Contribution of a pumped-storage hydropower plant to reduce the scheduling costs of an isolated power system with high wind power penetration

AbstractThe paper aims at demonstrating that the consideration of constant start-up costs and ramps of the thermal generating units for assessing the contribution of pumped-hydro energy storage to reduce the scheduling costs of hydrothermal power systems with high wind penetration, may yield unrealistic results. For this purpose, an isolated power system is used as a case study. The contribution of a pumped-storage hydropower plant to reduce the system scheduling costs is assessed in the paper by using a hydrothermal weekly unit commitment model. The model considers different start-up costs and ramps of the thermal generating units as a function of the start-up type. The effects of including pumped hydro energy storage in the system on the integration of wind energy, and on the start-ups and capacity factors of the thermal generating units are also evaluated. The results of the paper demonstrate that the consideration of constant start-up costs and ramps of the thermal generating units yields unrealistic results, and that the pumped-storage hydropower plant may help reduce the system scheduling costs by 2.5–11% and integrate wind power and may allow dispensing with some inflexible thermal generating units

Irrigation distribution networks' vulnerability to climate change

Climate change will lead to changed demands on ex isting irrigation systems. This paper presents a methodology for investigating the performance of irrigation networks under climate change, and applies this to an irrigation network in Cordoba , southern Spain. The methodology uses emission scenarios (A2 and B2) developed by the Interg overnmental Panel on Climate Change. A global climate model (HadCM3) is used with downscali ng to predict climate variables for 2050 and 2080 under the emission scenarios. Euro pean agricultural policy scenario s are used to predict future cropping patterns. Irrigation water requirements are th en estimated for various combinations of these climate and cropping pattern scenarios, and the perfo rmance of the irrigation network is evaluated in terms of the equity and adequacy of pressure at the outlets, using EPANET. The methodology was applied to the Fuente Palmera irrigation district, which supplies water on-demand for drip irrigation. The results show that climate change would have a major impact on network performance with the existing cropping pattern, but that expected chang es in cropping pattern would reduce this impact

Sistema de simulación para el diseño lógico y de computadores

En el presente artículo se presenta el programa de apoyo a la docencia que ha sido desarrollado por profesores de la asignatura de Introducción a los Ordenadores. Dicho programa permite la simulación de circuitos lógicos, ya sean básicos o de gran complejidad. La finalidad del simulador es la de ayudar a comprender el funcionamiento de las diferentes. arquitecturas de computadores que se estudian en la asignatura y para ello se introduce en la parte práctica como herramienta de trabajo habitual. Las diferentes características del simulador permiten el diseño de arquitecturas nuevas, la simulación lógica de los diseños y el tratamiento de los bancos de memoria

The 2016 seismic series in the south Alboran Sea: Seismotectonics, Coulomb Failure Stress changes and implications for the active tectonics in the area

