231 research outputs found
Phase Fluctuations in Bose-Einstein Condensates
We demonstrate the existence of phase fluctuations in elongated Bose-Einstein
Condensates (BECs) and study the dependence of those fluctuations on the system
parameters. A strong dependence on temperature, atom number, and trapping
geometry is observed. Phase fluctuations directly affect the coherence
properties of BECs. In particular, we observe instances where the phase
coherence length is significantly smaller than the condensate size. Our method
of detecting phase fluctuations is based on their transformation into density
modulations after ballistic expansion. An analytic theory describing this
transformation is developed.Comment: 11 pages, 7 figure
Observation of Phase Fluctuations in Bose-Einstein Condensates
The occurrence of phase fluctuations due to thermal excitations in
Bose-Einstein condensates (BECs) is studied for a variety of temperatures and
trap geometries. We observe the statistical nature of the appearence of phase
fluctuations and characterize the dependence of their average value on
temperature, number of particles and the trapping potential. We find pronounced
phase fluctuations for condensates in very elongated traps in a broad
temperature range. The results are of great importance for the realization of
BEC in quasi 1D geometries, for matter wave interferometry with BECs, as well
as for coherence properties of guided atom laser beams.Comment: 4 pages, 4 figure
Physics with Coherent Matter Waves
This review discusses progress in the new field of coherent matter waves, in
particular with respect to Bose-Einstein condensates. We give a short
introduction to Bose-Einstein condensation and the theoretical description of
the condensate wavefunction. We concentrate on the coherence properties of this
new type of matter wave as a basis for fundamental physics and applications.
The main part of this review treats various measurements and concepts in the
physics with coherent matter waves. In particular we present phase manipulation
methods, atom lasers, nonlinear atom optics, optical elements, interferometry
and physics in optical lattices. We give an overview of the state of the art in
the respective fields and discuss achievements and challenges for the future
Gene expression of peripheral blood mononuclear cells and CD8+ T cells from gilts after PRRSV infection
Porcine reproductive and respiratory syndrome virus (PRRSV) is a positive-stranded RNA virus, which emerged in Europe and U.S.A. in the late 1980s and has since caused huge economic losses. Infection with PRRSV causes mild to severe respiratory and reproductive clinical symptoms in pigs. Alteration of the host immune response by PRRSV is associated with the increased susceptibility to secondary viral and bacterial infections resulting in more serious and chronic disease. However, the expression profiles underlying innate and adaptive immune responses to PRRSV infection are yet to be further elucidated. In this study, we investigated gene expression profiles of PBMCs and CD8+ T cells after PRRSV AUT15-33 infection. We identified the highest number of differentially expressed genes in PBMCs and CD8+ T cells at 7 dpi and 21 dpi, respectively. The gene expression profile of PBMCs from infected animals was dominated by a strong innate immune response at 7 dpi which persisted through 14 dpi and 21 dpi and was accompanied by involvement of adaptive immunity. The gene expression pattern of CD8+ T cells showed a strong adaptive immune response to PRRSV, leading to the formation of highly differentiated CD8+ T cells starting from 14 dpi. The hallmark of the CD8+ T-cell response was the increased expression of effector and cytolytic genes (PRF1, GZMA, GZMB, GZMK, KLRK1, KLRD1, FASL, NKG7), with the highest levels observed at 21 dpi. Temporal clustering analysis of DEGs of PBMCs and CD8+ T cells from PRRSV-infected animals revealed three and four clusters, respectively, suggesting tight transcriptional regulation of both the innate and the adaptive immune response to PRRSV. The main cluster of PBMCs was related to the innate immune response to PRRSV, while the main clusters of CD8+ T cells represented the initial transformation and differentiation of these cells in response to the PRRSV infection. Together, we provided extensive transcriptomics data explaining gene signatures of the immune response of PBMCs and CD8+ T cells after PRRSV infection. Additionally, our study provides potential biomarker targets useful for vaccine and therapeutics development
Effect of Training on the Reliability of Satiety Evaluation and Use of Trained Panellists to Determine the Satiety Effect of Dietary Fibre: A Randomised Controlled Trial
