Development of a computer algorithm for the analysis of variable-frequency AC drives: Case studies included

The development of computer software for performance prediction and analysis of voltage-fed, variable-frequency AC drives for space power applications is discussed. The AC drives discussed include the pulse width modulated inverter (PWMI), a six-step inverter and the pulse density modulated inverter (PDMI), each individually connected to a wound-rotor induction motor. Various d-q transformation models of the induction motor are incorporated for user-selection of the most applicable model for the intended purpose. Simulation results of selected AC drives correlate satisfactorily with published results. Future additions to the algorithm are indicated. These improvements should enhance the applicability of the computer program to the design and analysis of space power systems

City and Countryside Revisited. Comparative rent movements in London and the South-East, 1580-1914

Economic historians have traditionally argued that urban growth in England was driven primarily by prior improvements in agricultural supply in the two centuries before the industrial revolution. Recent revisionist scholarship by writers such as Jan Luiten van Zanden and Robert Allen has suggested that 'the city drove the countryside, not the reverse'. This paper assembles new serial data on urban and agricultural rent movements in Kent, Essex and London, from 1580-1914, which enables us to provide a tentative estimate of the strength of the urban variable and the productivity of land across the rural-urban continuum. Our initial findings support the revisionist view, and throw new light on London's position within the wider metropolitan region. Comparative rent movements suggests a greater continuity between town and countryside than has often been assumed, with sharp increases in rental values occurring on the rural-urban fringes of London and the lower Medway valley

Micrococcal Nuclease Does Not Substantially Bias Nucleosome Mapping

We have mapped sequence-directed nucleosome positioning on genomic DNA molecules using high-throughput sequencing. Chromatins, prepared by reconstitution with either chicken or frog histones, were separately digested to mononucleosomes using either micrococcal nuclease (MNase) or caspase-activated DNase (CAD). Both enzymes preferentially cleave internucleosomal (linker) DNA, although they do so by markedly different mechanisms. MNase has hitherto been very widely used to map nucleosomes, although concerns have been raised over its potential to introduce bias. Having identified the locations and quantified the strength of both the chicken or frog histone octamer binding sites on each DNA, the results obtained with the two enzymes were compared using a variety of criteria. Both enzymes displayed sequence specificity in their preferred cleavage sites, although the nature of this selectivity was distinct for the two enzymes. In addition, nucleosomes produced by CAD nuclease are 8–10 bp longer than those produced with MNase, with the CAD cleavage sites tending to be 4–5 bp further out from the nucleosomal dyad than the corresponding MNase cleavage sites. Despite these notable differences in cleavage behaviour, the two nucleases identified essentially equivalent patterns of nucleosome positioning sites on each of the DNAs tested, an observation that was independent of the histone type. These results indicate that biases in nucleosome positioning data collected using MNase are, under our conditions, not significant

