1944-11-02, Ray to Mrs. Calkins

This collection contains seven correspondence from 2ndLt. Norris K. Calkins, USAAF to his parents during the Second World War. Also included are ten correspondence to his parents in regards to his missing in action and subsequent killing in action status. Ephemera from his father Norris R. Calkins from the First World War is also included.https://digitalcommons.chapman.edu/nkcalkins_condolence_letters/1011/thumbnail.jp

Donating Behavior in Children: The Effects of the Model\u27s Similarity to the Observer, the Observer\u27s Familiarity With the Model and Parental Models

Model similarity and familiarity were investigated for adult and similar aged models demonstrating prosocial behavior. Third, fourth and fifth graders (75 male and 75 female) participated. Subjects were given questionnaires regarding their most and least preferred peers and their most preferred parent. The models were described as similar to the subject for some groups. Subjects were given instructions concerning a sorting task and cash certificates they would earn. Fifty control subjects viewed a video that contained neither prosocial nor antisocial behavior. For the remaining subjects, a 2 (sex of subject) X 2 (similar age model versus adult model) X 5 (treatment) factorial design was employed. The 5 treatment factors were: unfamiliar models described as a) similar, b) dissimilar, c) with no similarity mentioned, and familiar models who were d) preferred (either a best friend or preferred parent), and e) least preferred (either a least preferred peer or parent). Subjects (except the control group) saw a video taped model who demonstrated a sorting task and collected 20 certificates. All models shared 10 certificates by placing them in a canister marked for the poor children . Subjects completed the task and had an opportunity to share while alone. Significantly more sharing occurred in the similar age than in the adult model group. Both of which imitated more than the control group. There was no difference in the imitation of males and females overall. There was no difference between the groups that saw unfamiliar models who were described as similar and the groups that saw unfamiliar models with no similarity mentioned. Each of these produced more imitative donating than the control, the familiar preferred model, and the unfamiliar model described as dissimilar groups. The familiar least preferred model group shared more than the control group. There were significant interaction effects between sex and treatment and between sex, treatment, and age of model. Unfamiliar models with no similarity mentioned and peer models each produced more sharing than parent models. Subjects who observed an unfamiliar model described as similar donated more than those seeing an unfamiliar model described as dissimilar. An unfamiliar age-mate model produced more sharing than a familiar and preferred friend. Donations were greater when the subject observed a least preferred peer rather than a best friend. This difference was due to the female subjects\u27 performance

Spatial prediction of soil properties in two contrasting physiographic regions in Brazil

This study compared the performance of ordinary kriging (OK) and regression kriging (RK) to predict soil physical-chemical properties in topsoil (0-15 cm). Mean prediction of error and root mean square of prediction error were used to assess the prediction methods. Two watersheds with contrasting soil-landscape features were studied, for which the prediction methods were performed differently. A multiple linear stepwise regression model was performed with RK using digital terrain models (DTMs) and remote sensing images in order to choose the best auxiliary covariates. Different pedogenic factors and land uses control soil property distributions in each watershed, and soil properties often display contrasting scales of variability. Environmental covariables and predictive methods can be useful in one site study, but inappropriate in another one. A better linear correlation was found at Lavrinha Creek Watershed, suggesting a relationship between contemporaneous landforms and soil properties, and RK outperformed OK. In most cases, RK did not outperform OK at the Marcela Creek Watershed due to lack of linear correlation between covariates and soil properties. Since alternatives of simple OK have been sought, other prediction methods should also be tested, considering not only the linear relationships between covariate and soil properties, but also the systematic pattern of soil property distributions over that landscape

Predicting runoff risks by digital soil mapping

Digital soil mapping (DSM) permits continuous mapping soil types and properties through raster formats considering variation within soil class, in contrast to the traditional mapping that only considers spatial variation of soils at the boundaries of delineated polygons. The objective of this study was to compare the performance of SoLIM (Soil Land Inference Model) for two sets of environmental variables on digital mapping of saturated hydraulic conductivity and solum depth (A + B horizons) and to apply the best model on runoff risk evaluation. The study was done in the Posses watershed, MG, Brazil, and SoLIM was applied for the following sets of co-variables: 1) terrain attributes (AT): slope, plan curvature, elevation and topographic wetness index. 2) Geomorphons and terrain attributes (GEOM): slope, plan curvature, elevation and topographic wetness index combined with geomorphons. The most precise methodology was applied to predict runoff areas risk through the Wetness Index based on contribution area, solum depth, and saturated hydraulic conductivity. GEOM was the best set of co-variables for both properties, so this was the DSM model used to predict the runoff risk. The runoff risk showed that the critical months are from November to March. The new way to classify the landscape to use on DSM was demonstrated to be an efficient tool with which to model process that occurs on watersheds and can be used to forecast the runoff risk40113CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAIS - FAPEMIG471522/2012-0; 201987/2012-0; 305010/2013-1Sem informaçãoCAG-APQ-01423-11; CAG-PPM-00422-1

