Metastatic basal cell carcinoma of prostate in a young adult: A rare aggressive entity

Introduction: Prostate cancer is one of the commonest, malignancies affecting elderly males. Prostatic basal cell carcinoma, (PBCC) accounts for less than 0.01% of all prostate cancers.Observation: A 32-year-old man presented with hematuria and lower urinary tract symptoms. Clinical examination showed hard, nodular enlarged prostate with multiple penile hard nodules. His prostate-specific antigen (PSA) level was 0.91 ng/mL. Histopathological examination of the fingerguided prostate biopsy revealed a malignancy with features of basal cell carcinoma. Further imaging studies were performed and metastases were found in both lungs, penis, pelvic lymph nodes and right ischium.Conclusion: The current case highlights PBCC as a diagnostic pitfall which presented in a young adult with a normal PSA level

Assessment of Natural Resources for Conservation of Wetland in District Chamba

The Ramsar Convection of IUCN held in 1971 in Iran raised global attention on the conservation and management of wetlands. 3 wetlands in the Indian State of Himachal Pradesh have been declared a wetland of International importance. Thus it is felt necessary to reclaim and develop high altitude wetlands for its optimum potential use, but a reliable and accurate database is not available. The present endeavour aims at the generation of database in terms of physical aspects/ land use, the extent of water spread and its water quality, vegetation status of the catchment area and surroundings of the lake. The threats to high altitude wetlands have been identified and adequate measures for its conservation and management suggested

ESTIMATION OF BIOMASS AND CARBON POOL IN BARKOT FOREST RANGE, UK USING GEOSPATIAL TOOLS

The forest ecosystem is an important carbon sink and source containing majority of the aboveground terrestrial organic carbon. Carbon management in forests is the global concern to mitigate the increased concentration of green house gases in the atmosphere. The present study estimated vegetation carbon pool and biophysical spectral modelling to correlate biomass with reflectance/ derivatives in Barkot Forest Range, Uttarakhand. The study was carried out using Cartosat-1, IRS-P6 LISS-IV MX, IRS LISS-III, Landsat 7 ETM satellite data and ground data collected from stratified random sampling. Forest type and forest crown density was mapped using resolution merged Cartosat-1 and LISS-IV imagery. Growing stock, biomass and carbon was calculated for the individual sample plots using inventory-based biomass assessment technique. Field-inventoried data was correlated with the surface reflectance and derivatives of it. Among the four vegetation types, viz. Shorea robusta, S. robusta mixed, S. robusta Tectona grandis mixed, T. grandis plantation, mixed plantation, Grassland and Agriculture/ orchard, the S.robusta was found to be the dominant vegetation in the area, covering 55.86 km2 of the total area. The study revealed that the S.robusta with high density had the highest aboveground biomass (AGB) (t/ha) was found in S.robusta > 70% (530 t ha−1), followed by S.robusta 40–70% (486 t ha−1) and minimum was found in mixed plantation < 10% (101  ha−1). The general trend showed the decrease in AGB with decrease of forest density in each forest type category. The average AGB of S. robusta T. grandis forest was found (308 t ha−1–458 t ha−1) due to the dominancy of S. robusta trees. The study highlighted the invaluable role of geospatial technology and field inventory for growing stock, biomass and carbon assessment

Ectopic expression of alkaline phosphatase in proximal tubular brush border membrane of human renal cell carcinoma

AbstractThe present study was conducted to find out any alteration in the expression and activity of alkaline phosphatase in the brush border membrane (BBM) from renal cell carcinoma (RCC) in comparison to normal renal BBM. The specific activity of alkaline phosphatase was drastically reduced in homogenate as well as BBM from RCC kidney when compared to ALP activity in BBM of normal kidney. Kinetic studies revealed that diminished activity of alkaline phosphatase in BBM isolated from RCC was fraternized with decrease in maximal velocity (Vmax) and increase in affinity constant (Km) of the enzyme. SDS-PAGE studies showed that the BBM proteins having molecular weights ranging from 95 to 170 kDa were poorly expressed in RCC BBM in relative to normal kidney BBM. Incubation of SDS-PAGE gel with BCIP/NBT dye clearly showed that the expression of ALP in tumor renal BBM was markedly reduced as compared to normal kidney. Further, Western blot analysis using anti-alkaline phosphatase antibody also confirmed the reduced expression of ALP in tumor renal BBM. Lipid composition in reference to phospholipids, glycolipids and cholesterol in tumor renal BBM was altered to that of normal renal BBM, indicating alteration in membrane fluidity of tumor renal BBM

Assessment of Natural Resources for Conservation of Wetland in District Chamba

The Ramsar Convection of IUCN held in 1971 in Iran raised global attention on the conservation and management of wetlands. 3 wetlands in the Indian State of Himachal Pradesh have been declared a wetland of international importance. Thus it is felt necessary to reclaim and develop high altitude wetlands for its optimum potential use, but a reliable and accurate database is not available. The present endeavour aims at the generation of database in terms of physical aspects/ land use, the extent of water spread and its water quality, vegetation status of the catchment area and surroundings of the lake. The threats to high altitude wetlands have been identified and adequate measures for its conservation and management suggested

