BCS-BEC crossover in a random external potential

We investigate the ground state properties of a disordered superfluid Fermi gas across the BCS-BEC (Bose Einstein condensate) crossover. We show that, for weak disorder, both the depletion of the condensate fraction of pairs and the normal fluid density exhibit a nonmonotonic behavior as a function of the interaction parameter $1/k_Fa$, reaching their minimum value near unitarity. We find that, moving away from the weak coupling BCS regime, Anderson's theorem ceases to apply and the superfluid order parameter is more and more affected by the random potential.Comment: Revised version, one reference added, Phys. Rev. Lett. in pres

Lattice modulation spectroscopy of strongly interacting bosons in disordered and quasi-periodic optical lattices

We compute the absorption spectrum of strongly repulsive one-dimensional bosons in a disordered or quasi-periodic optical lattice. At commensurate filling, the particle-hole resonances of the Mott insulator are broadened as the disorder strength is increased. In the non-commensurate case, mapping the problem to the Anderson model allows us to study the Bose-glass phase. Surprisingly we find that a perturbative treatment in both cases, weak and strong disorder, gives a good description at all frequencies. In particular we find that the infrared absorption rate in the thermodynamic limit is quadratic in frequency. This result is unexpected, since for other quantities like the conductivity in one dimensional systems, perturbation theory is only applicable at high frequencies. We discuss applications to recent experiments on optical lattice systems, and in particular the effect of the harmonic trap.Comment: 11 pages, 8 figure

Luttinger liquid of trimers in Fermi gases with unequal masses

We investigate one dimensional attractive Fermi gases in spin-dependent optical lattices. We show that three-body bound states - "trimers" - exist as soon as the two tunneling rates are different. We calculate the binding energy and the effective mass of a single trimer. We then show numerically that for finite and commensurate densities $n_\uparrow=n_\downarrow/2$ an energy gap appears, implying that the gas is a one-component Luttinger liquid of trimers with suppressed superfluid ordering. The boundaries of this novel phase are given. We discuss experimental situations to test our predictions.Comment: 4 pages, 4 figures. Final accepted versio

Attractive Fermi gases with unequal spin populations in highly elongated traps

We investigate two-component attractive Fermi gases with imbalanced spin populations in trapped one dimensional configurations. The ground state properties are determined within local density approximation, starting from the exact Bethe-ansatz equations for the homogeneous case. We predict that the atoms are distributed according to a two-shell structure: a partially polarized phase in the center of the trap and either a fully paired or a fully polarized phase in the wings. The partially polarized core is expected to be a superfluid of the FFLO type. The size of the cloud as well as the critical spin polarization needed to suppress the fully paired shell, are calculated as a function of the coupling strength.Comment: Final accepted versio

Transport Properties in the "Strange Metal Phase" of High Tc Cuprates: Spin-Charge Gauge Theory Versus Experiments

The SU(2)xU(1) Chern-Simons spin-charge gauge approach developed earlier to describe the transport properties of the cuprate superconductors in the ``pseudogap'' regime, in particular, the metal-insulator crossover of the in-plane resistivity, is generalized to the ``strange metal'' phase at higher temperature/doping. The short-range antiferromagnetic order and the gauge field fluctuations, which were the key ingredients in the theory for the pseudogap phase, also play an important role in the present case. The main difference between these two phases is caused by the existence of an underlying statistical $\pi$-flux lattice for charge carriers in the former case, whereas the background flux is absent in the latter case. The Fermi surface then changes from small ``arcs'' in the pseudogap to a rather large closed line in the strange metal phase. As a consequence the celebrated linear in T dependence of the in-plane and out-of-plane resistivity is shown explicitly to recover. The doping concentration and temperature dependence of theoretically calculated in-plane and out-of-plane resistivity, spin-relaxation rate and AC conductivity are compared with experimental data, showing good agreement.Comment: 14 pages, 5 .eps figures, submitted to Phys. Rev. B, revised version submitted on 24 Oc

Emerging roles of 3D-culture systems in tackling tumor drug resistance

Drug resistance that affects patients universally is a major challenge in cancer therapy. The development of drug resistance in cancer cells is a multifactor event, and its process involves numerous mechanisms that allow these cells to evade the effect of treatments. As a result, the need to understand the molecular mechanisms underlying cancer drug sensitivity is imperative. Traditional 2D cell culture systems have been utilized to study drug resistance, but they often fail to mimic the 3D milieu and the architecture of real tissues and cell-cell interactions. As a result of this, 3D cell culture systems are now considered a comprehensive model to study drug resistance in vitro. Cancer cells exhibit an in vivo behavior when grown in a three-dimensional environment and react to therapy more physiologically. In this review, we discuss the relevance of main 3D culture systems in the study of potential approaches to overcome drug resistance and in the identification of personalized drug targets with the aim of developing patient-specific treatment strategies that can be put in place when resistance emerges

In-Plane Conductivity Anisotropy in Underdoped Cuprates in the Spin-Charge Gauge Approach

Applying the recently developed spin-charge gauge theory for the pseudogap phase in cuprates, we propose a self-consistent explanation of several peculiar features of the far-infrared in-plane AC conductivity, including a broad peak as a function of frequency and significant anisotropy at low temperatures, along with a similar temperature-dependent in-plane anisotropy of DC conductivity in lightly doped cuprates. The anisotropy of the metal-insulator crossover scale is considered to be responsible for these phenomena. The obtained results are in good agreement with experiments. An explicit proposal is made to further check the theory.Comment: 5 pages, 3 figures, to appear in Phys. Rev.