The Southern Alboran Sea, particularly the area offshore Al Hoceima Bay, presents moderate but continuous seismic activity since the Mw 6.0 1994 Al Hoceima earthquake. The maximum magnitude occurred in the area was a Mw 6.3 earthquake in the 2004 Al Hoceima – Tamasint seismic series. Since then, the seismicity in the Al Hoceima area has been usual, with maximum seismic magnitudes around 4. An increase in the seismic rate was registered during 2015, especially from May, culminating in the seismic series in January 2016. The mainshock occurred on January 25th 2016 with a magnitude Mw 6.3 and it was preceded by a Mw 5.1 foreshock on January 21st. The seismic series took place at the western end of the Alboran Ridge. Towards the northeast the Alboran Ridge bends, and seems to be connected with the NW-SE right-lateral transtensional Yusuf Fault. The recorded seismicity is mainly located in the Alboran Ridge area and along the N-S Al-Idrisi Fault that seems to continue southwards, towards the Al Hoceima Bay. The focal mechanisms calculated previously in the area showed a leftlateral strike-slip faulting with some normal component in the Alboran Ridge; but always within a complex system of diffuse deformation and high rupture type variability. We have used 41 computed focal mechanisms of this seismic series to analyze its seismotectonics and structural characteristics. To group the focal mechanisms we used a clustering algorithm using the spatial distribution of the events and also the type of rupture mechanism. For each cluster we have obtained the composed focal mechanism, associating it to a particular fault or family of structures. We have tested the mechanical compatibility of these structures by Coulomb Failure Stress transfer modeling. The mainshock of the series occurred in the Al Idrisi Fault intersecting the western Alboran Ridge. This event triggered aftershocks and independent series in left-lateral strike-slip faults associated with the Al Idrisi Fault System towards the south, but also in near pure reverse faults in the fault zone bounding the the Alboran Ridge. Both types of faults and rupture-mechanisms coexist, linked mechanically by stress transfer, being coeval the uplift of the Alboran Ridge and its northwestward displacement due to the left-lateral motion of the Al-Idrisi Fault. It is also discussed how the contrasting faulting processes and seismic ruptures are developed in two differentially oriented fault zones in the context the current NW-SE plate convergence between the African and Eurasian plates in the Westernmost Mediterranean

Alergia a la proteína de leche de vaca en la infancia: microbiota, hidrolizados y tolerancia

Trabajo presentado al XIII Workshop Sociedad Española de Microbiota, Probióticos y Prebióticos, celebrado en Valencia (España), del 7 la 9 de junio de 2022.Introducción La alergia a proteínas de leche de vaca (APLV) es la alergia alimentaria más frecuente en la infancia, habiéndose descrito posibles relaciones con la microbiota intestinal y con el tipo de alimentación. El objetivo de este trabajo es profundizar en el estudio de la microbiota intestinal en menores de un año con APLV y su relación con la adquisición de tolerancia y dieta, comparando muestras al diagnóstico y a los 6 meses de seguimiento con dieta de exclusión láctea. Metodología Se reclutaron 22 pacientes diagnosticados con APLV (14 mediados por IgE y 8 no mediados) y un grupo control de 25 niños sanos. Se recogieron muestras de heces y se realizó un análisis metataxonómico del ADNr 16S y de las regiones ITS de bifidobacterias por secuenciación. Se evaluaron las características clínico-epidemiológicas de los pacientes y se realizó un seguimiento a los 6 meses para evaluar tolerancia y el uso de distintas fórmulas terapéuticas de sustitución alimentaria. Resultados Se detectó un mayor porcentaje de secuencias pertenecientes al filo Actinobacteria (¿60%) en controles frente a casos (¿30%) al diagnóstico. Además, el patrón de abundancias relativas de bifidobacterias fue diferente entre controles y pacientes no mediados por IgE, con una menor proporción de B. longum en estos últimos. Tras la dieta de exclusión, sólo 3 de los pacientes, que estaban tomando distintos tipos de fórmulas terapéuticas, adquirió tolerancia, de los cuales 2 eran casos no mediados por IgE. Conclusiones En los pacientes APLV no IgE mediada se observaron perfiles microbianos distintos de los lactantes sanos, encontrándose a su vez en este grupo una mayor tolerancia al cabo de 6 meses. En tratamiento y seguimiento de la APLV la determinación de la microbiota intestinal puede ser clave para establecer posibles vínculos con la adquisición de tolerancia y el tipo de hidrolizado

The Al Hoceima 2016 seismic series. Strain partitioning and interaction of structures on a diffuse plate boundary

