Análisis y diagnóstico de la Iglesia de Santiago en Jerez de la Frontera (España)

The church of Santiago (Jerez de la Frontera, Spain) has its origin in a small chapel built in the XIII century. Three naves added in the XV century gave rise to the current temple. The church has been modified along the history due to two main reasons: (I) the interest for its enlargement and embellishment and (II) to solve some structural problems documented since the XVII century. The most relevant problems that have affected the structure can be summarized in two partial collapses (1695 and 1956) and the substitution of two columns (1902 and 1928) to prevent new catastrophes. However, at the beginning of the XXI century important damage in columns and walls caused to close the temple and initiate an ample investigation on the church and its structural behaviour. The conclusions of this analysis, together with a preliminary proposal for restoration, are the main goal of this paper.La Iglesia de Santiago (Jerez de la Frontera, España) tiene su origen en una pequeña capilla del siglo XIII. En el siglo XV se le añadieron tres naves, dando como resultado el templo actual. La Iglesia se ha modificado en determinadas ocasiones debido principalmente a: (I) el interés por ampliarla y embellecerla y (II) solucionar algunos problemas estructurales documentados desde el siglo XVII. De estos últimos, los más relevantes en relación a la estructura pueden resumirse en dos colapsos parciales (1695 y 1956) y la sustitución de dos pilares (1902 y 1928) para evitar otras dos catástrofes. Al inicio del siglo XXI, la nueva aparición de daños en pilares y muros condujo al cierre del templo y al inicio de una investigación sobre el comportamiento estructural de la iglesia. Las conclusiones de este análisis, junto a una propuesta preliminar para su reparación, constituyen el objetivo principal de este artículo

Model Comparison to Interpret the Kinetics of in vitroGas Production with Bovine Excreta Used as Inoculum.

New models to help interpret the kinetics of in vitrogas production with bovine excreta used as inoculum were suggested. Samples of L. leucocephala, G. sepiumand P. maximum, with different gas production profiles, were used. The samples were submitted to the procedure for gas production and the volumes were determined every 3 h, in the first 30 h; then at 36; 48; 72 and 96 h. Five models were compared (two monophase and three biphase), and the parameters for better adjustment were determined. Mean squared error and the Durbin-Watson test were used as comparison criteria. It was concluded that the monophase models fall short to describe the kinetics of in vitrogas production with bovine excreta; whereas the biphase models with simple exponential components are useful. The biphase equation, where V = 0 for t < L and V = B * (1 – EXP (- C * (t - L))) for t ≥L classified as the most useful work is done with syringes

Peatlands in the Toledo Mountains (central Spain): characterisation and conservation status.

We have limited knowledge about the biodiversity and vulnerability of peatlands in the lower-altitude mountains of the Iberian Peninsula, largely because peatlands have not been routinely differentiated from other habitat types in Spain. Understanding is now developing about the ecology of peatlands in central Spain, but they are already under severe threat of conversion and degradation. In this article we describe the results of a field survey and literature review study to characterise and describe the current condition of peatlands in the Toledo Mountains in terms of their typology, the representation of habitat types protected by European (EU) designations, threats, endangered plant species, and conservation status. Our results suggest that the principal threats are overgrazing by domestic animals and ungulates (red deer and wild boar), fire, expansion of cereal crops, drying-out and erosion. Disturbance is most severe in areas that are not protected by nature conservation designations, where peatlands are especially vulnerable to damage arising from human activities

Parallel workflows to personalize clinical guidelines recommendations: application to gestational diabetes mellitus

The MobiGuide system provides patients with personalized decision support tools, based on computerized clinical guidelines, in a mobile environment. The generic capabilities of the system will be demonstrated applied to the clinical domain of Gestational Diabetes (GD). This paper presents a methodology to identify personalized recommendations, obtained from the analysis of the GD guideline. We added a conceptual parallel part to the formalization of the GD guideline called "parallel workflow" that allows considering patient?s personal context and preferences. As a result of analysing the GD guideline and eliciting medical knowledge, we identified three different types of personalized advices (therapy, measurements and upcoming events) that will be implemented to perform patients? guiding at home, supported by the MobiGuide system. These results will be essential to determine the distribution of functionalities between mobile and server decision support capabilities

Reliability and validity of the geriatric depression scale in a sample of Portuguese older adults with mild-to-moderate cognitive impairment

Although the Geriatric Depression Scale (GDS) is a well-established instrument for the assessment of depressive symptoms in older adults, this has not been validated specifically for Portuguese older adults with cognitive impairment. The objective of this study was to analyze the psychometric properties of two Portuguese versions of the GDS (GDS-27 and GDS-15) in a sample of Portuguese older adults with mild-to-moderate cognitive impairment. Clinicians assessed for major depressive disorder and cognitive functioning in 117 participants with mild-to-moderate cognitive decline (76.9% female, Mage = 83.66 years). The internal consistency of GDS-27 and GDS-15 were 0.874 and 0.812, respectively. There was a significant correlation between GDS-27 and GDS-15 with the Beck Depression Inventory-II (GDS-27: rho = 0.738, p < 0.001; GDS-15: rho = 0.760, p < 0.001 ), suggesting good validity. A cutoff point of 15/16 in GDS-27 and 8/9 in GDS-15 resulted in the identification of persons with depression (GDS-27: sensitivity 100%, specificity 63%; GDS-15: sensitivity 90%, specificity 62%). Overall, the GDS-27 and GDS-15 are reliable and valid instruments for the assessment of depression in Portuguese-speaking older adults with cognitive impairment.info:eu-repo/semantics/publishedVersio

