573 research outputs found
Laser induced fluorescence for axion dark matter detection: a feasibility study in YLiF:Er
We present a detection scheme to search for QCD axion dark matter, that is
based on a direct interaction between axions and electrons explicitly predicted
by DFSZ axion models. The local axion dark matter field shall drive transitions
between Zeeman-split atomic levels separated by the axion rest mass energy . Axion-related excitations are then detected with an upconversion scheme
involving a pump laser that converts the absorbed axion energy (
hundreds of eV) to visible or infrared photons, where single photon
detection is an established technique. The proposed scheme involves rare-earth
ions doped into solid-state crystalline materials, and the optical transitions
take place between energy levels of electron configuration. Beyond
discussing theoretical aspects and requirements to achieve a cosmologically
relevant sensitivity, especially in terms of spectroscopic material properties,
we experimentally investigate backgrounds due to the pump laser at temperatures
in the range K. Our results rule out excitation of the upper Zeeman
component of the ground state by laser-related heating effects, and are of some
help in optimizing activated material parameters to suppress the
multiphonon-assisted Stokes fluorescence.Comment: 8 pages, 5 figure
Feedback cooling of the normal modes of a massive electromechanical system to submillikelvin temperature
We apply a feedback cooling technique to simultaneously cool the three
electromechanical normal modes of the ton-scale resonant-bar gravitational wave
detector AURIGA. The measuring system is based on a dc Superconducting Quantum
Interference Device (SQUID) amplifier, and the feedback cooling is applied
electronically to the input circuit of the SQUID. Starting from a bath
temperature of 4.2 K, we achieve a minimum temperature of 0.17 mK for the
coolest normal mode. The same technique, implemented in a dedicated experiment
at subkelvin bath temperature and with a quantum limited SQUID, could allow to
approach the quantum ground state of a kilogram-scale mechanical resonator.Comment: 4 pages, 4 figure
18F-FDG PET-Derived Volume-Based Parameters to Predict Disease-Free Survival in Patients with Grade III Breast Cancer of Different Molecular Subtypes Candidates to Neoadjuvant Chemotherapy
We investigated whether baseline [F-18] Fluorodeoxyglucose (F-18-FDG) positron emission tomography (PET)-derived semiquantitative parameters could predict disease-free survival (DFS) in patients with grade III breast cancer (BC) of different molecular subtypes candidate to neoadjuvant chemotherapy (NAC). For each F-18-FDG-PET/CT scan, the following parameters were calculated in the primary tumor (SUVmax, SUVmean, MTV, TLG) and whole-body (WB_SUVmax, WB_MTV, and WB_TLG). Receiver operating characteristic (ROC) analysis was used to determine the capability to predict DFS and find the optimal threshold for each parameter. Ninety-five grade III breast cancer patients with different molecular types were retrieved from the databases of the University Hospital of Padua and the University Hospital of Ferrara (luminal A: 5; luminal B: 34; luminal B-HER2: 22; HER2-enriched: 7; triple-negative: 27). In luminal B patients, WB_MTV (AUC: 0.75; best cut-off: WB_MTV > 195.33; SS: 55.56%, SP: 100%; p = 0.002) and WB_TLG (AUC: 0.73; best cut-off: WB_TLG > 1066.21; SS: 55.56%, SP: 100%; p = 0.05) were the best predictors of DFS. In luminal B-HER2 patients, WB_SUVmax was the only predictor of DFS (AUC: 0.857; best cut-off: WB_SUVmax > 13.12; SS: 100%; SP: 71.43%; p < 0.001). No parameter significantly affected the prediction of DFS in patients with grade III triple-negative BC. Volume-based parameters, extracted from baseline F-18-FDG PET, seem promising in predicting recurrence in patients with grade III luminal B and luminal B- HER2 breast cancer undergoing NAC
Intramuscular injection of vectorized-scFvMC1 reduces pathological tau in two different tau transgenic models
Trunk Restraint Therapy: The Continuous Use Of The Harness Could Promote Feedback Dependence In Poststroke Patients: A Randomized Trial.