bFGF and its low affinity receptors in the pathogenesis of HIV-associated nephropathy in transgenic mice

bFGF and its low affinity receptors in the pathogenesis of HIV-associated nephropathy in transgenic mice. HIV-associated nephropathy is characterized by extensive tubulointerstitial disease with epithelial cell injury, microcystic proliferation, and tubular regeneration with glomerulosclerosis. To explore the role of bFGF as a mediator of HIV-induced interstitial disease, we utilized an HIV transgenic mouse model that manifests clinical and histological features observed in patients. In transgenic mice, simultaneous renal epithelial cell proliferation and injury were detected in vivo. In areas of microcystic proliferation, immunoreactive bFGF colocalized with extracellular matrix. Kidneys from transgenic mice had increased bFGF low affinity binding sites, particularly in the renal interstitium. In vitro, transgenic renal tubular epithelial cells proliferated more rapidly and generated tubular structures spontaneously, in marked contrast to nontransgenic renal cells where these pathologic features could be mimicked by exogenous bFGF. These studies suggest that renal bFGF and its receptors play an important role in the pathogenesis of HIV-associated nephropathy

Antipsychotics and Torsadogenic Risk: Signals Emerging from the US FDA Adverse Event Reporting System Database

Background: Drug-induced torsades de pointes (TdP) and related clinical entities represent a current regulatory and clinical burden. Objective: As part of the FP7 ARITMO (Arrhythmogenic Potential of Drugs) project, we explored the publicly available US FDA Adverse Event Reporting System (FAERS) database to detect signals of torsadogenicity for antipsychotics (APs). Methods: Four groups of events in decreasing order of drug-attributable risk were identified: (1) TdP, (2) QT-interval abnormalities, (3) ventricular fibrillation/tachycardia, and (4) sudden cardiac death. The reporting odds ratio (ROR) with 95 % confidence interval (CI) was calculated through a cumulative analysis from group 1 to 4. For groups 1+2, ROR was adjusted for age, gender, and concomitant drugs (e.g., antiarrhythmics) and stratified for AZCERT drugs, lists I and II (http://www.azcert.org, as of June 2011). A potential signal of torsadogenicity was defined if a drug met all the following criteria: (a) four or more cases in group 1+2; (b) significant ROR in group 1+2 that persists through the cumulative approach; (c) significant adjusted ROR for group 1+2 in the stratum without AZCERT drugs; (d) not included in AZCERT lists (as of June 2011). Results: Over the 7-year period, 37 APs were reported in 4,794 cases of arrhythmia: 140 (group 1), 883 (group 2), 1,651 (group 3), and 2,120 (group 4). Based on our criteria, the following potential signals of torsadogenicity were found: amisulpride (25 cases; adjusted ROR in the stratum without AZCERT drugs = 43.94, 95 % CI 22.82-84.60), cyamemazine (11; 15.48, 6.87-34.91), and olanzapine (189; 7.74, 6.45-9.30). Conclusions: This pharmacovigilance analysis on the FAERS found 3 potential signals of torsadogenicity for drugs previously unknown for this risk

An overview of harms associated with β-lactam antimicrobials: where do the carbapenems fit in?

The US Institute of Medicine's focus on patient safety has motivated hospital administrators to facilitate a culture of safety. As a result, subcommittees of the pharmacy and therapeutics committee have emerged in many hospitals to focus on adverse events and patient safety. Antimicrobial harms have gained the attention of practicing clinicians and hospital formulary committees, because they top the list of drugs that are associated with adverse events and because of certain serious harms that have ultimately led to the withdrawal of some antimicrobial agents. In the near future, several antimicrobials in the late phase of development will become available for clinical use (ceftobiprole, ceftaroline, and telavancin), and others (doripenem and dalbavancin) have recently joined the armamentarium. Because new antimicrobials will become part of the treatment armamentarium, it is important to discuss our current understanding of antimicrobial harms in general. Although not thought of as traditional adverse events, Clostridium difficile infection and development of resistance during therapy are adverse events that occur as a result of antimicrobial exposure and therefore are discussed. In addition, a distillation of our current understanding of β-lactam specific adverse events will be provided. Finally, new methods of administration are being evaluated that may influence peak concentration-related antimicrobial adverse events