A Study on Proteolytic Enzyme Activity in the Erythrocytes of Diabetic Patients

The present study demonstrates the possibility of increased proteolytic activities in diabetic individuals. Proteolytic activity was measured by the amount of amino group released by the erythrocyte lysate of the diabetic individual using phenylhydrazine treated hemoglobin as substrate. The proteolytic activity in erythrocyte lysates against oxidatively damaged hemoglobin was significantly increased in diabetic individuals compared to controls (p<0.001).The result of this study indicates that in diabetic individuals, proteolytic enzymes degrade many oxidatively altered proteins preventing the accumulation of altered and damaged proteins in the cell

B-meson signatures of a Supersymmetric U(2) flavor model

We discuss B-meson signatures of a Supersymmetric U(2) flavor model, with relatively light (electroweak scale masses) third generation right-handed scalars. We impose current B and K meson experimental constraints on such a theory, and obtain expectations for B->X_s gamma, B->X_s glue, B->X_s l+ l-, B->phi K_s, B_s-B_sbar mixing, and the dilepton asymmetry in B_s. We show that such a theory is compatible with all current data, and furthermore, could reconcile the apparent deviations from Standard Model predictions that have been found in some experiments.Comment: 37 pages, 21 figures, RevTeX4; v.2 - minor modifications to improve readability. Published versio

Circulating antigen tests and urine reagent strips for diagnosis of active schistosomiasis in endemic areas

Background: Point-of-care (POC) tests for diagnosing schistosomiasis include tests based on circulating antigen detection and urine reagent strip tests. If they had sufficient diagnostic accuracy they could replace conventional microscopy as they provide a quicker answer and are easier to use. Objectives: To summarise the diagnostic accuracy of: a) urine reagent strip tests in detecting activeSchistosoma haematobium infection, with microscopy as the reference standard; and b) circulating antigen tests for detecting active Schistosoma infection in geographical regions endemic for Schistosoma mansoni or S. haematobium or both, with microscopy as the reference standard. Search methods: We searched the electronic databases MEDLINE, EMBASE, BIOSIS, MEDION, and Health Technology Assessment (HTA) without language restriction up to 30 June 2014. Selection criteria We included studies that used microscopy as the reference standard: for S. haematobium, microscopy of urine prepared by filtration, centrifugation, or sedimentation methods; and for S. mansoni, microscopy of stool by Kato-Katz thick smear. We included studies on participants residing in endemic areas only. Data collection and analysis: Two review authors independently extracted data, assessed quality of the data using QUADAS-2, and performed meta-analysis where appropriate. Using the variability of test thresholds, we used the hierarchical summary receiver operating characteristic (HSROC) model for all eligible tests (except the circulating cathodic antigen (CCA) POC for S. mansoni, where the bivariate random-effects model was more appropriate). We investigated heterogeneity, and carried out indirect comparisons where data were sufficient. Results for sensitivity and specificity are presented as percentages with 95% confidence intervals (CI). Main results; We included 90 studies; 88 from field settings in Africa. The median S. haematobiuminfection prevalence was 41% (range 1% to 89%) and 36% for S. mansoni (range 8% to 95%). Study design and conduct were poorly reported against current standards. Tests for S. haematobium Urine reagent test strips versus microscopy Compared to microscopy, the detection of microhaematuria on test strips had the highest sensitivity and specificity (sensitivity 75%, 95% CI 71% to 79%; specificity 87%, 95% CI 84% to 90%; 74 studies, 102,447 participants). For proteinuria, sensitivity was 61% and specificity was 82% (82,113 participants); and for leukocyturia, sensitivity was 58% and specificity 61% (1532 participants). However, the difference in overall test accuracy between the urine reagent strips for microhaematuria and proteinuria was not found to be different when we compared separate populations (P = 0.25), or when direct comparisons within the same individuals were performed (paired studies; P = 0.21). When tests were evaluated against the higher quality reference standard (when multiple samples were analysed), sensitivity was marginally lower for microhaematuria (71% vs 75%) and for proteinuria (49% vs 61%). The specificity of these tests was comparable. Antigen assay Compared to microscopy, the CCA test showed considerable heterogeneity; meta-analytic sensitivity estimate was 39%, 95% CI 6% to 73%; specificity 78%, 95% CI 55% to 100% (four studies, 901 participants). Tests for S. mansoni Compared to microscopy, the CCA test meta-analytic estimates for detecting S. mansoni at a single threshold of trace positive were: sensitivity 89% (95% CI 86% to 92%); and specificity 55% (95% CI 46% to 65%; 15 studies, 6091 participants) Against a higher quality reference standard, the sensitivity results were comparable (89% vs 88%) but specificity was higher (66% vs 55%). For the CAA test, sensitivity ranged from 47% to 94%, and specificity from 8% to 100% (four studies, 1583 participants). Authors' conclusions: Among the evaluated tests for S. haematobium infection, microhaematuria correctly detected the largest proportions of infections and non-infections identified by microscopy. The CCA POC test for S. mansoni detects a very large proportion of infections identified by microscopy, but it misclassifies a large proportion of microscopy negatives as positives in endemic areas with a moderate to high prevalence of infection, possibly because the test is potentially more sensitive than microscopy

