An all-in-one web tool to apply CTD quality control, format data, and generate metadata under SeaDataNet criteria

Professional data centres of the Pan-European region active in marine data collection, in particular National Oceanographic Data Centres (NODCs), routinely share diverse datasets through SeaDataNet, a distributed Marine Data Infrastructure. This network provides on-line integrated databases of standardized quality. Sharing marine data through SeaDataNet is an optimal way of ensuring FAIR principles: Findable, Accessible, Interoperable and Reusable. However, submission of data to this infrastructure demands a set of technical tasks that cover quality control processing, adoption of common vocabularies, implement file format standards and preparation of associated metadata. Although common software tools are made available to NODCs to facilitate data and metadata preparation (see https://www.seadatanet.org/Software) these tasks continuous to be complex and time-consuming. For example, the technician must use MIKADO software to generate INSPIRE-complaint metadata and adopt SeaDataNet Common Vocabularies; NEMO software to transform the original file to a common data transport format; and OCTOPUS software to check the compliance of a file. Additional software must be used to quality check and properly flag each individual record.En prens

Simplifying quality control and standardization of CTD data under SeaDataNet requirements

Sharing marine data through SeaDataNet infrastructure ensures preservation and promotes reusability. Submission of data to this infrastructure demands a set of technical tasks that cover quality control processing, adoption of common vocabularies, implement le format standards and preparation of associated metadata. Although common software tools are made available to Data Centres and/or End Users to facilitate data and metadata preparation, these tasks continuous to be complex and time-consuming. To speed-up this process, a Python-Flask web application is presented here to quality check and create metadata and data according to SeaDataNet requirements. The web tool focuses on CTD vertical pro les, although code could be easily adapted to process other type of records

Poliquistosis renal y aneurismas cerebrales: Presentación de un caso

Los autores presentan un caso típico de aneurismas arteriales cerebrales asociados a poliquistosis renal de carácter familiar. La rotura de uno de los aneurismas en una sesión de hemodiálisis provocó una hemorragia subaracnoidea que, a pesar del diagnóstico y tratamiento quirúrgico precoz, evolucionó fatalmente

The metadata catalogue of the Spanish Institute of Oceanography: a tool to implement the EU Marine Strategy Framework Directive (MSFD)

The Spanish Institute of Oceanography (IEO-CSIC) is responsible, among other aspects, for scientific and technical advice for the Government's fisheries policy as well as for the protection and sustainability of the marine environment. Thus, the IEO-CSIC plays a key role in the implementation of the Marine Strategy Framework Directive (MSFD), an EU legislative act that seeks to achieve a good environmental status of European marine waters and protect the resource base on which sustain economic and social activities related to the sea. Under this commission, the IEO-CSIC generates a large amount of marine data characterized by its spatial dispersion during acquisition as well as by its different typology. One of the main tasks is to safeguard data and to disclose what data exists and where, how and when it has been acquired and, in addition, to provide access to that data through the collaboration with different national and international organizations. To this end, the data and metadata are subjected to quality control and formatted for integration into a national Spatial Data Infrastructure (SDI). This SDI has a GeoNetwork catalogue (http://datos.ieo.es) with ~ 2800 oceanographic campaigns. The metadata of the campaigns known as Cruise Summary Report (CSR) follow the ISO 19139, and although similar to those reported to the pan European SeaDataNet infrastructure, here they have been adapted following an XSL transformation to facilitate the data discovery to the Spanish community. CSRs constitute the parent metadata for ~ 250 layers associated with the implementation of the MSFD. Thus, the INSPIRE-compliant layers with biological, geological and physical resource data can be found through the catalogue and are linked to the corresponding map services. Finally, relevant metadata for the implementation of the MSFD are harvested in other national infrastructures, as the InfoMar catalogue (http://www.infomar.miteco.es/), promoted by the Ministry for the Ecological Transition and the Demographic Challenge and maintained by the CEDEX

Quantum size effects in Pb islands on Cu(111): Electronic-structure calculations

The appearance of "magic" heights of Pb islands grown on Cu(111) is studied by self-consistent electronic structure calculations. The Cu(111) substrate is modeled with a one-dimensional pseudopotential reproducing the essential features, i.e. the band gap and the work function, of the Cu band structure in the [111] direction. Pb islands are presented as stabilized jellium overlayers. The experimental eigenenergies of the quantum well states confined in the Pb overlayer are well reproduced. The total energy oscillates as a continuous function of the overlayer thickness reflecting the electronic shell structure. The energies for completed Pb monolayers show a modulated oscillatory pattern reminiscent of the super-shell structure of clusters and nanowires. The energy minima correlate remarkably well with the measured most probable heights of Pb islands. The proper modeling of the substrate is crucial to set the quantitative agreement.Comment: 4 pages, 4 figures. Submitte

Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper

BACKGROUND AND OBJECTIVES: Treatment of spasticity poses a major challenge given the complex clinical presentation and variable efficacy and safety profiles of available drugs. We present a systematic review of the pharmacological treatment of spasticity in multiple sclerosis (MS) patients. METHODS: Controlled trials and observational studies were identified. Scientific evidence was evaluated according to pre-specified levels of certainty. RESULTS: The evidence supports the use of baclofen, tizanidine and gabapentin as first-line options. Diazepam or dantrolene could be considered if no clinical improvement is seen with the previous drugs. Nabiximols has a positive effect when used as add-on therapy in patients with poor response and/or tolerance to first-line oral treatments. Despite limited evidence, intrathecal baclofen and intrathecal phenol show a positive effect in severe spasticity and suboptimal response to oral drugs. CONCLUSION: The available studies on spasticity treatment offer some insight to guide clinical practice but are of variable methodological quality. Large, well-designed trials are needed to confirm the effectiveness of antispasticity agents and to produce evidence-based treatment algorithms

Las células presentadoras de antígeno y su papel en el síndrome reproductivo y respiratorio porcino

Las células presentadoras de antígeno son aquellas células encargadas de capturar, procesar y presentar antígenos con la finalidad de lograr una respuesta inmune efectiva por parte del organismo. Su papel, como centinelas, es crucial durante el transcurso de diversas enfermedades infecciosas. El estudio de estas células tras la infección con el virus del Síndrome Reproductivo y Respiratorio Porcino nos da información para abordar nuevas estrategias de control frente a esta enfermedad.Antigen presenting cells are able to capture, process and present antigens in order to develop an effective immune response. The role of these cells during infectious diseases is crucial to control the disease. Thus, the study of these cells after the infection with Porcine Reproductive and Respiratory Syndrome Virus gives us useful information on how to control this disease

Potential Role of Mic60/Mitofilin in Parkinson’s Disease

There are currently no treatments that hinder or halt the inexorable progression of Parkinson’s disease (PD). While the etiology of PD remains elusive, evidence suggests that early dysfunction of mitochondrial respiration and homeostasis play a major role in PD pathogenesis. The mitochondrial structural protein Mic60, also known as mitofilin, is critical for maintaining mitochondrial architecture and function. Loss of Mic60 is associated with detrimental effects on mitochondrial homeostasis. Growing evidence now implicates Mic60 in the pathogenesis of PD. In this review, we discuss the data supporting a role of Mic60 and mitochondrial dysfunction in PD. We will also consider the potential of Mic60 as a therapeutic target for treating neurological disorders