Chiral gravity in higher dimensions

We construct a chiral theory of gravity in 7 and 8 dimensions, which are equivalent to Einstein-Cartan theory using less variables. In these dimensions, we can construct such higher dimensional chiral gravity because of the existence of gravitational instanton. The octonionic-valued variables in the theory represent the deviation from the gravitational instanton, and from their non-associativity, prevents the theory to be SO(n) gauge invariant. Still the chiral gravity holds G_2 (7-D), and Spin(7) (8-D) gauge symmetry.Comment: 18 pages, no figures. Minor typos corrected. Updated reference

New Complete Non-compact Spin(7) Manifolds

We construct new explicit metrics on complete non-compact Riemannian 8-manifolds with holonomy Spin(7). One manifold, which we denote by A_8, is topologically R^8 and another, which we denote by B_8, is the bundle of chiral spinors over $S^4$. Unlike the previously-known complete non-compact metric of Spin(7) holonomy, which was also defined on the bundle of chiral spinors over S^4, our new metrics are asymptotically locally conical (ALC): near infinity they approach a circle bundle with fibres of constant length over a cone whose base is the squashed Einstein metric on CP^3. We construct the covariantly-constant spinor and calibrating 4-form. We also obtain an L^2-normalisable harmonic 4-form for the A_8 manifold, and two such 4-forms (of opposite dualities) for the B_8 manifold. We use the metrics to construct new supersymmetric brane solutions in M-theory and string theory. In particular, we construct resolved fractional M2-branes involving the use of the L^2 harmonic 4-forms, and show that for each manifold there is a supersymmetric example. An intriguing feature of the new A_8 and B_8 Spin(7) metrics is that they are actually the same local solution, with the two different complete manifolds corresponding to taking the radial coordinate to be either positive or negative. We make a comparison with the Taub-NUT and Taub-BOLT metrics, which by contrast do not have special holonomy. In an appendix we construct the general solution of our first-order equations for Spin(7) holonomy, and obtain further regular metrics that are complete on manifolds B^+_8 and B^-_8 similar to B_8.Comment: Latex, 29 pages. Appendix obtaining general solution of first-order equations and additional complete Spin(7) manifolds adde

You turn me cold: evidence for temperature contagion

Introduction During social interactions, our own physiological responses influence those of others. Synchronization of physiological (and behavioural) responses can facilitate emotional understanding and group coherence through inter-subjectivity. Here we investigate if observing cues indicating a change in another's body temperature results in a corresponding temperature change in the observer. Methods Thirty-six healthy participants (age; 22.9±3.1 yrs) each observed, then rated, eight purpose-made videos (3 min duration) that depicted actors with either their right or left hand in visibly warm (warm videos) or cold water (cold videos). Four control videos with the actors' hand in front of the water were also shown. Temperature of participant observers' right and left hands was concurrently measured using a thermistor within a Wheatstone bridge with a theoretical temperature sensitivity of <0.0001°C. Temperature data were analysed in a repeated measures ANOVA (temperature × actor's hand × observer's hand). Results Participants rated the videos showing hands immersed in cold water as being significantly cooler than hands immersed in warm water, F(1,34) = 256.67, p0.1). There was however no evidence of left-right mirroring of these temperature effects p>0.1). Sensitivity to temperature contagion was also predicted by inter-individual differences in self-report empathy. Conclusions We illustrate physiological contagion of temperature in healthy individuals, suggesting that empathetic understanding for primary low-level physiological challenges (as well as more complex emotions) are grounded in somatic simulation

Vascular endothelial growth factor in children with neuroblastoma: a retrospective analysis

BACKGROUND: Despite aggressive therapy, advanced stage neuroblastoma patients have poor survival rates. Although angiogenesis correlates with advanced tumour stage and plays an important role in determining the tumour response to treatment in general, clinical data are still insufficient, and more clinical evaluations are needed to draw conclusions. The aim of this study was to evaluate vascular endothelial growth factor (VEGF) expression in patients with neuroblastoma, determine whether it correlates with other prognostic factors and/or therapeutic response, and to assess should VEGF be considered in a routine diagnostic workup. ----- MATERIALS AND METHODS: VEGF expression was determined by immunohistochemistry using anti-VEGF antibody in paraffin embedded primary tumour tissue from 56 neuroblastoma patients. Semiquantitative expression of VEGF was estimated and compared with gender, age, histology, disease stage, therapy, and survival. Statistical analyses, including multivariate analysis, were performed. ----- RESULTS: VEGF expression correlated with disease stage and survival in neuroblastoma patients. Combination of VEGF expression and disease stage as a single prognostic value for survival (P-value = 0.0034; odds ratio (OR) (95%CI) = 26.17 (2.97-230.27) exhibited greater correlation with survival than individually. Hematopoietic stem cell transplantation significantly improved survival of the advanced stage patients with high VEGF expression. ----- CONCLUSION: VEGF expression should be considered in a routine diagnostic workup of children with neuroblastoma, especially in those more than 18 months old and with advanced disease stage. High VEGF expression at the time of disease diagnosis is a bad risk prognostic factor, and can be used to characterize subsets of patients with an unfavourable outcome

