Future vector microprocessor extensions for data aggregations

As the rate of annual data generation grows exponentially, there is a demand to aggregate and summarise vast amounts of information quickly. In the past, frequency scaling was relied upon to push application throughput. Today, Dennard scaling has ceased and further performance must come from exploiting parallelism. Single instruction-multiple data (SIMD) instruction sets offer a highly efficient and scalable way of exploiting data-level parallelism (DLP). While microprocessors originally offered very simple SIMD support targeted at multimedia applications, these extensions have been growing both in width and functionality. Observing this trend, we use a simulation framework to model future SIMD support and then propose and evaluate five different ways of vectorising data aggregation. We find that although data aggregation is abundant in DLP, it is often too irregular to be expressed efficiently using typical SIMD instructions. Based on this observation, we propose a set of novel algorithms and SIMD instructions to better capture this irregular DLP. Furthermore, we discover that the best algorithm is highly dependent on the characteristics of the input. Our proposed solution can dynamically choose the optimal algorithm in the majority of cases and achieves speedups between 2.7x and 7.6x over a scalar baseline.The research leading to these results has received funding from the RoMoL ERC Advanced Grant GA no 321253 and is supported in part by the European Union (FEDER funds) under contract TTIN2015-65316-P. Timothy Hayes is supported by a FPU research grant from the Spanish MECD.Peer ReviewedPostprint (published version

Towards Healing the Blindness of Score Matching

Score-based divergences have been widely used in machine learning and statistics applications. Despite their empirical success, a blindness problem has been observed when using these for multi-modal distributions. In this work, we discuss the blindness problem and propose a new family of divergences that can mitigate the blindness problem. We illustrate our proposed divergence in the context of density estimation and report improved performance compared to traditional approaches

POSTER: An Integrated Vector-Scalar Design on an In-order ARM Core

In the low-end mobile processor market, power, energy and area budgets are significantly lower than in other markets (e.g. servers or high-end mobile markets). It has been shown that vector processors are a highly energy-efficient way to increase performance; however adding support for them incurs area and power overheads that would not be acceptable for low-end mobile processors. In this work, we propose an integrated vector-scalar design for the ARM architecture that mostly reuses scalar hardware to support the execution of vector instructions. The key element of the design is our proposed block-based model of execution that groups vector computational instructions together to execute them in a coordinated manner.The research leading to these results has received funding from the RoMoL ERC Advanced Grant GA no 321253 and is supported in part by the European Union (FEDER funds) under contract TIN2015-65316-P. This research has been also supported the Agency for Management of University and Research Grants (AGAUR - FI-DGR 2014).Peer ReviewedPostprint (author's final draft

Sustentabilidad/sostenibilidad de los medios comunitarios y universitarios: tres provocaciones para pensar nuevas realidades

Estudiar y reflexionar sobre las prácticas de gestión de las emisoras comunitarias ocupa un lugar importante en mi trabajo y formación desde hace más de 15 años. Esto sucede dada mi condición de militante del movimiento de radios comunitarias como miembro cofundador en Ahijuna FM 94.7, emisora cooperativa afincada en el sur del Gran Buenos Aires (GBA). Mi interés y preocupación siempre estuvo asociada a complejizar la mirada sobre los procesos y condiciones que permitan la sostenibilidad en el tiempo de los proyectos político-comunicacionales de las emisoras. Particularmente también el foco estuvo puesto en la resolución del trabajo y los aspectos económicos que permitan su sustentabilidad. En ese proceso es que, además de sostener mi trabajo como docente-investigador y extensionista universitario, orienté mi formación de posgrado al estudio de las industrias culturales en la Universidad Nacional de Quilmes (UNQ).Facultad de Periodismo y Comunicación Socia

Unveiling the gravitationally unstable disc of a massive star-forming galaxy using NOEMA and MUSE

Using new high-resolution data of CO (2-1), H-alpha and H-beta obtained with the Northern Extended Millimeter Array (NOEMA) and the Multi-Unit Spectroscopic Explorer (MUSE) at the Very Large Telescope, we have performed a Toomre-Q disc stability analysis and studied star formation, gas depletion times and other environmental parameters on sub-kpc scales within the z~0 galaxy SDSS J125013.84+073444.5 (LARS 8). The galaxy hosts a massive, clumpy disc and is a proto-typical analogue of main-sequence galaxies at z~1-2. We show that the massive (molecular) clumps in LARS 8 are the result of an extremely gravitationally unstable gas disc, with large scale instabilities found across the whole extent of the rotating disc, with only the innermost 500 pc being stabilized by its bulgelike structure. The radial profiles further reveal that - contrary to typical disc galaxies - the molecular gas depletion time decreases from more than 1 Gyr in the center to less than ~100 Myr in the outskirts of the disc, supporting the findings of a Toomre-unstable disc. We further identified and analysed 12 individual massive molecular clumps. They are virialized and follow the mass-size relation, indicating that on local (cloud/clump) scales the stars form with efficiencies comparable to those in Milky Way clouds. The observed high star formation rate must thus be the result of triggering of cloud/clump formation over large scales due to disc instability. Our study provides evidence that "in-situ" massive clump formation (as also observed at high redshifts) is very efficiently induced by large-scale instabilities.Comment: Submitted to MNRA

