Bubbly cavitating flow generation and investigation of its erosional nature for biomedical applications

This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the Italian Union of Thermofluid dynamics, the Process Intensification Network, HEXAG - the Heat Exchange Action Group and the Institute of Mathematics and its Applications.The paper presents a study of the generation of hydrodynamic bubbly cavitation in microchannels to investigate the destructive energy output resulting from this phenomenon and its potential use in biomedical applications. The research performed in this study includes the experimental results from bubbly cavitation experiments and the findings showing the destructive effects of bubbly cavitating flow on selected specimens and cells. The bubbles caused by hydrodynamic cavitation are highly destructive at the surfaces of the target medium on which they are carefully focused. The resulting destructive energy output could be effectively used for good means such as destroying kidney stones or killing infected cancer cells. Motivated by this potential, the cavitation damage (material removal) to cancerous cells and chalk pieces having similar material properties as calcium phosphate in human bones was investigated. Also the potential of hydrodynamic bubbly cavitation generated at the microscale for biomedical treatments was revealed using the microchannel configuration of a microorifice (with an inner diameter of 0.147 mm and a length of 1.52cm).This work was supported by Sabancı University Internal Grant for Research Program under Grant FRG-C47004

Radiological study on mandibular ramus asymmetry in young population

Background: The aim of this study was to estimate the prevalence of ramus asymmetries related to age and gender in a young population and the influence of growth spurt on ramus asymmetry. Materials and methods: The study consisted of 776 panoramic radiographs of individuals aged 9 to 21 years (335 males and 441 females). Individuals were divided into two groups with respect of linear growth spurt as age 12 in females and age 14 in males. The first group consisted of females aged between 9 and 11 and males between 9 and 13. The second group consisted of females aged between 12 and 21 and males between 14 and 21. Bilateral ramus heights on each radiograph were measured. A panoramic software programme was used to measure the ramus heights. Quantitative data was tested by Student’s t test. Qualitative data was tested by χ2 test. The intraclass correlation coefficient was calculated for the magnitude error of the measurement. Results: The mean of ramus asymmetry was found to be 2.90% ± 2.58%. Significant differences between the right and left ramus height ratios were observed (p < 0.01). There was a high prevalence (10.8%) of ramus asymmetry, which did not correlate with the age and gender of the patients. Conclusions: This study revealed a high prevalence of ramus asymmetry in 9–21- -year-old population. Within the limitations of this study, it can be concluded that ramus asymmetry should be carefully evaluated in all ages for the potential relation with temporomandibular dysfunctions and also for orthodontic anomalies

Single dose of intra-muscular platelet rich plasma reverses the increase in plasma iron levels in exercise-induced muscle damage: A pilot study

Background Platelet rich plasma (PRP) therapy is widely used in enhancing the recovery of skeletal muscle from injury. However, the impact of intramuscular delivery of PRP on hematologic and biochemical responses has not been fully elucidated in exercise-induced muscle damage. The purpose of this investigation the effects of intramuscular delivery of PRP on hematologic and biochemical responses and recovery strategy muscle damage induced by high intensity muscle exercise (exercise-induced muscle damage, EIMD). Methods Moderately active male volunteers participated in this study and were assigned to a control group (control, n = 6) and PRP administration group (PRP, n = 6). The subjects performed exercise with a load of 80% one repetition maximum (1RM) maximal voluntary contraction of the elbow flexors until point of exhaustion of the non-dominant arm was reached. The arms were treated with saline or autologous PRP post-24 h EIMD. Venous blood samples were obtained in the morning to establish a baseline value and 1–4 days post-exercise and were analyzed for serum ferritin, iron, iron binding capacity (IBC), creatinine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and alanine aminotransferase (ALT). Results The baseline levels of plasma iron, ferritin, IBC, CK, LDH, AST, and ALT were similar in both the control and PRP groups. However, 24-h following exercise a significant increase in these parameters was observed in both groups between 1 and 4 days during the recovery period. Interestingly, PRP administration decreased plasma iron levels compared to the control on the second day post-exercise. Plasma IBC increased in PRP group from Days 2 to 4 post-exercise compared to the control group whilst PRP administration had no effect on plasma ferritin, CK, AST, ALT, or LDH. Conclusion Acute exhaustive exercise increased muscle damage markers, including plasma iron, IBC, and ferritin levels, indicating muscle damage induced by exercise. PRP administration improves inflammation by reversing the increase in the iron levels post-exercise without displaying any myotoxicity and may have a role to play in the recovery of exercise-induced muscle damage

High-sensitivity noncontact atomic force microscope/scanning tunneling microscope (nc AFM/STM) operating at subangstrom oscillation amplitudes for atomic resolution imaging and force spectroscopy

Cataloged from PDF version of article.We describe a new, highly sensitive noncontact atomic force microscope/scanning tunneling microscope (STM) operating in ultrahigh vacuum (UHV) with subangstrom oscillation amplitudes for atomic resolution imaging and force-distance spectroscopy. A novel fiber interferometer with similar to4x10(-4) A/rootHz noise level is employed to detect cantilever displacements. Subangstrom oscillation amplitude is applied to the lever at a frequency well below the resonance and changes in the oscillation amplitude due to tip-sample force interactions are measured with a lock-in amplifier. Quantitative force gradient images can be obtained simultaneously with the STM topography. Employment of subangstrom oscillation amplitudes lets us perform force-distance measurements, which reveal very short-range force interactions, consistent with the theory. Performance of the microscope is demonstrated with quantitative atomic resolution images of Si(111)(7x7) and force-distance curves showing short interaction range, all obtained with <0.25 Angstrom lever oscillation amplitude. Our technique is not limited to UHV only and operation under liquids and air is feasible. (C) 2003 American Institute of Physics

USING DECISION TREES FOR ESTIMATING MODE CHOICE OF TRIPS IN BUCA-IZMIR

Decision makers develop transportation plans and models for providing sustainable transport systems in urban areas. Mode Choice is one of the stages in transportation modelling. Data mining techniques can discover factors affecting the mode choice. These techniques can be applied with knowledge process approach. In this study a data mining process model is applied to determine the factors affecting the mode choice with decision trees techniques by considering individual trip behaviours from household survey data collected within Izmir Transportation Master Plan. From this perspective transport mode choice problem is solved on a case in district of Buca-Izmir, Turkey with CRISP-DM knowledge process model

Interview with John O. Honnold

For transcript, click the Download button above. For video index, click the link below. John O. Honnold was the William A. Schnader Professor of Commercial Law at the University of Pennsylvania Law School, after joining the school\u27s faculty in 1946.[His academic focus was private international law. From 1969 to 1974 he served as chief of legal staff for the United Nations Commission on International Trade Law (UNCITRAL), where he was instrumental in drafting the U.N. Convention on Contracts for the International Sale of Goods.He died in 2011

Interview with John O. Honnold

For transcript, click the Download button above. For video index, click the link below. John O. Honnold was the William A. Schnader Professor of Commercial Law at the University of Pennsylvania Law School, after joining the school\u27s faculty in 1946.[His academic focus was private international law. From 1969 to 1974 he served as chief of legal staff for the United Nations Commission on International Trade Law (UNCITRAL), where he was instrumental in drafting the U.N. Convention on Contracts for the International Sale of Goods.He died in 2011

Time‐ and Frequency‐Domain Characteristics of Atrial Electrograms During Sinus Rhythm and Atrial Fibrillation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87064/1/j.1540-8167.2011.02022.x.pd

Complex Electrograms Within the Coronary Sinus: Time- and Frequency-Domain Characteristics, Effects of Antral Pulmonary Vein Isolation, and Relationship to Clinical Outcome in Patients with Paroxysmal and Persistent Atrial Fibrillation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73243/1/j.1540-8167.2008.01175.x.pd