Signal-Jamming in a Sequential Auction

In a recurring auction early bids may reveal bidders’ types, which in turn affects bidding in later auctions. Bidders take this into account and may bid in a way that conceals their private information until the last auction is played. The present paper analyzes the equilibrium of a sequence of ?rst-price auctions assuming bidders have stable private values. We show that signal-jamming occurs and explore the dynamics of equilibrium prices

Histological and fluorescence microscopic examination of the bone/implant interface in orthodontic miniscrews (Mondeal®)

The temporary nature of orthodontic implants demands optimisation of size and design in order to minimise damage and risk to the patient. Slender and shorter miniscrews offer the advantage over conventional implants of easier and more ubiquitous positioning with minimised risk of injury to neighbouring anatomical structures such as tooth roots, nerves or vessels. The question is raised, however, as to what extent these advantages are gained at the price of diminished stability or a more unfavourable bone interface. In order to evaluate the screw/bone interface, 14 orthodontic miniscrews (Mondeal Medical Systems, diameter: 1.5 mm, length: 9 mm) were inserted into the right and left mandibles of 7 pigs (Sus scrofa domestica). Bone fluorochromes were administered in a defined order for polychrome sequencing. The samples gathered after 70 days were analysed using histological techniques and fluorescence microscopy. The lower part of the self-tapping thread displayed undisturbed bone apposition. Fluorescence microscopy revealed remodelling and bone apposition within the thread grooves

Critical considerations on the diagnostic appraisal, adaptation and remodelling of bone graft substitutes

The diagnostic assessment of skeletal defects has a long-standing tradition. As a result of the development of new bone grafting materials, the demands on diagnostic assessment have also increased. The mode and quality of diagnostic appraisal are crucial to further clinical use and outcome prediction. Alongside traditional clinical and biological techniques, molecular biological methods have gained a broad scope of application and will be used even more frequently in the future

Lack of Methyl-CpG Binding Protein 2 (MeCP2) Affects Cell Fate Refinement During Embryonic Cortical Development

During differentiation, neurons progressively restrict their fate repressing the expression of specific genes. Here we describe the involvement in such developmental steps of the methyl-CpG binding protein 2 (MeCP2), an epigenetic factor that participates to chromatin folding and transcriptional regulation. We previously reported that, due to transcriptional impairments, the maturation of Mecp2 null neurons is delayed. To evaluate whether this could stem from altered progenitors proliferation and differentiation, we investigated whether lack of Mecp2 affects these features both in vitro and in vivo. We show that in Mecp2 null embryonic cortexes the expression of genes defining the identity of proliferating neuroprogenitors is enriched and that their permanence in the G1 phase is prolonged. Moreover, the number of cells transitioning from a stage of maturation to a more mature one is increased in Mecp2 null embryonic cortices, in line with the central role of G1 for cell identity refinement. We thus suggest that, possibly due to the lack of proper transcriptional control normally exerted by Mecp2, fate refinement is impaired in developing null cells. We propose that the maturation delay affecting the developing Mecp2 null cortex originates, at least in part, from deranged mechanisms of cell fate refinement

Análise crítica do programa da reforma educativa para o ensino do português LS na 7ª classe em Angola

Dissertação para a obtenção de grau de Mestre em Ensino de Português Como Língua Segunda/ Língua EstrangeiraA situação actual da língua portuguesa em Angola desperta interesse de estudo em várias áreas. A questão do seu ensino, enquanto língua segunda, é a vertente que se destaca neste Trabalho. Recentemente o Governo angolano promulgou a 2ª Reforma Educativa com o objectivo de melhorar o sistema de ensino – aprendizagem. A língua portuguesa está em destaque. Não só por assumir o papel de língua oficial e de escolaridade, mas também por ser o veículo de comunicação internacional e de confluência com as línguas locais maioritariamente Bantu. É neste contexto que se procura dar a melhor resposta à necessidade de formação de usuários proficientes de PLS, e isto requer a elaboração e aplicação de metodologias que respondam ao desafio. Nesta perspectiva, propusemo-nos realizar o estudo com o título: Análise Crítica do Programa da Reforma Educativa para o Ensino do Português LS na 7ª Classe em Angola, com os objectivos essenciais de analisar as propostas metodológicas e sugerir melhorias. Para tal, servimo-nos do método empírico consubstanciado na consulta da bibliografia especializada e na de documentos reitores da Reforma. O Trabalho organiza-se em cinco capítulos, conclusão, sugestões, bibliografia e anexos. Da análise feita concluímos que a 2ª Reforma Educativa de Angola é um projecto ambicioso, com resultados aceitáveis, mas ainda distantes do ideal preconizado. Urge que se melhorem as condições de trabalho, de investigação, de ensino e infra-estruturais. Para a língua portuguesa em especial, a aposta na (re)qualificação dos quadros e a implementação de mais e melhores condições é fulcral. Do Programa vê-se uma estrutura diversificada que, se bem aplicada, facilita a aquisição de conhecimentos científicos e heurísticos. Porém as metodologias e as estratégias tendem mais para a mecanização do processo de ensino – aprendizagem. Aqui o papel do professor é fundamental, não só no respeito e cumprimento do legislado, mas sobretudo com uma perspectiva crítica construtiva

