2,167 research outputs found
Provenance-Centered Dataset of Drug-Drug Interactions
Over the years several studies have demonstrated the ability to identify
potential drug-drug interactions via data mining from the literature (MEDLINE),
electronic health records, public databases (Drugbank), etc. While each one of
these approaches is properly statistically validated, they do not take into
consideration the overlap between them as one of their decision making
variables. In this paper we present LInked Drug-Drug Interactions (LIDDI), a
public nanopublication-based RDF dataset with trusty URIs that encompasses some
of the most cited prediction methods and sources to provide researchers a
resource for leveraging the work of others into their prediction methods. As
one of the main issues to overcome the usage of external resources is their
mappings between drug names and identifiers used, we also provide the set of
mappings we curated to be able to compare the multiple sources we aggregate in
our dataset.Comment: In Proceedings of the 14th International Semantic Web Conference
(ISWC) 201
Simulation of primordial object formation
We have included the chemical rate network responsible for the formation of
molecular Hydrogen in the N-body hydrodynamic code, Hydra, in order to study
the formation of the first cosmological at redshifts between 10 and 50. We have
tested our implementation of the chemical and cooling processes by comparing
N-body top hat simulations with theoretical predictions from a semi-analytic
model and found them to be in good agreement. We find that post-virialization
properties are insensitive to the initial abundance of molecular hydrogen. Our
main objective was to determine the minimum mass () of perturbations
that could become self gravitating (a prerequisite for star formation), and the
redshift at which this occurred. We have developed a robust indicator for
detecting the presence of a self-gravitating cloud in our simulations and find
that we can do so with a baryonic particle mass-resolution of 40 solar masses.
We have performed cosmological simulations of primordial objects and find that
the object's mass and redshift at which they become self gravitating agree well
with the results from the top hat simulations. Once a critical
molecular hydrogen fractional abundance of about 0.0005 has formed in an
object, the cooling time drops below the dynamical time at the centre of the
cloud and the gas free falls in the dark matter potential wells, becoming self
gravitating a dynamical time later.Comment: 45 pages, 17 figures, submitted to Ap
Compact smallest eigenvalue expressions in Wishart-Laguerre ensembles with or without fixed-trace
The degree of entanglement of random pure states in bipartite quantum systems
can be estimated from the distribution of the extreme Schmidt eigenvalues. For
a bipartition of size M\geq N, these are distributed according to a
Wishart-Laguerre ensemble (WL) of random matrices of size N x M, with a
fixed-trace constraint. We first compute the distribution and moments of the
smallest eigenvalue in the fixed trace orthogonal WL ensemble for arbitrary
M\geq N. Our method is based on a Laplace inversion of the recursive results
for the corresponding orthogonal WL ensemble by Edelman. Explicit examples are
given for fixed N and M, generalizing and simplifying earlier results. In the
microscopic large-N limit with M-N fixed, the orthogonal and unitary WL
distributions exhibit universality after a suitable rescaling and are therefore
independent of the constraint. We prove that very recent results given in terms
of hypergeometric functions of matrix argument are equivalent to more explicit
expressions in terms of a Pfaffian or determinant of Bessel functions. While
the latter were mostly known from the random matrix literature on the QCD Dirac
operator spectrum, we also derive some new results in the orthogonal symmetry
class.Comment: 25 pag., 4 fig - minor changes, typos fixed. To appear in JSTA
KPZ equation in one dimension and line ensembles
For suitably discretized versions of the Kardar-Parisi-Zhang equation in one
space dimension exact scaling functions are available, amongst them the
stationary two-point function. We explain one central piece from the technology
through which such results are obtained, namely the method of line ensembles
with purely entropic repulsion.Comment: Proceedings STATPHYS22, Bangalore, 200
MassTRIX: mass translator into pathways
Recent technical advances in mass spectrometry (MS) have brought the field of metabolomics to a point where large numbers of metabolites from numerous prokaryotic and eukaryotic organisms can now be easily and precisely detected. The challenge today lies in the correct annotation of these metabolites on the basis of their accurate measured masses. Assignment of bulk chemical formula is generally possible, but without consideration of the biological and genomic context, concrete metabolite annotations remain difficult and uncertain. MassTRIX responds to this challenge by providing a hypothesis-driven approach to high precision MS data annotation. It presents the identified chemical compounds in their genomic context as differentially colored objects on KEGG pathway maps. Information on gene transcription or differences in the gene complement (e.g. samples from different bacterial strains) can be easily added. The user can thus interpret the metabolic state of the organism in the context of its potential and, in the case of submitted transcriptomics data, real enzymatic capacities. The MassTRIX web server is freely accessible at http://masstrix.or
Wishart and Anti-Wishart random matrices
We provide a compact exact representation for the distribution of the matrix
elements of the Wishart-type random matrices , for any finite
number of rows and columns of , without any large N approximations. In
particular we treat the case when the Wishart-type random matrix contains
redundant, non-random information, which is a new result. This representation
is of interest for a procedure of reconstructing the redundant information
hidden in Wishart matrices, with potential applications to numerous models
based on biological, social and artificial intelligence networks.Comment: 11 pages; v2: references updated + some clarifications added; v3:
version to appear in J. Phys. A, Special Issue on Random Matrix Theor
Exact Minimum Eigenvalue Distribution of an Entangled Random Pure State
A recent conjecture regarding the average of the minimum eigenvalue of the
reduced density matrix of a random complex state is proved. In fact, the full
distribution of the minimum eigenvalue is derived exactly for both the cases of
a random real and a random complex state. Our results are relevant to the
entanglement properties of eigenvectors of the orthogonal and unitary ensembles
of random matrix theory and quantum chaotic systems. They also provide a rare
exactly solvable case for the distribution of the minimum of a set of N {\em
strongly correlated} random variables for all values of N (and not just for
large N).Comment: 13 pages, 2 figures included; typos corrected; to appear in J. Stat.
