229 research outputs found
Universal scaling of the order-parameter distribution in strongly disordered superconductors
We investigate theoretically and experimentally the statistical properties of
the inhomogeneous order-parameter distribution (OPD) at the verge of the
superconductor-insulator transition (SIT). We find within two prototype
fermionic and bosonic models for disordered superconductors that one can
identify a universal rescaling of the OPD. By performing scanning-tunneling
microscopy experiments in three samples of NbN with increasing disorder we show
that such a rescaling describes also with an excellent accuracy the
experimental data. These results can provide a breakthrough in our
understanding of the SIT.Comment: 11 pages, 8 figures, revised version submitted to PR
COUNTERVAILING VASCULAR EFFECTS OF ROSIGLITAZONE IN HIGH CARDIOVASCULAR RISK MICE: ROLE OF OXIDATIVE STRESS AND PRMT-1.
In the present study, we tested the hypothesis that the PPARgamma (peroxisome-proliferator-activated receptor gamma) activator rosiglitazone improves vascular structure and function in aged hyperhomocysteinaemic MTHFR (methylene tetrahydrofolate reductase) gene heterozygous knockout (mthfr+/-) mice fed a HCD (high-cholesterol diet), a model of high cardiovascular risk. One-year-old mthfr+/- mice were fed or not HCD (6 mg x kg-1 of body weight x day-1) and treated or not with rosiglitazone (20 mg x kg-1 of body weight x day-1) for 90 days and compared with wild-type mice. Endothelium-dependent relaxation of carotid arteries was significantly impaired (-40%) only in rosiglitazone-treated HCD-fed mthfr+/- mice. Carotid M/L (media-to-lumen ratio) and CSA (cross-sectional area) were increased (2-fold) in mthfr+/- mice fed or not HCD compared with wild-type mice (P<0.05). Rosiglitazone reduced M/L and CSA only in mthfr+/- mice fed a normal diet. Superoxide production was increased in mthfr+/- mice fed HCD treated or not with rosiglitazone, whereas plasma nitrite was decreased by rosiglitazone in mice fed or not HCD. PRMT-1 (protein arginine methyltransferase-1), involved in synthesis of the NO (nitric oxide) synthase inhibitor ADMA (asymmetric omega-NG,NG-dimethylarginine), and ADMA were increased only in rosiglitazone-treated HCD-fed mthfr+/- mice. Rosiglitazone had both beneficial and deleterious vascular effects in this animal model of high cardiovascular risk: it prevented carotid remodelling, but impaired endothelial function in part through enhanced oxidative stress and increased ADMA production in mice at high cardiovascular risk
A process very similar to multifractional Brownian motion
In Ayache and Taqqu (2005), the multifractional Brownian (mBm) motion is
obtained by replacing the constant parameter of the fractional Brownian
motion (fBm) by a smooth enough functional parameter depending on the
time . Here, we consider the process obtained by replacing in the
wavelet expansion of the fBm the index by a function depending on
the dyadic point . This process was introduced in Benassi et al (2000)
to model fBm with piece-wise constant Hurst index and continuous paths. In this
work, we investigate the case where the functional parameter satisfies an
uniform H\"older condition of order \beta>\sup_{t\in \rit} H(t) and ones
shows that, in this case, the process is very similar to the mBm in the
following senses: i) the difference between and a mBm satisfies an uniform
H\"older condition of order ; ii) as a by product, one
deduces that at each point the pointwise H\"older exponent of is
and that is tangent to a fBm with Hurst parameter .Comment: 18 page
Global regularity criterion for the 3D Navier-Stokes equations involving one entry of the velocity gradient tensor
In this paper we provide a sufficient condition, in terms of only one of the
nine entries of the gradient tensor, i.e., the Jacobian matrix of the velocity
vector field, for the global regularity of strong solutions to the
three-dimensional Navier-Stokes equations in the whole space, as well as for
the case of periodic boundary conditions
Statistical properties of power-law random banded unitary matrices in the delocalization-localization transition regime
Power-law random banded unitary matrices (PRBUM), whose matrix elements decay
in a power-law fashion, were recently proposed to model the critical statistics
of the Floquet eigenstates of periodically driven quantum systems. In this
work, we numerically study in detail the statistical properties of PRBUM
ensembles in the delocalization-localization transition regime. In particular,
implications of the delocalization-localization transition for the fractal
dimension of the eigenvectors, for the distribution function of the eigenvector
components, and for the nearest neighbor spacing statistics of the eigenphases
are examined. On the one hand, our results further indicate that a PRBUM
ensemble can serve as a unitary analog of the power-law random Hermitian matrix
model for Anderson transition. On the other hand, some statistical features
unseen before are found from PRBUM. For example, the dependence of the fractal
dimension of the eigenvectors of PRBUM upon one ensemble parameter displays
features that are quite different from that for the power-law random Hermitian
matrix model. Furthermore, in the time-reversal symmetric case the nearest
neighbor spacing distribution of PRBUM eigenphases is found to obey a
semi-Poisson distribution for a broad range, but display an anomalous level
repulsion in the absence of time-reversal symmetry.Comment: 10 pages + 13 fig
Variable exponent Besov-Morrey spaces
In this paper we introduce Besov-Morrey spaces with all indices variable and study some fundamental properties. This includes a description in terms of Peetre maximal functions and atomic and molecular decompositions. This new scale of non-standard function spaces requires the introduction of variable exponent mixed Morrey-sequence spaces, which in turn are defined within the framework of semimodular spaces. In particular, we obtain a convolution inequality involving special radial kernels, which proves to be a key tool in this work.publishe
Multicentre prospective evaluation of histological and molecular criterion for diagnosis of prosthetic-joint infection
Objectives:
This multicenter prospective study was performed to assess the contribution of broad range PCR diagnosis in prosthetic-joint infection (PJI).
