137 research outputs found
Detection of Atmospheric Cherenkov Radiation Using Solar Heliostat Mirrors
The gamma-ray energy region between 20 and 250 GeV is largely unexplored.
Ground-based atmospheric Cherenkov detectors offer a possible way to explore
this region, but large Cherenkov photon collection areas are needed to achieve
low energy thresholds. This paper discusses the development of a Cherenkov
detector using the heliostat mirrors of a solar power plant as the primary
collector. As part of this development, we built a prototype detector
consisting of four heliostat mirrors and used it to record atmospheric
Cherenkov radiation produced in extensive air showers created by cosmic ray
particles.Comment: 16 latex pages, 8 postscript figures, uses psfig.sty, to be published
in Astroparticle Physic
The STACEE-32 Ground Based Gamma-ray Detector
We describe the design and performance of the Solar Tower Atmospheric
Cherenkov Effect Experiment detector in its initial configuration (STACEE-32).
STACEE is a new ground-based gamma ray detector using the atmospheric Cherenkov
technique. In STACEE, the heliostats of a solar energy research array are used
to collect and focus the Cherenkov photons produced in gamma-ray induced air
showers. The large Cherenkov photon collection area of STACEE results in a
gamma-ray energy threshold below that of previous detectors.Comment: 45 pages, 25 figures, Accepted for publication in Nuclear Instruments
and Methods
OSETI with STACEE: A Search for Nanosecond Optical Transients from Nearby Stars
We have used the STACEE high-energy gamma-ray detector to look for fast
blue-green laser pulses from the vicinity of 187 stars. The STACEE detector
offers unprecedented light-collecting capability for the detection of
nanosecond pulses from such lasers. We estimate STACEE's sensitivity to be
approximately 10 photons per square meter at a wavelength of 420 nm. The stars
have been chosen because their characteristics are such that they may harbor
habitable planets and they are relatively close to Earth. Each star was
observed for 10 minutes and we found no evidence for laser pulses in any of the
data sets.Comment: 38 pages, 12 figures. Accepted for publication in Astrobiolog
A perturbative approach to decays into two mesons
The modified perturbative approach in which transverse degrees of freedom as
well as Sudakov suppressions are taken into account, is applied to decays
into two mesons. The influence of various model parameters (CKM matrix
elements, decay constant, mesonic wave functions) on the results as well as
short distance corrections to the weak Hamiltonian are discussed in some
detail. The perturbative contributions to the decays yield branching ratios
of the order of which values are well below the upper
limit for the branching ratio as measured by CLEO.Comment: 26 pages, RevTex, 6 figures appended (compressed and uuencode using
'uufiles'
Very high energy observations of the BL Lac objects 3C 66A and OJ 287
Using the Solar Tower Atmospheric Cherenkov Effect Experiment (STACEE), we
have observed the BL Lac objects 3C 66A and OJ 287. These are members of the
class of low-frequency-peaked BL Lac objects (LBLs) and are two of the three
LBLs predicted by Costamante and Ghisellini to be potential sources of very
high energy (>100 GeV) gamma-ray emission. The third candidate, BL Lacertae,
has recently been detected by the MAGIC collaboration. Our observations have
not produced detections; we calculate a 99% CL upper limit of flux from 3C 66A
of 0.15 Crab flux units and from OJ 287 our limit is 0.52 Crab. These limits
assume a Crab-like energy spectrum with an effective energy threshold of 185
GeV.Comment: 24 pages, 15 figures, Accepted for publication in Astroparticle
Physic
A High Statistics Search for Ultra-High Energy Gamma-Ray Emission from Cygnus X-3 and Hercules X-1
We have carried out a high statistics (2 Billion events) search for
ultra-high energy gamma-ray emission from the X-ray binary sources Cygnus X-3
and Hercules X-1. Using data taken with the CASA-MIA detector over a five year
period (1990-1995), we find no evidence for steady emission from either source
at energies above 115 TeV. The derived upper limits on such emission are more
than two orders of magnitude lower than earlier claimed detections. We also
find no evidence for neutral particle or gamma-ray emission from either source
on time scales of one day and 0.5 hr. For Cygnus X-3, there is no evidence for
emission correlated with the 4.8 hr X-ray periodicity or with the occurrence of
large radio flares. Unless one postulates that these sources were very active
earlier and are now dormant, the limits presented here put into question the
earlier results, and highlight the difficulties that possible future
experiments will have in detecting gamma-ray signals at ultra-high energies.Comment: 26 LaTeX pages, 16 PostScript figures, uses psfig.sty to be published
in Physical Review
Strengthening the composite protective shield of light-weight ship against ballistic impacts: analytical and experimental
Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat
FUT2 Variants Confer Susceptibility to Familial Otitis Media
Non-secretor status due to homozygosity for the common FUT2 variant c.461G>A (p.Trp154∗) is associated with either risk for autoimmune diseases or protection against viral diarrhea and HIV. We determined the role of FUT2 in otitis media susceptibility by obtaining DNA samples from 609 multi-ethnic families and simplex case subjects with otitis media. Exome and Sanger sequencing, linkage analysis, and Fisher exact and transmission disequilibrium tests (TDT) were performed. The common FUT2 c.604C>T (p.Arg202∗) variant co-segregates with otitis media in a Filipino pedigree (LOD = 4.0). Additionally, a rare variant, c.412C>T (p.Arg138Cys), is associated with recurrent/chronic otitis media in European-American children (p = 1.2 × 10−5) and US trios (TDT p = 0.01). The c.461G>A (p.Trp154∗) variant was also over-transmitted in US trios (TDT p = 0.01) and was associated with shifts in middle ear microbiota composition (PERMANOVA p 20 were combined, FUT2 variants were over-transmitted in trios (TDT p = 0.001). Fut2 is transiently upregulated in mouse middle ear after inoculation with non-typeable Haemophilus influenzae. Four FUT2 variants—namely p.Ala104Val, p.Arg138Cys, p.Trp154∗, and p.Arg202∗—reduced A antigen in mutant-transfected COS-7 cells, while the nonsense variants also reduced FUT2 protein levels. Common and rare FUT2 variants confer susceptibility to otitis media, likely by modifying the middle ear microbiome through regulation of A antigen levels in epithelial cells. Our families demonstrate marked intra-familial genetic heterogeneity, suggesting that multiple combinations of common and rare variants plus environmental factors influence the individual otitis media phenotype as a complex trait
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
DNA methylation quantitative trait locus (mQTL) analyses on 32,851 participants identify genetic variants associated with DNA methylation at 420,509 sites in blood, resulting in a database of >270,000 independent mQTLs.Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantitative trait locus (mQTL) analyses on 32,851 participants, identifying genetic variants associated with DNAm at 420,509 DNAm sites in blood. We present a database of >270,000 independent mQTLs, of which 8.5% comprise long-range (trans) associations. Identified mQTL associations explain 15-17% of the additive genetic variance of DNAm. We show that the genetic architecture of DNAm levels is highly polygenic. Using shared genetic control between distal DNAm sites, we constructed networks, identifying 405 discrete genomic communities enriched for genomic annotations and complex traits. Shared genetic variants are associated with both DNAm levels and complex diseases, but only in a minority of cases do these associations reflect causal relationships from DNAm to trait or vice versa, indicating a more complex genotype-phenotype map than previously anticipated.Molecular Epidemiolog
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