The unavoidable costs of ethnicity : a review of evidence on health costs

This report was commissioned by the Advisory Committee on Resource Allocation (ACRA), and prepared by the Centre for Health Services Studies (CHESS) and the Centre for Research in Ethnic Relations (CRER) at the University of Warwick. The NHS Executive does not necessarily assent to the factual accuracy of the report, nor necessarily share the opinions and recommendations of the authors. The study reviews the evidence concerning the degree to which the presence of populations of minority ethnic origin was associated with ‘unavoidable additional costs’ in health service delivery. While local health authorities retail full autonomy in their use of funds allocated to them under the Hospital and Community Health Services formula, the size of that budget is governed by a set of weightings applied to their population, to allow for factors known to influence levels of need, and the costs of providing services. The study began by considering the definitions used in describing ‘ethnicity’ and ethnic groups in relevant medical and social policy literature. It is clear that no fixed set of terms can be adopted, and that flexibility is required to respond to social changes. The terms used in the 1991 Census, with additions to allow for local and contemporary developments, provide a suitable baseline but require additional information on religion language and migration history for clinical and health service delivery planning. There have been notable developments in health service strategy to meet the needs of black and minority ethnic groups which have been encouraged by good practice guidelines and local initiatives. Together with research into epidemiology and ethnic monitoring of services, these have enlarged understanding of the impact of diversity. A conceptual model is developed which explores the potential for such diversity to lead to variations in the cost of providing health services to a multi-ethnic population. The research team reviewed the existing published evidence relating to ethnic health and disease treatment in medical, social science, academic and practitioner literature, using conventional techniques. Additional evidence was located through trawls of ‘grey’ literature in specialist collections, and through contacting all English health districts with a request for information. A number of authorities and trusts provided written and oral evidence, and a bibliography of key materials is provided. Key issues considered include the need for and use of, interpreter and translation services, the incidence of ‘ethnically-specific’ disease, and variations in the prevalence and cost of treating ‘common’ conditions in minority ethnic populations. Sources of variation are discussed, and a ‘scoping’ approach adopted to explore the extent to which these variations could be adequately modelled. It is clear that while some additional costs can be identified, and seen to be unavoidable, there are other areas where the presence of minority populations may lead to lessened pressures on budgets, or where provision of ‘ethnic-specific’ facilities may be alternative to existing needs. The literature provides a range of estimates which can be used in a modelling exercise, but is deficient in many respects, particularly in terms of precise costs associated with procedure and conditions, or in associating precise and consistent categories of ethnic group with epidemiological and operational service provision data. Certain other activities require funding to set them up, and may not be directly related to population size. There is considerable variation in the approaches adopted by different health authorities, and many services are provided by agencies not funded by NHS budgets. The study was completed before the announcement of proposed changes in health service commissioning which may have other implications for ethnic diversity. The presence of minorities is associated with the need to provide additional services in respect of interpreting and translation, and the media of communication. In order to achieve clinical effectiveness, a range of advocacy support facilities or alternative models of provision seem to be desirable. Ethnic diversity requires adaptation and additional evidence in order to inform processes of consultation and commissioning. Minority populations do create demands for certain additional specific clinical services not required by the bulk of the majority population: it is not yet clear to what extent the reverse can be stated since research on ‘under-use’ is less well developed. Some variations in levels of need, particularly those relating to established clinical difference in susceptibility or deprivation, are already incorporated in funding formulae although it is not clear how far the indicators adequately reflect these factors. Costs are not necessarily simply related to the size of minority populations. The provision of services to meet minority needs is not always a reflection of their presence, but has frequently depended upon the provision of additional specific funds. There is a consensus that the NHS research and development strategy should accept the need for more work to establish the actual levels of need and usage of service by ethnic minority groups, and that effort should be made to use and improve the growing collection of relevant information through ethnic monitoring activities. A variety of modelling techniques are suggested, and can be shown to have the potential to provide practical guidance to future policy in the field. Current data availability at a national or regional scale is inadequate to provide estimates of the ‘additional costs of ethnicity’ but locally collected data and the existence of relevant policy initiatives suggest that a focused study in selected districts would provide sufficiently robust information to provide reliable estimates. The review has demonstrated that there are costs associated with the presence of minority ethnic groups in the population which can be shown to be unavoidable and additional, but that others are either ‘desirable’ or ‘alternative’. It would be wrong to assume that all cost pressures of this nature are in the same direction. Our study has drawn attention to deficiencies in data collection and budgeting which may hinder investigation of the effectiveness of the service in general. The process of drawing attention to ethnic minority needs itself leads to developments in services which are functional and desirable for the majority population

Promoting Engaged Scholarship Among Undergraduate University Students

The School Research Partnership (SRP) is an engaged scholarship program that promotes collaboration among undergraduate students, community partners, and university advisors. In this case study, we describe the Research Consultation Project (RCP), an undergraduate student independent study project that uses a community-based research approach to connect students, faculty, and community partners to help address critical societal issues. In the RCP, undergraduate students function as research consultants for representatives of local school districts or leaders of other community agencies and organizations such as a county commissioner or a nonprofit focused on post-secondary education opportunities for youth. The students work under the supervision of an advisor to address questions posed by the policymaker or practitioner. RCP meets different but complementary needs of the students and partners in ways that bridge student academic and applied learning, research, policy, and practice

Biases in estimates of air pollution impacts: the role of omitted variables and measurement errors

Observational studies often use linear regression to assess the effect of ambient air pollution on outcomes of interest, such as human health outcomes or crop yields. Yet pollution datasets are typically noisy and include only a subset of potentially relevant pollutants, giving rise to both measurement error bias (MEB) and omitted variable bias (OVB). While it is well understood that these biases exist, less is understood about whether these biases tend to be positive or negative, even though it is sometimes falsely claimed that measurement error simply biases regression coefficient estimates towards zero. In this paper, we show that more can be said about the direction of these biases under the realistic assumptions that the concentrations of different types of air pollutants are positively correlated with each other and that each type of pollutant has a nonpositive association with the outcome variable. In particular, we demonstrate both theoretically and using simulations that under these two assumptions, the OVB will typically be negative and that more often than not the MEB for null pollutants or for pollutants that are perfectly measured will be negative. We also provide precise conditions, which are consistent with the assumptions, under which we prove that the biases are guaranteed to be negative. While the discussion in this paper is motivated by studies assessing the effect of air pollutants on crop yields, the findings are also relevant to regression-based studies assessing the effect of air pollutants on human health outcomes

