Strategy and Organisational Cybersecurity: A Knowledge-Problem Perspective

Purpose: The purpose of this paper is to frame organisational cybersecurity through a strategic lens, as a function of an interplay of pragmatism, inference, holism and adaptation. The authors address the hostile epistemic climate for intellectual capital management presented by the dynamics of cybersecurity as a phenomenon. The drivers of this hostility are identified and their implications for research and practice are discussed. Design/methodology/approach: The philosophical foundations of cybersecurity in its relation with strategy, knowledge and intellectual capital are explored through a review of the literature as a mechanism to contribute to the emerging theoretical underpinnings of the cybersecurity domain. Findings: This conceptual paper argues that a knowledge-based perspective can serve as the necessary platform for a phenomenon-based view of organisational cybersecurity, given its multi-disciplinary nature. Research limitations/implications: By recognising the knowledge-related vectors, mechanisms and tendencies at play, a novel perspective on the topic can be developed: cybersecurity as a “knowledge problem”. In order to facilitate such a perspective, the paper proposes an emergent epistemology, rooted in systems thinking and pragmatism. Practical implications: In practice, the knowledge-problem narrative can underpin the development of new organisational support constructs and systems. These can address the distinctiveness of the strategic challenges that cybersecurity poses for the growing operational reliance on intellectual capital. Originality/value: The research narrative presents a novel knowledge-based analysis of organisational cybersecurity, with significant implications for both interdisciplinary research in the field, and practice

The effectiveness of land based exercise compared to decompressive surgery in the management of lumbar spinal-canal stenosis: a systematic review

<p>Abstract</p> <p>Background</p> <p>Lumbar spinal stenosis (LSS) is prevalent in those over the age of 65 years and the leading cause of spinal surgery in this population. Recent systematic reviews have examined the effectiveness of conservative management for LSS, but not relative to surgical interventions. The aim of this review was to systematically examine the effectiveness of land based exercise compared with decompressive surgery in the management of patients with LSS.</p> <p>Methods</p> <p>A systematic review of randomised controlled trials and clinical trials was undertaken. The databases MEDLINE, Embase, CINAHL, PEDro and Cochrane Library Register of Controlled Trials were searched from January 2000 to June 2011. Only studies that included subjects with lumbar spinal canal stenosis were considered in this review. Studies also had to use a patient reported functional outcome measure for a land based exercise intervention or lumbar decompressive surgery.</p> <p>Results</p> <p>Only one study compared the effectiveness of exercise and decompressive surgery for LSS. Surgery demonstrated statistically significant improvements in patient reported functional outcome scores at 6, 12 and 24-months post-intervention (<it>p </it>< 0.01). To facilitate further analysis, the results from 12 exercise and 10 surgical intervention arms were compared using percentage change in patient reported functional outcome measure scores. Exercise interventions showed initial improvements, ranging from 16 to 29% above baseline. All decompressive surgical interventions demonstrated greater and sustained improvements over 2-years (range 38-67% improvement) with moderate to large effect sizes. The most commonly reported complications associated with surgery were dural tears, while details of adverse effects were lacking in exercise interventions.</p> <p>Conclusions</p> <p>This systematic review of the recent literature demonstrates that decompressive surgery is more effective than land based exercise in the management of LSS. However, given the condition's slowly progressive nature and the potential for known surgical complications, it is recommended that a trial of conservative management with land based exercise be considered prior to consideration of surgical intervention.</p

A Meta-Analytic Review and Experimental Study Exploring Links between Aggression and the Oxytocinergic System in Mice and Human Populations

Interpersonal aggression is a significant source of individual and societal distress. For this reason, countless research projects have attempted to identify the biological and psychological determinants of aggressive behaviour. An emerging body of literature suggests that the nonapeptide oxytocin (OT), generally regarded as a facilitator of prosocial behaviours, can instead amplify aggression and hostility under certain contexts. The current dissertation was designed to clarify the association between OT and aggression, by investigating this relation in both animal and human samples. In the first study, we conducted a systematic meta-analysis of genetic OT-knockout animal-model studies. Relative to genetically unmodified controls, OT receptor knockout mice were found to exhibit significantly elevated aggression, across all behavioural paradigms and outcome measures. Other forms of genetic modification were found to be less reliably associated with subsequent aggression, suggesting that prenatal OT exposure plays a critical role in the development of aggressive behaviour in adulthood. Evidence of contextual and individual variability was also observed. In the second study, we investigated the association between exogenous OT administration and a form of cognitive bias that may be predictive of future aggressive behaviours: autobiographical memory retrieval biases. We found that, under placebo, high-aggression participants exhibited greater difficulty retrieving specific memories of positive events. Following OT administration, the retrieval of specific memories for positive cue words was selectively improved in high-aggression individuals. Additionally, such individuals rated the emotional valence of their autobiographical memories less negatively under OT, when compared to placebo. Importantly, these findings were exclusive to memories retrieved within a social context. Recollections produced in a non-social environment were rated less positively following OT administration, exclusively for high-aggression participants. These findings again suggest important individual and contextual variability and highlight the potentially deleterious effects of OT administration in the absence of social contact. Together, these studies indicate that OT does modulate the frequency of aggressive behaviours, as well as the cognitive biases that may precede them. Critically, these data also highlight important developmental, individual, and contextual considerations, which in turn allows us to identify viable targets for future research