Lo que el agua no se llevó : El rescate de la memoria

En abril de 2013, en La Plata, se produjo un gran inundación que afectó a más de la mitad la ciudad. Algunos de los barrios afectados fueron Los Hornos, San Carlos, Villa Elvira, Tolosa, La Loma, Barrio Norte. Una de cada cuatro personas se vieron directamente afectadas por la catástrofe, mientras que la cifra ronda el 60% de la población del partido si se contemplan los que perdieron un auto o los que sufrieron otro tipo de perjuicios. En lo psicológico, los daños no pueden ser cuantificados, pero la tragedia dejó secuelas en la mayoría de la población, según el relato de “médicos sin fronteras” que saben de este tipo de tragedias (Funes, 2003), y de acuerdo con los relatos recogidos . Muestra de ello es la psicosis que se generó en la ultima tormenta, a tres años del hecho traumático, por un mensaje viralizado que anunciaba una nueva inundación en la ciudad y que generó el cierre de comercios, escuelas y una verdadera crisis de pánico en muchas personas (La Nación, 2016).Facultad de Periodismo y Comunicación Socia

Accounting for dominance to improve genomic evaluations of dairy cows for fertility and milk production traits

Background: Dominance effects may contribute to genetic variation of complex traits in dairy cattle, especially for traits closely related to fitness such as fertility. However, traditional genetic evaluations generally ignore dominance effects and consider additive genetic effects only. Availability of dense single nucleotide polymorphisms (SNPs) panels provides the opportunity to investigate the role of dominance in quantitative variation of complex traits at both the SNP and animal levels. Including dominance effects in the genomic evaluation of animals could also help to increase the accuracy of prediction of future phenotypes. In this study, we estimated additive and dominance variance components for fertility and milk production traits of genotyped Holstein and Jersey cows in Australia. The predictive abilities of a model that accounts for additive effects only (additive), and a model that accounts for both additive and dominance effects (additive + dominance) were compared in a fivefold cross-validation. Results: Estimates of the proportion of dominance variation relative to phenotypic variation that is captured by SNPs, for production traits, were up to 3.8 and 7.1 % in Holstein and Jersey cows, respectively, whereas, for fertility, they were equal to 1.2 % in Holstein and very close to zero in Jersey cows. We found that including dominance in the model was not consistently advantageous. Based on maximum likelihood ratio tests, the additive + dominance model fitted the data better than the additive model, for milk, fat and protein yields in both breeds. However, regarding the prediction of phenotypes assessed with fivefold cross-validation, including dominance effects in the model improved accuracy only for fat yield in Holstein cows. Regression coefficients of phenotypes on genetic values and mean squared errors of predictions showed that the predictive ability of the additive + dominance model was superior to that of the additive model for some of the traits. Conclusions: In both breeds, dominance effects were significant (

Cyberinfrastructure for Preservation of Stream and River Ecology

2008 S.C. Water Resources Conference - Addressing Water Challenges Facing the State and Regio

Turning the Tide: Five Years of Achieving the Dream in Community Colleges

In 2004, Lumina Foundation for Education launched “Achieving the Dream: Community Colleges Count,” a national initiative aimed at improving success among community college students, particularly low-income students and students of color. Now encompassing more than 130 institutions in 24 states and the District of Columbia, Achieving the Dream helps community colleges build a “culture of evidence” by using student records and other data to examine students’ performance over time and to identify barriers to academic progress. From there, community colleges are expected to develop intervention strategies designed to improve student outcomes; conduct further research on student progress; and bring effective programs to scale. As a result, it is anticipated that colleges will see measurable improvements over time in student outcomes, including increased progress through developmental education and college-level “gatekeeper” (introductory) courses, grades, persistence, and completion of credentials

SPAG5 as a prognostic biomarker and chemotherapy sensitivity predictor in breast cancer: a retrospective, integrated genomic, transcriptomic, and protein analysis