MOMIC: A multi-omics pipeline for data analysis, integration and interpretation

Background and Objectives: The burst of high-throughput omics technologies has given rise to a new era in systems biology, offering an unprecedented scenario for deriving meaningful biological knowledge through the integration of different layers of information. Methods: We have developed a new software tool, MOMIC, that guides the user through the application of different analysis on a wide range of omic data, from the independent single-omics analysis to the combination of heterogeneous data at different molecular levels. Results: The proposed pipeline is developed as a collection of Jupyter notebooks, easily editable, reproducible and well documented. It can be modified to accommodate new analysis workflows and data types. It is accessible via momic.us.es, and as a docker project available at github that can be locally installed. Conclusions: MOMIC offers a complete analysis environment for analysing and integrating multi-omics data in a single, easy-to-use platform.Ministerio de Economía y Competitividad TIN2017-88209-C2-2-RJunta de Andalucía P18-RT-2778Junta de Andalucía US-1263341Ministerio de Ciencia e Innovación IPT-2011-0952-90000

Genome Wide Meta-Analysis identifies common genetic signatures shared by heart function and Alzheimer’s disease

Genètica de malalties; Medicina molecularGenética de enfermedades; Medicina molecularDisease genetics; Molecular medicineEchocardiography has become an indispensable tool for the study of heart performance, improving the monitoring of individuals with cardiac diseases. Diverse genetic factors associated with echocardiographic measures have been previously reported. The impact of several apoptotic genes in heart development identified in experimental models prompted us to assess their potential association with human cardiac function. This study aimed at investigating the possible association of variants of apoptotic genes with echocardiographic traits and to identify new genetic markers associated with cardiac function. Genome wide data from different studies were obtained from public repositories. After quality control and imputation, a meta-analysis of individual association study results was performed. Our results confirmed the role of caspases and other apoptosis related genes with cardiac phenotypes. Moreover, enrichment analysis showed an over-representation of genes, including some apoptotic regulators, associated with Alzheimer’s disease. We further explored this unexpected observation which was confirmed by genetic correlation analyses. Our findings show the association of apoptotic gene variants with echocardiographic indicators of heart function and reveal a novel potential genetic link between echocardiographic measures in healthy populations and cognitive decline later on in life. These findings may have important implications for preventative strategies combating Alzheimer’s disease

Automatic blood glucose classification for gestational diabetes with feature selection: decision trees vs neural networks

Automatic blood glucose classification may help specialists to provide a better interpretation of blood glucose data, downloaded directly from patients glucose meter and will contribute in the development of decision support systems for gestational diabetes. This paper presents an automatic blood glucose classifier for gestational diabetes that compares 6 different feature selection methods for two machine learning algorithms: neural networks and decision trees. Three searching algorithms, Greedy, Best First and Genetic, were combined with two different evaluators, CSF and Wrapper, for the feature selection. The study has been made with 6080 blood glucose measurements from 25 patients. Decision trees with a feature set selected with the Wrapper evaluator and the Best first search algorithm obtained the best accuracy: 95.92%

Iberian acid peatlands: types, origin and general trends of development.

ABSTRACT: In the present study we reviewed the genesis, development and classification of peatlands in the Iberian 1. The region has a wide variety of peatlands which are classified according to their biogeochemical, geomorphological and ecological characteristics into different types of bogs and fens. 2. Most of the peatlands occur in the Atlantic region followed by the Mediterranean and Alpine regions. Fens are more widely distributed than bogs, and blanket and raised bogs are mainly found in the Eurosiberian biogeographical region. 3. In many of the fens, the last active peat-forming cycle occurred during the Late Holocene (43 %). In most of the bogs, the peat-forming cycle occurred in the Middle Holocene (70 %), although in a substantial proportion of blanket bogs these processes occurred in the Early Holocene (30 %). 4. The peat formed in the last active cycle is, on average, thicker in raised bogs (322 cm) than in blanket bogs (257 cm) and fens (156 cm). 5. Vertical peat accumulation rates varied between 16 and 30 yr cm-1 in more than 40 % of the peatlands. The accumulation rates differed significantly between the different types of peatlands and were highest in the raised bogs. The accumulation rates were very variable in the fens. 6. The genesis, evolution and types of Iberian peatlands are similar to those observed in peatlands in northern latitudes in Europe and North America.Our research has been made possible by the following project grants: INCITE09-200-019-PR (Xunta de Galicia Government); DESIRÈ-HAR2013-43701-P (Spanish Ministry of Economy and Competitiveness); and Relictflora-P11-RNM-7033 (Excellence Research Projects Program from the Andalusian Government)