568 research outputs found
Ising Model on the Affine Plane
We demonstrate that the Ising model on a general triangular graph with 3
distinct couplings corresponds to an affine transformed conformal
field theory (CFT). Full conformal invariance of the minimal CFT is
restored by introducing a metric on the lattice through the map which relates critical couplings to the ratio of the dual
hexagonal and triangular edge lengths. Applied to a 2d toroidal lattice, this
provides an exact lattice formulation in the continuum limit to the Ising CFT
as a function of the modular parameter. This example can be viewed as a quantum
generalization of the finite element method (FEM) applied to the strong
coupling CFT at a Wilson-Fisher IR fixed point and suggests a new approach to
conformal field theory on curved manifolds based on a synthesis of simplicial
geometry and projective geometry on the tangent planes
C5 Palsy After Cervical Spine Surgery: A Multicenter Retrospective Review of 59 Cases.
STUDY DESIGN: A multicenter, retrospective review of C5 palsy after cervical spine surgery.
OBJECTIVE: Postoperative C5 palsy is a known complication of cervical decompressive spinal surgery. The goal of this study was to review the incidence, patient characteristics, and outcome of C5 palsy in patients undergoing cervical spine surgery.
METHODS: We conducted a multicenter, retrospective review of 13 946 patients across 21 centers who received cervical spine surgery (levels C2 to C7) between January 1, 2005, and December 31, 2011, inclusive. P values were calculated using 2-sample t test for continuous variables and χ(2) tests or Fisher exact tests for categorical variables.
RESULTS: Of the 13 946 cases reviewed, 59 patients experienced a postoperative C5 palsy. The incidence rate across the 21 sites ranged from 0% to 2.5%. At most recent follow-up, 32 patients reported complete resolution of symptoms (54.2%), 15 had symptoms resolve with residual effects (25.4%), 10 patients did not recover (17.0%), and 2 were lost to follow-up (3.4%).
CONCLUSION: C5 palsy occurred in all surgical approaches and across a variety of diagnoses. The majority of patients had full recovery or recovery with residual effects. This study represents the largest series of North American patients reviewed to date
Which outcomes are most important to measure in patients with COVID-19 and how and when should these be measured? Development of an international standard set of outcomes measures for clinical use in patients with COVID-19: a report of the International Consortium for Health Outcomes Measurement (ICHOM) COVID-19 Working Group.
Objectives: The COVID-19 pandemic has resulted in widespread morbidity and mortality with the consequences expected to be felt for many years. Significant variation exists in the care even of similar patients with COVID-19, including treatment practices within and between institutions. Outcome measures vary among clinical trials on the same therapies. Understanding which therapies are of most value is not possible unless consensus can be reached on which outcomes are most important to measure. Furthermore, consensus on the most important outcomes may enable patients to monitor and track their care, and may help providers to improve the care they offer through quality improvement. To develop a standardised minimum set of outcomes for clinical care, the International Consortium for Health Outcomes Measurement (ICHOM) assembled a working group (WG) of 28 volunteers, including health professionals, patients and patient representatives. Design: A list of outcomes important to patients and professionals was generated from a systematic review of the published literature using the MEDLINE database, from review of outcomes being measured in ongoing clinical trials, from a survey distributed to patients and patient networks, and from previously published ICHOM standard sets in other disease areas. Using an online-modified Delphi process, the WG selected outcomes of greatest importance. Results: The outcomes considered by the WG to be most important were selected and categorised into five domains: (1) functional status and quality of life, (2) mental functioning, (3) social functioning, (4) clinical outcomes and (5) symptoms. The WG identified demographic and clinical variables for use as case-mix risk adjusters. These included baseline demographics, clinical factors and treatment-related factors. Conclusion: Implementation of these consensus recommendations could help institutions to monitor, compare and improve the quality and delivery of care to patients with COVID-19. Their consistent definition and collection could also broaden the implementation of more patient-centric clinical outcomes research.</p
Stealth dark matter spectrum using LapH and Irreps
We present non-perturbative lattice calculations of the low-lying meson and
baryon spectrum of the SU(4) gauge theory with fundamental fermion
constituents. This theory is one instance of stealth dark matter, a class of
strongly coupled theories, where the lowest mass stable baryon is the dark