Phy
Effects of a Protein Preload on Gastric Emptying, Glycemia, and Gut Hormones After a Carbohydrate Meal in Diet-Controlled Type 2 Diabetes
OBJECTIVE: We evaluated whether a whey preload could slow gastric emptying, stimulate incretin hormones, and attenuate postprandial glycemia in type 2 diabetes. RESEARCH DESIGN AND METHODS: Eight type 2 diabetic patients ingested 350 ml beef soup 30 min before a potato meal; 55 g whey was added to either the soup (whey preload) or potato (whey in meal) or no whey was given. RESULTS: Gastric emptying was slowest after the whey preload (P < 0.0005). The incremental area under the blood glucose curve was less after the whey preload and whey in meal than after no whey (P < 0.005). Plasma glucose-dependent insulinotropic polypeptide, insulin, and cholecystokinin concentrations were higher on both whey days than after no whey, whereas glucagon-like peptide 1 was greatest after the whey preload (P < 0.05). CONCLUSIONS: Whey protein consumed before a carbohydrate meal can stimulate insulin and incretin hormone secretion and slow gastric emptying, leading to marked reduction in postprandial glycemia in type 2 diabetes.Jing Ma, Julie E. Stevens, Kimberly Cukier, Anne F. Maddox, Judith M. Wishart, Karen L. Jones, Peter M. Clifton, Michael Horowitz, and Christopher K. Rayne
The Social context of motorcycle riding and the key determinants influencing rider behavior: A qualitative investigation
Objective: Given the increasing popularity of motorcycle riding and heightened risk of injury or death associated with being a rider, this study explored rider behaviour as a determinant of rider safety and, in particular, key beliefs and motivations which influence such behaviour. To enhance the effectiveness of future education and training interventions, it is important to understand ridersā own views about what influences how they ride. Specifically, this study sought to identify key determinants of ridersā behaviour in relation to the social context of riding including social and identity-related influences relating to the group (group norms and group identity) as well as the self (moral/personal norm and self-identity). ----- ----- Method: Qualitative research was undertaken via group discussions with motorcycle riders (n = 41). Results: The findings revealed that those in the group with which one rides represent an important source of social influence. Also, the motorcyclist (group) identity was associated with a range of beliefs, expectations, and behaviours considered to be normative. Exploration of the construct of personal norm revealed that riders were most cognizant of the āwrong things to doā when riding; among those issues raised was the importance of protective clothing (albeit for the protection of others and, in particular, pillion passengers). Finally, self-identity as a motorcyclist appeared to be important to a riderās self-concept and was likely to influence their on-road behaviour. ----- ----- Conclusion: Overall, the insight provided by the current study may facilitate the development of interventions including rider training as well as public education and mass media messages. The findings suggest that these interventions should incorporate factors associated with the social nature of riding in order to best align it with some of the key beliefs and motivations underpinning ridersā on-road behaviours
An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation
BACKGROUND
PREDICT is a breast cancer prognostic and treatment benefit model implemented online. The overall fit of the model has been good in multiple independent case series, but PREDICT has been shown to underestimate breast cancer specific mortality in women diagnosed under the age of 40. Another limitation is the use of discrete categories for tumour size and node status resulting in 'step' changes in risk estimates on moving between categories. We have refitted the PREDICT prognostic model using the original cohort of cases from East Anglia with updated survival time in order to take into account age at diagnosis and to smooth out the survival function for tumour size and node status.
METHODS
Multivariable Cox regression models were used to fit separate models for ER negative and ER positive disease. Continuous variables were fitted using fractional polynomials and a smoothed baseline hazard was obtained by regressing the baseline cumulative hazard for each patients against time using fractional polynomials. The fit of the prognostic models were then tested in three independent data sets that had also been used to validate the original version of PREDICT.
RESULTS
In the model fitting data, after adjusting for other prognostic variables, there is an increase in risk of breast cancer specific mortality in younger and older patients with ER positive disease, with a substantial increase in risk for women diagnosed before the age of 35. In ER negative disease the risk increases slightly with age. The association between breast cancer specific mortality and both tumour size and number of positive nodes was non-linear with a more marked increase in risk with increasing size and increasing number of nodes in ER positive disease. The overall calibration and discrimination of the new version of PREDICT (v2) was good and comparable to that of the previous version in both model development and validation data sets. However, the calibration of v2 improved over v1 in patients diagnosed under the age of 40.
CONCLUSIONS
The PREDICT v2 is an improved prognostication and treatment benefit model compared with v1. The online version should continue to aid clinical decision making in women with early breast cancer
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