The effects of intranasal oxytocin administration on resting state electroencephalography frontal asymmetry

Research suggests that the nonapeptide oxytocin plays an important role in social functioning, and that the intranasal administration of exogenous oxytocin promotes prosocial behaviours. The mechanisms underlying oxytocin’s effects on social cognition and behaviour are not yet well understood. One viable hypothesis is that oxytocin acts upon frontal asymmetry. Relative left frontal neural activation has been consistently associated with approach behaviours and shares a number of other similarities with intranasal oxytocin administration. For the first time, we examined the hypothesis that oxytocin increases relative left frontal neural activation using electroencephalography methodology. In a double-blind within-subject experiment, 48 participants self-administered a 24 I.U. dose of intranasal oxytocin and placebo approximately one week apart. Following drug administration, alpha band power was recorded at frontal and parietal sites during eight 60 second trials. Intranasal oxytocin administration did not produce any significant changes in frontal asymmetry (F(1, 47) = .273, p= .604, partial η2 = .006). This relation did not interact with sex nor measures of depression, which have been shown to moderate the effects of intranasal oxytocin in prior investigations. Oxytocin administration does not appear to increase relative left frontal neural activation. Additional considerations and interpretations are discussed

Insights into the structures adopted by titanocalix[6 and 8]arenes and their use in the ring opening polymerization of cyclic esters

Interaction of p-tert-butylcalix[6]areneH6, L1H6, with [TiCl4] afforded the complex [Ti2Cl3(MeCN)2(OH2)(L1H)][Ti2Cl3(MeCN)3(L1H)]∙4.5MeCN (1∙4.5MeCN), in which two pseudo octahedral titanium centres are bound to one calix[6]arene. A similar reaction but employing THF resulted in the THF ring-opened product [Ti4Cl2(μ3-O)2(NCMe)2(L)2(O(CH2)4Cl)2]∙4MeCN (2∙4MeCN), where LH4 = p-tert-butylcalix[4]areneH4. Interaction of L1H6 with TiF4 (3 equiv.) led, after work-up, to the complex [(TiF)2(μ -F)L1H]2∙6.5MeCN (3∙6.5MeCN). Treatment of p-tert-butylcalix[8]areneH8, L2H8, with [TiCl4] led to the isolation of the complex [(TiCl)2(TiClNCMe)2(μ3-O)2(L2)]∙1.5MeCN (4∙1.5MeCN). From a similar reaction, a co-crystallized complex [Ti4O2Cl4(MeCN)2(L2)][Ti3Cl6(MeCN)5(OH2)(L2H2)]·H2O∙11MeCN (5·H2O 11MeCN) was isolated. Extension of the L2H8 chemistry to [TiBr4] afforded, depending on the stoichiometry, the complexes [(TiBr)2(TiBrNCMe)2(μ3-O)2(L2)]∙6MeCN (6∙6MeCN) or [Ti(NCMe)2Br]2[Ti(O)Br2(NCMe)](L2)]∙7.5MeCN (7∙7.5MeCN), whilst use of [TiF4] afforded complexes containing Ca2+ and Na+, thought to originate from drying agents, namely [Ti8CaF20(OH2)Na2(MeCN)4(L2)2]∙14MeCN (8∙14MeCN), [Na(MeCN)2][Ti8CaF20NaO16(L2)2]∙7MeCN (9∙7MeCN) or [Na]6[Ti8F20Na(MeCN)2(L2)][Ti8F20Na(MeCN)0.5(L2)]∙15.5(C2H3N) (10∙15.5MeCN). In the case of TiI4, the ladder [(TiI)2(TiINCMe)2(μ3-O)2(L2)]∙7.25CH2Cl2 (11∙7.25CH2Cl2) was isolated. These complexes have been screened for their potential to act as catalysts in the ring opening polymerization (ROP) of ε-caprolactone (ε-CL), δ-valerolactone (δ-VL) and rac-lactide (r-LA), both in air and N2. For ε-CL and δ-VL, moderate activity at 130 oC over 24 h was observed for 1, 9 and 11; for r-LA, only 1 exhibited reasonable activity. In the case of the co-polymerization of ε-CL with δ-VL, the complexes 1 and 11 afforded reasonable conversions and low molecular weight polymers, whilst 4, 6, and 9 were less effective. None of the complexes proved to be active in the co-polymerization of ε-CL and r-LA under the conditions employed herein

Lithium calix[4]arenes: structural studies and use in the ring opening polymerization of cyclic esters

