Climate research Netherlands : research highlights

In the Netherlands the temperature has risen, on average, by 1.6°C since 1900. Regional climate scenarios for the 21st century developed by the Dutch Royal Meteorological Institute [1] show that temperature in the Netherlands will continue to rise and mild winters and hot summers will become more common. On average winters will become wetter and extreme precipitation amounts will increase. The intensity of extreme rain showers in summer will increase and the sea level will continue to rise. Changing climate will affect all segments and sectors of the society and the economy of the Netherlands, but it also brings new opportunities for major innovation

A novel method to determine buffer strip effectiveness on deep soils

Unfertilized buffer strips (BS) generally improve surface water quality. High buffer strip effectiveness (BSE) has been reported for sloping shallow aquifers, but experimental data for plain landscapes with deeply permeable soils is lacking. We tested a novel method to determine BSE on a 20-m-deep, permeable sandy soil. Discharge from soil to ditch was temporarily collected in an in-stream reservoir to measure its quantity and quality, both for a BS and a reference (REF) treatment. Treatments were replicated once for the first, and three times for the next three leaching seasons. No significant BSE was obtained for nitrogen and phosphorus species in the reservoirs. Additionally, water samples were taken from the upper groundwater below the treatments. The effect of BS for nitrate was much bigger in upper groundwater than in the reservoirs that also collected groundwater from greater depths that were not influenced by the treatments. We conclude that measuring changes in upper groundwater to assess BSE is only valid under specific hydrogeological conditions. We propose an alternative experimental set-up for future research, including extra measurements before installing the BS and REF treatments to deal with spatial and temporal variability. The use of such data as covariates will increase the power of statistical tests by decreasing between-reservoir variability

Concurrent TNFRSF1A R92Q and pyrin E230K mutations in a child with multiple sclerosis

We report a 16-year-old female patient with a severe course of multiple sclerosis and concomitant symptoms suggestive of a hereditary autoinflammatory disease. Genetic analyses revealed that she inherited a TNFRSF1A R92Q mutation from her mother and a pyrin E230K mutation from her father. To our knowledge, this is the first report of a patient with severe childhood multiple sclerosis and mutations in two genes which predispose to hereditary autoinflammatory disorders. We speculate that these mutations contribute to early multiple sclerosis manifestation and enhance the inflammatory damage inflicted by the autoimmune response

MRI evidence for altered venous drainage and intracranial compliance in mild traumatic brain injury.

To compare venous drainage patterns and associated intracranial hydrodynamics between subjects who experienced mild traumatic brain injury (mTBI) and age- and gender-matched controls. Thirty adult subjects (15 with mTBI and 15 age- and gender-matched controls) were investigated using a 3T MR scanner. Time since trauma was 0.5 to 29 years (mean 11.4 years). A 2D-time-of-flight MR-venography of the upper neck was performed to visualize the cervical venous vasculature. Cerebral venous drainage through primary and secondary channels, and intracranial compliance index and pressure were derived using cine-phase contrast imaging of the cerebral arterial inflow, venous outflow, and the craniospinal CSF flow. The intracranial compliance index is the defined as the ratio of maximal intracranial volume and pressure changes during the cardiac cycle. MR estimated ICP was then obtained through the inverse relationship between compliance and ICP. Compared to the controls, subjects with mTBI demonstrated a significantly smaller percentage of venous outflow through internal jugular veins (60.9±21% vs. controls: 76.8±10%; p = 0.01) compensated by an increased drainage through secondary veins (12.3±10.9% vs. 5.5±3.3%; p<0.03). Mean intracranial compliance index was significantly lower in the mTBI cohort (5.8±1.4 vs. controls 8.4±1.9; p<0.0007). Consequently, MR estimate of intracranial pressure was significantly higher in the mTBI cohort (12.5±2.9 mmHg vs. 8.8±2.0 mmHg; p<0.0007). mTBI is associated with increased venous drainage through secondary pathways. This reflects higher outflow impedance, which may explain the finding of reduced intracranial compliance. These results suggest that hemodynamic and hydrodynamic changes following mTBI persist even in the absence of clinical symptoms and abnormal findings in conventional MR imaging

On the Road to Sustainability? A Review of a Half-Century of Biodiversity Conservation Successes in Nepal and Some Thoughts on Future Needs

We review the history, over the past half-century, of biodiversity conservation legislation and programs in Nepal. We especially consider how they have evolved in light of some earlier concerns resulting from, for example, the strict “fines and fences” conservation approaches first implemented in the 1970s, to pressing issues that emerged over time such as park-people and wildlife-human conflicts, poaching and illegal wildlife trade. We also consider how the implementation of international conservation agreements and demographic and political changes have affected conservation programs in Nepal. We finish by discussing conservation in the context of sustainable development and conclude with some thoughts on future research and managerial needs in a rapidly-changing world

Graph-Based Shape Analysis Beyond Context-Freeness

We develop a shape analysis for reasoning about relational properties of data structures. Both the concrete and the abstract domain are represented by hypergraphs. The analysis is parameterized by user-supplied indexed graph grammars to guide concretization and abstraction. This novel extension of context-free graph grammars is powerful enough to model complex data structures such as balanced binary trees with parent pointers, while preserving most desirable properties of context-free graph grammars. One strength of our analysis is that no artifacts apart from grammars are required from the user; it thus offers a high degree of automation. We implemented our analysis and successfully applied it to various programs manipulating AVL trees, (doubly-linked) lists, and combinations of both

Methodological considerations when translating "burnout"

No study has systematically examined how researchers address cross-cultural adaptation of burnout. We conducted an integrative review to examine how researchers had adapted the instruments to the different contexts. We reviewed the Content Validity Indexing scores for the Maslach Burnout Inventory-Human Services Survey from the 12-country comparative nursing workforce study, RN4CAST. In the integrative review, multiple issues related to translation were found in existing studies. In the cross-cultural instrument analysis, 7 out of 22 items on the instrument received an extremely low kappa score. Investigators may need to employ more rigorous cross-cultural adaptation methods when attempting to measure burnout