Can Ice-Like Structures Form on Non-Ice-Like Substrates? The Example of the K-feldspar Microcline

Feldspar minerals are the most common rock formers in Earth’s crust. As such they play an important role in subjects ranging from geology to climate science. An atomistic understanding of the feldspar structure and its interaction with water is therefore desirable, not least because feldspar has been shown to dominate ice nucleation by mineral dusts in Earth’s atmosphere. The complexity of the ice/feldspar interface arising from the numerous chemical motifs expressed on the surface makes it a challenging system. Here we report a comprehensive study of this challenging system with ab initio density functional theory calculations. We show that the distribution of Al atoms, which is crucial for the dissolution kinetics of tectosilicate minerals, differs significantly between the bulk environment and on the surface. Furthermore, we demonstrate that water does not form ice-like overlayers in the contact layer on the most easily cleaved (001) surface of K-feldspar. We do, however, identify contact layer structures of water that induce ice-like ordering in the second overlayer. This suggests that even substrates without an apparent match with the ice structure may still act as excellent ice nucleating agents

Stargardt disease: clinical features, molecular genetics, animal models and therapeutic options

Stargardt disease (STGD1; MIM 248200) is the most prevalent inherited macular dystrophy and is associated with disease-causing sequence variants in the gene ABCA4 Significant advances have been made over the last 10 years in our understanding of both the clinical and molecular features of STGD1, and also the underlying pathophysiology, which has culminated in ongoing and planned human clinical trials of novel therapies. The aims of this review are to describe the detailed phenotypic and genotypic characteristics of the disease, conventional and novel imaging findings, current knowledge of animal models and pathogenesis, and the multiple avenues of intervention being explored

Power system stability enhancement through the optimal, passivity-based, placement of SVCs

Over the last decades, several techniques have been proposed for the optimal placement of FACTS devices across power systems. Although these techniques were shown to improve \il{power system} operation, they are usually computationally intractable while having serious inherent limitations. In this paper, we present a novel approach to guide the SVC location identification in order to enhance power system stability. Specifically, the proposed method exploits findings in passivity-based control analysis and design in order to address the most vulnerable -in terms of passivity- buses of the system and consequently the optimal locations for SVC installation. We then show how the incorporation of SVCs at the aforementioned buses can passivate the system and provide \il{guarantees} for increased stability. Furthermore, we provide a brief discussion regarding the sizing and the number of required SVC devices in order to guarantee such stability improvement. Finally, we illustrate our results with simulations on the IEEE 68 bus system and show that both the dynamic response and the damping of the system are significantly improved

The impact of an upper tropospheric teleconnection pattern on precipitation extremes over Cyprus

International audienceThe objective of this study is to estimate the duration, frequency and intensity of precipitation extreme episodes in Cyprus, in relation with the two phases of the Eastern Mediterranean teleconnection Pattern (EMP), during winter for the period 1958?2005. A standardised teleconnection index was employed to determine the phases (positive and negative) and the strength of the EMP. The identification of the precipitation extremes was performed with the aid of four climatic indices. It was found that during the positive phase of the pattern, the length of dry periods reduces while that of wet periods increases, being followed by increase of frequency of extreme wet days and precipitation intensity. On the contrary, during the negative phase, the dry spells become longer in accordance with shortening of the wet spells, decrease of the number of extreme wet days and precipitation intensity

The New Pretender: A Large UK Case Series of Retinal Injuries in Children Secondary to Handheld Lasers

Purpose: To characterize a large single-center series of retinal injuries in children secondary to handheld laser devices, with emphasis on potential prognostic factors. / Design: Retrospective case series. / Methods: Sixteen children (24 eyes) with retinal injuries secondary to handheld lasers were identified from our electronic patient record system. Case notes, digital fundus photography, and spectral-domain optical coherence tomography images were reviewed. / Results: The mean age of affected children was 12.7 years (range 9–16 years), with 12 male and 4 female subjects. Mean follow up was 5.4 months (range 1–23 months). Five children (31%) were referred as suspected retinal dystrophies. The mean logMAR visual acuity at presentation was 0.30 (20/40) (range −0.20 [20/12.5] to 1.6 [20/800]). Eleven children (69%; 15 eyes) had “mild” injuries with focal retinal disruption confined to the photoreceptor and ellipsoid layers; such injuries were associated with a better prognosis, the mean visual acuity at presentation being 0.10 (20/25). “Moderate” injuries were seen in 3 eyes of 2 children, with retinal disruption confined to the outer retinal layer but diffuse rather than focal in nature. Three patients (4 eyes) had “severe” injuries, with subfoveal outer retinal architecture loss and overlying hyperreflective material in inner retinal layers. / Conclusion: Retinal injuries secondary to handheld laser devices may be difficult to diagnose and are likely underreported. It is important that such data are in the public domain, so regulatory authorities recognize the importance of laser retinopathy as an avoidable cause of childhood visual impairment and take steps to minimize the incidence and impact of laser injuries

Preliminary verification results of the DWD limited area model LME and evaluation of its storm forecasting skill over the area of Cyprus

A preliminary verification and evaluation is made of the forecast fields of the non-hydrostatic limited area model LME of the German Weather Service (DWD), for a recent three month period. For this purpose, observations from two synoptic stations in Cyprus are utilized. In addition, days with depressions over the area were selected in order to evaluate the model's forecast skill in storm forecasting

