Argentin

Localization lengths of ultrathin disordered gold and silver nanowires

The localization lengths of ultrathin disordered Au and Ag nanowires are estimated by calculating the wire conductances as functions of wire lengths. We study Ag and Au monoatomic linear chains, and thicker Ag wires with very small cross sections. For the monoatomic chains we consider two types of disorder: bounded random fluctuations of the interatomic distances, and the presence of random substitutional impurities. The effect of impurity atoms on the nanowire conductance is much stronger. Our results show that electrical transport in ultrathin disordered wires may occur in the strong localization regime, and with relatively small amounts of disorder the localization lengths may be rather small. The localization length dependence on wire thickness is investigated for Ag nanowires with different impurity concentrations.Comment: 6 pages, postscript figures included, submitted to PR

Estudio inicial de la estructura genética del conejo ibicenco a aprtir de información genealógica.

Aumentar el número de gazapos destetados por coneja y parto es un objetivo importante para incrementar la rentabilidad del sector cunícola industrial con efectos directos. La mejora genética de la prolificidad en las líneas de madres ha demostrado ser una estrategia eficaz para alcanzar este objetivo; sin embargo otras vías, como la influencia de diferentes fuentes de grasa en las dietas de conejas reproductoras, han sido muy poco estudiadas. Los ácidos grasos (AG) n-3 interfieren en la fisiología reproductiva porque pueden modular las enzimas involucradas en el metabolismo de las prostaglandinas y del colesterol que es el precursor de los esteroides como la progesterona (revisado en Gulliver et al., 2012). El objetivo de este trabajo es estudiar si la suplementación con AG poliinsaturados (PUFA) n-3 de las dietas de conejas durante la recría puede afectar a la tasa de ovulación y a la síntesis esteroidogénica ovárica determinada mediante las concentraciones de progesterona plasmática

Free-electron Model for Mesoscopic Force Fluctuations in Nanowires

When two metal electrodes are separated, a nanometer sized wire (nanowire) is formed just before the contact breaks. The electrical conduction measured during this retraction process shows signs of quantized conductance in units of G_0=2e^2/h. Recent experiments show that the force acting on the wire during separation fluctuates, which has been interpreted as being due to atomic rearrangements. In this report we use a simple free electron model, for two simple geometries, and show that the electronic contribution to the force fluctuations is comparable to the experimentally found values, about 2 nN.Comment: 4 pages, 3 figures, reference correcte

RNAi screens for Rho GTPase regulators of cell shape and YAP/TAZ localisation in triple negative breast cancer.

In order to metastasise, triple negative breast cancer (TNBC) must make dynamic changes in cell shape. The shape of all eukaryotic cells is regulated by Rho Guanine Nucleotide Exchange Factors (RhoGEFs), which activate Rho-family GTPases in response to mechanical and informational cues. In contrast, Rho GTPase-activating proteins (RhoGAPs) inhibit Rho GTPases. However, which RhoGEFs and RhoGAPS couple TNBC cell shape to changes in their environment is very poorly understood. Moreover, whether the activity of particular RhoGEFs and RhoGAPs become dysregulated as cells evolve the ability to metastasise is not clear. Towards the ultimate goal of identifying RhoGEFs and RhoGAPs that are essential for TNBC metastasis, we performed an RNAi screen to isolate RhoGEFs and RhoGAPs that contribute to the morphogenesis of the highly metastatic TNBC cell line LM2, and its less-metastatic parental cell line MDA-MB-231. For ~6 million cells from each cell line, we measured 127 different features following the depletion of 142 genes. Using a linear classifier scheme we also describe the morphological heterogeneity of each gene-depleted population

Are environmental risk factors for current wheeze in the International Study of Asthma and Allergies in Childhood (ISAAC) phase three due to reverse causation?

BACKGROUND: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) measured the global prevalence of symptoms of asthma in children. We undertook comprehensive analyses addressing risk factors for asthma symptoms in combination, at both the individual and the school level, to explore the potential role of reverse causation due to selective avoidance or confounding by indication. OBJECTIVE: To explore the role of reverse causation in risk factors of asthma symptoms. METHODS: We compared two sets of multilevel logistic regression analyses, using (a) individual level exposure data and (b) school level average exposure (ie prevalence), in two different age groups. In individual level analyses, reverse causation is a possible concern if individual level exposure statuses were changed as a result of asthma symptoms or diagnosis. School level analyses may suffer from ecologic confounding, but reverse causation is less of a concern because individual changes in exposure status as a result of asthma symptoms would only have a small effect on overall school exposure levels. RESULTS: There were 131 924 children aged 6-7 years (2428 schools, 25 countries) with complete exposure, outcome and confounder data. The strongest associations in individual level analyses (fully adjusted) were for current paracetamol use (odds ratio = 2.06; 95% confidence interval 1.97-2.16), early life antibiotic use (1.65; 1.58-1.73) and open fire cooking (1.44; 1.26-1.65). In school level analyses, these risk factors again showed increased risks. There were 238 586 adolescents aged 13-14 years (2072 schools, 42 countries) with complete exposure, outcome and confounder data. The strongest associations in individual level analyses (fully adjusted) were for current paracetamol use (1.80; 1.75-1.86), cooking on an open fire (1.32; 1.22-1.43) and maternal tobacco use (1.23; 1.18-1.27). In school level analyses, these risk factors again showed increased risks. CONCLUSIONS & CLINICAL RELEVANCE: These analyses strengthen the potentially causal interpretation of previously reported individual level findings, by providing evidence against reverse causation

Digestibilidad y respuesta ovárica de conejas reproductoras alimentadas con dietas suplementadas con ácidos grasos poliinsaturados n-3

Aumentar el número de gazapos destetados por coneja y parto es un objetivo importante para incrementar la rentabilidad del sector cunícola industrial con efectos directos. La mejora genética de la prolificidad en las líneas de madres ha demostrado ser una estrategia eficaz para alcanzar este objetivo; sin embargo otras vías, como la influencia de diferentes fuentes de grasa en las dietas de conejas reproductoras, han sido muy poco estudiadas. Los ácidos grasos (AG) n-3 interfieren en la fisiología reproductiva porque pueden modular las enzimas involucradas en el metabolismo de las prostaglandinas y del colesterol que es el precursor de los esteroides como la progesterona (revisado en Gulliver et al., 2012). El objetivo de este trabajo es estudiar si la suplementación con AG poliinsaturados (PUFA) n-3 de las dietas de conejas durante la recría puede afectar a la tasa de ovulación y a la síntesis esteroidogénica ovárica determinada mediante las concentraciones de progesterona plasmática

TCAD Simulations of High-Aspect-Ratio Nano-biosensor for Label-Free Sensing Application

In this paper, we are presenting simulations of junctionless ion-sensitive field-effect transistor (JL-ISFET) as a pH sensor. Our approach is based on a combination of analytical and numerical methods to reveal the impact of the device geometry and structure on its performance. To have a realistic representation of the fabricated device, further simulations are carried which portray the sensing of surface potential by introducing interface trap charges between the oxide layer and electrolyte. Here, we present our initial steps that belong to a more complex and physically more elaborate simulation framework, which will lead to a better device sensing and fabrication choices of more generic biosensors, in a transition from analytical models to numerical simulations to include effects such as surface roughness and defects in the oxide