Intake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer: A Prospective Analysis of the EPIC Study

Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the total and individual classes and subclasses of (poly)phenols and the risk of PCa, including clinically relevant subtypes. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort included 131,425 adult men from seven European countries. (Poly)phenol intake at baseline was assessed by combining validated center/country-specific dietary questionnaires and the Phenol-Explorer database. Multivariable-adjusted Cox proportional hazards models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI). In total, 6939 incident PCa cases (including 3501 lowgrade and 710 high-grade, 2446 localized and 1268 advanced, and 914 fatal Pca cases) were identified during a mean follow-up of 14 years. No associations were observed between the total intake of (poly)phenols and the risk of PCa, either overall (HRlog2 = 0.99, 95% CI 0.94–1.04) or according to PCa subtype. Null associations were also found between all classes (phenolic acids, flavonoids, lignans, and stilbenes) and subclasses of (poly)phenol intake and the risk of PCa, overall and according to PCa subtype. The results of the current large prospective cohort study do not support any association between (poly)phenol intake and PCa incidence.La Marato de TV-3 553/C/2019 PID2020-114921RB-C21 PI18/0191 PI22/0412CIBERFES CB16/10/00269Instituto de Salud Carlos III Spanish GovernmentEuropean Union (EU)Generalitat de Catalunya's Agency AGAUR 2021SGR00687Maria de Maeztu Unit of Excellence CEX2021-001234-MMICIN/AEI/FEDER, UEEuropean Union (EU) 2005328Department of Epidemiology and Biostatistics, School of Public HealthDanish Cancer SocietyLigue nationale contre le cancerInstitut Gustave RoussyMutuelle Generale de l'Education NationaleInstitut National de la Sante et de la Recherche Medicale (Inserm)Deutsche KrebshilfeHelmholtz AssociationGerman Institute of Human Nutrition Potsdam-Rehbruecke (DIfE)Federal Ministry of Education & Research (BMBF)Fondazione AIRC per la ricerca sul cancroCompagnia di San PaoloDutch Ministry of Public Health, Welfare and Sports (VWS)Netherlands Cancer Registry (NKR)LK Research FundsDutch Prevention FundsNetherlands Organization for Scientific Research (NWO)Health Research Fund (FIS)-Instituto de Salud Carlos III (ISCIII)Regional Governments of Andalucia, Asturias, Basque Country, Murcia and NavarraCatalan Institute of Oncology-ICO (Spain)Swedish Cancer SocietySwedish Research Council and County Councils of Skane and Vaesterbotten (Sweden)Cancer Research UK 14136 C8221/A29017UK Research & Innovation (UKRI) Medical Research Council UK (MRC) 1000143 MR/M012190/1Sara Borrell CPII20/00009Generalitat de Catalunya's Agency AGAUR 2021SGR00481Miguel Servet IIInstituto de Salud Carlos III Spanish Governmen

Estudio comparativo de las habilidades sociales de niños con trastorno de Asperger con niños y niñas de desarrollo normotípico en edades de 6 a 8 años integrados en Educación Primaria

En el marco de las competencias sociales, pretendemos analizar y comparar las habilidades sociales que presentan un grupo con Trastorno de asperger y otro normotípico de niñas y niños en edades y nivel de escolaridad equivalente. Los participantes fueron 20, 10 con trastorno Asperger y 10 normotípicos, de edades entre 6 y 8 años, cursando entre el primero a tercero básico (primaria). Ambos grupos fueron equiparados en Edad Cronológica y Cociente Intelectual. Se evaluaron los dos grupos con el CHIS (Monjas, 2009a). Utilizamos un diseño no experimental, ex-post-facto. Para comparar la muestra y comprobar las hipótesis aplicamos la t de student. Concluimos que el grupo con Trastorno de Asperger presenta menores habilidades sociales en las seis subescalas que el grupo normotípico. Palabras claves: Habilidades sociales, Trastorno de Asperger, Trastorno Espectro AutistaMáster en Investigación Aplicada a la Educació

Dexamethasone-doped nanoparticles improve mineralization, crystallinity and collagen structure of human dentin

zation. This study aims to evaluate bonding ability and both mechanical and chemical behavior of demineralized dentin infiltrated with polymeric nanoparticles doped with dexamethasone (Dex-NPs). Methods: Dentin conditioned surfaces were infiltrated with NPs, Dex-NPs or Dex-Zn-NPs. Bonded interfaces were also created and stored for 24 h or 21d, and then submitted to microtensile bond strength testing. Dentin remineralization was analyzed by Nanohardness, Young’s modulus and Raman analysis. Results: At 21d of storage, dentin treated with undoped-NPs attained the lowest nanohardness and Young’s modulus. Dex-NPs and Zn-Dex-NPs increased dentin nanohardness and Young’s modulus after 21d Raman analysis showed high remineralization, crystallinity, crosslinking and better structure of collagen when functionalized Dex-NPs were present at the dentin interface. Conclusions: Infiltration of dentin with Dex-NPs promoted functional remineralization as proved by nanomechanical and morpho-chemical evaluation tests. Dexamethasone in dentin facilitated crystallographic maturity, crystallinity and improved maturity and secondary structure of dentin collagen. Clinical significance: Using dexamethasone-functionalized NPs before resin infiltration is a clear option to obtain dentin remineralization, as these NPs produce the reinforcement of the dentin structure, which will lead to the improvement of the longevity of resin restorationsGrant PID2020-114694RB-I00 funded by MCIN/AEI 10.13039/501100011033Funding for open access charge: Universidad de Granada / CBUA

Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability

R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive regulatory roles but are also a source of genomic instability. One key cellular mechanism to prevent R-loop accumulation centers on the conserved THO/TREX complex, an RNA-binding factor involved in transcription elongation and RNA export that contributes to messenger ribonucleoprotein (mRNP) assembly, but whose precise function is still unclear. To understand how THO restrains harmful R-loops, we searched for new THO-interacting factors. We found that human THO interacts with the Sin3A histone deacetylase complex to suppress co-transcriptional R-loops, DNA damage, and replication impairment. Functional analyses show that histone hypo-acetylation prevents accumulation of harmful R-loops and RNA-mediated genomic instability. Diminished histone deacetylase activity in THO- and Sin3A-depleted cell lines correlates with increased R-loop formation, genomic instability, and replication fork stalling. Our study thus uncovers physical and functional crosstalk between RNA-binding factors and chromatin modifiers with a major role in preventing R-loop formation and RNA-mediated genome instability.European Research Council ERC2014 AdG669898 TARLOOPMinisterio de Economía y Competitividad BFU2013-42918-P, BFU2016-75058-PJunta de Andalucía BIO123

Design and technical evaluation of an enhanced location-awareness service enabler for spatial disorientation management of elderly with mild cognitive impairment

The progressive ageing of population has turned the mild cognitive impairment (MCI) into a prevalent disease suffered by elderly. Consequently, the spatial disorientation has become a significant problem for older people and their caregivers. The ambient-assisted living applications are offering location-based services for empowering elderly to go outside and encouraging a greater independence. Therefore, this paper describes the design and technical evaluation of a location-awareness service enabler aimed at supporting and managing probable wandering situations of a person with MCI. Through the presence capabilities of the IP multimedia subsystem (IMS) architecture, the service will alert patient's contacts if a hazardous situation is detected depending on his location. Furthermore, information about the older person's security areas has been included in the user profile managed by IMS. In doing so, the service enabler introduced contribute to “context-awareness” paradigm allowing the adaptation and personalization of services depending on user's context and specific conditions or preferences

AALUMO: a user model ontology for ambient assisted living services supported in next-generation networks

Ambient Assisted Living (AAL) services are emerging as context-awareness solutions to support elderly people?s autonomy. The context-aware paradigm makes applications more user-adaptive. In this way, context and user models expressed in ontologies are employed by applications to describe user and environment characteristics. The rapid advance of technology allows creating context server to relieve applications of context reasoning techniques. Specifically, the Next Generation Networks (NGN) provides by means of the presence service a framework to manage the current user's state as well as the user's profile information extracted from Internet and mobile context. This paper propose a user modeling ontology for AAL services which can be deployed in a NGN environment with the aim at adapting their functionalities to the elderly's context information and state

How Continuous Monitoring Changes the Interaction of Patients with a Mobile Telemedicine System

The use of continuous glucose monitor changes the way patients manage their diabetes, as observed in the increased number of daily insulin bolus, the increased number of daily BG measurements, and the differences in the distribution of BG measurements throughout the day. Continuous monitoring also increases the interaction of patients with the information system and modifies their patterns of use

La villa romana de Los Mondragones (Granada): Un nuevo yacimiento arqueológico en el entorno de Iliberis

La villa romana de Los Mondragones es un yacimiento arqueológico inédito aparecido recientemente en Granada y que permite estudiar la estructura y funcionamiento sincrónico y diacrónico de una villa romana desde el siglo I d.C. hasta el siglo VII d.C., aportando datos relevantes para el conocimiento del ager de la antigua ciudad de Iliberis.Artículo revisado por pare

Análisis de la formación en liderazgo para el ejercicio profesional en el campo de la administración contable percibida por los estudiantes de 8vo a 11vo semestre de la Universidad del Valle sede Palmira, año 2019.

El presente documento titulado "ANÁLISIS DE LA FORMACIÓN EN LIDERAZGO PARA EL EJERCICIO PROFESIONAL EN EL CAMPO DE LA ADMINISTRACIÓN CONTABLE PERCIBIDA POR LOS ESTUDIANTES DE 8vo A 11vo SEMESTRE DE LA UNIVERSIDAD DEL VALLE SEDE PALMIRA, AÑO 2019" tiene por objetivo analizar la percepción de los estudiantes e indagar en los profesores del programa académico de Contaduría Pública de la Universidad del Valle Sede Palmira sobre la formación en liderazgo, para ello se realizan encuestas y entrevistas respectivamente, además del análisis comparativo con la Universidad hermana como lo es la Universidad Libre Secciona! Cali, de la que se tomará el Proyecto Educativo del Programa de Contaduría Pública, la Malla Curricular del Programa y los Contenidos Programáticos de las asignaturas con enfoque directo e indirecto en formación de liderazgo versus la Universidad del Valle sede Palmira, para lograr identificar las principales diferencias y darle a conocer a la Universidad del Valle sede Palmira, los aspectos en los que se debe trabajar para tener una mejora continua y gozar del gran prestigio.PregradoCONTADOR(A) PÚBLIC

Electronic Report Generation Web Service evaluated within a Telemedicine System

This work presents a generic tool based on a client-server architecture that generates electronic reports helping the evaluation process of any information system. For the specific evaluation of telemedicine systems the defined reports cover four dimensions: auditory of the system; evolution of clinical protocols; results from the questionnaires for user acceptance and quality of life; and surveillance of clinical variables. The use of a Web Service approach allows multiplatform use of the developed electronic report service and the modularity followed in the implementation enables easy system evolution and scalability