Effects of abdominal and vaginal hysterectomy on anorectal functions along with quality of life of the patient

Objectives and background:Hysterectomy is the most commonly performed major gynecological operation for both benign and malign gynecologic conditions. After hysterectomy, although some investigators have declared an increased incidence of urinary and anorectal dysfunction, some others could not show any connection. Methods: The voluntary patients were divided in two groups: abdominal hysterectomy (Group 1) and vaginal hysterectomy (Group 2). Anal manometry and all the other examinations of the patients were performed at the Department of General Surgery Endoscopy Unit of Ankara University, Faculty of Medicine. Results: When the quality of life of the patients was assessed before the operation and on the 12 th post-operative month via the SF-36 form; it can be seen that body pain parameters of the patients in Group 1 had significantly improved and there is no statistical difference in other parameters. When the effect of hysterectomy on the quality of life of the patients was evaluated by the “Cleveland Clinic Global Quality of Life” form, the statistically significant improvement in the quality of life of the patients in Group 2 was observed. Conclusion: If the type of operation (vaginal or abdominal) is performed due to benign causes, it does not affect the urinary and anorectal functions of the patients. Depending on the decrease of complaints of the patients, it has a positive effect on the quality of life. © 2018 Birsen et al

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Effects of abdominal and vaginal hysterectomy on anorectal functions along with quality of life of the patient

Objectives and background:Hysterectomy is the most commonly performed major gynecological operation for both benign and malign gynecologic conditions. After hysterectomy, although some investigators have declared an increased incidence of urinary and anorectal dysfunction, some others could not show any connection. Methods: The voluntary patients were divided in two groups: abdominal hysterectomy (Group 1) and vaginal hysterectomy (Group 2). Anal manometry and all the other examinations of the patients were performed at the Department of General Surgery Endoscopy Unit of Ankara University, Faculty of Medicine. Results: When the quality of life of the patients was assessed before the operation and on the 12 th post-operative month via the SF-36 form; it can be seen that body pain parameters of the patients in Group 1 had significantly improved and there is no statistical difference in other parameters. When the effect of hysterectomy on the quality of life of the patients was evaluated by the “Cleveland Clinic Global Quality of Life” form, the statistically significant improvement in the quality of life of the patients in Group 2 was observed. Conclusion: If the type of operation (vaginal or abdominal) is performed due to benign causes, it does not affect the urinary and anorectal functions of the patients. Depending on the decrease of complaints of the patients, it has a positive effect on the quality of life. © 2018 Birsen et al

Chemical constituents and cytotoxic activity of Ranunculus pedatus subsp. Pedatus

[No abstract available]05/ECZ/013This research was supported by Ege University Research Fund (No. 05/ECZ/013), Izmir, Turkey. The authors also thank Prof. Dr. Alessandra Braca for NMR and MS spectral measurements. -

Chemo-profiling of some Turkish Galanthus L. (Amaryllidaceae) species and their anticholinesterase activity

Amaryllidaceae family, consisting of economically important plants with ornamental value, is very well-known for its isoquinoline alkaloids with variable biological activities and chemical structures. Among these alkaloids, an effective acetylcholinesterase inhibitor galanthamine, is prescribed widely in the treatment of Alzheimer's disease. Plants of the Amaryllidaceae family are therefore, subjected to intensive research to find potent cholinesterase inhibitors. The chemical composition of three Galanthus species including Galanthus krasnovii A.P. Khokhr., Galanthus gracilis ?elak. and an endemic species Galanthus peshmenii A.P. Davis & C.D. Brickell were analyzed by GC–MS. In total, twenty-five alkaloids with various chemical structure types and a lignan, namely epipinoresinol were identified. Cholinesterase inhibitory potentials of the plant extracts were also determined by in vitro Ellman's method. Extracts of Galanthus krasnovii bulbs displayed the most promising acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities (AChE: IC50: 8.26 µg/mL and BuChE: IC50: 6.23 µg/mL). © 2020Ege Üniversitesi: 13/ECZ/018 Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAK: 104T272This work was partially supported by Ege University , Research Fund (Project Number: 13/ECZ/018 ), and TUBITAK ( Scientific and Technological Research Council of Turkey , Project Number: 104T272 )

GC-MS investigation and acetylcholinesterase inhibitory activity of Galanthus rizehensis

GC-MS (gas chromatography-mass spectrometry) analyses of alkaloids in the aerial parts and bulbs of Galanthus rizehensis Stern (Amaryllidaceae), collected during two different vegetation periods, was performed. Twenty three alkaloids were identified in four different alkaloid extracts. Acetylcholinesterase (AChE) inhibitory activities of the alkaloid extracts were tested. Both the highest alkaloid diversity and the most potent inhibitory activity (IC50 12.94 µg/ml) were obtained in extracts from the bulbs of G. rizehensis collected during the fruiting period. © 2013 Verlag der Zeitschrift für Naturforschung, Tübingen