1,177 research outputs found
RelaçÔes de gĂȘnero em um debate sobre MecĂąnica QuĂąntica e visĂ”es de CiĂȘncia entre graduandos de FĂsica
Um dos efeitos das diferenças entre gĂȘneros nas aulas de ciĂȘncias Ă© o estĂmulo Ă s lideranças masculinas e a predominĂąncia dos pontos de vista dos garotos. A presente pesquisa investigou as relaçÔes de gĂȘnero entre graduandos em FĂsica quanto ao exercĂcio do papel de parceiro mais capaz em um debate mediado por um questionĂĄrio sobre conceitos da MecĂąnica QuĂąntica (MQ) e visĂ”es de ciĂȘncia (VC). Os resultados da anĂĄlise do discurso dos estudantes sinalizam para a maior propensĂŁo de que os garotos assumam a posição de parceiros mais capazes por meio de um discurso de autoridade e que algumas estudantes tenham habilidades alternativas para exercĂȘ-la, adotando um discurso jocoso e crĂtico
Comparison of software for computing the action of the matrix exponential
The implementation of exponential integrators requires the action of the matrix exponential and related functions of a large matrix. There are various methods in the literature for carrying out this task. In this paper we describe a new implementation of a method based on interpolation at Leja points. We numerically compare this method with others from the literature. As we are interested in exponential intergrators we choose the test examples from spatial discretization of time dependent partial differential equations in two and three space dimensions. The test matrices thus have large eigenvalues and can be nonnormal
Optimal management of acute kidney injury in critically ill patients with invasive fungal infections being treated with liposomal amphotericin B.
Critically ill patients are at risk of developing both acute kidney injury (AKI) and invasive fungal infections (IFIs). Prompt and efficient treatment of the IFI is essential for the survival of the patient. This article examines three distinct clinical situations where liposomal amphotericin B, a broad-spectrum antifungal agent, was successfully used in the setting of AKI. The first was Aspergillus infection in a 63-year-old man with bleeding oesophageal varices related to advanced liver disease. The second was gastrointestinal mucormycosis in a 74-year-old man who developed a small bowel obstruction following an autologous stem cell transplant for mantle cell lymphoma. The third was a Fusarium infection in a 32-year-old woman on immunosuppression for a bilateral lung transplant for cystic fibrosis. In all three cases, liposomal amphotericin B was required for urgent management of the patient's IFI. We discuss the rationale for treatment with a potentially nephrotoxic agent in this setting
Adverse Drug Reactions in a Complementary Medicine Hospital: A Prospective, Intensified Surveillance Study
Background. Anthroposophic medicine is one of the widely used approaches of complementary and alternative medicine. However, few prospective studies have generated safety data on its use. Objectives. We aimed to assess adverse drug reactions (ADRs) caused by anthroposophical medicines (AMEDs) in the anthroposophical Community Hospital Havelhoehe, GERMANY. Study Design and Methods. Between May and November 2007, patients of six medical wards were prospectively assessed for ADRs. Suspected ADRs occurring during hospitalization were documented and classified in terms of organ manifestation (WHO SOC-code), causality (according to the Uppsala Monitoring Centre WHO criteria), and severity. Only those ADRs with a severity of grade 2 and higher according to the CTCAE classification system are described here. Results. Of the 3,813 patients hospitalized, 174 patients (4.6%) experienced 211 ADRs (CTCAE grade 2/3 n = 191, 90.5%, CTCAE grade 4/5 n = 20, 9.5%) of which 57 ADRs (27.0%) were serious. The median age of patients with ADRs (62.1% females) was 72.0 (IQR: 61.0; 80.0). Six patients (0.2%) experienced six ADRs (2.8% of ADRs) caused by eight suspected AMEDs, all of which were mild reactions (grade 2). Conclusion. Our data show that ADRs caused by AMEDs occur rarely and are limited to mild symptoms
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