646 research outputs found
Selective measurement of anti-tTG antibodies in coeliac disease and IgA deficiency : an alternative pathway
Objective
To determine the ability of selective antibody testing to screen for coeliac disease in
the presence of IgA deficiency and to define the sensitivity of a pathway using this
method (Figure1).
Method
All IgA and IgG anti-tTG tests performed at our centre between January 2008 and
December 2009, using the Immunocap 250 analyser, were retrospectively reviewed.
Positive results were correlated with histology. Results were used to validate our
diagnostic pathway.
Results
12,289 consecutive serological tests were reviewed. IgA deficient patients gave either
an “error” reading or very low response on the Immunocap 250 analyser. Subsequent
testing of this sub-group demonstrated raised IgG anti-tTG antibodies in those with
histologically proven coeliac disease.
Conclusions
Using our antibody screening pathway, which involves the selective use of IgG antitTG,
sensitivity increased from 87% to 92% in those with IgA deficiency. Adoption
of this pathway for coeliac screening would negate the routine screening of
immunoglobulin levels, with resultant cost saving
Dying of a hundred good symptoms: why good security can still fail - a literature review and analysis
Many organizations suffer serious information security incidents, despite having taken positive steps towards achieving good security standards. The authors hypothesize that these issues are often as a result of security arrangements not being sufficiently integrated with businesses. We believe that adopting an enterprise architecture (EA) approach to implementing information security – commonly referred to as an ‘Enterprise Information Security Architecture’ (EISA) – will deliver substantial benefits. Our paper has reviewed and analyzed literature concerning the root causes of information security incidents and describes a novel approach with 8 domains for ensuring critical factors are considered when building an EISA framework
Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF-alpha stimulated proinflammatory environment
SCOPE:
Monocyte adhesion to the vascular endothelium is a crucial step in the early stages of atherogenesis. This study aims to investigate the capacity of an anthocyanin (ACN) and phenolic acid (PA)-rich fraction (RF) of a wild blueberry, single ACNs (cyanidin, malvidin, delphinidin) and related metabolites (protocatechuic, syringic and gallic acid) to counteract monocytes (THP-1) adhesion to endothelial cells (HUVECs) in a tumor necrosis \u3b1 (TNF-\u3b1) mediated pro-inflammatory environment.
METHODS AND RESULTS:
HUVECs were incubated with different concentrations (from 0.01 to 10 \u3bcg mL-1 ) of the compounds for 24 h. Labelled monocytic THP-1 cells were added to HUVECs and their adhesion was induced by TNF-\u3b1 (100 ng mL-1 ). ACN-RF reduced THP-1 adhesion to HUVECs with a maximum effect at 10 \u3bcg mL-1 (-33%). PA-RF counteracted THP-1 adhesion at 0.01, 0.1 and 1 \u3bcg mL-1 (-45%, -48.7% and -27.6%, respectively), but not at maximum concentration. Supplementation with gallic acid reduced THP-1 adhesion to HUVECs with a maximum effect at 1 \u3bcg mL-1 (-29.9%), while malvidin-3-glucoside and syringic acid increased the adhesion. No effect was observed for the other compounds.
CONCLUSION:
These results suggest that ACNs/PA-RF may prevent atherogenesis while the effects of the single ACNs and metabolites are controversial and merit further exploration
Международная трудовая миграция и нелегальная миграция в России
Огляд монографії: Метелев С.Е. Международная трудовая миграция и нелегальная миграция в России. Монография. – М.: Юнити. – 2006. – 175 с
Two-Phase Flow Simulations of Surface Waves in Wind-Forced Conditions
The paper is devoted to two-phase flow simulations and investigates the
ability of a diffusive interface Cahn-Hilliard Volume-of-Fluid model to capture
the dynamics of the air-sea interface at geophysically relevant Reynolds
numbers. It employs a hybrid filtered/averaging Improved Detached Eddy
Simulation method to model turbulence, and utilizes a continuum model to
account for surface tension if the diffuse interface is under-resolved by the
grid. A numerical wind-wave tank is introduced to limit computational costs and
results obtained for two wind-wave conditions are analyzed in comparison to
experimental data at matched Reynolds numbers. The focus of the comparison is
on both time-averaged and wave-coherent quantities, and includes pressure,
velocity as well as modeled and resolved Reynolds stresses. In general,
numerical predictions agree well with the experimental measurements and
reproduce many wave-dependent flow features. Reynolds stresses near the water
surface are found to be especially important in modulating the critical layer
height. It is concluded that the diffusive interface approach proves to be a
promising method for future studies of air-sea interface dynamics in
geophysically relevant flows
Annihilation of Charged Particles
The kinetics of irreversible annihilation of charged particles performing
overdamped motion induced by long-range interaction force, , is investigated. The system exhibits rich kinetic behaviors
depending on the force exponent . In one dimension we find that the
densities decay as and when
and , respectively, with logarithmic correction at
. For , the asymptotic behavior is shown to be
dependent on system size.Comment: 17 pages, plain TeX, 3 figures available upon request from
[email protected]
Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors
Purpose Wild blueberries (WB) (Vaccinium angustifolium) are rich sources of polyphenols, such as flavonols, phenolic acids and anthocyanins (ACNs), reported to decrease the risk of cardiovascular and degenerative diseases. This study investigated the effect of regular consumption of a WB or a placebo (PL) drink on markers of oxidative stress, inflammation and endothelial function in subjects with risk factors for cardiovascular disease. Methods Eighteen male volunteers (ages 47.8 ? 9.7 years; body mass index 24.8 ? 2.6 kg/m2) received according to a cross-over design, a WB (25 g freeze-dried powder, providing 375 mg of ACNs) or a PL drink for 6 weeks, spaced by a 6-week wash-out. Endogenous and oxidatively induced DNA damage in blood mononuclear cells, serum interleukin levels, reactive hyperemia index, nitric oxide, soluble vascular adhesion molecule concentration and other variables were analyzed. In conclusion, the consumption of the WB drink for 6 weeks significantly reduced the levels of oxidized DNA bases and increased the resistance to oxidatively induced DNA damage. Future studies should address in greater detail the role of WB in endothelial functio
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