Compound-specific amino acid ¹⁵N stable isotope probing of nitrogen assimilation by the soil microbial biomass using gas chromatography/combustion/isotope ratio mass spectrometry

RATIONALE: Organic nitrogen (N) greatly exceeds inorganic N in soils, but the complexity and heterogeneity of this important soil N pool make investigations into the fate of N‐containing additions and soil organic N cycling challenging. This paper details a novel approach to investigate the fate of applied N in soils, generating quantitative measures of microbial assimilation and of newly synthesized soil protein. METHODS: Laboratory incubation experiments applying (15)N‐ammonium, (15)N‐nitrate and (15)N‐glutamate were carried out and the high sensitivity and selectivity of gas chromatography/combustion/isotope ratio mass spectrometry (GC/C/IRMS) exploited for compound‐specific (15)N stable isotope probing ((15)N‐SIP) of extracted incubation soil amino acids (AAs; as N‐acetyl, O‐isopropyl derivatives). We then describe the interpretation of these data to obtain a measure of the assimilation of the applied (15)N‐labelled substrate by the soil microbial biomass and an estimate of newly synthesised soil protein. RESULTS: The cycling of agriculturally relevant N additions is undetectable via bulk soil N content and δ (15)N values and AA concentrations. The assimilation pathways of the three substrates were revealed via patterns in AA δ (15)N values with time, reflecting known biosynthetic pathways (e.g. ammonium uptake occurs first via glutamate) and these data were used to expose differences in the rates and fluxes of the applied N substrates into the soil protein pool (glutamate > ammonium > nitrate). CONCLUSIONS: Our compound‐specific (15)N‐SIP approach using GC/C/IRMS offers a number of insights, inaccessible via existing techniques, into the fate of applied (15)N in soils and is potentially widely applicable to the study of N cycling in any soil, or indeed, in any complex ecosystem. © 2016 The Authors. Rapid Communications in Mass Spectrometry Published by John Wiley & Sons Ltd

Can aerosols be trapped in open flows?

The fate of aerosols in open flows is relevant in a variety of physical contexts. Previous results are consistent with the assumption that such finite-size particles always escape in open chaotic advection. Here we show that a different behavior is possible. We analyze the dynamics of aerosols both in the absence and presence of gravitational effects, and both when the dynamics of the fluid particles is hyperbolic and nonhyperbolic. Permanent trapping of aerosols much heavier than the advecting fluid is shown to occur in all these cases. This phenomenon is determined by the occurrence of multiple vortices in the flow and is predicted to happen for realistic particle-fluid density ratios.Comment: Animation available at http://www.pks.mpg.de/~rdvilela/leapfrogging.htm

A statistical analysis of sounding derived indices and parameters for extreme and non-extreme thunderstorm events over Cyprus

The main purpose of this study is to provide a simple statistical analysis of several stability indices and parameters for extreme and non-extreme thunderstorm events during the period 1997 to 2001 in Cyprus. For this study, radiosonde data from Athalassa station (35°1´ N, 33°4´ E) were analyzed during the aforementioned period. The stability indices and parameters set under study are the K index, the Total Totals (TT) index, the Convective Available Potential Energy related parameters such as Convective Available Potential Energy (CAPE), Downdraft CAPE (DCAPE) and the Convective Inhibition (CIN), the Vorticity Generator Parameter (VGP), the Bulk Richardson Number (BRN), the BRN Shear and the Storm Relative Helicity (SRH). An event is categorized as extreme, if primarily, CAPE was non zero and secondary, if values of both the K and the TotalTotals (TT) indices exceeded 26.9 and 50, respectively. The cases with positive CAPE but lower values of the other indices, were identified as non-extreme. By calculating the median, the lower and upper limits, as well as the lower and upper quartiles of the values of these indices, the main characteristics of their distribution were determined

Ice formation on kaolinite: Insights from molecular dynamics simulations

The formation of ice affects many aspects of our everyday life as well as important technologies such as cryotherapy and cryopreservation. Foreign substances almost always aid water freezing through heterogeneous ice nucleation, but the molecular details of this process remain largely unknown. In fact, insight into the microscopic mechanism of ice formation on different substrates is difficult to obtain even if state-of-the-art experimental techniques are used. At the same time, atomistic simulations of heterogeneous ice nucleation frequently face extraordinary challenges due to the complexity of the water-substrate interaction and the long time scales that characterize nucleation events. Here, we have investigated several aspects of molecular dynamics simulations of heterogeneous ice nucleation considering as a prototypical ice nucleating material the clay mineral kaolinite, which is of relevance in atmospheric science. We show via seeded molecular dynamics simulations that ice nucleation on the hydroxylated (001) face of kaolinite proceeds exclusively via the formation of the hexagonal ice polytype. The critical nucleus size is two times smaller than that obtained for homogeneous nucleation at the same supercooling. Previous findings suggested that the flexibility of the kaolinite surface can alter the time scale for ice nucleation within molecular dynamics simulations. However, we here demonstrate that equally flexible (or non flexible) kaolinite surfaces can lead to very different outcomes in terms of ice formation, according to whether or not the surface relaxation of the clay is taken into account. We show that very small structural changes upon relaxation dramatically alter the ability of kaolinite to provide a template for the formation of a hexagonal overlayer of water molecules at the water-kaolinite interface, and that this relaxation therefore determines the nucleation ability of this mineral