Background: Although the use of proliferation markers/profiles has been recommended when choosing the appropriate systemic-treatment for breast cancer (BC), the best molecular-marker/test that should be used needs to be identified. Methods: To identify factors that drive proliferation and its associated features in BC an artificial neural network (ANN) based integrative data-mining methodology was applied to three cohorts [(Nottingham-discovery (ND), Uppsala and METABRIC (Molecular Taxonomy of Breast Cancer International Consortium)]. The most prominent genes in the resulting interactome-map were then identified. Given that SPAG5 was associated with many features of proliferation, featured prominently in the interactome-map and has a fundamental role in mitotic-progression,, we hypothesized that it could be a better indicator of proliferation activity. (BC). Subsequently to test if it could provide a more accurate guide for the delivery of systemic therapies in BC, we investigated the clinico-pathological utility of SPAG5: gene copy number aberrations (CNAs); mRNA and protein expression, in over 10,000 BCs. Integrated analysis of SPAG5-gene CNAs, transcript and protein expression was conducted in the ND cohort (n=171) and validated in the METABRIC cohort (n=1980). In addition, the associations of SPAG5 CNAs, transcript and/or protein with BC specific survival (BCSS), disease free survival (DFS) and/or distant relapse free survival (DRFS) were analysed in multiple cohorts including Uppsala (n=249), METABRIC, three-untreated lymph node (LN) negative cohorts (n=684), a combined multicentre clinical data set (n=5439), Nottingham historical early-stage-primary BC (Nottingham-HES-BC; n=1650), Nottingham oestrogen receptor (ER) negative BC (n=697), Nottingham anthracycline-Neoadjuvant-chemotherapy (Nottingham-AC-Neo-ACT; n=200), and MD Anderson Cancer Centre Taxane/anthracycline (MDACC-T/AC-Neo-ACT; n=508) cohorts. The association of SPAG5 transcript and protein expression with pathological response rate (pCR) were also tested in [MDACC-T/AC-Neo-ACT (n=508) and the phase II trial NCT00455533; n=253)] and [Nottingham-AC-Neo-ACT (n=200)] cohorts; respectively. Findings: SPAG5 gene gain/amplification at the Ch17q11·2 locus was found in 10.4% of BC (206/1980 (; METABRIC) and was reported in 19·4% of PAM50-HER2 (46/237) and 17·8% of PAM50-LumB (87/488). SPAG5-CNA gain/amplification and high SPAG5-transcript and SPAG5-protein were associated with increased risk of death from BC [Uppsala; (HR (CI 95%): 1·50 (1·18-1·92); p=0·00010, METABRIC; (HR (CI 95%): 1·68 (1·40-2·01) p<0·0001), and Nottingham-HSE-BC; (HR (CI 95%): 1·68 (1·32-2·12), p<0·0001); respectively]. Multivariable Cox regression models, including other validated-prognostic factors, (Uppsala: age, size, LN-stage, genomic grade index (GGI), ER, TP53 mutation and MKi67; METABRIC: age, size, LN-stage, histologic-grade, ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), hormone-therapy, chemotherapy, interaction term of SPAG5 and both chemotherapyy and hormonotherapy; Desmedt-untreated LN- cohort: ER, Nottingham prognostic index (NPI), 76-gene prognostic signature (Veridex) and Adjuvant-Online (AOL); Nottingham-HES-BC: menopausal status, size, LN- stage, histologic-grade, ER, PR, HER2, ki67, hormone-therapy, chemotherapy, interaction term of SPAG5 and both chemotherapy[y and hormonotherapy), showed that high SPAG5-transcript and high SPAG5-protein were associated with shorter BCSS [Uppsala: (HR (CI 95%): 1·62 (1·03-2·53) p=0·036); METABRIC: (HR (CI 95%): 1·27 (1·02-1·58) p=0·034); Desmedt-untreated LN- cohort: (HR (CI 95%): 2·34 (1·24-4·42) p=0·0090), and Nottingham-HES-BC (HR (CI 95%): 1·73 (1·23-2·46) p=0·0020); respectively]. In ER-negative-BC with high SPAG5-protein, administration of anthracycline-adjuvant-chemotherapy had reduced the risk of death by 60% compared to chemotherapy-naive (HR (95% CI): 0·37 (0·20-0·60); p=0·0010). A multivariable Cox regression analysis, which included other validated prognostic factors for chemotherapy (e.g., menopausal status, size, lymph node stage, histologic grade, ER, PR, HER2, Bcl2, chemotherapy, interaction term of SPAG5 and both chemotherapy[y), revealed that SPAG5-transcript+ was independently associated with decreased risk of DRFS after receiving Taxane/anthracycline-Neo-ACT [MDACC-T/AC-Neo-ACT: (HR (CI 95%): 0·68 (0·48-0·97); p=0·0070)]. In multivariable logistic regression analysis, both SPAG5-transcript+ and SPAG5-protein+ and were independent predictors for higher pCR after combination-cytotoxic chemotherapy [MDACC-T/AC-Neo-ACT: (OR (95% CI) 1·71 (1·07-2·74); p=0·024), and Nottingham-AC-Neo-AC: (OR (95% CI): 8·75 (2·42-31); p=0·0010); respectively]. Interpretation: SPAG5 is a novel amplified gene on Ch17q11.2 in PAM50-LumB and PAM-HER2 BC, and its transcript and protein products are independent prognostic and predictive biomarkers, with potential clinical utility as a biomarker for combination cytotoxic chemotherapy sensitivity, especially in ER- BC