In vivo magnetic resonance spectroscopy in the brain of Cdkl5 null mice reveals a metabolic profile indicative of mitochondrial dysfunctions

Mutations in the X‐linked CDKL5 gene cause CDKL5 deficiency disorder (CDD), a severe neurodevelopmental condition mainly characterized by infantile epileptic encephalopathy, intellectual disability, and autistic features. The molecular mechanisms underlying the clinical symptoms remain largely unknown and the identification of reliable biomarkers in animal models will certainly contribute to increase our comprehension of CDD as well as to assess the efficacy of therapeutic strategies. Here, we used different Magnetic Resonance (MR) methods to disclose structural, functional, or metabolic signatures of Cdkl5 deficiency in the brain of adult mice. We found that loss of Cdkl5 does not cause cerebral atrophy but affects distinct brain areas, particularly the hippocampus. By in vivo proton‐MR spectroscopy (MRS), we revealed in the Cdkl5 null brain a metabolic dysregulation indicative of mitochondrial dysfunctions. Accordingly, we unveiled a significant reduction in ATP levels and a decrease in the expression of complex IV of mitochondrial electron transport chain. Conversely, the number of mitochondria appeared preserved. Importantly, we reported a significant defect in the activation of one of the major regulators of cellular energy balance, the adenosine monophosphate‐activated protein kinase (AMPK), that might contribute to the observed metabolic impairment and become an interesting therapeutic target for future preclinical trials. In conclusion, MRS revealed in the Cdkl5 null brain the presence of a metabolic dysregulation suggestive of a mitochondrial dysfunction that permitted to foster our comprehension of Cdkl5 deficiency and brought our interest towards targeting mitochondria as therapeutic strategy for CDD

Diamond deposition on modified silicon substrates: Making diamond atomic force microscopy tips for nanofriction experiments

Fine-crystalline diamond particles are grown on standard Si atomic force microscopy tips, using hot filament-assisted chemical vapor deposition. To optimize the conditions for diamond deposition, first a series of experiments is carried out using silicon substrates covered by point-topped pyramids as obtained by wet chemical etching. The apexes and the edges of the silicon pyramids provide favorable sites for diamond nucleation and growth. The investigation of the deposited polycrystallites is done by means of optical microscopy, scanning electron microscopy and micro-Raman spectroscopy. The resulting diamond-terminated tips are tested in ultra high vacuum using contact-mode atomic force microscope on a stepped surface of sapphire showing high stability, sharpness, and hardnes

A note on revenue effects of asymmetry in private-value auctions

We formulate a way to study whether the asymmetry of buyers (in the sense of having different prior probability distributions of valuations) is helpful to the seller in private-value auctions (asked first by Cantillon [2001]). In our proposed formulation, this question corresponds to two important questions previously asked: Does a first-price auction have higher revenue than a second-price auction when buyers have asymmetric distributions (asked by Maskin and Riley [2000])? And does a seller enhance revenue by releasing information (asked by Milgrom and Weber[1982])? This is shown by constructing two Harsanyi games of incomplete information each having the same ex-ante distribution of valuations but in one beliefs are symmetric while in the other beliefs are sometimes asymmetric. Our main result is that answers to all three questions coincide when values are independent and are related when values are affiliated

Improving polio vaccination during supplementary campaigns at areas of mass transit in India

<p>Abstract</p> <p>Background</p> <p>In India, children who are traveling during mass immunization campaigns for polio represent a substantial component of the total target population. These children are not easily accessible to health workers and may thus not receive vaccine. Vaccination activities at mass transit sites (such as major intersections, bus depots and train stations), can increase the proportion of children vaccinated but the effectiveness of these activities, and factors associated with their success, have not been rigorously evaluated.</p> <p>Methods</p> <p>We assessed data from polio vaccination activities in Jyotiba Phule Nagar district, Uttar Pradesh, India, conducted in June 2006. We used trends in the vaccination results from the June activities to plan the timing, locations, and human resource requirements for transit vaccination activities in two out of the seven blocks in the district for the July 2006 supplementary immunization activity (SIA). In July, similar data was collected and for the first time vaccination teams also recorded the proportion of children encountered each day who were vaccinated (a new monitoring system).</p> <p>Results</p> <p>In June, out of the 360,937 total children vaccinated, 34,643 (9.6%) received vaccinations at mass transit sites. In the July SIA, after implementation of a number of changes based on the June monitoring data, 36,475 children were vaccinated at transit sites (a 5.3% increase). Transit site vaccinations in July increased in the two intervention blocks from 18,194 to 21,588 (18.7%) and decreased from 16,449 to 14,887 (9.5%) in the five other blocks. The new monitoring system showed the proportion of unvaccinated children at street intersection transit sites in the July campaign decreased from 24% (1,784/7,405) at the start of the campaign to 3% (143/5,057) by the end of the SIA, consistent with findings from the more labor-intensive post-vaccination coverage surveys routinely performed by the program.</p> <p>Conclusions</p> <p>Analysis of vaccination data from transit sites can inform program management changes leading to improved outcomes in polio immunization campaigns. The number of vaccinated children encountered should be routinely recorded by transit teams and may provide a useful, inexpensive alternative mechanism to assess program coverage.</p