482 research outputs found
Importance of the loading factor in transport CO2 emissions
This paper is focusing on the influence of the loading factor on CO2 emissions, from freight and passengers. A
common approach in economics to relate greenhouse gas (GHG) emissions to economic activity is the ASIF model (Unander & Schipper 2000). However, this model has been
elaborated for all economic sectors, and it doesnât take into account the vehicle load factor for the calculation of transport emissions. The objective of this paper is to include the loading factor into the ASIF approach. First, we will include this loading factor into the ASIF equation, aggregating step by step from trip level to macro level; loading will appear as a result of empty running, vehicle capacity and occupancy rate (section 2). Then section 3 will analyse the relationship between loading factor and energy consumption, per type of vehicle. Section 4 will focus on issues concerning freight, as well as section 5 for passengers. The examples will be mainly taken from road transport, which causes most of transport CO2 emissions. Then our conclusion will draw attention on data needs and policy implications
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Magnetoelastic coupling and ferromagnetic-type in-gap spin excitations in multiferroic α-Cu2V2O7
We investigate magnetoelectric coupling and low-energy magnetic excitations in multiferroic α-Cu2V2O7 by detailed thermal expansion, magnetostriction, specific heat and magnetization measurements in magnetic fields up to 15 T and by high-field/high-frequency electron spin resonance studies. Our data show negative thermal expansion in the temperature range â€200 K under study. Well-developed anomalies associated with the onset of multiferroic order (canted antiferromagnetism with a significant magnetic moment and ferroelectricity) imply pronounced coupling to the structure. We detect anomalous entropy changes in the temperature regime up to âŒ80 K which significantly exceed the spin entropy. Failure of GrĂŒneisen scaling further confirms that several dominant ordering phenomena are concomitantly driving the multiferroic order. By applying external magnetic fields, anomalies in the thermal expansion and in the magnetization are separated. Noteworthy, the data clearly imply the development of a canted magnetic moment at temperatures above the structural anomaly. Low-field magnetostriction supports the scenario of exchange-striction driven multiferroicity. We observe low-energy magnetic excitations well below the antiferromagnetic gap, i.e., a ferromagnetic-type resonance branch associated with the canted magnetic moment arising from Dzyaloshinsii-Moriya (DM) interactions. The anisotropy parameter meV indicates a sizeable ratio of DM- and isotropic magnetic exchange
Client self-assessment in community aged care: A comparative study involving older Australians and their case managers
Self-assessment of support needs is a relatively new and under-researched phenomenon in domiciliary aged care. This article outlines the results of a comparative study focusing on whether a self-assessment approach assists clients to identify support needs and the degree to which self-assessed needs differ from an assessment conducted by community care professionals. A total of 48 older people and their case managers completed a needs assessment tool. Twenty-two semi-structured interviews were used to ascertain older people’s views and preferences regarding the self-assessment process. The study suggests that while a co-assessment approach as outlined in this article has the potential to assist older people to gain a better understanding of their care needs as well as the assessment process and its ramifications, client self-assessment should be seen as part of a co-assessment process involving care professionals. Such a co-assessment process allows older people to gain a better understanding of their support needs and the wider community aged care context. The article suggests that a co-assessment process involving both clients and care professionals contains features that have the capacity to enhance domiciliary aged care
Blinatumomab compared with standard of care for the treatment of adult patients with relapsed/refractory Philadelphia chromosome–positive B-precursor acute lymphoblastic leukemia
Background: A single-arm, phase 2 trial demonstrated the efficacy and safety of blinatumomab, a bispecific T-cell\u2013engaging antibody construct, in patients with relapsed/refractory (r/r) Philadelphia chromosome\u2013positive (Ph+) acute lymphoblastic leukemia (ALL), a rare hematologic malignancy with limited treatment options. This study compared outcomes with blinatumomab with those of a historical control treated with the standard of care (SOC). Methods: The blinatumomab trial enrolled adult patients with Ph+ ALL who were r/r to at least 1 second-generation tyrosine kinase inhibitor (n = 45). Propensity score analysis (PSA) was used to compare outcomes with blinatumomab with those of an external cohort of similar patients receiving SOC chemotherapy (n = 55). The PSA mitigated confounding variables between studies by adjusting for imbalances in the age at diagnosis and start of treatment, sex, duration from diagnosis to most recent treatment, prior allogeneic hematopoietic stem cell transplantation, prior salvage therapy, and number of salvage therapies. Bayesian data augmentation was applied to improve power to 80% with data from a phase 3 blinatumomab study in r/r Philadelphia chromosome\u2013negative ALL. Results: In the PSA, the rate of complete remission or complete remission with partial hematologic recovery was 36% for blinatumomab and 25% for SOC, and this resulted in an odds ratio of 1.54 (95% confidence interval [CI], 0.61-3.89) or 1.70 (95% credible interval [CrI], 0.94-2.94) with Bayesian data augmentation. Overall survival favored blinatumomab over SOC, with a hazard ratio of 0.81 (95% CI, 0.57-1.14) or 0.77 (95% CrI, 0.61-0.96) with Bayesian data augmentation. Conclusions: These results further support blinatumomab as a treatment option for patients with r/r Ph+ ALL
The Coronae of AR Lac
We observed the coronally active eclipsing binary, AR Lac, with the High
Energy Transmission Grating on Chandra for a total of 97 ks, spaced over five
orbits, at quadratures and conjunctions. Contemporaneous and simultaneous EUV
