Factores de riesgo psicosocial en la modalidad integral de Hogares Comunitarios de la Institución de Fundalimentos Dosquebradas, 2019

CD-T 613.62 O1f; 120 pEl trabajo investigativo, se realizó durante un período comprendido entre diciembre de 2018 a marzo de 2019, en un operador del Instituto Colombiano de Bienestar Familiar, la institución Fundalimentos con los trabajadores de la modalidad Hogares Comunitarios Integrales del municipio de Dosquebradas, cuyas actividades abarcan la prestación de servicio en atención integral a niños y niñas entre los 18 meses a los 5 años.Universidad Libre Seccional Pereir

Política pública de salud mental del departamento de Caldas: un aporte al bienestar y a la inclusión

Esta cartilla es una presentación sencilla del informe de investigación titulado Lineamientos y elementos que debe considerar la Administración Departamental en la consolidación de una política pública en Salud Mental. El estudio del que forma parte es el resultado de la construcción colectiva de los lineamientos de la Política Pública departamental en Salud Mental, con énfasis en la disminución de la oferta y la demanda de sustancias psicoactiva

Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study

Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels and low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT dysfunction through measurements of the adiponectin/leptin ratio (ALR), the adipo-insulin resistance index (Adipo-IRi), fasting/postprandial (F/P) immunometabolic phenotyping and direct F/P differential gene expression in AT biopsies obtained from symptom-free adults from the GEMM family study. AT dysfunction was evaluated through associations of the ALR with F/P insulin-glucose axis, lipid-lipoprotein metabolism, and inflammatory markers. A relevant pattern of negative associations between decreased ALR and markers of systemic low-grade metaflammation, HOMA, and postprandial cardiovascular risk hyperinsulinemic, triglyceride and GLP-1 curves was found. We also analysed their plasma non-coding microRNAs and shotgun lipidomics profiles finding trends that may reflect a pattern of adipose tissue dysfunction in the fed and fasted state. Direct gene differential expression data showed initial patterns of AT molecular signatures of key immunometabolic genes involved in AT expansion, angiogenic remodelling and immune cell migration. These data reinforce the central, early role of AT dysfunction at the molecular and systemic level in the pathogenesis of IR and immunometabolic disorders

Latin American study of hereditary breast and ovarian cancer LACAM : a genomic epidemiology approach

Q2Q1Artículo original1-13Purpose: Hereditary Breast and Ovarian Cancer (HBOC) syndrome is responsible for ~5–10% of all diagnosed breast and ovarian cancers. Breast cancer is the most common malignancy and the leading cause of cancer-related mortality among women in Latin America (LA). The main objective of this study was to develop a comprehensive understanding of the genomic epidemiology of HBOC throughout the establishment of The Latin American consortium for HBOC-LACAM, consisting of specialists from 5 countries in LA and the description of the genomic results from the first phase of the study. Methods: We have recruited 403 individuals that fulfilled the criteria for HBOC from 11 health institutions of Argentina, Colombia, Guatemala, Mexico and Peru. A pilot cohort of 222 individuals was analyzed by NGS gene panels. One hundred forty-three genes were selected on the basis of their putative role in susceptibility to different hereditary cancers. Libraries were sequenced in MiSeq (Illumina, Inc.) and PGM (Ion Torrent-Thermo Fisher Scientific) platforms. Results: The overall prevalence of pathogenic variants was 17% (38/222); the distribution spanned 14 genes and varied by country. The highest relative prevalence of pathogenic variants was found in patients from Argentina (25%, 14/57), followed by Mexico (18%, 12/68), Guatemala (16%, 3/19), and Colombia (13%, 10/78). Pathogenic variants were found in BRCA1 (20%) and BRCA2 (29%) genes. Pathogenic variants were found in other 12 genes, including high and moderate risk genes such as MSH2, MSH6, MUTYH, and PALB2. Additional pathogenic variants were found in HBOC unrelated genes such as DCLRE1C, WRN, PDE11A, and PDGFB. Conclusion: In this first phase of the project, we recruited 403 individuals and evaluated the germline genetic alterations in an initial cohort of 222 patients among 4 countries. Our data show for the first time in LA the distribution of pathogenic variants in a broad set of cancer susceptibility genes in HBOC. Even though we used extended gene panels, there was still a high proportion of patients without any detectable pathogenic variant, which emphasizes the larger, unexplored genetic nature of the disease in these populations

La Dorada, Caldas : un lugar mágico lleno de paz y emociones mil ¡Que viva mi terruño que tanto amo! : recopilación de cuentos folclóricos

En el libro recupera cuentos folclóricos, versos, canciones, juegos y mitos producto de la tradición oral difundida en La Dorada Caldas y le da reconocimiento a los narradores de la cultura oral del poblado.In the book, he recovers folk tales, verses, songs, games and myths that are the product of the oral tradition spread in La Dorada Caldas and gives recognition to the narrators of the oral culture of the town.El fantasma -- Anécdota de la patasola -- Historia del mohán -- El pollito pio -- Nos ayudamos -- La emboscada -- Toño un amigo con diversidad -- El horripilante olvido en medio de un temblor -- Valoremos -- Mito de un arriero -- El juego de la candela -- Canción el capitán de un buque -- Versos -- Multiplicadores de la cultura oral.na66 página

Colombian consensus recommendations for diagnosis, management and treatment of the infection by SARS-COV-2/ COVID-19 in health care facilities - Recommendations from expert´s group based and informed on evidence