Quantifying geological uncertainty in metamorphic phase equilibria modelling; a Monte Carlo assessment and implications for tectonic interpretations

Pseudosection modelling is rapidly becoming an essential part of a petrologist’s toolkit and often forms the basis of interpreting the tectonothermal evolution of a rock sample, outcrop, or geological region. Of the several factors that can affect the accuracy and precision of such calculated phase diagrams, “geological” uncertainty related to natural petrographic variation at the hand sample- and/or thin section-scale is rarely considered. Such uncertainty influences the sample’s bulk composition, which is the primary control on its equilibrium phase relationships and thus the interpreted pressure–temperature (P–T) conditions of formation. Two case study examples—a garnet–cordierite granofels and a garnet–staurolite–kyanite schist—are used to compare the relative importance that geological uncertainty has on bulk compositions determined via (1) X-ray fluorescence (XRF) or (2) point counting techniques. We show that only minor mineralogical variation at the thin-section scale propagates through the phase equilibria modelling procedure and affects the absolute P–T conditions at which key assemblages are stable. Absolute displacements of equilibria can approach ±1 kbar for only a moderate degree of modal proportion uncertainty, thus being essentially similar to the magnitudes reported for analytical uncertainties in conventional thermobarometry. Bulk compositions determined from multiple thin sections of a heterogeneous garnet–staurolite–kyanite schist show a wide range in major-element oxides, owing to notable variation in mineral proportions. Pseudosections constructed for individual point count-derived bulks accurately reproduce this variability on a case-by-case basis, though averaged proportions do not correlate with those calculated at equivalent peak P–T conditions for a whole-rock XRF-derived bulk composition. The main discrepancies relate to varying proportions of matrix phases (primarily mica) relative to porphyroblasts (primarily staurolite and kyanite), indicating that point counting preserves small-scale petrographic features that are otherwise averaged out in XRF analysis of a larger sample. Careful consideration of the size of the equilibration volume, the constituents that comprise the effective bulk composition, and the best technique to employ for its determination based on rock type and petrographic character, offer the best chance to produce trustworthy data from pseudosection analysis.RMP acknowledges a NERC postgraduate grant (reference number NE/H524781/1) for funding analytical work performed at the University of Oxford, UK

The effect of exercise interventions on inflammatory biomarkers in healthy, physically inactive subjects: a systematic review

Background: Increases in physical activity ameliorate low-grade systemic inflammation in disease populations such as type 2 diabetes mellitus and coronary artery disease. The effects of aerobic and resistance training (RT) on inflammatory biomarker profiles in non-disease, physically inactive individuals are unknown. Methods: A systematic review of randomized controlled trials measuring the effect of aerobic and resistance exercise on pro-inflammatory biomarkers in healthy, inactive adult populations was conducted. The available peer-reviewed literature was searched from January 1990 to June 2016 using the electronic databases PubMed and Scopus. A narrative synthesis of review findings was constructed with discussion of the impact of aerobic, resistance and combined training on C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-8, interleukin-1β and tumour necrosis factor-α. Results: The initial search revealed 1596 potentially relevant studies. Application of the study eligibility criteria led to the full-text review of 54 articles with 11 studies deemed suitable for inclusion. Review of related articles and the reference lists of the 54 full-text articles led to the inclusion of 2 additional studies. The review revealed inconsistent findings relating to the effect of aerobic training and RT on CRP and IL-6. Studies of older-aged adults (>65 years old) demonstrated the greatest and most consistent reduction in inflammatory biomarkers post-training intervention. Conclusions: A paucity of evidence exists relating to the effect of exercise training on inflammatory markers in non-disease, physically inactive adults. The available evidence suggests potential for the greatest benefit to be seen in older populations and with higher intensity aerobic exercise

Late Tertiary history of hydrothermal deposition at the East Pacific Rise, 19°S: Correlation to volcano‐tectonic events

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95132/1/grl3614.pd