spectra and photometry were also obtained with the Extreme Ultraviolet
Explorer. Significant variability in both X-ray and EUV fluxes were observed,
dominated by at least one X-ray flare and one EUV flare. We saw no evidence of
primary or secondary eclipses. X-ray flux modulation was largest at high
temperature, indicative of flare heating of coronal plasma. Line widths
interpreted in terms of Doppler broadening suggest that both binary stellar
components are active. From line fluxes obtained from total integrated spectra,
we have modeled the emission measure and abundance distributions. A strong
maximum was found in the differential emission measure, characterized by peaks
at log T = 6.9 and 7.4, together with a weak but significant cooler maximum
near log T=6.2, and a moderately strong hot tail from log T= 7.6-8.2. Coronal
abundances have a broad distribution and show no simple correlation with first
ionization potential. While the resulting model spectrum generally agrees very
well with the observed spectrum, there are some significant discrepancies,
especially among the many Fe L-lines. Both the emission measure and abundance
distributions are qualitatively similar to prior determinations from other
X-ray and ultraviolet spectra, indicating some long-term stability in the
overall coronal structure.Comment: 31 pages, 8 figures, 3 tables; Accepted for publication in the
Astrophysical Journal (tentatively October 1, 2003
Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study
p53 plays a critical role in regulating diverse biological processes: DNA repair, cell cycle arrest, apoptosis, and senescence. The p53 pathway has therefore served as the focus of multiple drug-discovery efforts. p53 is negatively regulated by hDMX and hDM2; prior studies have identified 14-3-3 proteins as hDMX and hDM2 client proteins. 14-3-3 proteins are adaptor proteins that modulate localisation, degradation and interactions of their targets in response to phosphorylation. Thus, 14-3-3 proteins may indirectly modulate the interaction between hDMX or hDM2 and p53 and represent potential targets for modulation of the p53 pathway. In this manuscript, we report on the biophysical and structural characterization of peptide/protein interactions that are representative of the interaction between 14-3-3 and hDMX or hDM2. The data establish that proximal phosphosites spaced ~20-25 residues apart in both hDMX and hDM2 co-operate to facilitate high-affinity 14-3-3 binding and provide structural insight that can be utilized in future stabilizer/inhibitor discovery efforts
Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators
The glucocorticoid receptor (GR) is a ligand-dependent transcription factor that plays a central role in inflammation. The GR activity is also modulated via protein-protein interactions, including binding of 14-3-3 proteins induced by GR phosphorylation. However, the specific phosphorylation sites on the GR that trigger these interactions and their functional consequences are less clear. Hence, we sought to examine this system in more detail. We used phosphorylated GR peptides, biophysical studies, and X-ray crystallography to identify key residues within the ligand-binding domain of the GR, T524 and S617, whose phosphorylation results in binding of the representative 14-3-3 protein 14-3-3ζ. A kinase screen identified misshapen-like kinase 1 (MINK1) as responsible for phosphorylating T524 and Rho-associated protein kinase 1 for phosphorylating S617; cell-based approaches confirmed the importance of both GR phosphosites and MINK1 but not Rhoassociated protein kinase 1 alone in inducing GR-14-3-3 binding. Together our results provide molecular-level insight into 14-3-3-mediated regulation of the GR and highlight both MINK1 and the GR-14-3-3 axis as potential targets for future therapeutic intervention
From the Heart of The Ghoul: C and N Abundances in the Corona of Algol B
Chandra Low Energy Transmission Grating Spectrograph observations of Algol
have been used to determine the abundances of C and N in the secondary star for
the first time. The analysis was performed relative to similar observations of
an adopted "standard" star HR 1099. It is demonstrated that HR 1099 and Algol
are coronal twins in many respects and that their X-ray spectra are very
similar in nearly all details, except for the observed strengths of C and N
lines. The H-like transitions of C and N in the coronae of Algol and HR 1099
demonstrate that the surface abundances of Algol B have been strongly modified
by CN-processing, as shown earlier by Schmitt & Ness (2002). It is found that N
is enhanced in Algol B by a factor of 3 compared to HR 1099. No C lines are
detected in the Algol spectrum, indicating a C depletion relative to HR 1099 by
a factor of 10 or more. These C and N abundances indicate that Algol B must
have lost at least half of its initial mass, and are consistent with
predictions of evolutionary models that include non-conservative mass transfer
and angular momentum loss through magnetic activity. Little or no dredge-up of
material subjected to CN-processing has occurred on the subgiant component of
HR 1099. It is concluded that Fe is very likely depleted in the coronae of both
Algol and HR 1099 relative to their photospheres by 0.5 dex, and C, N and O by
0.3 dex. Instead, Ne is enhanced by up to 0.5 dex.Comment: 17 pages, 4 figures, ApJ accepte
The Radio Corona of AR Lacertae
We present multifrequency VLA and VLBA observations at 8.4 GHz of the RS CVn
system AR Lac, that were performed in autumn 1997 simultaneously with X-ray
observations obtained from Rodono` et al. (1999). Our VLBA data indicate a
resolved source with dimension close to the system separation, while the study
of the flux density curve evidences a small amplitude outside of the eclipse
variability. The derived five-frequencies spectra, combined with the size
information from VLBA data, are compared with gyrosynchrotron emission from a
two component structured source. A comparison with the results of the X-ray
observations allow us to exclude the possibility that thermal gyrosynchrotron
is responsible for the radio emission, but it is compatible with the hypothesis
of co-spatial X-ray and radio emitting sources.Comment: 9 pages, 7 figures. Accepted for publication in A&
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