EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial

More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369

Enforcing Multifunctionality: A Pressure-Induced Spin-Crossover Photomagnet

Photomagnetic compounds are usually achieved by assembling preorganized individual molecules into rationally designed molecular architectures via the bottom-up approach. Here we show that a magnetic response to light can also be enforced in a nonphotomagnetic compound by applying mechanical stress. The nonphotomagnetic cyano-bridged Fe^II–Nb^IV coordination polymer {[Fe^II(pyrazole)₄]₂[Nb^IV(CN)₈]·4H₂O}_<i>n</i> (<b>FeNb</b>) has been subjected to high-pressure structural, magnetic and photomagnetic studies at low temperature, which revealed a wide spectrum of pressure-related functionalities including the light-induced magnetization. The multifunctionality of <b>FeNb</b> is compared with a simple structural and magnetic pressure response of its analog {[Mn^II(pyrazole)₄]₂[Nb^IV(CN)₈]·4H₂O}_<i>n</i> (<b>MnNb</b>). The <b>FeNb</b> coordination polymer is the first pressure-induced spin-crossover photomagnet

Complexes polymériques de métaux de transition à ligands nitronyl et polycyanures : synthèse, structure et magnétisme

Ce travail concerne la synthèse, les études structurales par diffraction des rayons X et l'étude des propriétés magnétiques de complexes polymériques à base du radical nitronyl nitroxyde ou imino nitroxyde, d'un métal de transition paramagnétique et d'anions polycyanures tels dicyanamide, cyanure d'argent et tricyanocuivre(I). Par l'association des briques metal-radical et d'anions polycyanide, nous avons trouvé des composés présentant des structures zero-, mono-, bi- et tri- dimensionnelles. Les composés contenant la brique Mn-radical présentent une interaction intramoléculaire ferromagnétique tandis que les composés contenant le motif Cu-radical possèdent un comportement antiferromagnétiques.RENNES1-BU Sciences Philo (352382102) / SudocSudocFranceF

EXPANSION SEMIGROUPS IN PROBABILISTIC METRIC SPACES

Abstract. We present some new results on the existence and the approximation of common fixed point of expansive mappings and semigroups in probabilistic metric spaces

Structure, magnetic, and electrochemical properties of complexes of 3d-metals as redox-active units for assembling coordination polymers and porous coordination polymer on their basis

International audienceMononuclear complexes ML2 (MII = Fe, Co, Cu, Zn) and porous coordination polymer [\Fe2NiO(Piv)6\\CoL2\1.5] n (LH is the Schiff base of pyridine-4-carboxylic acid hydrazide and pyridine-2-carbaldehyde, and Piv– is pivalate) were synthesized and characterized. The structures of the compounds were determined by X-ray diffraction analyses. Each ML2 molecule contains two 4-pyridine fragments capable of coordinating metal ions. Polymer [\Fe2NiO(Piv)6\\CoL2\1.5] n was formed by cross-linking of trinuclear units with the CoL2 bridge. The temperature dependences of the magnetic susceptibility of CoL2, FeL2, and [\Fe2NiO(Piv)6\\CoL2\1.5] n were studied. The magnetic properties of [\Fe2NiO(Piv)6\\CoL2\1.5] n were described as a superposition of the susceptibilites of the trinuclear and mononuclear units, and their interaction was taken into account in the framework of the molecular field model. The magnetic properties of CoL2 in the individual state and in the framework of [\Fe2NiO(Piv)6\\CoL2\1.5] n were interpreted using a model taking into account the spin—orbit coupling in the Co2+ ion and the splitting of its levels by crystal field. For FeL2, a model taking into account the zero-field splitting of the ground state of the Fe2+ ion was used. Several redox processes were found for ML2 in a solution and for [\Fe2NiO(Piv)6\\CoL2\1.5] n in a suspension by cyclic voltammetry. The CoL2 and FeL2 complexes can catalyze the electrochemical dehalogenation of freon CF2ClCFCl2 but exhibit no activity in the dehalogenation of CHCl3; ZnL2 did not show catalytic activity in the dehalogenation of both substrate