ANGIOTENSIN-CONVERTING ENZYME IN PATIENTS WITH CHRONIC RENAL FAILURE ON HEMODIALYSIS

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Impedance spectroscopy study of water uptake and long-term degradation of immersed polyimide coatings

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1994.Vita.Includes bibliographical references (p. 167-170).by Krassimir P. Nenov.Ph.D

SEPARATORY QUANTITATIVE BACTERIURIA IN PYELONEPHRITIS

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STUDY OF SOME INDICES OF KALLIKREIN-KININ SYSTEM AND OF ANGIOTENSIN-CONVERTING ENZYME (KININASE II) IN PLASMA OF RATS ON HEMOPERFUSION WITH NON-ION-EXCHANGE RESIN

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KALLIKREIN-KININ SYSTEM (KKS) AND ANGIOTENSIN CONVERTING ENZYME ACTIVITY (ACE) IN PATIENTS ON PERIODIC HA•MODIALYSIS (PHD) TREATED WITH RECOMBINANT HUMAN ERYTHROPOIETIN (rhEPO)

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CLINICAL APPLICATION OF THE HAEMOPERFUSION DEVICES BULSORB 160 COMBINED WITH HAEMODIALYSIS

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NEW PRODUCT FROM BULGARIAN ROSE

The chemical composition of extract from rosa (Rosa damascena Mill.) by extraction with tetrafluoroethane was analyzed using GC and GC/MS. The main compounds (concentration higher than 3%) of extract were: phenylethyl alcohol (59.08%) and citronellol (12.31%).The chemical composition of extract from rosa (Rosa damascena Mill.) by extraction with tetrafluoroethane was analyzed using GC and GC/MS. The main compounds (concentration higher than 3%) of extract were: phenylethyl alcohol (59.08%) and citronellol (12.31%)

Environment-Driven Coherent Population Transfer Governs the Ultrafast Photophysics of Tryptophan

By combining UV transient absorption spectroscopy with sub-30-fs temporal resolution and CASPT2/MM calculations, we present a complete description of the primary photo-induced processes in solvated tryptophan. Our results shed new light on the role of the solvent in the relaxation dynamics of tryptophan. We unveil two consecutive coherent population transfer events involving the lowest two singlet excited states: a sub-50-fs non-adiabatic La-->Lb transfer through a conical intersection and a subsequent 220 fs reverse Lb-->La transfer due to solvent assisted adiabatic stabilization of the La state. Vibrational fingerprints in the transient absorption spectra provide compelling evidence of a vibronic coherence established between the two excited states from the earliest times after photoexcitation and lasting until the back-transfer to La is complete. The demonstration of response to the environment as a driver of coherent population dynamics among the excited states of tryptophan closes the long debate on its solvent-assisted relaxation mechanisms and extends its application as a local probe of protein dynamics to the ultrafast timescales

Genetic deletion of fibroblast growth factor 14 recapitulates phenotypic alterations underlying cognitive impairment associated with schizophrenia

Cognitive processing is highly dependent on the functional integrity of gamma-amino-butyric acid (GABA) interneurons in the brain. These cells regulate excitability and synaptic plasticity of principal neurons balancing the excitatory/inhibitory tone of cortical networks. Reduced function of parvalbumin (PV) interneurons and disruption of GABAergic synapses in the cortical circuitry result in desynchronized network activity associated with cognitive impairment across many psychiatric disorders, including schizophrenia. However, the mechanisms underlying these complex phenotypes are still poorly understood. Here we show that in animal models, genetic deletion of fibroblast growth factor 14 (Fgf14), a regulator of neuronal excitability and synaptic transmission, leads to loss of PV interneurons in the CA1 hippocampal region, a critical area for cognitive function. Strikingly, this cellular phenotype associates with decreased expression of glutamic acid decarboxylase 67 (GAD67) and vesicular GABA transporter (VGAT) and also coincides with disrupted CA1 inhibitory circuitry, reduced in vivo gamma frequency oscillations and impaired working memory. Bioinformatics analysis of schizophrenia transcriptomics revealed functional co-clustering of FGF14 and genes enriched within the GABAergic pathway along with correlatively decreased expression of FGF14, PVALB, GAD67 and VGAT in the disease context. These results indicate that Fgf14(-/-) mice recapitulate salient molecular, cellular, functional and behavioral features associated with human cognitive impairment, and FGF14 loss of function might be associated with the biology of complex brain disorders such as schizophrenia

Electron and ion spectroscopy of azobenzene in the valence and core shells

Azobenzene is a prototype and a building block of a class of molecules of extreme technological interest as molecular photo-switches. We present a joint experimental and theoretical study of its response to irradiation with light across the UV to x-ray spectrum. The study of valence and inner shell photo-ionization and excitation processes combined with measurement of valence photoelectron-photoion coincidence and mass spectra across the core thresholds provides a detailed insight into the site- and state-selected photo-induced processes. Photo-ionization and excitation measurements are interpreted via the multi-configurational restricted active space self-consistent field method corrected by second order perturbation theory. Using static modeling, we demonstrate that the carbon and nitrogen K edges of azobenzene are suitable candidates for exploring its photoinduced dynamics thanks to the transient signals appearing in background-free regions of the NEXAFS and XPS