46 research outputs found
How does image quality affect radiologists' perceived ability for image interpretation and lesion detection in digital mammography?
OBJECTIVES: To study how radiologists' perceived ability to interpret digital mammography (DM) images is affected by decreases in image quality. METHODS: One view from 45 DM cases (including 30 cancers) was degraded to six levels each of two acquisition-related issues (lower spatial resolution and increased quantum noise) and three post-processing-related issues (lower and higher contrast and increased correlated noise) seen during clinical evaluation of DM systems. The images were shown to fifteen breast screening radiologists from five countries. Aware of lesion location, the radiologists selected the most-degraded mammogram (indexed from 1 (reference) to 7 (most degraded)) they still felt was acceptable for interpretation. The median selected index, per degradation type, was calculated separately for calcification and soft tissue (including normal) cases. Using the two-sided, non-parametric Mann-Whitney test, the median indices for each case and degradation type were compared. RESULTS: Radiologists were not tolerant to increases (medians: 1.5 (calcifications) and 2 (soft tissue)) or decreases (median: 2, for both types) in contrast, but were more tolerant to correlated noise (median: 3, for both types). Increases in quantum noise were tolerated more for calcifications than for soft tissue cases (medians: 3 vs. 4, p = 0.02). Spatial resolution losses were considered less acceptable for calcification detection than for soft tissue cases (medians: 3.5 vs. 5, p = 0.001). CONCLUSIONS: Perceived ability of radiologists for image interpretation in DM was affected not only by image acquisition-related issues but also by image post-processing issues, and some of those issues affected calcification cases more than soft tissue cases. KEY POINTS: • Lower spatial resolution and increased quantum noise affected the radiologists' perceived ability to interpret calcification cases more than soft tissue lesion or normal cases. • Post-acquisition image processing-related effects, not only image acquisition-related effects, also impact the perceived ability of radiologists to interpret images and detect lesions. • In addition to current practices, post-acquisition image processing-related effects need to also be considered during the testing and evaluation of digital mammography systems
From the set-up of a screening program of breast cancer patients to the identification of the first BRCA mutation in the DR Congo
Image-guided breast biopsy and localisation: recommendations for information to women and referring physicians by the European Society of Breast Imaging
Abstract: We summarise here the information to be provided to women and referring physicians about percutaneous breast biopsy and lesion localisation under imaging guidance. After explaining why a preoperative diagnosis with a percutaneous biopsy is preferred to surgical biopsy, we illustrate the criteria used by radiologists for choosing the most appropriate combination of device type for sampling and imaging technique for guidance. Then, we describe the commonly used devices, from fine-needle sampling to tissue biopsy with larger needles, namely core needle biopsy and vacuum-assisted biopsy, and how mammography, digital breast tomosynthesis, ultrasound, or magnetic resonance imaging work for targeting the lesion for sampling or localisation. The differences among the techniques available for localisation (carbon marking, metallic wire, radiotracer injection, radioactive seed, and magnetic seed localisation) are illustrated. Type and rate of possible complications are described and the issue of concomitant antiplatelet or anticoagulant therapy is also addressed. The importance of pathological-radiological correlation is highlighted: when evaluating the results of any needle sampling, the radiologist must check the concordance between the cytology/pathology report of the sample and the radiological appearance of the biopsied lesion. We recommend that special attention is paid to a proper and tactful approach when communicating to the woman the need for tissue sampling as well as the possibility of cancer diagnosis, repeat tissue sampling, and or even surgery when tissue sampling shows a lesion with uncertain malignant potential (also referred to as “high-risk” or B3 lesions). Finally, seven frequently asked questions are answered
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Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk.
Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing primary invasive breast cancer. This study aimed to evaluate the association between a recently validated PRS of 313 germline variants (PRS313) and contralateral breast cancer (CBC) risk. We included 56,068 women of European ancestry diagnosed with first invasive breast cancer from 1990 onward with follow-up from the Breast Cancer Association Consortium. Metachronous CBC risk (N = 1,027) according to the distribution of PRS313 was quantified using Cox regression analyses. We assessed PRS313 interaction with age at first diagnosis, family history, morphology, ER status, PR status, and HER2 status, and (neo)adjuvant therapy. In studies of Asian women, with limited follow-up, CBC risk associated with PRS313 was assessed using logistic regression for 340 women with CBC compared with 12,133 women with unilateral breast cancer. Higher PRS313 was associated with increased CBC risk: hazard ratio per standard deviation (SD) = 1.25 (95%CI = 1.18-1.33) for Europeans, and an OR per SD = 1.15 (95%CI = 1.02-1.29) for Asians. The absolute lifetime risks of CBC, accounting for death as competing risk, were 12.4% for European women at the 10th percentile and 20.5% at the 90th percentile of PRS313. We found no evidence of confounding by or interaction with individual characteristics, characteristics of the primary tumor, or treatment. The C-index for the PRS313 alone was 0.563 (95%CI = 0.547-0.586). In conclusion, PRS313 is an independent factor associated with CBC risk and can be incorporated into CBC risk prediction models to help improve stratification and optimize surveillance and treatment strategies
Common germline polymorphisms associated with breast cancer-specific survival
Abstract
Introduction
Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium.
Methods
A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value <0.05 were included. Single nucleotide polymorphisms that had been previously reported as nominally associated with at least one survival outcome were evaluated in the pooled analysis of over 37,000 breast cancer cases for association with breast cancer-specific survival. Previous associations were evaluated using a one-sided test based on the reported direction of effect.
