Keeping watch over Colombia’s slumbering volcanoes

The Volcanological and Seismological Observatories of Manizales, Pasto and Popayan (Colombian Geological Survey) monitor and study the active volcanoes of Colombia using seismological, geodetic, geochemical and other techniques. Since 2009, permanent GNSS stations have been installed to complement classical geodetic measurements (e.g., tilt, EDM). At the moment, there are a total of 20 GNSS stations installed at Nevado del Ruiz, Cerro Machín, Puracé and Galeras volcanoes. Nevado del Ruiz has remained the most dynamic of the active Colombian volcanoes since its tragic eruption of 13 November 1985. The most significant deformation occurred between 2007 and 2012, when inflation, associated with magma migration and several small to moderate explosive eruptions in 2012 (VEI less or equal to 3), was observed. Galeras has experienced more than 25 moderate Vulcanian eruptions (VEI less or equal to 3) since 1989. In particular, the deformation network detected significant signals associated with magma migration and the extrusion of lava domes in 1991, 2005, 2008 and 2012. Puracé volcano has been the site of more than 10 minor eruptive episodes (VEI=2) in the past century, most recently in 1977. Monitoring of this volcano started in 1994. Unrest at Puracé since that time has been characterized by significant increases in seismic activity but with little or no deformation. We employ GAMIT/GLOBK to process GPS data from the monitoring network with support from the Volcano Disaster Assistance Program (U.S. Geological Survey). Additionally, differential processing is carried out using the commercial package Trimble 4D Control. Preliminary results for 2012 show no significant deformation at Puracé and Galeras volcanoes. On the other hand, the time series from Nevado del Ruiz shows a minor inflation (2-4 cm/yr) associated with the eruptive activity of 2012

Antimicrobial activity of nine extracts of sechium edule (Jacq) swartz

The antimicrobial properties of Sechium edule (Jacq) Swartz alcoholic extracts obtained according to the Farmacopea Argentina (6th edn) were tested against bacteria of clinical relevance as nosocomial pathogens. To evaluate antibacterial activity, the disc diffusion assay was carried out with several gram-positive bacteria (Enterococcus faecalis, Staphylococcus aureus, coagulase-negative staphylococci, Streptococcus pyogenes, Streptococcus agalactiae, Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212). This assay was suitable for the screening of a large number of extracts at one time. All ethanolic extracts showed activity against gram-positive bacteria. Minimal inhibitory concentration (MIC) values were determined with a microdilution assay. The highest activity was obtained with the 80% aqueous-ethanolic leaf extract (MIC values of 4.16/8.32 mg/ml against staphylococci and enterococci) and with the 96% ethanolic seed extract (MIC values of 8.32/16.64 mg/ml and /8.32 mg/ml against staphylococci and enterococci, respectively). The results indicate that both fluid extract and tincture have very good antimicrobial efficacy against all strains of multiresistant staphylococci and enterococci. In this study the minimal bactericidal concentration (MBC) values were identical to the MIC values or twofold higher than the corresponding MIC. This may indicate a bactericidal effect. Stored extracts have similar anti-staphylococcal and anti-enterococcal activity to recently obtained extracts. The results obtained might be considered sufficient to warrant further studies aimed at isolation and identification of the active principle.Fil: Ordoñez, Alicia Lucia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Gómez, José D.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Cudmani, Norma Mercedes. Gobierno de la Provincia de Tucumán. Ministerio de Salud. Sistema Provincial de Salud. Hospital de Clínicas "Dr. Nicolás Avellaneda"; Argentina. Gobierno de la Provincia de Tucumán. Ministerio de Salud. Departamento Bioquímico; ArgentinaFil: Vattuone, Marta Amelia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Isla, Maria Ines. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto de Bioprospección y Fisiología Vegetal; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales; Argentin

Trade-Offs in Fairness and Preference Judgments

At the heart of many debates about distributive justice is the widely assumed trade-off between equality and efficiency (Okun, 1975). In the present chapter, equality refers to the distribution of income within a society. Equality increases whenever income variability is reduced. Efficiency refers to the goods and services that result from a given input – production, physical capital, or human labor. Efficiency increases whenever society produces more from the same input. Trade-offs between equality and efficiency occur because increases in one often lead to decreases in the other. An egalitarian society satisfies basic needs by establishing programs that redistribute wealth. But those programs can reduce efficiency when they introduce bureaucratic waste or diminish financial incentives. A reduction in efficiency can lead to fewer investments, fewer jobs, and declining productivity

Goals Gone Wild: The Systematic Side Effects of Overprescribing Goal Setting

Goal setting is one of the most replicated and influential paradigms in the management literature. Hundreds of studies conducted in numerous countries and contexts have consistently demonstrated that setting specific, challenging goals can powerfully drive behavior and boost performance. Advocates of goal setting have had a substantial impact on research, management education, and management practice. In this article, we argue that the beneficial effects of goal setting have been overstated and that systematic harm caused by goal setting has been largely ignored. We identify specific side effects associated with goal setting, including a narrow focus that neglects nongoal areas, distorted risk preferences, a rise in unethical behavior, inhibited learning, corrosion of organizational culture, and reduced intrinsic motivation. Rather than dispensing goal setting as a benign, over-the-counter treatment for motivation, managers and scholars need to conceptualize goal setting as a prescription-strength medication that requires careful dosing, consideration of harmful side effects, and close supervision. We offer a warning label to accompany the practice of setting goals

