Rivestimenti anticorrosivi che consentono il risparmio energetico e riducono l’impatto ambientale

Il risparmio energetico e la tutela dell’ambiente sono sempre più considerati una priorità. I rivestimentiprotettivi, se è stato specificato il ciclo idoneo e lo stesso è stato correttamente applicato, possono giocare unruolo rilevante nel raggiungimento degli obiettivi citati. Il presente documento espone una serie di tecnologiee soluzioni specificatamente sviluppate per la protezione di scambiatori di calore liquido/liquido edaria/liquido ed approfondisce come l’utilizzo di rivestimenti dotati di elevate resistenze alla corrosioneaumenti anche l’efficienza degli apparecchi riducendo significativamente i costi di gestione, come risultatoassolutamente non trascurabile connesso alla corretta protezione anticorrosiva

Effect of Progressive Integration of On-Board Systems Design Discipline in an MDA Framework for Aircraft Design with Different Level of Systems Electrification

The on-board design discipline is sometimes ignored during the first aircraft design iterations. It might be understandable when a single on-board system architecture is considered, especially when a conventional architecture is selected. However, seeing the trend towards systems electrification, multiple architectures can be defined and each one should be evaluated during the first tradeoff studies. In this way, the systems design discipline should be integrated from the first design iterations. This paper deals with a progressive integration of the discipline to examine the partial or total effect of the systems design inside an MDA workflow. The study is carried out from a systems design perspective, analyzing the effect of electrification on aircraft design, with different MDA workflow arrangements. Starting from a non-iterative systems design, other disciplines such as aircraft performance, engine design, and aircraft synthesis are gradually added, increasing the sensibility of the aircraft design to the different systems architectures. The results show an error of 40% in on-board systems assessment when the discipline is not fully integrated. Finally, using the work-flow which allows for greater integration, interesting differences can be noted when comparing systems with different levels of electrification. A possible mass saving of 2.6% of aircraft MTOM can be reached by properly selecting the systems technologies used

Assessing the Integration of Electrified On-Board Systems in an MDAO framework for a small transport aircraft

The integration of on-board systems design within the aircraft design process is often considered only in the late part of the initial design. This is acceptable for civil aircraft using standard technology systems. However, facing with MEA and AEA concepts and different possible architectures, the systems design and the assessment of their effects on the overall aircraft should be moved up in the usual design process. This paper deals with evaluation of the effect of different on-board systems architecture, with a different electrification level, on the overall aircraft design. These effects have been evaluated using three different MDA workflows developed within the AGILE4.0 European research project. The workflows are defined with an increasing number of disciplines to show how the effect of a proper selection of a systems architecture is differently caught by each one. In this way it is possible to define which disciplines should be included for the systems architecture assessment. The results show a save of 1% of MTOM for the AEA applied to a small turboprop aircraft when only the OBS mass is assessed. Increasing workflow complexity, adding performance and engine design the save increase to 1.2%. Finally, the save increases to 1.3% when the effect on engine SFC is also considered

Value-based health-care principles in health-care organizations

Purpose: This study aims to analyze the value-based health-care model in defining a strategy to guide the evolution of health-care organizations toward a value-oriented model. To improve the quality of care by ensuring economic sustainability, it is necessary to redefine the concept of competition in healthcare and align it with the concept of maximizing value for patients. Design/methodology/approach: Performance measurement is a crucial aspect of the analysis of health-care organizations. Porter developed an effective analytical technique and presented the measurement of health-care outcomes based on health conditions, the efficiency of health-care organizations and the type of service provided. Findings: Clinical outcomes and data on the costs of care of each patient are essential to evaluate improvement in treatment value over time. Engaging in the evaluation of what happens to patients in their course of care enables the expansion of the measurement of outcomes because it measures all the health services related to it. Originality/value: Building a health-care system based on the value and continuous improvement of care and services provided is a goal shared by many countries and international organizations. Today, the analysis of outcomes is important for making informed decisions, directing and planning clinical and organizational changes by improving the quality of care and services

A model-based rams estimation methodology for innovative aircraft on-board systems supporting mdo applications

