Investigations on the Enzymatic Synthesis of Novel Glycolipids - Establishment and optimization of the synthesis including product characterization

Within this thesis the lipase-catalyzed synthesis of amino sugar fatty acid esters in organic solvents was demonstrated. This synthesis was characterized and optimized by the variation of several crucial reaction parameters. Further the establishment of a screening assay to detect lipase activity in organic solvents and glycolipid syntheses in deep eutectic solvents were successfully performed

So near yet so far: fine phonetic differences in tonal alignment and temporal structure in close contact varieties

R scripts and data frames to accompany the conference paper of the same name. The three R files contain the scripts on which the analyses in Pöhnlein, J. & Kleber, F. (2023). So near yet so far: fine phonetic differences in tonal alignment and temporal structure in close contact varieties. Proceedings of the 20th International Congress of Phonetic Sciences (ICPhS), Prague, Czech Republic are based. The three txt files contain the corresponding input data that needs to be loaded in R prior to run the respective analysis script

The emergence of obstruent-intrinsic f0 and VOT as cues to the fortis/lenis contrast in West Central Bavarian

R scripts and data frames to accompany the conference paper of the same name. The analyses in Pöhnlein, J. & Kleber, F. (2023). The emergence of obstruent-intrinsic f0 and VOT as cues to the fortis/lenis contrast in West Central Bavarian. Proceedings of the 24th Annual Conference of the International Speech Communication Association (INTERSPEECH), Dublin, Ireland are based on the three R script files. The three data files (two txt, one Rdata) contain the corresponding input data that needs to be loaded in R prior to run the respective analysis script

Методика подготовки преподавателей профильной дисциплины к реализации интегрированного предметно-языкового подхода

Разработка методики подготовки преподавателей профильной дисциплины к реализации интегрированного предметно-языкового подхода, разработка и апробация курса повышения квалификации для преподавателей профильной дисциплины, разработанного на платформе LMS Moodle.Development of a methodology for preparing teachers of a specialized discipline for the implementation of CLIL, development and testing of an advanced training course developed on the LMS Moodle platform and aimed to prepare teachers of a specialized discipline to implement CLI

Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders.

Parenteral nutrition (PN) is a life-saving therapy providing nutritional support in patients with digestive tract complications, particularly in preterm neonates due to their gut immaturity during the first postnatal weeks. Despite this, PN can also result in several gastrointestinal complications that are the cause or consequence of gut mucosal atrophy and gut microbiota dysbiosis, which may further aggravate gastrointestinal disorders. Consequently, the use of PN presents many unique challenges, notably in terms of the potential role of the gut microbiota on the functional and clinical outcomes associated with the long-term use of PN. In this review, we synthesize the current evidence on the effects of PN on gut microbiome in infants and children suffering from diverse gastrointestinal diseases, including necrotizing enterocolitis (NEC), short bowel syndrome (SBS) and subsequent intestinal failure, liver disease and inflammatory bowel disease (IBD). Moreover, we discuss the potential use of pre-, pro- and/or synbiotics as promising therapeutic strategies to reduce the risk of severe gastrointestinal disorders and mortality. The findings discussed here highlight the need for more well-designed studies, and harmonize the methods and its interpretation, which are critical to better understand the role of the gut microbiota in PN-related diseases and the development of efficient and personalized approaches based on pro- and/or prebiotics