Results
Fifty-six variants from 45 previous publications were evaluated in the meta-analysis. Fifty-four of these were evaluated in the full set of 37,954 breast cancer cases with 2,900 events and the two additional variants were evaluated in a reduced sample size of 30,000 samples in order to ensure independence from the previously published studies. Five variants reached nominal significance (P <0.05) in the pooled GWAS data compared to 2.8 expected under the null hypothesis. Seven additional variants were associated (P <0.05) with ER-positive disease.
Conclusions
Although no variants reached genome-wide significance (P <5 x 10−8), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels
International day of radiology : breast imaging
November 8, 2016, is the International Day of Radiology (IDoR), which is dedicated to breast imaging and the essential role that radiology plays in the detection, diagnosis, and management of diseases of the breast (http://www.internationaldayofradiology.com). On the website, you can find the book to honour the International Day of Radiology, Screening & Beyond, which provides an amazing overview of breast imaging, with contributions from many of the world’s top breast radiologists
IPhone TrueDepth® cameras performance compared to optical 3D scanner for imaging the compressed breast shape
Modelling of the breast surface shape under compression in the cranio-caudal and medio-lateral oblique views could advance the development of image processing techniques and of dosimetric estimates in digital mammography and digital breast tomosynthesis. Our goal is to compare the performance of a previously tested and used optical structured light scanning system (SLSS) capable of capturing the breast shape under compression to that of an infrared smartphone-based SLSS. Their performance was compared by scanning a cuboid phantom and two breast shaped phantoms (30 mm and 74 mm thick). Ten scans of the cuboid phantom were acquired with each scanner, and the measured length and thickness of the scanned shape were compared against the ground truth and between the two scanners. The performance of the scanners regarding breast-like phantoms was evaluated by calculating the maximum and mean distance, along with the root mean square difference, between each scanners result and against the matching ground truth. The cuboid phantom analysis showed a statistical difference for the thickness measurement in both scanners and in the length measurement for the optical scanner (p<0.05). However, no statistical difference was found between the scanner measurements. For the breast-like phantoms, the higher maximum distances were found in the infrared scans, but the mean distance between ground truth surface and the scans showed equivalent performance for both scanners. Our results suggest that the smartphone-based SLSS performance is sufficient to be used to create a complete three-dimensional model of the breast shape
Breast imaging surveillance after curative treatment for primary non-metastasised breast cancer in non-high-risk women: a systematic review
OBJECTIVES: The article summarises the available guidelines on breast imaging surveillance after curative treatment for locoregional breast cancer. METHODS: A systematic review of practice guidelines published from 1 January 2007 to 1 January 2017 was performed according to PRISMA methodology. The search was conducted for the EMBASE, MEDLINE, Cochrane and Centre for Reviews and Dissemination databases. On 8 July 2018, all included guidelines were updated to the most recent version. RESULTS: Twenty-one guidelines originating from 18 publishing bodies matched criteria. Publishing bodies consisted of seven governmental institutions, nine medical societies and two mixed collaborations. Publishing boards consisted of six radiological, four oncological, and 11 multidisciplinary teams. Annual bilateral mammography surveillance after breast-conserving therapy was recommended by 17/18 (94.4%) publishing bodies. Annual contralateral mammography surveillance after mastectomy was recommended by 13/18 (72.2%) publishing bodies. Routine use of digital breast tomosynthesis was recommended by 1/18 (5.6%) publishing bodies. Routine breast ultrasound surveillance was recommended by 2/18 (11.1%), deemed optional by 4/18 (22.2%) and not supported by 8/18 (44.4%) publishing bodies. Routine breast magnetic resonance imaging (MRI) surveillance was not recommended by 16/18 (88.9%) publishing bodies, although 6/18 (33.3%) specified subgroups for systematic MRI surveillance. CONCLUSIONS: Annual mammography is currently the 'gold standard' for breast imaging surveillance. The role of digital breast tomosynthesis (DBT) remains to be further investigated. Most guidelines do not recommend routine breast ultrasound or MRI surveillance, unless indicated by additional risk factors.status: publishe
A statistical evaluation of eye-tracking data of screening mammography: Effects of expertise and experience on image reading
status: publishe
A statistical evaluation of eye-tracking data of screening mammography: Effects of expertise and experience on image reading
Screening mammography has been widely used over the last few decades to detect breast cancers at an early stage using low-dose X-ray imaging. Being able to detect breast lesions early is highly beneficial for the patients as it makes treatment more successful and increases the chance of recovery. However, lesion detection is prone to false negative and false positive results due to the subtlety or low prevalence of the lesions, which compromises patient safety. It is critical to understand human perception and interpretation of images and use such understanding to develop ways to help increase the accuracy of cancer detection. In this paper, we present a large-scale eye-tracking study where 1,568 eye movement trials of expert breast radiologists, trainee radiologists, and physicists were recorded while assessing a large number of mammogram images. First, we statistically analysed viewers’ gaze behaviour based on their mean fixation duration. Results demonstrated that there was no difference amongst experts, and that trainees’ mean fixation duration was significantly shorter than experts and physicists’ fixation duration was significantly longer than that of the experts. Second, we evaluated spatial gaze deployment of the three viewer groups and quantified the difference between groups. Results showed that trainees and physicists deviated from where expert radiologists looked in images, and trainees performed better than physicists in terms of focusing on regions of interest. Finally, we investigated the saccadic behaviour of viewers and illustrated the differences between viewer groups in terms of saccade amplitudes and orientations