Introduction to LGBTQ+ Studies

Introduction to LGBTQ+ Studies was a collaborative, multi-year open textbook project that engaged faculty authors, librarians, a university press, and OER professionals. The resulting textbook takes a cross-disciplinary approach to the study of LGBTQ+ issues that helps students grasp core concepts through a variety of different perspectives. The text offers accessible, academically sound information on a wide range of topics, including history, culture, and Queer Theory; an exploration of LGBTQ+ relationships, families, parenting, health, and education; and how to conduct research on LGBTQ+ topics. This case study will cover the project’s transformation through years of development, including engaging a large group of participants, working with a funding body, releasing a beta edition, incorporating feedback, and partnering with a university press

On the long term change in the geomagnetic activity during the 20th century

International audienceThe analysis of the aa index series presented in this paper clearly shows that during the last century (1900 to 2000) the number of quiet days (Aa<20 nT) drastically di- minished from a mean annual value greater than 270 days per year at the end of the nineteenth century to a mean value of 160 quiet days per year one hundred years later. This de- crease is mainly due to the decrease of the number of very quiet days (Aa<13 nT). We show that the so-evidenced de- crease in the number of quiet days cannot be accounted for by drift in the aa baseline resulting in a systematic underes- timation of aa during the first quarter of the century: a 2– 3 nT overestimation in the aa increase during the 20th cen- tury would lead to a 20–40% overestimation in the decrease of the number of quiet days during the same period.The quiet days and very quiet days correspond to periods during which the Earth encounters slow solar wind streams flowing in the heliosheet during the period where the solar magnetic field has a dipolar geometry. Therefore, the ob- served change in the number of quiet days is the signature of a long term evolution of the solar coronal field topology. It may be interpreted in terms of an increase in the magnitude of the solar dipole, the associated decrease of the heliosheet thickness accounting for the observed decrease in the number of quiet days

Equinox transition at the magnetic equator in Africa: analysis of ESF ionograms

International audienceWe study equatorial night-time F layer behaviour from quarter-hourly ionograms at Korhogo/Ivory Coast (9.2° N, 5° W, dip lat. −2.4°) during local Spring March–April 1995, declining solar flux period, according to the magnetic activity. The height and thickness of the F-layer are found to vary intensely with time and from one day to the next. At time of the equinox transition, by the end of March, a net change of the nightly height-time variation is observed. The regime of a single height peak phase before 22 March changes to up to three main F-layer height phases after 30 March, each associated to a dominant mechanism. The first phase is identified to the post-sunset E×B pulse, the second phase associated to a change in the wind circulation phenomenon and the third one attributed to pre-sunrise phenomena. The influence of the magnetic activity is identified by the increase in the second peak amplitude. After the 21 April magnetic-equinox period, the height-time morphology becomes more irregular suggesting meridional wind abatement. The initiation, the growth and the maintenance of ESF are explored in relation to these nightly variations. The Rayleigh-Taylor instability is clearly identified as main precursor phenomenon. This is followed by the P-type (F-layer peak spread) structures, the whole with no specific dependence on the magnetic activity and on the F-layer phases, in contrast to further I and F-type (Inside and Frequency spread) ESFs. We discuss our results in the light of recent advanced experiments in Peru and the pacific

West African equatorial ionospheric parameters climatology based on Ouagadougou ionosonde station data from June 1966 to February 1998

This study is the first which gives the climatology of West African equatorial ionosphere by using Ouagadougou station through three solar cycles. It has permitted to show the complete morphology of ionosphere parameters by analyzing yearly variation, solar cycle and geomagnetic activity, seasonal evolution and diurnal development. This work shows that almost all ionospheric parameters have 11-year solar cycle evolution. Seasonal variation shows that only &lt;I&gt;fo&lt;/I&gt;F2 exhibits annual, winter and semiannual anomaly. &lt;I&gt;fo&lt;/I&gt;F2 seasonal variation has permitted us to identify and characterize solar events effects on F2 layer in this area. In fact (1) during quiet geomagnetic condition &lt;I&gt;fo&lt;/I&gt;F2 presents winter and semiannual anomalies asymmetric peaks in March/April and October. (2) The absence of winter anomaly and the presence of equinoctial peaks are the most visible effects of fluctuating activity in &lt;I&gt;fo&lt;/I&gt;F2 seasonal time profiles. (3) Solar wind shock activity does not modify the profile of &lt;I&gt;fo&lt;/I&gt;F2 but increases ionization. (4) The absence of asymmetry peaks, the location of the peaks in March and October and the increase of ionization characterize recurrent storm activity. F1 layers shows increasing trend from cycle 20 to cycle 21. Moreover, E layer parameters seasonal variations exhibit complex structure. It seems impossible to detect fluctuating activity effect in E layer parameters seasonal variations but shock activity and wind stream activity act to decrease E layer ionization. It can be seen from Es layer parameters seasonal variations that wind stream activity effect is fairly independent of solar cycle. E and Es layers critical frequencies and virtual heights diurnal variations let us see the effects of the greenhouse gases in these layers