The reduction of aircraft operating costs is one of the most important objectives addressed by aeronautical manufactures and research centers in the last decades. In order to reach this objective, one of the current ways is to develop innovative on-board system architectures, which can bring to lower fuel and maintenance costs. The development and optimization of these new aircraft on-board systems can be addressed through a Multidisciplinary Design Optimization (MDO) approach, which involves different disciplines. One relevant discipline in this MDO problem is Reliability, Availability, Maintainability and Safety (RAMS), which allows the assessment of the reliability and safety of aircraft systems. Indeed the development of innovative systems cannot comply with only performance requirements, but also with reliability and safety constraints. Therefore, the RAMS discipline plays an important role in the development of innovative on-board systems. In the last years, different RAMS models and methods have been defined, considering both conventional and innovative architectures. However, most of them rely on a document-based approach, which makes difficult and time consuming the use of information gained through their analysis to improve system architectures. On the contrary, a model-based approach would make easier and more accessible the study of systems reliability and safety, as explained in several studies. Model Based Systems Engineering (MBSE) is an emerging approach that is mainly used for the design of complex systems. However, only a few studies propose this approach for the evaluation of system safety and reliability. The aim of this paper is therefore to propose a MBSE approach for model-based RAMS evaluations. The paper demonstrates that RAMS models can be developed to quickly and more effectively assess the reliability and safety of conventional and innovative on-board system architectures. In addition, further activities for the integration of the model-based RAMS methodology within MDO processes are described in the paper

Multidisciplinary design of a more electric regional aircraft including certification constraints

The use of electrified on-board systems is increasingly more required to reduce aircraft complexity, polluting emissions, and its life cycle cost. However, the more and all-electric aircraft configurations are still uncommon in the civil aviation context and their certifiability has yet to be proven in some aircraft segments. The aim of the present paper is to define a multidisciplinary design problem which includes some disciplines pertaining to the certification domain. In particular, the study is focused on the preliminary design of a 19 passengers small regional turboprop aircraft. Different on-board systems architectures with increasing electrification levels are considered. These architectures imply the use of bleedless technologies including electrified ice protection and environmental control systems. The use of electric actuators for secondary surfaces and landing gear are also considered. The aircraft design, which includes aerodynamic, structural, systems and propulsion domains, is then assessed by some certification disciplines. In particular, minimum performance, external noise and safety assessments are included in the workflow giving some insights on the aircraft certifiability. The results show a reduction of 3% of MTOM and 3% of fuel mass depending on the systems architecture selected. From the certification side, the design has proven to be certifiable and the margins with the certification constraint can be controlled to improve the overall design

Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors

Systemic chemotherapy has been relatively ineffective in the treatment of malignant brain tumors even though systemic chemotherapy drugs are small molecules that can readily extravasate across the porous blood-brain tumor barrier of malignant brain tumor microvasculature. Small molecule systemic chemotherapy drugs maintain peak blood concentrations for only minutes, and therefore, do not accumulate to therapeutic concentrations within individual brain tumor cells. The physiologic upper limit of pore size in the blood-brain tumor barrier of malignant brain tumor microvasculature is approximately 12 nanometers. Spherical nanoparticles ranging between 7 nm and 10 nm in diameter maintain peak blood concentrations for several hours and are sufficiently smaller than the 12 nm physiologic upper limit of pore size in the blood-brain tumor barrier to accumulate to therapeutic concentrations within individual brain tumor cells. Therefore, nanoparticles bearing chemotherapy that are within the 7 to 10 nm size range can be used to deliver therapeutic concentrations of small molecule chemotherapy drugs across the blood-brain tumor barrier into individual brain tumor cells. The initial therapeutic efficacy of the Gd-G5-doxorubicin dendrimer, an imageable nanoparticle bearing chemotherapy within the 7 to 10 nm size range, has been demonstrated in the orthotopic RG-2 rodent malignant glioma model. Herein I discuss this novel strategy to improve the effectiveness of systemic chemotherapy for the treatment of malignant brain tumors and the therapeutic implications thereof