Impact of fludarabine-based induction therapy on outcome of FLT3-/NPM1+ cytogenetically normal acute myeloid leukemia.

3openopenTiribelli, M; Geromin, A; Damiani, DTiribelli, Mario; Geromin, A; Damiani, Daniel

DOMÍNIO DE CIDADES, GUERRA ASSIMÉTRICA E A PRIVATIZAÇÃO DA SEGURANÇA

The domination of cities is a new modality of property crimes, considered an evolution of robberies known as new cangaço. It is distinguished by exerting control over cities for a period of hours, paralyzing their security forces, obstructing entrances and exits. As a way of combating this criminal modality, the state police have carried out simulations of attacks on cities considered possible targets for gangs, even training the civilian population. This characteristic can be considered an asymmetric conflict war, where the conflicts are in the urban space, involving its populations as a whole, not only military and criminal agents. However, both police and criminals point to the new technologies of private security companies and values ​​as the main response to the dominance of cities, demonstrating the gray areas between private and public in security. This is an ethnographic-inspired research, with emphasis on qualitative research methods. The field work was carried out for a year, between São Paulo and Paraná, locations where emblematic cases of city domination took place.O domínio de cidades é uma nova modalidade dos crimes ao patrimônio, considerado uma evolução dos roubos conhecidos como novo cangaço. Distingue-se por exercer o controle sobre cidades por um período de horas, paralisando suas forças de segurança, obstruindo entradas e saídas. Como forma de combate a tal modalidade criminal as polícias estaduais tem realizado simulações de ataques às cidades consideradas possíveis alvos das quadrilhas, treinando até mesmo a população civil. Tal característica pode ser considerada uma guerra de conflito assimétrico, onde os conflitos estão no espaço urbano, envolvendo suas populações como um todo, não somente militares e agentes criminais. Porém, tanto os policiais como os criminosos apontam as novas tecnologias das empresas de segurança privada e valores como a principal resposta ao domínio de cidades, demonstrando as zonas cinzentas entre privado e público na segurança. Trata-se de uma pesquisa de inspiração etnográfica, com ênfase em métodos qualitativos de pesquisa. O trabalho de campo foi realizado por um ano, entre São Paulo e Paraná, localidades onde aconteceram casos emblemáticos de domínio de cidades

Between legal and illegal: the dynamics of cargo theft and its gray areas

O artigo discute o crime patrimonial na modalidade do roubo de cargas. Analisa as dinâmicas criminais em que está inserido, assim como as respostas institucionais e empresariais para controlá-lo. Aborda o roubo de cargas como expressão das zonas cinzentas que se estabelecem entre o lícito e ilícito, entre o público e o privado. Descreve as duas principais tipologias desse crime: os praticados “na loca” e os especializados. Aborda a participação de grupos criminosos organizados nessa modalidade de crime. Discute ainda a figura relevante nessa modalidade criminosa que é o receptador. O argumento central do artigo é que o crime de roubo de cargas por afetar os interesses de corporações econômicas, promove uma articulação destas com os setores públicos, sobretudo a polícia com vistas à sua contenção. A Intervenção Militar na Segurança Pública no Rio de Janeiro, em 2018, expressa essa mobilização de corporações junto às esferas governamentais de forma a promover uma ação de grande envergadura não só policial, mas também política. A metodologia usada foi a da pesquisa documental junto aos órgãos policiais e das forças armadas; entrevistas com policiais civis e militares, oficiais do alto comando das forças armadas, empresários, executivos de empresas e pessoas detidas pelo crime do roubo de cargas.Palavras-chave: roubo de carga; dinâmica criminal; crime contra o patrimônio.The article discusses property crime in the form of cargo theft. It analyzes the criminal dynamics in which it is inserted, as well as the institutional and business responses to control it. It addresses cargo theft as an expression of gray areas that are established between legal and illegal, between public and private. It describes the two main types of this crime: those committed “on the spot” and specialized ones. It addresses the participation of organized criminal groups in this type of crime. It also discusses the relevant figure in this criminal modality, which is the receiver. The central argument of the article is that the crime of cargo theft because it affects the interests of economic corporations, promotes an articulation of these with the public sectors, especially the police, with a view to their containment. The Military Intervention in Public Security in Rio de Janeiro, in 2018, expresses this mobilization of economic corporations in government spheres in order to promote a wide-ranging action not only police, but also political. The methodology used was that of documentary research with the police and armed forces; interviews with civilian and military police, officers of the high command of the armed forces, businessmen, company executives and persons detained for the crime of cargo theft.Keywords: cargo theft; criminal dynamics; crime against property

