Determinación de limitantes de producción en bovinos doble propósito de Caldas, Quindío y Risaralda.

La Regional 9 de Corpoica, la conforman los departamentos de Caldas, Quindío o y Risaralda, y los municipios anexos de Puerto Boyacá y Puerto Salgar, con una población bovina de 848.568 cabezas de ganado, de las cuales 370.358 corresponden a bovinos doble propósito con 10.852 productores . . De acuerdo con el diagnóstico tecnológico de la Regional Nueve el sistema .de producción de bovinos doble propósito (B.D.P.), fue calificado como prioritario, según diferentes criterios utilizados siendo seguido por los sistemas de carne y leche, en su orden.Ganado de doble propósito-Ganadería doble propósit

Prospective vision on virtual education in AntioquiaColombia: Horizon 2050 [Visión prospectiva sobre la educación virtual en Antioquia-Colombia: Horizonte 2050]

Governments are devoting significant resources to propose strategies that disseminate and exploit into prospective studies. In 2019, the Government of Antioquia (Department located in Colombia) launched a program called 'Antioquia 2050', which it is based on a long-term planning process. It is a rigorous exercise to offer projections to new politicians and their future generations. One of the axes analyzed was education. This article presents a prospective study on virtual education in the Antioquia region (Colombia). The methodology of the study consisted of a participatory and integrative series of techniques mostly used in prospective exercises (panel of experts, Delphi method, scenarios). Some interesting data collected suggested the benefits of virtual platforms, by allowing the educational system to scale up at a lower cost and with greater reach. Evidence found in this research showed that higher education in 20 years would represent a basic and/or minimal condition in Antioquia. The connectivity of the human being with technology will facilitate the incorporation of virtual learning mechanisms from everyday life in a ubiquitous way; at any time and place in their daily lives. The results of this study were shared in the 'Summit of wise men (Cumbre de visionarios)', an event that took place at the end of 2019. Additionally, the study is also part of the research project 'Adaptive learning management tool based on problems to enhance collaborative work in virtual courses at university level', co-financed by Colciencias (Proposal Call 8042018). © 2020 AISTI

Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease.

X-linked immunodeficiency with magnesium defect, EBV infection, and neoplasia (XMEN) disease are caused by deficiency of the magnesium transporter 1 (MAGT1) gene. We studied 23 patients with XMEN, 8 of whom were EBV naive. We observed lymphadenopathy (LAD), cytopenias, liver disease, cavum septum pellucidum (CSP), and increased CD4-CD8-B220-TCR alpha beta(+) T cells (alpha beta DNTs), in addition to the previously described features of an inverted CD4/CD8 ratio, CD4(+) T lymphocytopenia, increased B cells, dysgammaglobulinemia, and decreased expression of the natural killer group 2, member D (NKG2D) receptor. EBV-associated B cell malignancies occurred frequently in EBV-infected patients. We studied patients with XMEN and patients with autoimmune lymphoproliferative syndrome (ALPS) by deep immunophenotyping (32 immune markers) using time-of-flight mass cytometry (CyTOF). Our analysis revealed that the abundance of 2 populations of naive B cells (CD20(+)CD27(-)CD22(+)IgM(+)HLA-DR(+)CXCR5(+)CXCR4(++)CD10(+)CD38(+) and CD20(+)CD27(-)CD22(+)IgM(+)HLA-DR(+)CXCR5(+)CXCR4(+)CD10(-)CD38(-)) could differentially classify XMEN, ALPS, and healthy individuals. We also performed glycoproteomics analysis on T lymphocytes and show that XMEN disease is a congenital disorder of glycosylation that affects a restricted subset of glycoproteins. Transfection of MAGT1 mRNA enabled us to rescue proteins with defective glycosylation. Together, these data provide new clinical and pathophysiological foundations with important ramifications for the diagnosis and treatment of XMEN disease

Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease

X-linked immunodeficiency with magnesium defect, EBV infection, and neoplasia (XMEN) disease are caused by deficiency of the magnesium transporter 1 (MAGT1) gene. We studied 23 patients with XMEN, 8 of whom were EBV naive. We observed lymphadenopathy (LAD), cytopenias, liver disease, cavum septum pellucidum (CSP), and increased CD4-CD8-B220-TCRαβ+ T cells (αβDNTs), in addition to the previously described features of an inverted CD4/CD8 ratio, CD4+ T lymphocytopenia, increased B cells, dysgammaglobulinemia, and decreased expression of the natural killer group 2, member D (NKG2D) receptor. EBV-associated B cell malignancies occurred frequently in EBV-infected patients. We studied patients with XMEN and patients with autoimmune lymphoproliferative syndrome (ALPS) by deep immunophenotyping (32 immune markers) using time-of-flight mass cytometry (CyTOF). Our analysis revealed that the abundance of 2 populations of naive B cells (CD20+CD27-CD22+IgM+HLA-DR+CXCR5+CXCR4++CD10+CD38+ and CD20+CD27-CD22+IgM+HLA-DR+CXCR5+CXCR4+CD10-CD38-) could differentially classify XMEN, ALPS, and healthy individuals. We also performed glycoproteomics analysis on T lymphocytes and show that XMEN disease is a congenital disorder of glycosylation that affects a restricted subset of glycoproteins. Transfection of MAGT1 mRNA enabled us to rescue proteins with defective glycosylation. Together, these data provide new clinical and pathophysiological foundations with important ramifications for the diagnosis and treatment of XMEN disease

Memorias. Encuentro de Experiencias en Inventarios y Monitoreo Biológico

Las discusiones temáticas alrededor de la consolidación del Inventario Nacional de Biodiversidad para Colombia y la Red de Monitoreo de Biodiversidad como una estrategia de largo plazo, sin duda temas complejos que requerirán de grandes esfuerzos, coordinación y generosidad institucional y personal, los podrá apreciar el lector a lo largo del presente documento, esperando que pueda entender también la importancia que tienen los resultados y la agenda propuesta si en el futuro queremos tomar decisiones con bases científicas