488 research outputs found
More on the Tensor Response of the QCD Vacuum to an External Magnetic Field
In this Letter we discuss a few issues concerning the magnetic susceptibility
of the quark condensate and the Son-Yamamoto (SY) anomaly matching equation. It
is shown that the SY relation in the IR implies a nontrivial interplay between
the kinetic and WZW terms in the chiral Lagrangian. It is also demonstrated
that in a holographic framework an external magnetic field triggers mixing
between scalar and tensor fields. Accounting for this, one may calculate the
magnetic susceptibility of the quark condensate to all orders in the magnetic
field.Comment: 20 pages, 2 figure
Massive MIMO goes Sub-GHz: Implementation and Experimental Exploration for LPWANs
Low-Power Wide-Area Networks operating in the unlicensed bands are being
deployed to connect a rapidly growing number of Internet-of-Things devices.
While the unlicensed sub-GHz band offers favorable propagation for long-range
connections, measurements show that the energy consumption of the nodes is
still mostly dominated by the wireless transmission affecting their autonomy.
We investigate the potential benefits of deploying massive MIMO technology to
increase system reliability and at the same time support low-energy devices
with good coverage at sub-GHz frequencies. The impact of different antenna
configurations and propagation conditions is analyzed. Both actual average
experienced array gain and channel hardening are examined. The assessment
demonstrates the effect of channel hardening as well as the potential benefits
of the experienced array gain. These measurements serve as a first assessment
of the channel conditions of massive MIMO at sub-GHz frequencies and are, to
the best of our knowledge, the first of its kind
Expanding Duplication of Free Fatty Acid Receptor-2 (GPR43) Genes in the Chicken Genome
International audienceFree fatty acid receptors (FFAR) belong to a family of five G-protein coupled receptors that are involved in the regulation of lipidmetabolism, so that their loss of function increases the risk of obesity. The aim of this study was to determine the expansion of genesencoding paralogs of FFAR2 in the chicken, considered as amodel organism for developmental biology and biomedical research. Byestimating the gene copy number using quantitative polymerase chain reaction, genomic DNA resequencing, and RNA sequencingdata, we showed the existence of 23 ±1.5 genes encoding FFAR2 paralogs in the chicken genome. The FFAR2 paralogs shared anidentity from 87.2%up to 99%. Extensive gene conversion was responsible for this high degree of sequence similarities betweenthese genes, and this concerned especially the four amino acids known to be critical for ligand binding. Moreover, elevated nonsynonymous/synonymous substitutionratios onsomeamino acids withinor inclose-vicinity of the ligand-bindinggroove suggest thatpositive selectionmay have reduced the effective rate of gene conversion in this region, thus contributing to diversify the function ofsome FFAR2 paralogs. All the FFAR2 paralogs were located on a microchromosome in a same linkage group. FFAR2 genes wereexpressed in different tissues and cells such as spleen, peripheral blood mononuclear cells, abdominal adipose tissue, intestine, andlung, with the highest rate of expression in testis. Further investigations are needed to determine whether these chicken-specificevents along evolution are the consequence of domestication and may play a role in regulating lipid metabolism in this species
Colored Motifs Reveal Computational Building Blocks in the C. elegans Brain
Background: Complex networks can often be decomposed into less complex sub-networks whose structures can give hints about the functional
organization of the network as a whole. However, these structural
motifs can only tell one part of the functional story because in this
analysis each node and edge is treated on an equal footing. In real
networks, two motifs that are topologically identical but whose nodes
perform very different functions will play very different roles in the
network.
Methodology/Principal Findings: Here, we combine structural information
derived from the topology of the neuronal network of the nematode C.
elegans with information about the biological function of these nodes,
thus coloring nodes by function. We discover that particular
colorations of motifs are significantly more abundant in the worm brain
than expected by chance, and have particular computational functions
that emphasize the feed-forward structure of information processing in
the network, while evading feedback loops. Interneurons are strongly
over-represented among the common motifs, supporting the notion that
these motifs process and transduce the information from the sensor
neurons towards the muscles. Some of the most common motifs identified
in the search for significant colored motifs play a crucial role in the
system of neurons controlling the worm's locomotion.
Conclusions/Significance: The analysis of complex networks in terms of
colored motifs combines two independent data sets to generate insight
about these networks that cannot be obtained with either data set
alone. The method is general and should allow a decomposition of any
complex networks into its functional (rather than topological) motifs
as long as both wiring and functional information is available
Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice
Protein citrullination plays a role in several autoimmune diseases. Its involvement in murine and human type 1 diabetes has recently been recognized through the discovery of antibodies and T-cell reactivity against citrullinated peptides. In the current study, we demonstrate that systemic inhibition of peptidylarginine deiminases (PADs), the enzymes mediating citrullination, through BB-Cl-amidine treatment, prevents diabetes development in NOD mice. This prevention was associated with reduced levels of citrullination in the pancreas, decreased circulating autoantibody titers against citrullinated GRP78 and reduced spontaneous NETosis of bone marrow-derived neutrophils. Moreover, BB-Cl-amidine treatment induced a shift from Th1 to Th2 cytokines in the serum and an increase in the frequency of regulatory T cells in the blood and spleen. In the pancreas, BB-Cl-amidine treatment preserved insulin production and was associated with a less destructive immune infiltrate, characterized by reduced frequencies of effector memory CD4+ T cells and a modest reduction in the frequency of IFNÎł-producing CD4+ and CD8+ T cells. Our results point to a role of citrullination in the pathogenesis of autoimmune diabetes, with PAD inhibition leading to disease prevention through modulation of immune pathways. These findings provide insight in the potential of PAD inhibition for treating autoimmune diseases like type 1 diabetes
Holographic rho mesons in an external magnetic field
We study the rho meson in a uniform magnetic field eB using a holographic
QCD-model, more specifically a D4/D8/Dbar8 brane setup in the confinement phase
at zero temperature with two quenched flavours. The parameters of the model are
fixed by matching to corresponding dual field theory parameters at zero
magnetic field. We show that the up- and down-flavour branes respond
differently to the presence of the magnetic field in the dual QCD-like theory,
as expected because of the different electromagnetic charge carried by up- and
down-quark. We discuss how to recover the Landau levels, indicating an
instability of the QCD vacuum at eB = m_rho^2 towards a phase where charged rho
mesons are condensed, as predicted by Chernodub using effective QCD-models. We
improve on these existing effective QCD-model analyses by also taking into
account the chiral magnetic catalysis effect, which tells us that the
constituent quark masses rise with eB. This turns out to increase the value of
the critical magnetic field for the onset of rho meson condensation to eB = 1.1
m_rho^2 = 0.67 GeV^2. We briefly discuss the influence of pions, which turn out
to be irrelevant for the condensation in the approximation made.Comment: 26 pages, 10 .pdf figures, v2: version accepted for publication in
JHE
- …