El terremoto principal de la serie sísmica tuvo lugar el 25 de enero de 2016, con una magitud Mw 6.3, que fue precedido por un premonitorio de magnitud Mw 5.1 el día 21 de enero. Hemos utilizado 41 mecanismos focales para analizar las características sismotectónicas y estructurales de la serie. Para agrupar los mecanismo focales hemos utilizado un algoritmo de agrupamiento jerárquico espacial y por el tipo de rotura del mecanismo. De cada agrupación hemos obtenido el mecanismo focal medio y lo hemos asociado a una estructura o familia de estructuras. Hemos comprobado la compatibilidad mecánica de estas estructuras mediante transferencia de esfuerzos de Coulomb. El evento principal de la serie se produjo en la Falla de Al Idrisi intersectando la cresta de Alborán. Este evento disparó réplicas y series independientes en fallas de desgarre asociadas al sistema de Falla de Al Idrisi hacia el sur, pero también en fallas inversas asociadas al levantamiento de la Cresta de Alborán hacia el este; produciendose una partición de la deformación entre ambos tipos de estructuras interaccionando por transferencia de esfuerzos.The mainshock of seismic series took place on January 25, 2016, with a Mw 6.3 magnitude, which was preceded by a premonitory of magnitude Mw 5.1 on 21 January. We have used 41 focal mechanisms to analyze the seismotectonics and the structural characteristics of the series. To cluster the focal mechanisms we used a hierarchical clustering algorithm using the spatial distribution of the events and also the type of rupture mechanism. For each cluster we have obtained the average focal mechanism and have been associated with a structure or family of structures. We have tested the mechanical compatibility of these structures by Coulomb stress transfer modelling. The mainshock of the series occurred in the Al Idrisi Fault intersecting the Alboran Ridge. This event triggered aftershocks and independent series in strike-slip faults associated with the Al Idrisi Fault System towards the south, but also in reverse faults associated with the lifting of the Alboran Ridge eastward; producing a strain partitioning between both types of structures interacting by stress transfer.Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEMinisterio de Economía y Competitividad (MINECO)pu

Extracellular cysteine disulfide bond break at Cys122 disrupts PIP2-dependent Kir2.1 channel function and leads to arrhythmias in Andersen-Tawil Syndrome

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Extracellular Kir2.1C122Y Mutant Upsets Kir2.1-PIP2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome.