We have structurally characterized a number of lithiated calix[4]arenes, where the bridge in the calix[4]arene is thia (–S–, LS H4), sulfinyl (–SO–, LSOH4), sulfonyl (–SO2–, LSO2H4), dimethyleneoxa (–CH2OCH2–, LCOCH4) or methylene (–CH2–, LH4). In the case of L4SH4, interaction with LiOtBu led to the isolation of the complex [Li8(L4S)2(THF)4]5THF (15THF), whilst similar interaction of L4SOH4 led to the isolation of [Li6(L4SOH)2(THF)2]5(THF) (2$5THF). Interestingly, the mixed sulfinyl/sulfonyl complexes [Li8(calix[4] arene(SO)(SO2) SO1.68)2)2(THF)6]8(THF) (38THF) and Li5Na(LSO/3SO2H)2(THF)5]7.5(THF) (47.5(THF) have also been characterized. Interaction of LiOtBu with LSO2H4 and LCOCH4 afforded [Li5L4SO2(OH)(THF)4]2THF (5$2THF) and [Li6(LCOC)2(HOtBu)2]0.78THF1.22hexane (60.78THF1.22hexane), respectively. In the case of LH4, reaction with LiOtBu in THF afforded a monoclinic polymorph [LH2Li2(thf)(OH2)2]3THF (73THF) of a known triclinic form of the complex, whilst reaction of the de-butylated analogue of LH4, namely de-BuLH4, afforded a polymeric chain structure {[Li5(de-BuL)(OH)(NCMe)3]2MeCN}n (82MeCN). For comparative catalytic studies, the complex [Li6(LPr)2(H2O)2]hexane (9 hexane), where LPr2H2 ¼ 1,3-di-n-propyloxycalix[4]areneH2, was also prepared. The molecular crystal structures of 1–9 are reported, and their ability to act as catalysts for the ring opening (co-)/polymerization (ROP) of the cyclic esters 3-caprolactone, d-valerolactone, and rac-lactide has been investigated. In most of the cases, complex 6 outperformed the other systems, allowing for higher conversions and/or greated polymer Mn

Do pesticide and pathogen interactions drive wild bee declines?

There is clear evidence for wild insect declines globally. Habitat loss, climate change, pests, pathogens and environmental pollution have all been shown to cause detrimental effects on insects. However, interactive effects between these stressors may be the key to understanding reported declines. Here, we review the literature on pesticide and pathogen interactions for wild bees, identify knowledge gaps, and suggest avenues for future research fostering mitigation of the observed declines. The limited studies available suggest that effects of pesticides most likely override effects of pathogens. Bees feeding on flowers and building sheltered nests, are likely less adapted to toxins compared to other insects, which potential susceptibility is enhanced by the reduced number of genes encoding detoxifying enzymes compared with other insect species. However, to date all 10 studies using a fully-crossed design have been conducted in the laboratory on social bees using Crithidia spp. or Nosema spp., identifying an urgent need to test solitary bees and other pathogens. Similarly, since laboratory studies do not necessarily reflect field conditions, semi-field and field studies are essential if we are to understand these interactions and their potential effects in the real-world. In conclusion, there is a clear need for empirical (semi-)field studies on a range of pesticides, pathogens, and insect species to better understand the pathways and mechanisms underlying their potential interactions, in particular their relevance for insect fitness and population dynamics. Such data are indispensable to drive forward robust modelling of interactive effects in different environmental settings and foster predictive science. This will enable pesticide and pathogen interactions to be put into the context of other stressors more broadly, evaluating their relative importance in driving the observed declines of wild bees and other insects. Ultimately, this will enable the development of more effective mitigation measures to protect bees and the ecosystem services they supply

Association of urinary uromodulin with kidney&nbsp;function decline and mortality: the&nbsp;health ABC study .

BackgroundUrine uromodulin (uUMOD) is a protein secreted by the kidney tubule. Recent studies have suggested that higher uUMOD may be associated with improved kidney and mortality outcomes.MethodsUsing a case-cohort design, we evaluated the association between baseline uUMOD levels and ≥&nbsp;30% estimated glomerular filtration rate (eGFR) decline, incident chronic kidney disease (CKD), rapid kidney function decline, and mortality using standard and modified Cox proportional hazards regression.ResultsThe median value of uUMOD was 25.8&nbsp;µg/mL, mean age of participants was 74 years, 48% were women, and 39% were black. Persons with higher uUMOD had lower prevalence of diabetes and coronary artery disease (CAD), and had lower systolic blood pressure. Persons with higher uUMOD also had higher eGFR, lower urinary albumin to creatinine ratio (ACR), and lower C-reactive protein (CRP). There was no association of uUMOD with &gt;&nbsp;30% eGFR decline. In comparison to those in the lowest quartile of uUMOD, those in the highest quartile had a significantly (53%) lower risk of incident CKD (CI 73%, 18%) and a 51% lower risk of rapid kidney function decline (CI 76%, 1%) after multivariable adjustment. Higher uUMOD was associated with lower risk of mortality in demographic adjusted models, but not after multivariable adjustment.ConclusionHigher levels of uUMOD are associated with lower risk of incident CKD and rapid kidney function decline. Additional studies are needed in the general population and in persons with advanced CKD to confirm these findings.