A primer-independent DNA polymerase-based method for competent whole-genome amplification of intermediate to high GC sequences

The dataset (raw sequencing data) that supports the findings of this study are archived in the Universidad Autónoma de Madrid data repository e‐cienciaDatos in DOI: 10.21950/HCNDGMultiple displacement amplification (MDA) has proven to be a useful technique for obtaining large amounts of DNA from tiny samples in genomics and metagenomics. However, MDA has limitations, such as amplification artifacts and biases that can interfere with subsequent quantitative analysis. To overcome these challenges, alternative methods and engineered DNA polymerase variants have been developed. Here, we present new MDA protocols based on the primer-independent DNA polymerase (piPolB), a replicative-like DNA polymerase endowed with DNA priming and proofreading capacities. These new methods were tested on a genomes mixture containing diverse sequences with high-GC content, followed by deep sequencing. Protocols relying on piPolB as a single enzyme cannot achieve competent amplification due to its limited processivity and the presence of ab initio DNA synthesis. However, an alternative method called piMDA, which combines piPolB with Φ29 DNA polymerase, allows proficient and faithful amplification of the genomes. In addition, the prior denaturation step commonly performed in MDA protocols is dispensable, resulting in a more straightforward protocol. In summary, piMDA outperforms commercial methods in the amplification of genomes and metagenomes containing high GC sequences and exhibits similar profiling, error rate and variant determination as the non-amplified samplesMCIN/AEI/10.13039/501100011033 and ERDF A way of making Europe [PGC2018-09723-A-I00 and PID2021-123403NB-I00 to M.R.R.]; C. Egas’ laboratory was funded by the European Union′s Horizon 2020 Research and Innovation Program [685474]; METAFLUIDICS project; C.D.O. and C.M.C. were holder of Fellowships from the Spanish Ministry of University [FPU16/02665] and Spanish Ministry of Science and Innovation [PRE2019-087304], respectivel

Bacteria with Phosphate Solubilizing Capacity Alter Mycorrhizal Fungal Growth Both Inside and Outside the Root and in the Presence of Native Microbial Communities.

Arbuscular mycorrhizal fungi (AMF) and phosphate solubilizing Pseudomonas bacteria (PSB) could potentially interact synergistically because PSB solubilize phosphate into a form that AMF can absorb and transport to the plant. However, very little is known about the interactions between these two groups of microorganisms and how they influence the growth of each other. We tested whether different strains of bacteria, that have the capacity to solubilize phosphate, are able to grow along AMF hyphae and differentially influence the growth of AMF both outside the roots of carrot in in vitro conditions and inside the roots of potato in the presence of a microbial community. We found strong effects of AMF on the growth of the different bacterial strains. Different bacterial strains also had very strong effects on the growth of AMF extraradical hyphae outside the roots of carrot and on colonization of potato roots by AMF. The differential effects on colonization occurred in the presence of a microbial community. Our results show that these two important groups of rhizosphere microorganisms indeed interact with each other. Such interactions could potentially lead to synergistic effects between the two groups but this could depend on whether the bacteria truly solubilize phosphate in the rhizosphere in the presence of microbial communities

Dealing with diversity: State strategies on ethnic minority management in Southeast Asia

Southeast Asia’s ethnic, political and cultural diversity continues to pose major policy and governance hurdles in enforcing a common community born out of the post-colonial nationalist baggage of almost all the region’s countries. ASEAN’s “non-interference” clause gives leeway to each member state to respond to its ethnic diversity with nation-building projects through exclusionary governance. With this leeway, each Southeast Asian country’s nation-building policieslegitimize a particular, existing ethno-nationalist or “ethno-religious” majority at the expense of democratic accountability. This study proposes a preliminary quantitative model which uses regression analysis to compare Southeast Asian countries’ data on their religious and ethnic populations. The initial model categorizes the types of minority management strategies depending on their respective ethnic heterogeneity. This study hypothesizes that a) states with moreethnically homogenous populations will have more exclusionary and violent state policies towards minorities, while b) states with more heterogeneous populations will have fewer exclusionary and violent policies. The results indicate a moderate causality between the two variables and may be correlated with additional variables such as the level of democratic consolidation (as tabulated by the Polity IV democratic index) and the centralized structure of governance

Community-based incidence of acute renal failure

There is limited information about the true incidence of acute renal failure (ARF). Most studies could not quantify disease frequency in the general population as they are hospital-based and confounded by variations in threshold and the rate of hospitalization. Earlier studies relied on diagnostic codes to identify non-dialysis requiring ARF. These underestimated disease incidence since the codes have low sensitivity. Here we quantified the incidence of non-dialysis and dialysis-requiring ARF among members of a large integrated health care delivery system – Kaiser Permanente of Northern California. Non-dialysis requiring ARF was identified using changes in inpatient serum creatinine values. Between 1996 and 2003, the incidence of non-dialysis requiring ARF increased from 322.7 to 522.4 whereas that of dialysis-requiring ARF increased from 19.5 to 29.5 per 100 000 person-years. ARF was more common in men and among the elderly, although those aged 80 years or more were less likely to receive acute dialysis treatment. We conclude that the use of serum creatinine measurements to identify cases of non-dialysis requiring ARF resulted in much higher estimates of disease incidence compared with previous studies. Both dialysis-requiring and non-dialysis requiring ARFs are becoming more common. Our data underscore the public health importance of ARF