Allogeneic hematopoietic stem cell transplantation could improve survival of cytogenetically normal adult acute myeloid leukemia patients with DNMT3A mutations

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/115978/1/ajh24135.pd

Super-high-risk germ-cell tumors: a clinical entity. Report of eleven cases.

peer reviewedAmong patients suffering from nonseminomatous germ-cell tumor, with a poor prognosis, a subset underwent respiratory failure and died very early in the course of their treatment. Between 1982 and 1989, 11 out of 56 such patients (20%) died within the first 5 weeks of chemotherapy. The clinical, radiological, biological and infectious characteristics of these patients were analyzed. Nine patients had extensive pulmonary metastases and the 2 others presented a bulky mediastinal mass with pleural effusion. All patients experienced acute respiratory distress during chemotherapy and underwent mechanical ventilation. All patients were febrile, and septicemia was documented in 7 cases. WHO grade 4 and grade 1-2 renal toxicities occurred in 3 and 4 patients respectively. There was no tumor lysis syndrome. All patients died within 35 days from the start of therapy; 4 were autopsied. These 11 patients represent a clinical entity, having what we called super-high-risk germ cell tumors. Early death is related to pulmonary distress within the first 5 weeks of therapy. The origin of the pulmonary distress is multifactorial: bulky disease of the chest, infection, and interstitial fibrosis. Immediate full-dose standard chemotherapy in association with intensive supportive care is recommended in the management of these patients

Comprehensive molecular and clinical characterization of NUP98 fusions in pediatric acute myeloid leukemia

NUP98 fusions comprise a family of rare recurrent alterations in AML, associated with adverse outcomes. In order to define the underlying biology and clinical implications of this family of fusions, we performed comprehensive transcriptome, epigenome, and immunophenotypic profiling of 2,235 children and young adults with AML and identified 160 NUP98 rearrangements (7.2%), including 108 NUP98-NSD1 (4.8%), 32 NUP98-KDM5A (1.4%) and 20 NUP98-X cases (0.9%) with 13 different fusion partners. Fusion partners defined disease characteristics and biology; patients with NUP98-NSD1 or NUP98-KDM5A had distinct immunophenotypic, transcriptomic, and epigenomic profiles. Unlike the two most prevalent NUP98 fusions, NUP98-X variants are typically not cryptic. Furthermore, NUP98-X cases are associated with WT1 mutations, and have epigenomic profiles that resemble either NUP98-NSD1 or NUP98-KDM5A. Cooperating FLT3-ITD and WT1 mutations define NUP98-NSD1, and chromosome 13 aberrations are highly enriched in NUP98-KDM5A. Importantly, we demonstrate that NUP98 fusions portend dismal overall survival, with the noteworthy exception of patients bearing abnormal chromosome 13 (clinicaltrials gov. Identifiers: NCT00002798, NCT00070174, NCT00372593, NCT01371981).</p

Limited clinical relevance of mitochondrial DNA mutation and gene expression analyses in ovarian cancer

<p>Abstract</p> <p>Background</p> <p>In recent years, numerous studies have investigated somatic mutations in mitochondrial DNA in various tumours. The observed high mutation rates might reflect mitochondrial deregulation; consequently, mutation analyses could be clinically relevant. The purpose of this study was to determine if mutations in the mitochondrial D-loop region and/or the level of mitochondrial gene expression could influence the clinical course of human ovarian carcinomas.</p> <p>Methods</p> <p>We sequenced a 1320-base-pair DNA fragment of the mitochondrial genome (position 16,000-750) in 54 cancer samples and in 44 corresponding germline control samples. In addition, six transcripts (<it>MT-ATP6, MT-CO1, MT-CYB, MT-ND1</it>, <it>MT-ND6</it>, and <it>MT-RNR1</it>) were quantified in 62 cancer tissues by real-time RT-PCR.</p> <p>Results</p> <p>Somatic mutations in the D-loop sequence were found in 57% of ovarian cancers. Univariate analysis showed no association between mitochondrial DNA mutation status or mitochondrial gene expression and any of the examined clinicopathologic parameters. A multivariate logistic regression model revealed that the expression of the mitochondrial gene <it>RNR1 </it>might be used as a predictor of tumour sensitivity to chemotherapy.</p> <p>Conclusion</p> <p>In contrast to many previously published papers, our study indicates rather limited clinical relevance of mitochondrial molecular analyses in ovarian carcinomas. These discrepancies in the clinical utility of mitochondrial molecular tests in ovarian cancer require additional large, well-designed validation studies.</p