Geomagnetic Activity Control of Irregularities Occurrences Over the Crests of the African EIA

Abstract This paper investigated the behavior of ionospheric irregularities over the African equatorial ionization anomaly (EIA) crests during intense geomagnetic storms that occurred from 2012 to 2015. Irregularities were monitored using the rate of change of TEC index along with variations of the horizontal component of the Earth's magnetic field (H) and ionospheric electric current disturbance (Diono). The predictive capability of the Prompt Penetration Equatorial Electric Field Model (PPEFM) was assessed by comparing prompt penetration electric field (PPEF) inferred from interplanetary electric field and Diono with PPEF derived from the PPEFM, with emphasis on how well the model reproduced enhancement/reduction in the prereversal enhancement (PRE). Eastward PPEF triggered short duration irregularities on 23 April 2012, 17 March 2013, and 20 February 2014 while westward electric field reduced them thereafter. The PPEFM rightly predicted enhancement (reduction) in PRE on 17 March 2013 (19 February 2014) when irregularities were triggered (inhibited). It, however, showed no change in the PRE on 23 April 2012 and 20 February 2014. During the storms recoveries, irregularities were always inhibited/reduced over the trough by westward disturbance dynamo and the inhibition lasted longer during the superstorm of March 2015. Also, there was a hemispheric asymmetry in irregularities over the African EIA crests. On 16–17 July 2012, 15 November 2012, and 19 March 2013, there were differences in irregularities behavior. On these days, the asymmetry of the postsunset crests was pronounced in both hemispheres

Hyperthyroidism from autoimmune thyroiditis in a man with type 1 diabetes mellitus: a case report

<p>Abstract</p> <p>Introduction</p> <p>The presentation, diagnosis, clinical course and treatment of a man with hyperthyroidism secondary to autoimmune thyroiditis in the setting of type 1 diabetes mellitus has not previously been described.</p> <p>Case presentation</p> <p>A 32-year-old European-American man with an eight-year history of type 1 diabetes mellitus presented with an unintentional 22-pound weight loss but an otherwise normal physical examination. Laboratory studies revealed a suppressed thyroid-stimulating hormone concentration and an elevated thyroxine level, which are consistent with hyperthyroidism. His anti-thyroid peroxidase antibodies were positive, and his thyroid-stimulating immunoglobulin test was negative. Uptake of radioactive iodine by scanning was 0.5% at 24 hours. The patient was diagnosed with autoimmune thyroiditis. Six weeks following his initial presentation he became clinically and biochemically hypothyroid and was treated with thyroxine.</p> <p>Conclusion</p> <p>This report demonstrates that autoimmune thyroiditis presenting as hyperthyroidism can occur in a man with type 1 diabetes mellitus. Autoimmune thyroiditis may be an isolated manifestation of autoimmunity or may be part of an autoimmune polyglandular syndrome. Among patients with type 1 diabetes mellitus who present with hyperthyroidism, Graves' disease and other forms of hyperthyroidism need to be excluded as autoimmune thyroiditis can progress quickly to hypothyroidism, requiring thyroid hormone replacement therapy.</p

Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees

The radiation-attenuated Schistosoma mansoni vaccine is highly effective in rodents and primates but has never been tested in humans, primarily for safety reasons. To strengthen its status as a paradigm for a human recombinant antigen vaccine, we have undertaken a small-scale vaccination and challenge experiment in chimpanzees (Pan troglodytes). Immunological, clinical, and parasitological parameters were measured in three animals after multiple vaccinations, together with three controls, during the acute and chronic stages of challenge infection up to chemotherapeutic cure. Vaccination induced a strong in vitro proliferative response and early gamma interferon production, but type 2 cytokines were dominant by the time of challenge. The controls showed little response to challenge infection before the acute stage of the disease, initiated by egg deposition. In contrast, the responses of vaccinated animals were muted throughout the challenge period. Vaccination also induced parasite-specific immunoglobulin M (IgM) and IgG, which reached high levels at the time of challenge, while in control animals levels did not rise markedly before egg deposition. The protective effects of vaccination were manifested as an amelioration of acute disease and overall morbidity, revealed by differences in gamma-glutamyl transferase level, leukocytosis, eosinophilia, and hematocrit. Moreover, vaccinated chimpanzees had a 46% lower level of circulating cathodic antigen and a 38% reduction in fecal egg output, compared to controls, during the chronic phase of infection