Alien Registration- Lachance, Joseph P. (Augusta, Kennebec County)

https://digitalmaine.com/alien_docs/18406/thumbnail.jp

Integrated urban monitoring framework: a conceptual framework for land dynamics monitoring

Peer Reviewe

Evolving antibiotics against resistance : a potential platform for natural product development?

To avoid an antibiotic resistance crisis, we need to develop antibiotics at a pace that matches the rate of evolution of resistance. However, the complex functions performed by antibiotics—combining, e.g., penetration of membranes, counteraction of resistance mechanisms, and interaction with molecular targets— have proven hard to achieve with current methods for drug development, including target-based screening and rational design. Here, we argue that we can meet the evolution of resistance in the clinic with evolution of antibiotics in the laboratory. On the basis of the results of experimental evolution studies of microbes in general and antibiotic production in Actinobacteria in particular, we propose methodology for evolving antibiotics to circumvent mechanisms of resistance. This exploits the ability of evolution to find solutions to complex problems without a need for design. We review evolutionary theory critical to this approach and argue that it is feasible and has important advantages over current methods for antibiotic discovery

La régionalisation des précipitations : une revue bibliographique des développements récents

L'estimation de l'intensité de précipitations extrêmes est un sujet de recherche en pleine expansion. Nous présentons ici une synthèse des travaux de recherche sur l'analyse régionale des précipitations. Les principales étapes de l'analyse régionale revues sont les méthodes d'établissement de régions homogènes, la sélection de fonctions de distributions régionales et l'ajustement des paramètres de ces fonctions.De nombreux travaux sur l'analyse régionale des précipitations s'inspirent de l'approche développée en régionalisation des crues. Les méthodes de types indice de crues ont été utilisées par plusieurs auteurs. Les régions homogènes établies peuvent être contiguës ou non-contiguës. L'analyse multivariée a été utilisée pour déterminer plusieurs régions homogènes au Canada. L'adéquation des sites à l'intérieur d'une région homogène a souvent été validée par une application des L-moments, bien que d'autres tests d'homogénéité aient aussi été utilisés.La loi générale des valeurs extrêmes (GEV) est celle qui a le plus souvent été utilisée dans l'analyse régionale des précipitations. D'autres travaux ont porté sur la loi des valeurs extrêmes à deux composantes (TCEV), de même que sur des applications des séries partielles.Peu de travaux ont porté sur les relations intensité durée dans un contexte régional, ni sur les variations saisonnières des paramètres régionaux. Finalement, les recherches ont débuté sur l'application des concepts d'invariance d'échelle et de loi d'échelle. Ces travaux sont jugés prometteurs.Research on the estimation of extreme precipitation events is currently expanding. This field of research is of great importance in hydraulic engineering not only for the design of dams and dikes, but also for municipal engineering designs. In many cases, local data are scarce. In this context, regionalization methods are very useful tools. This paper summarizes the most recent work on the regionalization of precipitation. Steps normally included in any regionalization work are the delineation of homogenous regions, selection a regional probability distribution function and fitting the parameters.Methods to determine homogenous regions are first reviewed. A great deal of work on precipitation was inspired by methods developed for regional flow analysis, especially the index flood approach. Homogenous regions can be contiguous, but in many cases they are not. The region of influence approach, commonly used in hydrological studies, has not been often applied to precipitation data. Homogenous regions can be established using multivariate statistical approaches such as Principal Component Analysis or Factorial Analysis. These approaches have been used in a number of regions in Canada. Sites within a homogenous region may be tested for their appropriateness by calculating local statistics such as the coefficient of variation, coefficient of skewness and kurtosis, and by comparing these statistics to the regional statistics. Another common approach is the use of L-moments. L-moments are linear combinations of ordered statistics and hence are not as sensitive to outliers as conventional moments. Other homogeneity tests have also been used. They include a Chi-squared test on all regional quantiles associated with a given non-exceedance probability, and a Smirnoff test used to validate the inclusion of a station in the homogenous region.Secondly, we review the distributions and fitting methods used in regionalization of precipitation. The most popular distribution function used is the General Extreme Value (GEV) distribution. This distribution has been recommended for precipitation frequency analysis in the United Kingdom. For regional analysis, the GEV is preferred to the Gumbel distribution, which is often used for site-specific frequency analysis of precipitation extremes. L-moments are also often used to calculate the parameters of the GEV distribution. Some applications of the Two-Component Extreme Value (TCEV) distribution also exist. The TCEV has mostly been used to alleviate the concerns over some of the theoretical and practical restrictions of the GEV.Applications of the Partial Duration Series or Peak-Over-Threshold (POT) approach are also described. In the POT approach, events with a magnitude exceeding a certain threshold are considered in the analysis. The occurrence of such exceedances is modelled as a Poisson process. One of the drawbacks of this method is that it is sometimes necessary to select a relatively high threshold in order to comply with the assumption that observations are independent and identically distributed (i.i.d.). The use of a re-parameterised Generalised Pareto distribution has also been suggested by some researchers.Research on depth-duration relations on a regional scale is also discussed. Empirical approaches used in Canada and elsewhere are described. In most cases, the method consists of establishing a non-linear relationship between a quantile associated with a given duration and its return period to a reference quantile, such as a 1-hour rainfall with a 10-year return period. Depth duration relationships cannot be applied uniformly across Canada for events with durations exceeding two hours. Seasonal variability studies in regionalization are relatively scarce, but are required because of the obvious seasonality of precipitation. In many cases, seasonal regimes may lead to different regionalization approaches for the wet and the dry season. Some research has focused on the use of periodic functions to model regional parameters. Another approach consists of converting the occurrence data of a given event in an angular measurement and developing seasonal indices based on this angular measurement.Other promising avenues of research include the scaling approach. The debate over the possibility of scale invariance for precipitation is ongoing. Simple scaling was studied on a number of precipitation data, but the fact that intermittence is common in precipitation regimes and the presence of numerous zero values in the series does not readily lead to proper application of this approach. Recent research has shown that multiple scaling is likely a more promising avenue

