Copper complex of isatin Schiff base encapsulated in zeolite as active heterogeneous catalyst: an efficient protocol for the acetylation reaction

Copper (II) complex of 3-phenylimino-1,3-dihydro-indol-2-one encapsulated in the super cages of zeolite-Y has been synthesized by flexible ligand method and characterized by various physicochemical measurements. The catalytic activity of cationic exchanged zeolite, copper complex of ligand and complex encapsulated inside the zeolite was investigated for the decomposition of H2O2 and for the acetylation of p-cresol. All catalysts show good to excellent yield. The results showed that conversion of p-cresol varies in the order homogeneous complex \NaY-Zeolite\Cu-Y-Zeolite\heterogeneous comple

Hyaluronic Acid Nanomaterials in Targeted Drug Delivery for Cancer Therapy

Hyaluronic acid and the CD44 receptor have been the subject of 3D interaction and molecular analysis that has revealed crucial residues, binding specificity, stabilizing relationships, and structural insights within the complex. The analysis has focused on amino acid interactions. It is a crucial field of study with both fundamental and applied consequences because this understanding not only illuminates the molecular mechanisms directing their interaction but also shows promise for future therapeutic approaches. The new methods cover a variety of strategies, such as creating highly focused treatments, combining treatments with other well-known techniques like immunotherapy and chemotherapy, and moving toward customized medicine. Combining state-of-the-art nanotechnology with hyaluronan-based pharmaceuticals could improve lung cancer therapy's precision, bioavailability, and drug delivery. Clinical trials will be essential in proving these medicines' safety and effectiveness so that they may be incorporated into standard cancer treatment. Moreover, investigating immune regulation via hyaluronan may open up new avenues for bolstering the body's defenses against  cancer. With a calculated binding energy score of -6.70, the interaction between hyaluronan and the CD44 protein receptor was observed to be remarkably strong and favorable, suggesting a robust connection. This highlights the potential for utilizing hyaluronic nanomaterials to facilitate the targeted delivery of commercially available cancer drugs to specific cancer sites

Effects of slag content on the residual mechanical properties of ambient air-cured geopolymers exposed to elevated temperatures

This paper presents the effects of various slag contents on the residual compressive strength and physical properties of ambient air-cured fly ash-slag blended geopolymers after exposure to various elevated temperatures up to 800°C. The results showed an increasing trend in the compressive strength of ambient air-cured geopolymers with increase in the slag contents after exposure to 400 and 600°C temperatures. This trend deviated, however, at 800°C. Nevertheless, all the geopolymers showed reductions in control compressive strength at ambient temperature after exposure to elevated temperatures. The reductions were much higher at 600 and 800°C compared to 400°C. All the geopolymers exhibited significant damage in terms of cracking after exposure to a temperature of 800°C compared to 400 and 600°C and significant damage occurred at slag contents of 15–30%. Scanning electron microscopic (SEM) images of the above geopolymers also showed higher porosity at 800°C compared to 400 and 600°C. Traces of calcite/calcium silicate hydrate (CSH) peaks are observed in the X-ray diffraction (XRD) analysis of fly ash-slag geopolymers, and the intensity of those peaks increased with increases in slag contents. After exposure to elevated temperatures, the calcite/CSH peaks disappeared and new phases of nepheline and gehlenite were formed at 800°C in all the fly ash-slag geopolymers

Reinforcement of Nanocellulose as Green Agent in the Electronic Applications Associated with the Composites of Polymer Matrix

Due to their profusion, high durability, and rigidity, lesser weight and biodegradable nature nanocellulose (NC) is observed as the challenging tasks for the aspirants in making of the green composites. The continuous network of the cellulose nanoparticle connected through hydrogen bonding is happened mainly due to the reinforcing effect allocated to the mechanical reoccurrence phenomenon of the NC. When comparing with the nanocrystalline cellulose, the NC has significant convincing progress in the durability and rigidity, and the aspect ratio of the NC is higher than that of the NC crystal. The reinforcement effect of NC is the characteristic of the NC polymer interaction as well as the reinforcement effect eventualizing through stress transfer at the NC–polymer interface. Thus, the concentration of the reinforcement particle rises to the saturation level due to the frailty of the NC reinforcement constituent and due to surface compliance between the matrix and the filler. Due to its structural firmness and mechanical behaviors, the NC compounds are used in many industrial applications like tissue engineering, food packaging, and electronic applications. The stretchable electronic systems and instruments are awaiting the maximal attention due to its essential applications in certain domains, such as robotics artificial intelligence, brain control and machine interface, clinical devices, and health care electronic monitoring devices. In addition to that, when realizing the operational performance of electronic devices, the electronic instruments and systems must be physically expandable and flexible. The proposed study deems the technique of reinforcing the NC compounds as green agent in electronic applications, which has been associated with the composites of polymer matrix. The elongation could be achieved through the formulation of composition via elastomers. In addition, it is being focused on the illustration of functional soft development of materials that is inclusive of the conductive intrinsic polymers for the elongated electrodes and electrothermal conversion and vice versa, occupying the maximal area along with tactile sensing elements

Comparison of 2D simultaneous multi-slice and 3D GRASE readout schemes for pseudo-continuous arterial spin labeling of cerebral perfusion at 3 T

In this perfusion magnetic resonance imaging study, the performances of different pseudo-continuous arterial spin labeling (PCASL) sequences were compared: two-dimensional (2D) single-shot readout with simultaneous multislice (SMS), 2D single-shot echo-planar imaging (EPI) and multishot three-dimensional (3D) gradient and spin echo (GRASE) sequences combined with a background-suppression (BS) module. Whole-brain PCASL images were acquired from seven healthy volunteers. The performance of each protocol was evaluated by extracting regional cerebral blood flow (rCBF) measures using an inline morphometric segmentation prototype. Image data postprocessing and subsequent statistical analyses enabled comparisons at the regional and sub-regional levels. The main findings were as follows: (i) Mean global CBF obtained across methods was were highly correlated, and these correlations were significantly higher among the same readout sequences. (ii) Temporal signal-to-noise ratio and gray-matter-to-white-matter CBF ratio were found to be equivalent for all 2D variants but lower than those of 3D-GRASE. Our study demonstrates that the accelerated SMS readout can provide increased acquisition efficiency and/or a higher temporal resolution than conventional 2D and 3D readout sequences. Among all of the methods, 3D-GRASE showed the lowest variability in CBF measurements and thus highest robustness against noise