Optimal International Tax Coordination and Economic Integration: A Game-Theoretic Framework

The scope for optimal international coordination of indirect taxes is examined in a macroeconomic game-theoretic framework which encompasses two regionally integrated economies, which have a single goods market. In each country there are tax-financed non-tradeable public goods, while labor is immobile internationally. The analysis of both fixed and flexible wage versions of the model identifies a much wider spectrum of cooperative tax policies than has been previously recognized. In relation to non-cooperative Nash equilibria, cooperative Pareto-improving tax changes can entail not only uni-directional increases or decreases in rates, but also asymmetric directional changes. In particular, the constellation of such welfare improving tax changes is shown to depend critically on the countries'' relative preferences for private and public goods consumption, savings, as well as demand elasticity values relative to unit elasticity.econometrics;

Induced pi-facial discrimination in the alkylation of chiral derivatives of glycine.

Part A. The alkylation trans 2-arylcyclohexyl hippurates with a series of electrophiles was examined. The reaction stereoselectivity varied from 46 to 81% depending on the steric and electronic nature of the electrophile when (Ar = phenyl). Higher stereoselectivity was observed when reacting electrophiles of increasing pi-character. When the chiral auxiliary contained a naphthyl group the stereoselectivity was \u3e80% for every electrophile used. Part B. The alkylation of the trans 2-phenylcyclohexylamide of methyl glycinate with a series of electrophiles was examined. Incorporation of the chiral auxiliary on the amino terminus of the amino acid appears to induce good stereoselectivity only when the electrophiles contain a point of unsaturation. The reaction stereoselectivity ranged from 21 to 80% depending on the electronic nature of the electrophiles. It is proposed that a pi-stacking interaction between the aromatic group on the auxiliary and the unsaturated electrophiles was responsible for the high stereochemical excess observed. Source: Masters Abstracts International, Volume: 39-02, page: 0514. Adviser: John M. McIntosh. Thesis (M.Sc.)--University of Windsor (Canada), 1999

Epitopes in ChEBI - A Collaboration with the IEDB

*ChEBI background:* Chemical Entities of Biological Interest (ChEBI) is a curated database of small chemical entities important in biosystems. As well as a description of entities, it provides a semantically rich knowledge base; and an internal hierarchy that organises the entities by their molecular structure types and potential rôles.

*The ChEBI-IEDB collaboration:* The Immune Epitope and Analysis Resource (IEDB) is a project supported by contract from the National Institute of Allergy and Infectious Diseases (NIAID). Its goal is to make epitope-related data on infectious diseases and immune disorders freely available to researchers worldwide. In June 2009, ChEBI began working with the IEDB on a project aimed at incorporating into ChEBI, by manual curation, a pilot subset of immunologically important chemicals identified as immune epitopes.

*The significance of the project:* Numerous reports attest to an increasing global prevalence of immune-related diseases, with a multiplicity of contributing factors. This situation underscores the need for cross-talk among the various scientific disciplines, and makes ChEBI involvement in this project particularly relevant. 

*Collaboration outcome:* That collaboration among curators working on different databases can be reciprocally beneficial has been amply demonstrated by the ChEBI-IEDB teamwork described: while the incorporated IEDB items have substantially enriched ChEBI, the latter’s multiplicity of synonyms, structure tree lay-out and expertise in describing non-peptidic epitopes have been equally useful to the IEDB in facilitating the search process.
*Status quo and plans:* We continue to refine our task of assisting the identification, understanding and utilisation of biologically meaningful chemical entities by engaging in further joint projects

Gamma-synucleinopathy in mice (and humans?)

As a result of these findings we assessed the distribution of gamma-synuclein in spinal cord samples of sporadic and familial amyotrophic lateral sclerosis. Though not a component of any typical ALS-associated inclusion bodies, we identified gamma-synuclein positive structures in the corticospinal tracts of several of the cases examined. All these cases shared a common pronounced loss of upper motor neurons and demyelination of the spinal cord portion of their axons. We thus propose that the unidentified gamma-synuclein positive structures represent a novel corticospinal tract inclusion structure or alternatively present a novel marker of a subtype of amyotrophic lateral sclerosis with pronounced upper motor neuron involvement