Errors in CGAP xProfiler and cDNA DGED: the importance of library parsing and gene selection algorithms

<p>Abstract</p> <p>Background</p> <p>The Cancer Genome Anatomy Project (CGAP) xProfiler and cDNA Digital Gene Expression Displayer (DGED) have been made available to the scientific community over a decade ago and since then were used widely to find genes which are differentially expressed between cancer and normal tissues. The tissue types are usually chosen according to the ontology hierarchy developed by NCBI. The xProfiler uses an internally available flat file database to determine the presence or absence of genes in the chosen libraries, while cDNA DGED uses the publicly available UniGene Expression and Gene relational databases to count the sequences found for each gene in the presented libraries.</p> <p>Results</p> <p>We discovered that the CGAP approach often includes libraries from dependent or irrelevant tissues (one third of libraries were incorrect on average, with some tissue searches no correct libraries being selected at all). We also discovered that the CGAP approach reported genes from outside the selected libraries and may omit genes found within the libraries. Other errors include the incorrect estimation of the significance values and inaccurate settings for the library size cut-off values. We advocated a revised approach to finding libraries associated with tissues. In doing so, libraries from dependent or irrelevant tissues do not get included in the final library pool. We also revised the method for determining the presence or absence of a gene by searching the UniGene relational database, revised calculation of statistical significance and sorted the library cut-off filter.</p> <p>Conclusion</p> <p>Our results justify re-evaluation of all previously reported results where NCBI CGAP expression data and tools were used.</p

Consensus criteria for sensitive detection of minimal neuroblastoma cells in bone marrow, blood and stem cell preparations by immunocytology and QRT-PCR: recommendations by the International Neuroblastoma Risk Group Task Force

Disseminating disease is a predictive and prognostic indicator of poor outcome in children with neuroblastoma. Its accurate and sensitive assessment can facilitate optimal treatment decisions. The International Neuroblastoma Risk Group (INRG) Task Force has defined standardised methods for the determination of minimal disease (MD) by immunocytology (IC) and quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) using disialoganglioside GD2 and tyrosine hydroxylase mRNA respectively. The INRG standard operating procedures (SOPs) define methods for collecting, processing and evaluating bone marrow (BM), peripheral blood (PB) and peripheral blood stem cell harvest by IC and QRT-PCR. Sampling PB and BM is recommended at diagnosis, before and after myeloablative therapy and at the end of treatment. Peripheral blood stem cell products should be analysed at the time of harvest. Performing MD detection according to INRG SOPs will enable laboratories throughout the world to compare their results and thus facilitate quality-controlled multi-centre prospective trials to assess the clinical significance of MD and minimal residual disease in heterogeneous patient groups

New covariant Hamilton formalism for field theory

A novel covariant Hamilton formalism for field theories is proposed in terms of multi-contact structure which is a higher rank generalization of contact 1-form. This formulation is naturally derived from our previous work, Finsler-Kawaguchi Lagrange formulation. This new covariant Hamilton formulation has a strong covariance so that we can take not only time but also spacetime parameter arbitrarily. In other words, our formulation preliminarily includes the concept of spacetime and we should think of the solution submanifold as our spacetime

Lateral hopping of CO on Cu(111) induced by femtosecond laser pulses

We present a theoretical study of the lateral hopping of a single CO molecule on Cu (111) induced by femtosecond laser pulses by Mehlhorn et al. [Phys. Rev. Lett. 104, 076101 (2010)]. Our model assumes an intermode coupling between the CO frustrated translation (FT) and frustrated rotation (FR) modes with a weak and strong electronic friction coupling to hot electrons, respectively, and heat transfer between the FT mode and the substrate phonons. In this model the effective electronic friction coupling of the FT mode depends on the absorbed laser fluence F through the temperature of the FR mode. The calculated hopping yield as a function of F nicely reproduces the nonlinear increase observed above F=4.0 J/m(2). It is found that the electronic heating via friction coupling nor the phonon coupling alone cannot explain the experimental result. Both heatings are cooperatively responsible for CO hopping on Cu (111). The electronic heat transfer dominates over the phononic one at high F, where the effective electronic friction coupling becomes larger than the phononic coupling

Lateral hopping of CO molecules on Pt(111) surface by femtosecond laser pulses

Theory of heat transfer between adsorbate vibrational degrees of freedom and ultrafast laser heated hot electrons including vibrational intermode coupling is applied to calculate two-pulse correlation, laser fluence dependence and time dependence of lateral hopping of CO molecules from a step to terrace site on a stepped Pt (111) surface. The intermode coupling is a key ingredient to describe vibrational heating of the frustrated translation mode responsible for the CO hopping. The calculated results are in good agreement with the experimental results, especially if we scale down the experimentally determined absorbed fluence. It is found that CO hopping is induced by indirect heating of the FT mode by the FR mode with a strong frictional coupling to hot electrons