Methods:
Adult patients treated for PJI at 7 centers were included between December 2010 and March 2012. Six per-operative samples were obtained for each patient, 5 for conventional cultures and 16S rRNA gene real-time PCR followed by sequencing, and 1 for histopathological classification according to Morawietz. Cultures and PCR were performed in a highly standardized manner, with 3 quality controls of PCR analyses. An infection was considered as proved (3 criteria: per-operative, bacteriological and histological), probable (clinical or bacteriological criterium), or excluded (no criterium). Molecular criterium for predicting PJI was determined using the bacteriological one as reference (>=1 positive sample for virulent organism, and >=3 positive samples for coagulase-negative staphylococci (CoNS) and P. acnes).
Results:
299 patients were included, 264 with suspicion of sepsis (S) and 35 as controls (C). The 264 S presented with acute (19%), or chronic suspicion of PJI (81%). Infection was proved or probable in 212/264 S (80%), with the bacteriological criterium in 189/212 S (89%). Out of these, 156 (83%) had monomicrobial and 33 (17%) polymicrobial infections. The isolated pathogens were S. aureus (40%), CoNS (25%), streptococci (14%), Gram-Negative rods (10%), and anaerobes 8%.
Histology results were not available for 55 patients, leaving 244 patients available for analysis. Histological findings of infection (Morawietz types II or III) were present in 128/169 (76%) proved or probable infections, in 3 patients without any other criterium, and were absent in excluded infections (n=42) and controls (n=29). PCR results were not analysable for 32 patients (S=28, C=4), leaving 267 patients (S=236, C=31) available for analysis. Molecular criterium of infection was present in 63/68 (93%) proved infections, 83/124 (67%) probable infections, 3/42 excluded infections, 0/2 histological criterium alone and 2/31 controls. Molecular criterium of infection was absent in 34/189 (18%) culture-positive S, and present in 8/23 culture-negative S (8 patients treated with antibiotics).
Conclusions:
According to this multicenter prospective study, 16S rRNA gene real-time PCR is less susceptible than culture for diagnosis of PJI. Molecular analysis could be recommended in culture-negative patients who were receiving antibiotics
The prognosis of streptococcal prosthetic bone and joint infections depends on surgical management-A multicenter retrospective study
BACKGROUND: The optimal treatment of streptococcal prosthetic joint infections (PJIs) is unclear.
METHODS: A cohort of streptococcal PJIs was reviewed retrospectively in seven reference centers for the management of complex bone and joint infections, covering the period January 1, 2010 to December 31, 2012.
RESULTS: Seventy patients with monomicrobial infections were included: 47 had infections of total hip arthroplasty and 23 had infections of total knee arthroplasty. The median age was 77 years (interquartile range (IQR) 69-83 years), the median Charlson comorbidity score was 4 (IQR 3-6), and 15.6% (n=11) had diabetes. The most commonly identified streptococcal species were Streptococcus agalactiae and Streptococcus dysgalactiae (38.6% (n=27) and 17.1% (n=12), respectively). Debridement, antibiotics and implant retention (DAIR) was performed after a median time of 7 days (IQR 3-8 days), with polyethylene exchange (PE) in 21% of cases. After a minimum follow-up of 2 years, 27% of patients had relapsed, corresponding to 51.4% of DAIR treatment cases and 0% of one-stage (n=15) or two-stage (n=17) exchange strategy cases. Rifampicin or levofloxacin in combination therapy was not associated with a better outcome (adjusted p= 0.99). S. agalactiae species and DAIR treatment were associated with a higher risk of failure. On multivariate analysis, only DAIR treatment and S. agalactiae were independent factors of relapse. Compared to DAIR without PE, DAIR with PE was only associated with a trend towards a benefit (odds ratio 0.33, 95% confidence interval 0.06-1.96; adjusted p= 0.44).
CONCLUSIONS: Streptococcal PJIs managed with DAIR have a poor prognosis and S. agalactiae seems to be an independent factor of treatment failure
- …