Key Determinants of Team Success in Elite Men’s Wheelchair Basketball

Performance Analysis has become an integral part of the coaching process within elite wheelchair basketball, assisting staff with the delivery of augmented feedback (Fliess-Douer et al. 2016). Whilst previous attempts to explore the key determinants of success within wheelchair basketball have identified that stronger teams accumulate a greater number of assists, turnovers, free-throw and field goal shooting attempts (Gómez et al. 2015; Molik et al. 2009), the use of secondary box score data in such studies has been questioned for both its validity and reliability (Ziv et al. 2010). The purpose of this study, therefore, was to explore the key determinants of team success within elite men’s wheelchair basketball using a valid and reliable wheelchair basketball data collection system using primary data collected from match notation (see Francis et al., 2015). Following University ethical approval, footage from 31 men’s games at the 2015 European Wheelchair Basketball Championships was coded using a developed template in SportsCode (V10, SportsTec Inc.) that included 108 action variables grouped into 19 categorical variables: Time, Home Team, Away Team, Offensive Unit (3.0/3.5), Offensive Unit (4.0/4.5), Defensive Unit (3.0/3.5), Defensive Unit (4.0/4.5), Match Status, Start of Possession, Man Out Offence, Shot Taken, Shot Point, Shot Outcome, Shot Location, Shot Clock Remaining, End of Possession, Defensive System, Defensive Outcome and Possession. The template’s reliability had been assessed by Francis et al. (2015) (inter-observer reliability: 0-5% error; intra-observer reliability 0-5% error). The data was subjected to a two-stage statistical analysis procedure in R (R Core Team 2015). Stage 1: Chi-squared tests highlighted 15 categorical variables that were significantly (p<0.05) associated with final game outcome (winning versus losing). The category with the highest level of statistical significance was Match Status (p<0.001). Stage 2: The multicollinearity between explanatory categories were explored. Categories that demonstrated perfect collinearity were removed. Using a 70% sample of the data (4,288 possessions), a forward and backwards stepwise elimination approach was used to build a final model, which included seven categories comprising of 37 action variables: Match Status, Defensive Unit (3.0/3.5), Offensive Unit (3.0/3.5), Offensive Unit (4.0/4.5), Stage, Defensive System and Start of Possession. When tested against the remaining 30% data set an area under the curve value of 0.749 was achieved which suggests the model has ‘fair’ predictive qualities. The final model indicates the importance of maintaining a winning state throughout the game, selecting a unit which predominately comprises of three point players and countering when the defence are pressing. Coaches, players and support staff can utilise the findings from the study to assist with the planning of offensive and defensive game strategies by identifying areas for development within training sessions, supporting selection and line-up combinations and informing the decision-making process of coaches and players during performances

Combinational losses of synucleins reveal their differential requirements for compensating age-dependent alterations in motor behavior and dopamine metabolism

Synucleins are involved in multiple steps of the neurotransmitter turnover but the largely normal synaptic function in young adult animals completely lacking synucleins suggests their roles are dispensable for execution of these processes. Instead, they may be utilized for boosting the efficiency of certain molecular mechanisms in presynaptic terminals, with a deficiency of synuclein proteins sensitizing to or exacerbating synaptic malfunction caused by accumulation of mild alterations, which are commonly associated with aging. Although functional redundancy within the family has been reported, it is unclear whether the remaining synucleins can fully compensate for the deficiency of a lost family member, or whether some functions are specific for a particular member. We assessed several structural and functional characteristics of the nigrostriatal system of mice lacking members of the synuclein family in every possible combination and demonstrated that stabilization of the striatal dopamine level depends on the presence of α-synuclein and cannot be compensated for by other family members, whereas β-synuclein is required for efficient maintenance of animal’s balance and coordination in old age

Magnesium-specific ring expansion/contraction catalysed by the class II diterpene cyclase from pleuromutilin biosynthesis

The class II diterpene cyclase (DTC) from pleuromutilin biosynthesis uniquely mediates ‘A’ ring contraction of the initially formed decalin bicycle, yielding mutildienyl diphosphate (MPP). Catalysis requires a divalent metal cation co-factor. Intriguingly, selectively with magnesium, this DTC catalyzes ring expansion/contraction between MPP and halimadienyl diphosphate, providing some catalytic insight

Identifying critical supply chains and final products: An input-output approach to exploring the energy-water-food nexus

Recent advances in detailed multiregional input-output databases offers new opportunities to use these environmental accounting tools to explore the interrelationships between energy, water and food–the energy-water-food nexus. This paper takes the UK as a case study and calculates energy, water and food consumption-based accounts for 1997-2013. Policies, designed to reduce the environmental impact of consumption of products, can intervene at many stages in a product’s whole life-time from ‘cradle to gate’. We use input-output analysis techniques to investigate the interaction between the energy, water and food impacts of products at different points along their supply chains, from the extraction of material and burning of energy, to the point of final consumption. We identify the twenty most important final products whose large energy, water and food impacts could be captured by various demand-side strategies such as reducing food waste or dietary changes. We then use structural-path analysis to calculate the twenty most important supply chains whose impact could be captured by resource efficiency policies which act at the point of extraction and during the manufacturing process. Finally, we recognise that strategies that aim to reduce environmental impacts should not harm the socioeconomic well-being of the UK and her trade partners and suggest that pathways should be targeted where the employment and value added dependencies are relatively low

Manganese-catalyzed dehydrogenative synthesis of urea derivatives and polyureas

A.K. thanks the Leverhulme Trust for an early career fellowship (ECF-2019-161). M.B. wishes to thank the School of Chemistry and EaStCHEM for their support. A.E.O. gratefully acknowledges a fellowship from the Akwa Ibom State University (TETFund).Urea derivatives have significant applications in the synthesis of resin precursors, dyes, agrochemicals, and pharmaceutical drugs. Furthermore, polyureas are useful plastics with applications in coating, adhesive, and biomedical industries. However, the conventional methods for the synthesis of urea derivatives and polyureas involve toxic reagents such as (di)isocyanates, phosgene, CO, and azides. We present here the synthesis of (poly)ureas using much less toxic reagents─(di)amines and methanol─via a catalytic dehydrogenative coupling process. The reaction is catalyzed by a pincer complex of an earth-abundant metal, manganese, and liberates H2 gas, valuable by itself, as the only byproduct, making the overall process highly atom-economic. A broad variety of symmetrical and unsymmetrical urea derivatives and polyureas have been synthesized in moderate to quantitative yields using this catalytic protocol. Mechanistic insights have also been provided using experiments and DFT computation, suggesting that the reaction proceeds via an isocyanate intermediate.Publisher PDFPeer reviewe