The objective of this study was to evaluate the long-term effects of the task-specific training with trunk restraint compared with the free one in poststroke reaching movements. The design was randomized trial. The setting was University of Campinas (Unicamp). Twenty hemiparetic chronic stroke patients were selected and randomized into 2 training groups: trunk restraint group (TRG) (reaching training with trunk restraint) and trunk free group (TFG) (unrestraint reaching). Twenty sessions with 45 minutes of training were accomplished. The patients were evaluated in pretreatment (PRE), posttreatment (POST) and 3 months after the completed training (RET) (follow-up). Main outcome measures were modified Ashworth scale, Barthel index, Fugl-Meyer scale, and kinematic analysis (movement trajectory, velocity, angles). A significant improvement, which maintained in the RET test, was found in the motor (P < 0.001) and functional (P = 0.001) clinical assessments for both groups. For trunk displacement, only TFG obtained a reduction statistical significance from PRE to the POST test (P = 0.002), supporting this result in the RET test. Despite both groups presenting a significant increase in the shoulder horizontal adduction (P = 0.003), only TRG showed a significant improvement in the shoulder (P = 0.001--PRE to POST and RET) and elbow (P = 0.038--PRE to RET) flexion extension, and in the velocity rate (P = 0.03--PRE to RET). The trunk restraint therapy showed to be a long-term effective treatment in the enhancement of shoulder and elbow active joint range and velocity rate but not in the maintenance of trunk retention. Trial registration: NCT02364141.94e64
Axion search with a quantum-limited ferromagnetic haloscope
A ferromagnetic axion haloscope searches for Dark Matter in the form of
axions by exploiting their interaction with electronic spins. It is composed of
an axion-to-electromagnetic field transducer coupled to a sensitive rf
detector. The former is a photon-magnon hybrid system, and the latter is based
on a quantum-limited Josephson parametric amplifier. The hybrid system consists
of ten 2.1 mm diameter YIG spheres coupled to a single microwave cavity mode by
means of a static magnetic field. Our setup is the most sensitive rf
spin-magnetometer ever realized. The minimum detectable field is
T with 9 h integration time, corresponding to a limit on
the axion-electron coupling constant at 95% CL.
The scientific run of our haloscope resulted in the best limit on DM-axions to
electron coupling constant in a frequency span of about 120 MHz, corresponding
to the axion mass range -eV. This is also the first apparatus
to perform an axion mass scanning by changing the static magnetic field.Comment: 4 pages, 4 figure
Timing with resonant gravitational wave detectors: An experimental test
We measure the time of arrival of a force signal acting on a room temperature gravitational wave antenna. The antenna has a noise spectral density whose shape is a rescaled replica of that predicted for the two subkelvin antennas located in Italy, once at their sensitivity goal. is expressed as {t}_{0}{=t}_{\ensuremath{\varphi}}{+kT}_{0} where is half the natural period of oscillation of the antenna, |{t}_{\ensuremath{\varphi}}|l~{T}_{0}/2, and is an integer. We measure the phase part {t}_{\ensuremath{\varphi}} with an accuracy of {\ensuremath{\sigma}}_{{t}_{\ensuremath{\varphi}}}\ensuremath{\approx}174\mathrm{\ensuremath{\mu}}\mathrm{s}/\mathrm{S}\mathrm{N}\mathrm{R}, where SNR is the signal to noise ratio for the signal amplitude. We also find that, for the error on is \ensuremath{\delta}k\ensuremath{\ll}1 so that the total statistical error on the arrival time reduces to the phase error {\ensuremath{\sigma}}_{{t}_{\ensuremath{\varphi}}}. We discuss how this last result can be achieved even for smaller values of the SNR, by better tuning the modes of the antenna. We finally discuss the relevance of these results for source location and spuria events rejection with the two subkelvin detectors above
ON-LINE CONSISTENCY TESTS FOR BAR DETECTORS
In order to detect gravitational wave signals with resonant bar detectors using Wiener–Kolmogorov (WK) filters, both a model for the power spectrum density (PSD) of the noise and a signal template should be provided. As the analysis is not meant to handle non-gaussian data, we have to discriminate (and constrain to) time periods where the noise follows a quasi-stationary gaussian model. Within these periods, candidate events are selected in the WK filter output, and their fundamental parameters (time of arrival and amplitude) are computed. A necessary and sufficient condition for the reliability of such estimates is the consistency of the signal shape with the template. This is done performing a goodness-of-the-fit test
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