Right-handed Sneutrinos as Nonthermal Dark Matter

When the minimal supersymmetric standard model is augmented by three right-handed neutrino superfields, one generically predicts that the neutrinos acquire Majorana masses. We postulate that all supersymmetry (SUSY) breaking masses as well as the Majorana masses of the right-handed neutrinos are around the electroweak scale and, motivated by the smallness of neutrino masses, assume that the lightest supersymmetric particle (LSP) is an almost-pure right-handed sneutrino. We discuss the conditions under which this LSP is a successful dark matter candidate. In general, such an LSP has to be nonthermal in order not to overclose the universe, and we find the conditions under which this is indeed the case by comparing the Hubble expansion rate with the rates of the relevant thermalizing processes, including self-annihilation and co-annihilation with other SUSY and standard model particles.Comment: 17 pages v.2: References adde

Safety Recommendations for Evaluation and Surgery of the Head and Neck During the COVID-19 Pandemic

Importance The rapidly expanding novel coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2, has challenged the medical community to an unprecedented degree. Physicians and health care workers are at added risk of exposure and infection during the course of patient care. Because of the rapid spread of this disease through respiratory droplets, health care workers who come in close contact with the upper aerodigestive tract during diagnostic and therapeutic procedures, such as otolaryngologists–head and neck surgeons, are particularly at risk. A set of safety recommendations was created based on a review of the literature and communications with physicians with firsthand knowledge of safety procedures during the COVID-19 pandemic. Observations A high number of health care workers were infected during the first phase of the pandemic in the city of Wuhan, China. Subsequently, by adopting strict safety precautions, other regions were able to achieve high levels of safety for health care workers without jeopardizing the care of patients. The most common procedures related to the examination and treatment of upper aerodigestive tract diseases were reviewed. Each category was reviewed based on the potential risk imposed to health care workers. Specific recommendations were made based on the literature, when available, or consensus best practices. Specific safety recommendations were made for performing tracheostomy in patients with COVID-19. Conclusions and Relevance Preserving a highly skilled health care workforce is a top priority for any community and health care system. Based on the experience of health care systems in Asia and Europe, by following strict safety guidelines, the risk of exposure and infection of health care workers could be greatly reduced while providing high levels of care. The provided recommendations, which may evolve over time, could be used as broad guidance for all health care workers who are involved in the care of patients with COVID-19

Collider Signature of Bulk Neutrinos in Large Extra Dimensions

We consider the collider signature of right-handed neutrinos propagating in $\delta$ (large) extra dimensions, and interacting with Standard Model fields only through a Yukawa coupling to the left-handed neutrino and the Higgs boson. These theories are attractive as they can explain the smallness of the neutrino mass, as has already been shown. We show that if $\delta$ is bigger than two, it can result in an enhancement in the production rate of the Higgs boson, decaying either invisibly or to a $b$ anti-$b$ quark pair, associated with an isolated high $p_T$ charged lepton and missing transverse energy at future hadron colliders, such as the LHC. The enhancement is due to the large number of Kaluza-Klein neutrinos produced in the final state. The observation of the signal event would provide an opportunity to distinguish between the normal and inverted neutrino mass hierarchies, and to determine the absolute scale of neutrino masses by measuring the asymmetry of the observed event numbers in the electron and muon channels.Comment: 31 pages, 13 figures. v2: Added discussion on PDF uncertainties, added reference