Strain-induced effects in colloidal quantum dots: lifetime measurements and blinking statistics

Abstract A series of samples of CdSe/Cd x Zn 1−x S core/shell quantum dots have been synthesized in order to measure the influence of lattice-mismatch-induced strain on the photoluminescence (PL) and blinking behaviour. The PL spectra show a significant variation of the fluorescence wavelength even though the colloidal quantum dots (cQDs) are similar in size. The PL excitation spectra show a gradual splitting of the first exciton level as the proportion of Zn is increased in the shell and as the shell grows. On the other hand, blinking studies clearly demonstrate a significant dependence on the amount of Zn present in the shell. Distributions of on and off times go from the usual power-law distributions to power-law distributions with exponential cut-offs. These cut-offs become increasingly pronounced as the proportion of Zn increases. We interpret these results in the framework of diffusion-controlled electron transfer. Exciton relaxation lifetime measurements strongly suggest that lattice mismatch is responsible for a greater number of defects in core/shell cQDs. Therefore, strain and lattice mismatch are shown to be parameters of significant importance for the electronic structure of nanocrystals, influencing the photoluminescence, exciton relaxation lifetime and blinking behaviour

Association between e-alert implementation for detection of acute kidney injury and outcomes: a systematic review

Background. Electronic alerts (e-alerts) for acute kidney injury (AKI) in hospitalized patients are increasingly being implemented; however, their impact on outcomes remains uncertain. Methods. We performed a systematic review. Electronic databases and grey literature were searched for original studies published between 1990 and 2016. Randomized, quasi-randomized, observational and before-and-after studies that included hospitalized patients, implemented e-alerts for AKI and described their impact on one of care processes, patient-centred outcomes or resource utilization measures were included. Results. Our search yielded six studies (n = 10 165 patients). E-alerts were generally automated, triggered through electronic health records and not linked to clinical decision support. In pooled analysis, e-alerts did not improve mortality [odds ratio (OR) 1.05; 95% confidence intervals (CI), 0.84–1.31; n = 3 studies; n = 3425 patients; I2 = 0%] or reduce renal replacement therapy (RRT) use (OR 1.20; 95% CI, 0.91–1.57; n = 2 studies; n = 3236 patients; I2 = 0%). Isolated studies reported improvements in selected care processes. Pooled analysis found no significant differences in prescribed fluid therapy. Conclusions. In the available studies, e-alerts for AKI do not improve survival or reduce RRT utilization. The impact of e-alerts on processes of care was variable. Additional research is needed to understand those aspects of e-alerts that are most likely to improve care processes and outcomes

The genetic prehistory of southern Africa

Southern and eastern African populations that speak non-Bantu languages with click consonants are known to harbour some of the most ancient genetic lineages in humans, but their relationships are poorly understood. Here, we report data from 23 populations analyzed at over half a million single nucleotide polymorphisms, using a genome-wide array designed for studying human history. The southern African Khoisan fall into two genetic groups, loosely corresponding to the northwestern and southeastern Kalahari, which we show separated within the last 30,000 years. We find that all individuals derive at least a few percent of their genomes from admixture with non-Khoisan populations that began approximately 1,200 years ago. In addition, the east African Hadza and Sandawe derive a fraction of their ancestry from admixture with a population related to the Khoisan, supporting the hypothesis of an ancient link between southern and eastern AfricaComment: To appear in Nature Communication