BACKGROUND Andersen-Tawil syndrome type 1 is a rare heritable disease caused by mutations in the gene coding the strong inwardly rectifying K+ channel Kir2.1. The extracellular Cys (cysteine)122-to-Cys154 disulfide bond in the channel structure is crucial for proper folding but has not been associated with correct channel function at the membrane. We evaluated whether a human mutation at the Cys122-to-Cys154 disulfide bridge leads to Kir2.1 channel dysfunction and arrhythmias by reorganizing the overall Kir2.1 channel structure and destabilizing its open state. METHODS We identified a Kir2.1 loss-of-function mutation (c.366 A>T; p.Cys122Tyr) in an ATS1 family. To investigate its pathophysiological implications, we generated an AAV9-mediated cardiac-specific mouse model expressing the Kir2.1C122Y variant. We employed a multidisciplinary approach, integrating patch clamping and intracardiac stimulation, molecular biology techniques, molecular dynamics, and bioluminescence resonance energy transfer experiments. RESULTS Kir2.1C122Y mice recapitulated the ECG features of ATS1 independently of sex, including corrected QT prolongation, conduction defects, and increased arrhythmia susceptibility. Isolated Kir2.1C122Y cardiomyocytes showed significantly reduced inwardly rectifier K+ (IK1) and inward Na+ (INa) current densities independently of normal trafficking. Molecular dynamics predicted that the C122Y mutation provoked a conformational change over the 2000-ns simulation, characterized by a greater loss of hydrogen bonds between Kir2.1 and phosphatidylinositol 4,5-bisphosphate than wild type (WT). Therefore, the phosphatidylinositol 4,5-bisphosphate-binding pocket was destabilized, resulting in a lower conductance state compared with WT. Accordingly, on inside-out patch clamping, the C122Y mutation significantly blunted Kir2.1 sensitivity to increasing phosphatidylinositol 4,5-bisphosphate concentrations. In addition, the Kir2.1C122Y mutation resulted in channelosome degradation, demonstrating temporal instability of both Kir2.1 and NaV1.5 proteins. CONCLUSIONS The extracellular Cys122-to-Cys154 disulfide bond in the tridimensional Kir2.1 channel structure is essential for the channel function. We demonstrate that breaking disulfide bonds in the extracellular domain disrupts phosphatidylinositol 4,5-bisphosphate-dependent regulation, leading to channel dysfunction and defects in Kir2.1 energetic stability. The mutation also alters functional expression of the NaV1.5 channel and ultimately leads to conduction disturbances and life-threatening arrhythmia characteristic of Andersen-Tawil syndrome type 1.The authors thank the Centro Nacional de Investigaciones Cardiovasculares (CNIC) Viral Vectors Unit for producing the adeno-associated virus serotype 9. Confocal experiments were conducted at the CNIC Microscopy and Dynamic Imaging Unit. The authors thank the CNIC Bioinformatics Unit for generating the in silico homology modeling simulations, F-function analysis, and helpful discussions. The authors also thank the Centro de Supercomputación de Galicia for the use of the Finis Terrae III supercomputer to perform molecular dynamics studies. The CNIC was supported by the Instituto de Salud Carlos III, the Ministerio de Ciencia, Innovación y Universidades, and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIU/AEI/10.13039/501100011033). This work was supported by the National heart, Lung and Blood Institute under National Institutes of Health (NIH) grant R01HL163943; the La Caixa Banking Foundation project code HR18-00304 (grant LCF/PR/HR19/52160013); grants PI-FIS-2020, PI20/01220, PI-FIS-2023, and PI23/01039 from the Instituto de Salud Carlos III and cofunded by the Fondo Europeo de Desarrollo Regional (FEDER) and the European Union, respectively; grants PID2020-116935RB-I00 and BFU2016-75144-R funded by MICIU/AEI/10.13039/501100011033; the Fundación La Marató de TV3 (736/C/2020) amb el suport de la Fundació La Marató de TV3; the CIBER (Centro de Investigación Biomédica en Red) de Enfermedades Cardiovasculares (grant CB16/11/00458); the European Union’s Horizon 2020 grant agreement GA-965286; and the Program S2022/BMD7229-CM ARCADIACM funded by the Comunidad de Madrid to J. Jalife; grant PID2021-126423OB-C22 (to M. Martín-Martínez) funded by MICIU/AEI/10.13039/501100011033; and European Regional Development Fund (ERDF) grant PID2022-137214OB-C22 (to M. Gutierrez-Rodríguez) funded by MICIU/AEI/10.13039/501100011033. The imaging studies were performed in the TRIMA@CNIC (Infraestructura de Imagen Traslacional Avanzada del CNIC) node of the ICTS ReDIB (Infraestructuras Científicas y Técnicas Singulares: Red Distribuida de Imagen Biomédica) grant ICTS-2018- 04-CNIC-16 funded by MICIU/AEI/10.13039/501100011033 and ERDF, and project EQC2018-005070-P funded by MICIU/AEI/10.13039/501100011033 and FEDER. A.I. Moreno-Manuel holds an formación profesional universitaria (FPU) contract (FPU20/01569) from the Ministerio de Universidades. J.M. Ruiz Robles holds an FPU contract (FPU22/03253) from the Ministerio de Universidades. L.K. Gutiérrez holds an FPI contract (PRE2018-083530) from the Ministerio de Economía y Competitividad de España cofunded by the Fondo Social Europeo, attached to project SEV-2015-0505-18-2. I. Martínez-Carrascoso holds a PFIS (Contratos predoctorales de formación en investigación en salud) contract (FI21/00243) funded by Instituto de Salud Carlos III and the Fondo Social Europeo Plus cofunded by the European Union. M.L. Vera-Pedrosa held contract PEJD-2019-PRE/BMD15982 funded by the Consejería de Educación e Investigación de la Comunidad de Madrid y Fondo Social Europeo.S