matter candidate. This work constitutes the first milestone in the program to
study stealth dark matter self-interactions. Here, we focus on reducing excited
state contamination in the single baryon channel by applying the Laplacian
Heaviside method, as well as projecting our baryon operators onto the
irreducible representations of the octahedral group. We compare our resulting
spectrum to previous work involving Gaussian smeared non-projected operators
and find good agreement with reduced statistical uncertainties. We also present
the spectrum of the low-lying odd-parity baryons for the first time
Characterizing Gravitational Wave Detector Networks: From A to Cosmic Explorer
Gravitational-wave observations by the Laser Interferometer
Gravitational-Wave Observatory (LIGO) and Virgo have provided us a new tool to
explore the universe on all scales from nuclear physics to the cosmos and have
the massive potential to further impact fundamental physics, astrophysics, and
cosmology for decades to come. In this paper we have studied the science
capabilities of a network of LIGO detectors when they reach their best possible
sensitivity, called A#, and a new generation of observatories that are factor
of 10 to 100 times more sensitive (depending on the frequency), in particular a
pair of L-shaped Cosmic Explorer observatories (one 40 km and one 20 km arm
length) in the US and the triangular Einstein Telescope with 10 km arms in
Europe. We use a set of science metrics derived from the top priorities of
several funding agencies to characterize the science capabilities of different
networks. The presence of one or two A# observatories in a network containing
two or one next generation observatories, respectively, will provide good
localization capabilities for facilitating multimessenger astronomy and
precision measurement of the Hubble parameter. A network of two Cosmic Explorer
observatories and the Einstein Telescope is critical for accomplishing all the
identified science metrics including the nuclear equation of state,
cosmological parameters, growth of black holes through cosmic history, and make
new discoveries such as the presence of dark matter within or around neutron
stars and black holes, continuous gravitational waves from rotating neutron
stars, transient signals from supernovae, and the production of stellar-mass
black holes in the early universe. For most metrics the triple network of next
generation terrestrial observatories are a factor 100 better than what can be
accomplished by a network of three A# observatories.Comment: 45 pages, 20 figure
Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy
Corticobasal degeneration (CBD) is a neurodegenerative disorder affecting movement and cognition, definitively diagnosed only at autopsy. Here, we conduct a genome-wide association study (GWAS) in CBD cases (n = 152) and 3, 311 controls, and 67 CBD cases and 439 controls in a replication stage. Associations with meta-analysis were 17q21 at MAPT (P = 1.42 x 10(-12)),8p12 at lnc-KIF13B-1, a long non-coding RNA (rs643472;P = 3.41 x 10(-8)),and 2p22 at SOS1 (rs963731;P = 1.76 x 10(-7)). Testing for association of CBD with top progressive supranuclear palsy (PSP) GWAS single-nucleotide polymorphisms (SNPs) identified associations at MOBP (3p22;rs1768208;P = 2.07 x 10(-7)) and MAPT H1c (17q21;rs242557;P = 7.91 x 10(-6)). We previously reported SNP/transcript level associations with rs8070723/MAPT, rs242557/MAPT, and rs1768208/MOBP and herein identified association with rs963731/SOS1. We identify new CBD susceptibility loci and show that CBD and PSP share a genetic risk factor other than MAPT at 3p22 MOBP (myelin-associated oligodendrocyte basic protein)
K2-291b:A rocky super-Earth in a 2.2 day orbit
K2-291 (EPIC 247418783) is a solar-type star with a radius of R_star = 0.899
0.034 R_sun and mass of M_star=0.934 0.038 M_sun. From K2 C13 data,
we found one super-Earth planet (R_p = 1.589+0.095-0.072 R_Earth) transiting
this star on a short period orbit (P = 2.225177 +6.6e-5 -6.8e-5 days). We
followed this system up with adaptive-optic imaging and spectroscopy to derive
stellar parameters, search for stellar companions, and determine a planet mass.
From our 75 radial velocity measurements using HIRES on Keck I and HARPS-N on
Telescopio Nazionale Galileo, we constrained the mass of EPIC 247418783b to M_p
= 6.49 1.16 M_Earth. We found it necessary to model correlated stellar
activity radial velocity signals with a Gaussian process in order to more
accurately model the effect of stellar noise on our data; the addition of the
Gaussian process also improved the precision of this mass measurement. With a
bulk density of 8.84+2.50-2.03 g cm-3, the planet is consistent with an
Earth-like rock/iron composition and no substantial gaseous envelope. Such an
envelope, if it existed in the past, was likely eroded away by
photo-evaporation during the first billion years of the star's lifetime.Comment: Accepted to AJ, 15 pages, 8 figure
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