The role of UV photolysis and molecular transport in the generation of reactive species in a tissue model with a cold atmospheric pressure plasma jet

Cold atmospheric pressure plasma jets (plasma) operated in ambient air provide a rich source of reactive oxygen and nitrogen species (RONS), which are known to influence biological processes important in disease. In the plasma treatment of diseased tissue such as subcutaneous cancer tumors, plasma RONS need to first traverse an interface between the plasma-skin surface and second be transported to millimeter depths in order to reach deep-seated diseased cells. However, the mechanisms in the plasma generation of RONS within soft tissues are not understood. In this study, we track the plasma jet delivery of RONS into a tissue model target and we delineate two processes: through target delivery of RONS generated (primarily) in the plasma jet and in situ RONS generation by UV photolysis within the target. We demonstrate that UV photolysis promotes the rapid generation of RONS in the tissue model target's surface after which the RONS are transported to millimeter depths via a slower molecular process. Our results imply that the flux of UV photons from plasma jets is important for delivering RONS through seemingly impenetrable barriers such as skin. The findings have implications not only in treatments of living tissues but also in the functionalization of soft hydrated biomaterials such as hydrogels and extracellular matrix derived tissue scaffolds

Measurements of the transverse-momentum-dependent cross sections of J /ψ production at mid-rapidity in proton+proton collisions at s =510 and 500 GeV with the STAR detector

We present measurements of the differential cross sections of inclusive J/ψ meson production as a function of transverse momentum (pTJ/ψ) using the μ+μ- and e+e- decay channels in proton+proton collisions at center-of-mass energies of 510 and 500 GeV, respectively, recorded by the STAR detector at the Relativistic Heavy Ion Collider. The measurement from the μ+μ- channel is for

Bulk properties of the system formed in Au+Au collisions at sNN =14.5 GeV at the BNL STAR detector

We report systematic measurements of bulk properties of the system created in Au+Au collisions at sNN=14.5 GeV recorded by the STAR detector at the Relativistic Heavy Ion Collider (RHIC). The transverse momentum spectra of π±, K±, and p(p) are studied at midrapidity (|y|<0.1) for nine centrality intervals. The centrality, transverse momentum (pT), and pseudorapidity (η) dependence of inclusive charged particle elliptic flow (v2), and rapidity-odd charged particles directed flow (v1) results near midrapidity are also presented. These measurements are compared with the published results from Au+Au collisions at other energies, and from Pb+Pb collisions at sNN=2.76 TeV. The results at sNN=14.5 GeV show similar behavior as established at other energies and fit well in the energy dependence trend. These results are important as the 14.5-GeV energy fills the gap in μB, which is of the order of 100 MeV, between sNN=11.5 and 19.6 GeV. Comparisons of the data with UrQMD and AMPT models show poor agreement in general

Charge-dependent pair correlations relative to a third particle in p + Au and d + Au collisions at RHIC

Quark interactions with topological gluon configurations can induce chirality imbalance and local parity violation in quantum chromodynamics. This can lead to electric charge separation along the strong magnetic field in relativistic heavy-ion collisions – the chiral magnetic effect (CME). We report measurements by the STAR collaboration of a CME-sensitive observable in p+Au and d+Au collisions at 200 GeV, where the CME is not expected, using charge-dependent pair correlations relative to a third particle. We observe strong charge-dependent correlations similar to those measured in heavy-ion collisions. This bears important implications for the interpretation of the heavy-ion data

Measurement of inclusive J/ψ suppression in Au+Au collisions at sNN=200 GeV through the dimuon channel at STAR

J/ψ suppression has long been considered a sensitive signature of the formation of the Quark-Gluon Plasma (QGP) in relativistic heavy-ion collisions. In this letter, we present the first measurement of inclusive J/ψ production at mid-rapidity through the dimuon decay channel in Au+Au collisions at sNN=200 GeV with the STAR experiment. These measurements became possible after the installation of the Muon Telescope Detector was completed in 2014. The J/ψ yields are measured in a wide transverse momentum (pT) range of 0.15 GeV/c to 12 GeV/c from central to peripheral collisions. They extend the kinematic reach of previous measurements at RHIC with improved precision. In the 0-10% most central collisions, the J/ψ yield is suppressed by a factor of approximately 3 for pT>5 GeV/c relative to that in p+p collisions scaled by the number of binary nucleon-nucleon collisions. The J/ψ nuclear modification factor displays little dependence on pT in all centrality bins. Model calculations can qualitatively describe the data, providing further evidence for the color-screening effect experienced by J/ψ mesons in the QGP