La Asociación Colombiana de Infectología (ACIN) y el Instituto de Evaluación de Nuevas Tecnologías de la Salud (IETS) conformó un grupo de trabajo para desarrollar recomendaciones informadas y basadas en evidencia, por consenso de expertos para la atención, diagnóstico y manejo de casos de Covid 19. Estas guías son dirigidas al personal de salud y buscar dar recomendaciones en los ámbitos de la atención en salud de los casos de Covid-19, en el contexto nacional de Colombia

Expression of Membrane Progesterone Receptors in Eutopic and Ectopic Endometrium of Women with Endometriosis

Endometriosis is one of the most frequent gynecological diseases in reproductive age women, but its etiology is not completely understood. Endometriosis is characterized by progesterone resistance, which has been explained in part by a decrease in the expression of the intracellular progesterone receptor in the ectopic endometrium. Progesterone action is also mediated by nongenomic mechanisms via membrane progesterone receptors (mPRs) that belong to the class II members of the progesterone and adipoQ receptor (PAQR) family. The aim of the present study was to evaluate the expression at mRNA and protein levels of mPR members in the eutopic and ectopic endometrium of women with endometriosis. Total RNA and total protein were isolated from control endometrium (17 samples), eutopic endometrium (17 samples), and ectopic endometrium (9 samples). The expression of PAQR7 (mPRα), PAQR8 (mPRβ), and PAQR6 (mPRδ) at mRNA and protein levels was evaluated by RT-qPCR and Western blot, whereas PAQR5 (mPRγ) gene expression was evaluated by RT-qPCR. Statistical analysis between comparable groups was performed using one-way ANOVA followed by Tukey’s multiple comparisons test with a confidence interval of 95 %. The analysis of gene expression showed that PAQR7 and PAQR5 expression was lower in both eutopic and ectopic endometrium as compared to the endometrium of women without endometriosis, whereas the expression of PAQR8 and PAQR6 was only reduced in eutopic endometrium. Furthermore, mPRα and mPRβ protein content was decreased in the ectopic endometrium of women with endometriosis. Our results demonstrate a decrease in the expression and protein content of mPRs in eutopic and ectopic endometrium of patients with endometriosis, which could contribute to the progesterone resistance observed in patients with this disease

Carta de Psicología No. 53

Comprensión neuropsicológica de la enfermedad de Parkinson........3 María Fernanda Obregón Guavita Aprendizajes y experiencias en el semillero LAPSUCC: nuestro año como investigadores en neuropsicología ......6 Gabriel Almeida, María Paula Bernal, Laura Valentina Ruiz, Daniela Arévalo y Tatiana Manrique Entrenamiento cognitivo en el deterioro cognitivo leve - Trastorno neurocognitivo leve. 9 Luz Adriana Penagos, Angie Tatiana Contreras Cifuentes, Jhon Erick Chacón Ruiz, María Emily Triana, Daniela Alejandra Martínez Sarmiento, Valeria Valentina Palencia Amaya, Juliana Martínez Cárdenas, Natalia Caicedo Tamara, Johanna Castillo, María Lucía Blanco Parga, Ana Lorena Muñoz Valdés, Miguel Ángel Patarroyo, Sonia Gisela Ríos Cruz Articulación: de la educación media a superior...16 Daniela García, Camila Clavijo, Paola Peñuela, Tatiana Flores Mediación de la trascendencia en el ámbito educativo....18 Estefany Cuéllar González, Laura Camila Vargas López, Importancia de la orientación temporal en el niño........20 Andrómeda Katherine Gutiérrez Rueda, Claudia Paola Martínez Devia La castración química: el debate del populismo punitivo....22 Daniel Ricardo Riaño García, Laura Camila Jaimes Castillo, Angie Nathaly Infante , Hernández, Ever José López Cantero, Factores psicológicos en las personas privadas de la libertad condenadas por el delito de violencia intrafamiliar......26 Gerardo Andrés Merchán Mesa, Jordan Micaela Castelblanco Zamora, Ever José López Cantero, Karol Tatiana Triana Caballero, Katherine Álvarez Modelo ecológico para la compresión de las conductas infractoras en adolescentes.....29 Ana María Altamar Escorcia, Daniela Alvarado Ospina, María Isabel Castillo Camargo, Adriana Yulieth, Gómez Núñez, Ever José López Cantero, Luz Ángela Vega Gómez, Rocío Ordóñez Gómez, Bertha Liliana Ortiz Triviño y Lorena Osorio Rosales Inteligencia emocional y estrés académico en estudiantes universitarios.... 35 Johana Orozco, Valery Ramírez, María José Saavedra, y Javier Yépez Arrieta Uso de minería de textos para la exploración de creencias epistemológicas....37 Santiago Amaya Nassar Emociones, dinero, amigos y sexualidad en universitarios durante la cuarentena..... 42 Daniela Barbosa Sentido de comunidad: hacia una nueva conciencia comunitaria.....................45 Xiomara González Alarcón Participación y sentido de país.........47 Angie Lorena Ruiz, Andrea Lorena Villamil El semillero, una oportunidad de formación para estudiantes de pregrado y de especialización...........50 Liliana Quintero e Itala Marina Camargo Uso de minería de textos para el análisis de la participación de los egresados en los órganos de gobierno de las instituciones de educación superior .52 Sergio Andrés Flautero Mes