Background: The assessment of satiety effects on foods is commonly performed by untrained volunteers marking their perceived hunger or fullness on line scales, marked with pre-set descriptors. The lack of reproducibility of satiety measurement using this approach however results in the tool being unable to distinguish between foods that have small, but possibly important, differences in their satiety effects. An alternate approach is used in sensory evaluation; panellists can be trained in the correct use of the assessment line-scale and brought to consensus on the meanings of descriptors used for food quality attributes to improve the panel reliability. The effect of training on the reliability of a satiety panel has not previously been reported. Method: In a randomised controlled parallel intervention, the effect of training in the correct use of a satiety labelled magnitude scale (LMS) was assessed versus no-training. The test-retest precision and reliability of two hour postprandial satiety evaluation after consumption of a standard breakfast was compared. The trained panel then compared the satiety effect of two breakfast meals containing either a viscous or a non-viscous dietary fibre in a crossover trial.Results: A subgroup of the 23 panellists (n = 5) improved their test re-test precision after training. Panel satiety area under the curve, “after the training” intervention was significantly different to “before training” (p < 0.001). Reliability of the panel determined by intraclass correlation (ICC) of test and retest showed improved strength of the correlation from 0.70 pre-intervention to 0.95 post intervention. The trained “satiety expert panel” determined that a standard breakfast with 5g of viscous fibre gave significantly higher satiety than with 5g non-viscous fibre (area under curve (AUC) of 478.2, 334.4 respectively) (p ≤ 0.002). Conclusion: Training reduced between panellist variability. The improved strength of test-retest ICC as a result of the training intervention suggests that training satiety panellists can improve the discriminating power of satiety evaluation
Phytochemical characterization of South Africa bush tea (Athrixia phylicoides DC.)
A methanolic extract of bush tea (Athrixia phylicoides, Asteraceae) was evaluated sensorially.
A High Temperature Liquid Chromatography (HTLC)-coupled sensory-guided analysis was
performed on bush tea extract to identify potential taste modulating compounds. One fraction
showed bitter enhancing effects on caffeine. Fractionated using Fast Centrifugal Partition
Chromatography (FCPC) and preparative HPLC followed by structure elucidation using
NMR and LC-NMR led to the identification of three polymethoxylated flavones, quercetin-3'-
O-glucoside (1), as well as a methoxylated derivative (2). In addition, two dicaffeoyl quinic
acids and one coumaric acid ester (3) were isolated. Sensory evaluation of isolated
compounds led to the identification of quercetin-3'-O-glucoside as bitterness enhancing
principle.http://www.elsevier.com/locate/sajbhb201
Observation of direct processes in photoproduction at HERA
Jets in photoproduction events have been studied with the ZEUS detector for gammap centre-of-mass energies ranging from 130 to 2 50 GeV. The inclusive jet distributions give evidence for the dominance of resolved photon interactions. In the di-jet sample the direct processes are for the first time clearly isolated. Di-jet cross sections for the resolved and direct processes are given in a restricted kinematic range
Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications
Superparamagnetic iron oxide nanoparticles
can providemultiple benefits for biomedical applications
in aqueous environments such asmagnetic separation or
magnetic resonance imaging. To increase the colloidal
stability and allow subsequent reactions, the introduction
of hydrophilic functional groups onto the particles’
surface is essential. During this process, the original
coating is exchanged by preferably covalently bonded
ligands such as trialkoxysilanes. The duration of the
silane exchange reaction, which commonly takes more
than 24 h, is an important drawback for this approach. In
this paper, we present a novel method, which introduces
ultrasonication as an energy source to dramatically
accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove
the generic character, different functional groups were
introduced on the surface including polyethylene glycol
chains, carboxylic acid, amine, and thiol groups. Their
colloidal stability in various aqueous buffer solutions as
well as human plasma and serum was investigated to
allow implementation in biomedical and sensing
applications.status: publishe
Cytoprotective activity of minocycline includes improvement of mitochondrial coupling: the importance of minocycline concentration and the presence of VDAC
understanding and tackling poverty and vulnerability in mountain livelihoods in the hindu kush himalaya
This chapter critically reviews the existing knowledge on livelihoods, poverty, and vulnerability in the Hindu Kush Himalaya (HKH). Development in mountain areas and the practices of people in these areas are uniquely conditioned by distinct characteristics that we term "mountain specificities". Some of these specificities—such as inaccessibility, fragility, and marginality—constrain development. Others—such as abundant biological diversity, ecological niches, and adaptation mechanisms—present development opportunities for mountain people
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