Matter-gravity interaction in a multiply warped braneworld,

The role of a bulk graviton in predicting the signature of extra dimensions through collider-based experiments is explored in the context of a multiply warped spacetime. In particular it is shown that in a doubly warped braneworld model, the presence of the sixth dimension, results in enhanced concentration of graviton Kaluza Klein (KK) modes compared to that obtained in the usual 5-dimensional Randall-Sundrum model. Also, the couplings of these massive graviton KK modes with the matter fields on the visible brane turn out to be appreciably larger than that in the corresponding 5- dimensional model. The significance of these results are discussed in the context of KK graviton search at the Large Hadron Collider (LHC).Comment: 13 pages, 2 table

SmartEx: a case study on user profiling and adaptation in exhibition booths

An investigation into user profiling and adaptation with exhibition booth as a case study is reported. First a review of the field of exhibitions and trade fairs and a summary introduction to adaptation and profiling are given. We then introduce three criteria for the evaluation of exhibition booth: effectiveness, efficiency and affect. Effectiveness is related the amount of information collected, efficiency is a measurement of the time taken to collect the information, and affect is the perception of the experience and the mood booth visitors have during and after their visit. We have selected these criteria to assess adaptive and profiled exhibition booths, we call smart exhibition (SmartEx). The assessment is performed with an experiment with three test conditions (non-profiled/non adaptive, profiled/non-adaptive and profiled adaptive presentations). Results of the experiment are presented along discussion. While there is significant improvements of effectiveness and efficiency between the two-first test conditions, the improvement is not significant for the last test condition, for reasons explained. As for the affect, the results show that it has an under-estimated importance in people minds and that it should be addressed more carefully

Efficacy of Vyaghriharitaki Avaleha in the management of Vataja Kasa w.s.r. to Pulmonary Eosinophilia - An Open Label Randomized Controlled Clinical Trial

Background: Vataja Kasa (cough caused by Vata Dosha) occurs due to Pranavaha Srotodushti (causes of deformity in channels of respiratory system) characterized by dry paroxysmal cough that resembles Pulmonary eosinophilia (PE) with an elevated Absolute eosinophilic count (AEC) and eosinophilic lung infiltration. Vyaghriharitaki Avaleha is mentioned in Ayurveda classics under the context of Kasa (cough). The current study was carried out to assess its efficacy based on literary indications and the need for more potent medications to treat Vataja Kasa. Aim: Evaluation of the efficacy of Vyaghriharitaki Avaleha in the management of Vataja Kasa. Materials and Methods: A randomized, open label, parallel group, active controlled pre and post test clinical study was conducted comprising of 30 subjects. They were randomly allocated into 2 groups, subjects of Group A received Vyaghriharitaki Avaleha 5g BD and subjects of Group B received Vidangadi Churna 5g BD for 30 days. AEC and Signs &amp; symptoms of Vataja Kasa were assessed before (0th day) and after treatment (30th day), after follow up (45th day). The data obtained were recorded, tabulated and statistically analyzed using Unpaired t test, Paired t Test, Mann Whitney U Test, Wilcoxon Signed rank test. Results: Analysis of the data within groups showed statistically highly significant (p&lt;0.01) results and between the groups analysis showed statistically non-significant (p&gt;0.05) results in reducing AEC and signs &amp; symptoms of Vataja Kasa suggesting almost similar action of both drugs. Conclusion: It can be inferred that Vyaghriharitaki Avaleha is as efficient as Vidangadi Churna in the management of Vataja Kasa

Sneutrino cold dark matter, a new analysis: relic abundance and detection rates

We perform a new and updated analysis of sneutrinos as dark matter candidates, in different classes of supersymmetric models. We extend previous analyses by studying sneutrino phenomenology for full variations of the supersymmetric parameters which define the various models. We first revisit the standard Minimal Supersymmetric Standard Model, concluding that sneutrinos are marginally compatible with existing experimental bounds, including direct detection, provided they compose a subdominant component of dark matter. We then study supersymmetric models with the inclusion of right-handed fields and lepton-number violating terms. Simple versions of the lepton-number-violating models do not lead to phenomenology different from the standard case when the neutrino mass bounds are properly included. On the contrary, models with right-handed fields are perfectly viable: they predict sneutrinos which are compatible with the current direct detection sensitivities, both as subdominant and dominant dark matter components. We also study the indirect detection signals for such successful models: predictions for antiproton, antideuteron and gamma-ray fluxes are provided and compared with existing and future experimental sensitivities. The neutrino flux from the center of the Earth is also analyzed.Comment: 72 pages, 50 figures. The version on the archive has low-resolution figures. The paper with high resolution figures may be found through http://www.to.infn.it/~arina/papers or http://www.to.infn.it/~fornengo/Research/paperlist.htm