Estudio de recursos CLIL en el área de Conocimiento del medio

Trabajo Fin de Grado-Universidad de Salamanca, 2014[ES] Este trabajo trata sobre el ciclo vital de diversos animales. Un breve resumen de los aspectos más relevantes de la metodología CLIL (Content and Language Integrated Learning)[EN] This paper deals with the life cycle of various animals. A brief summary of the most important aspects of the CLIL (Content and Language Integrated Learning

The Tres Arroyos Granitic Aplite-Pegmatite Field (Central Iberian Zone, Spain): Petrogenetic Constraints from Evolution of Nb-Ta-Sn Oxides, Whole-Rock Geochemistry and U-Pb Geochronology

Abundant Li-Cs-Ta aplite-pegmatite dykes were emplaced in the western Central Iberian Zone of the Iberian Massif during the Variscan Orogeny. Their origin and petrogenetic relationships with the widespread granitoids have led to a currently rekindled discussion about anatectic vs. granitic origin for the pegmatitic melts. To deal with these issues, the aplite-pegmatite dykes from the Tres Arroyos area, which constitute a zoned pegmatitic field related to the Nisa-Alburquerque granitic batholith, have been studied. This work comprises a complete study of Nb-Ta-Sn oxides’ mineralogy, whole-rock geochemistry, and U-Pb geochronology of the aplite-pegmatites that have been grouped as barren, intermediate, and Li-rich. The most abundant Nb-Ta-Sn oxides from Tres Arroyos correspond to columbite-(Fe), columbite-(Mn) and cassiterite. Niobium-Ta oxides show a marked increase in the Mn/(Mn+Fe) ratio from the barren aplite-pegmatites up to the Li-rich bodies, whereas variations in the Ta/(Ta+Nb) ratio are not continuous. The probable factors controlling fractionation of Mn/Fe and Ta/Nb reflected in Nb-Ta oxides may be attributed to the crystallization of tourmaline, phosphates and micas. The lack of a progressive Ta/Nb increase with the fractionation may be also influenced by the high F and P availability in the parental pegmatitic melts. Most of the primary Nb-Ta oxides would have crystallized by punctual chemical variations in the boundary layer, whereas cassiterite formation would be related to an undercooling of the system. Whole-rock composition of the distinguished lithotypes reflects similar tendencies to those observed in mineral chemistry, supporting a single path of fractional crystallization from the parental Nisa-Alburquerque monzogranite up to the most evolved Li-rich aplite-pegmatites. The age of 305 ± 9 Ma, determined by LA-ICP-MS U-Pb dating of columbite-tantalite oxides, reinforces the linkage of the studied aplite-pegmatites and the cited parental monzogranite.This research was funded by the Spanish Ministry of Economy, Industry and Competitiveness (Project RTI2018-094097-B-100, with ERDF funds), the University of the Basque Country UPV/ EHU (grant GIU18/084) and the European Union’s Horizon 2020 Innovation Programme (grant agreement No 869274, project GREENPEG: New Exploration Tools for European Pegmatite Green-Tech Resources). Work of Idoia Garate-Olave has been supported also by the UPV/EHU by means of the “Convocatoria de contratación para la especialización de personal investigador doctor en la UPV/EHU 2019”

Escenarios de guerra: paseando por Madrid a través de su memoria

Este libro difunde los resultados de las investigaciones llevadas a cabo en distintos proyectos de investigación en los últimos años, presentados en la Semana de la Ciencia y la Tecnología de Madrid. En él se proponen tres itinerarios por los lugares más significativos del impacto de la Guerra Civil en Madrid que recogen aspectos de la historia, el arte, el patrimonio, la memoria y la vida cotidiana, apoyándose en las fuentes directas de quienes vivieron el conflicto

CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer

The CHL1 gene encodes a cell-adhesion molecule proposed as being a putative tumour-suppressor gene in breast cancer (BC). However, neither the underlying molecular mechanisms nor the clinical value of CHL1 downregulation in BC has been explored. The methylation status of three CpG sites in the CHL1 promoter was analysed by pyrosequencing in neoplastic biopsies from 142 patients with invasive BC and compared with that of non-neoplastic tissues. We found higher CHL1 methylation levels in breast tumours than in non-neoplastic tissues, either from mammoplasties or adjacent-to-tumour, which correlated with lower levels of protein expression in tumours measured by immunohistochemistry. A panel of five BC cell lines was treated with two epigenetic drugs, and restoration of CHL1 expression was observed, indicating in vitro dynamic epigenetic regulation. CHL1 was silenced by shRNA in immortalized but non-neoplastic mammary cells, and enhanced cell proliferation and migration, but not invasion, were found by real-time cell analysis. The prognostic value of CHL1 hypermethylation was assessed by the log-rank test and fitted in a Cox regression model. Importantly, CHL1 hypermethylation was very significantly associated with shorter progression-free survival in our BC patient series, independent of age and stage (p = 0.001). In conclusion, our results indicate that CHL1 is downregulated by hypermethylation and that this epigenetic alteration is an independent prognostic factor in BC

Wikipedia como herramienta de aprendizaje en el EEES en la docencia de la lengua española en la educación primaria

Memoria ID12-0109. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2012-2013

Implementación y desarrollo de plataforma online para prácticas docentes e investigación en Comunicación y Arte

Desarrollo de una plataforma online con contenidos vinculados a prácticas docentes e investigación destinada a alumnos de Grado y Máster en las titulaciones de Ciencias Sociales y Humanidades en el ámbito de las relaciones arte, comunicación audiovisual y publicidad

Five Patients with Disorders of Calcium Metabolism Presented with GCM2 Gene Variants

The GCM2 gene encodes a transcription factor predominantly expressed in parathyroid cells that is known to be critical for development, proliferation and maintenance of the parathyroid cells. A cohort of 127 Spanish patients with a disorder of calcium metabolism were screened for mutations by Next-Generation Sequencing (NGS). A targeted panel for disorders of calcium and phosphorus metabolism was designed to include 65 genes associated with these disorders. We observed two variants of uncertain significance (p.(Ser487Phe) and p.Asn315Asp), one likely pathogenic (p.Val382Met) and one benign variant (p.Ala393_Gln395dup) in the GCM2 gene in the heterozygous state in five families (two index cases had hypocalcemia and hypoparathyroidism, respectively, and three index cases had primary hyperparathyroidism). Our study shows the utility of NGS in unravelling the genetic origin of some disorders of the calcium and phosphorus metabolism, and confirms the GCM2 gene as an important element for the maintenance of calcium homeostasis. Importantly, a novel variant in the GCM2 gene (p.(Ser487Phe)) has been found in a patient with hypocalcemia.This study was supported by three grants from the Department of Health (2017111014, 2018111097 and 2019111052) and one grant from the Department of Education (IT1281-19) of the Basque Government. This work is generated within the Endocrine European Reference Network (Project ID number of Endo-ERN: 739527). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscrip

Novel Variant in the CNNM2 Gene Associated with Dominant Hypomagnesemia

The maintenance of magnesium (Mg2+) homeostasis is essential for human life. The Cystathionine-beta-synthase (CBS)-pair domain divalent metal cation transport mediators (CNNMs) have been described to be involved in maintaining Mg2+ homeostasis. Among these CNNMs, CNNM2 is expressed in the basolateral membrane of the kidney tubules where it is involved in Mg2+ reabsorption. A total of four patients, two of them with a suspected disorder of calcium metabolism, and two patients with a clinical diagnosis of primary tubulopathy were screened for mutations by Next-Generation Sequencing (NGS). We found one novel likely pathogenic variant in the heterozygous state (c.2384C>A; p.(Ser795*)) in theCNNM2gene in a family with a suspected disorder of calcium metabolism. In this family, hypomagnesemia was indirectly discovered. Moreover, we observed three novel variants of uncertain significance in heterozygous state in the other three patients (c.557G>C; p.(Ser186Thr), c.778A>T; p.(Ile260Phe), and c.1003G>A; p.(Asp335Asn)). Our study shows the utility of Next-Generation Sequencing in unravelling the genetic origin of rare diseases. In clinical practice, serum Mg2+ should be determined in calcium and PTH-related disorders.This study was supported by three grants from the Department of Health (2017111014, 2018111097 and 2019111052) and one grant from the Department of Education (IT1281-19) of the Basque Government. This work is generated within the Endocrine European Reference Network (Project ID number of Endo-ERN: 739527). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript