Implementation and analysis of list mode algorithm using tubes of response on a dedicated brain and breast PET

In this work we present an innovative algorithm for the reconstruction of PET images based on the List-Mode (LM) technique which improves their spatial resolution compared to results obtained with current MLEM algorithms. This study appears as a part of a large project with the aim of improving diagnosis in early Alzheimer disease stages by means of a newly developed hybrid PET-MR insert. At the present, Alzheimer is the most relevant neurodegenerative disease and the best way to apply an effective treatment is its early diagnosis. The PET device will consist of several monolithic LYSO crystals coupled to SiPM detectors. Monolithic crystals can reduce scanner costs with the advantage to enable implementation of very small virtual pixels in their geometry. This is especially useful for LM reconstruction algorithms, since they do not need a pre-calculated system matrix. We have developed an LM algorithm which has been initially tested with a large aperture (186 mm) breast PET system. Such an algorithm instead of using the common lines of response, incorporates a novel calculation of tubes of response. The new approach improves the volumetric spatial resolution about a factor 2 at the border of the field of view when compared with traditionally used MLEM algorithm. Moreover, it has also shown to decrease the image noise, thus increasing the image quality. © 2012 Elsevier B.V. All rights reserved.This work was supported by the Centre for Industrial Technological Development co-funded by FEDER through the Technology Fund (DREAM Project, IDI-20110718), by the Spanish Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I+D+I) under Grant. No. FIS2010-21216-CO2-01TEO 2008/114.Moliner Martínez, L.; Correcher, C.; González Martínez, AJ.; Conde Castellanos, PE.; Hernández Hernández, L.; Orero Palomares, A.; Rodríguez Álvarez, MJ.... (2013). Implementation and analysis of list mode algorithm using tubes of response on a dedicated brain and breast PET. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 702:129-132. https://doi.org/10.1016/j.nima.2012.08.029S12913270

The problem of uncertainty integration and geo - information harmonization

In infrastructural projects, communication between involved parties is difficult. This among other things, is caused by inferior quality and uncertain information concerning collected data and derived real world representations. Particularly in subsurface geotechnical representations uncertainties are high, since only sparse information is available for the interpretation. This leads to the introduction of "interpretational uncertainties" into the representation; that are, uncertainties introduced by the expert using own knowledge and experience for the data interpretation. This, in addition to the variety of data and information types, makes harmonization of geo-information extremely difficult. This paper summarizes available methods and software packages as used by different professionals in infrastructural development for the representation of real world and design objects as well as for the management of geo-information. Furthermore, it emphasizes existing problems and gaps towards harmonized handling of geo-information including uncertainty estimations; with focus on 'interpretational uncertainties' in subsurface representations